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Author:

Kang Yongyong (Kang Yongyong.) | Yang Xiaofei (Yang Xiaofei.) | Lin Jiadong (Lin Jiadong.) | Ye Kai (Ye Kai.)

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Abstract:

Phylogenetic tree is essential to understand evolution and it is usually constructed through multiple sequence alignment, which suffers from heavy computational burdens and requires sophisticated parameter tuning. Recently, alignment free methods based on k-mer profiles or common substrings provide alternative ways to construct phylogenetic trees. However, most of these methods ignore the global similarities between sequences or some specific valuable features, e.g., frequent patterns overall datasets. To make further improvement, we propose an alignment free algorithm based on sequential pattern mining, where each sequence is converted into a binary representation of sequential patterns among sequences. The phylogenetic tree is further constructed via clustering distance matrix which is calculated from pattern vectors. To increase accuracy for highly divergent sequences, we consider pattern weight and filtering redundancy sub-patterns. Both simulated and real data demonstrates our method outperform other alignment free methods, especially for large sequence set with low similarity.

Keyword:

alignment free multiple sequence alignment phylogenetic tree sequential pattern mining

Author Community:

  • [ 1 ] [Ye Kai]School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China. kaiye@xjtu.edu.cn.
  • [ 2 ] [Lin Jiadong]School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China. jiadong66@stu.xjtu.edu.cn.
  • [ 3 ] [Yang Xiaofei]School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China. xfyang@xjtu.edu.cn.
  • [ 4 ] [Kang Yongyong]School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China. kangyong@stu.xjtu.edu.cn.

Reprint Author's Address:

  • Xi An Jiao Tong Univ, Sch Elect & Informat Engn, Xian 710049, Shaanxi, Peoples R China.

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Source :

Genes

ISSN: 2073-4425

Year: 2019

Issue: 2

Volume: 10

3 . 7 5 9

JCR@2019

4 . 0 9 6

JCR@2020

ESI Discipline: MOLECULAR BIOLOGY & GENETICS;

ESI HC Threshold:156

JCR Journal Grade:4

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 4

SCOPUS Cited Count: 6

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 4

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