We　report　a　novel　biomimetic　drug　discovery　platform　using　high　expression　epidermal　growth　factor　receptor　(EGFR)　HEK　293　cell　membrane　camouflaged　magnetic　nanoparticles.　The　EGFR/magnetic　cell　membrane　nanoparticles　(MCMNs)　integrated　desirable　magnetic　features　and　special　binding　bioaffinity.　Application　of　this　drug-targeting　concept　is　expected　to　pave　ways　to　a　new　drug　discovery　strategy.