Multi-hole　probe　(MHP),　as　a　classical　measuring　instrument,　continues　to　play　an　important　role　in　the　pressure　and　velocity　measurements　for　industrial　applications　by　virtue　of　its　robust　and　reliable　performance　as　well　as　the　simple　structure　and　low　cost.　But　the　flow　directionality　limitations　and　the　low　efficiency　of　traditional　operations　become　obstacles　to　the　large-scale　measurements　of　MHPs.　In　this　paper,　an　improved　operating　method　is　adopted　for　conventional　MHPs　to　extend　their　measuring　range　of　incidence　angles,　and　a　corresponding　auto-measuring　system　has　been　developed　to　realize　automatic　calibration　and　measurement　of　MHPs　for　industrial　large-scale　flow　measurements.　Measurement　uncertainties　of　the　system　have　been　experimentally　analyzed,　verifying　a　good　accuracy:　errors　of　0.36A　degrees　in　pitch　angle,　0.40A　degrees　in　yaw　angle　and　0.83%　in　velocity　magnitude　(95%　CI).　Furthermore,　this　auto-measuring　system　has　been　applied　in　the　large-scale　measurements　on　different　radial　inlets　for　industrial　centrifugal　compressors,　which　provide　valuable　flow　information　that　was　not　previously　available　for　industrial　productions　and　assist　with　the　improvement　study.　Analysis　and　applications　in　this　paper　prove　that　the　developed　system　not　only　reduces　the　flow　directionality　limitations　of　conventional　MHPs,　but　also　significantly　improves　the　experimental　efficiency　and　the　control-precision　of　the　probe,　achieves　a　good　repeatability　and　ensures　the　reliability　of　the　experimental　data,　which　satisfies　the　requirements　of　large-scale　measurements　in　industrial　applications.　Meanwhile,　the　portability　of　the　system　makes　it　more　convenient　and　flexible　to　be　applied　in　various　industrial　productions.