Author：
Shi, Yongyong
(Shi, Yongyong.)
|
Li, Li
(Li, Li.)
|
Hu, Zhibin
(Hu, Zhibin.)
|
Li, Shuang
(Li, Shuang.)
|
Wang, Shixuan
(Wang, Shixuan.)
|
Liu, Jihong
(Liu, Jihong.)
|
Wu, Chen
(Wu, Chen.)
|
He, Lin
(He, Lin.)
|
Zhou, Jianfeng
(Zhou, Jianfeng.)
|
Li, Zhiqiang
(Li, Zhiqiang.)
|
Hu, Ting
(Hu, Ting.)
|
Chen, Yile
(Chen, Yile.)
|
Jia, Yao
(Jia, Yao.)
|
Wang, Shaoshuai
(Wang, Shaoshuai.)
|
Wu, Li
(Wu, Li.)
|
Cheng, Xiaodong
(Cheng, Xiaodong.)
|
Yang, Zhijun
(Yang, Zhijun.)
|
Yang, Ru
(Yang, Ru.)
|
Li, Xiong
(Li, Xiong.)
|
Huang, Kecheng
(Huang, Kecheng.)
|
Zhang, Qinghua
(Zhang, Qinghua.)
|
Zhou, Hang
(Zhou, Hang.)
|
Tang, Fangxu
(Tang, Fangxu.)
|
Chen, Zhilan
(Chen, Zhilan.)
|
Shen, Jian
(Shen, Jian.)
|
Jiang, Jie
(Jiang, Jie.)
|
Ding, Hu
(Ding, Hu.)
|
Xing, Hui
(Xing, Hui.)
|
Zhang, Shulan
(Zhang, Shulan.)
|
Qu, Pengpeng
(Qu, Pengpeng.)
|
Song, Xiaojie
(Song, Xiaojie.)
|
Lin, Zhongqiu
(Lin, Zhongqiu.)
|
Deng, Dongrui
(Deng, Dongrui.)
|
Xi, Ling
(Xi, Ling.)
|
Lv, Weiguo
(Lv, Weiguo.)
|
Han, Xiaobing
(Han, Xiaobing.)
|
Tao, Guangshi
(Tao, Guangshi.)
|
Yan, Lixing
(Yan, Lixing.)
|
Han, Zhedong
(Han, Zhedong.)
|
Li, Zhuang
(Li, Zhuang.)
|
Miao, Xiaoping
(Miao, Xiaoping.)
|
Pan, Shandong
(Pan, Shandong.)
|
Shen, Yuanming
(Shen, Yuanming.)
|
Wang, Hui
(Wang, Hui.)
|
Liu, Dan
(Liu, Dan.)
|
Gong, Ee
(Gong, Ee.)
|
Li, Zheng
(Li, Zheng.)
|
Zhou, Limei
(Zhou, Limei.)
|
Luan, Xiaomei
(Luan, Xiaomei.)
|
Wang, Chuping
(Wang, Chuping.)
|
Song, Qian
(Song, Qian.)
|
Wu, Sufang
(Wu, Sufang.)
|
Xu, Hongbin
(Xu, Hongbin.)
|
Shen, Jiawei
(Shen, Jiawei.)
|
Qiang, Fulin
(Qiang, Fulin.)
|
Ma, Gang
(Ma, Gang.)
|
Liu, Li
(Liu, Li.)
|
Chen, Xiaojun
(Chen, Xiaojun.)
|
Liu, Jibin
(Liu, Jibin.)
|
Wu, Jiangping
(Wu, Jiangping.)
|
Shen, Yan
(Shen, Yan.)
|
Wen, Yang
(Wen, Yang.)
|
Chu, Minjie
(Chu, Minjie.)
|
Yu, Jiang
(Yu, Jiang.)
|
Hu, Xiaoxia
(Hu, Xiaoxia.)
|
Fan, Yujuan
(Fan, Yujuan.)
|
He, Hongying
(He, Hongying.)
|
Jiang, Yanming
(Jiang, Yanming.)
|
Lei, Zhiying
(Lei, Zhiying.)
|
Liu, Cui
(Liu, Cui.)
|
Chen, Jianhua
(Chen, Jianhua.)
|
Zhang, Yuan
(Zhang, Yuan.)
|
Yi, Cunjian
(Yi, Cunjian.)
|
Chen, Shuangyun
(Chen, Shuangyun.)
|
Li, Wenjin
(Li, Wenjin.)
|
Wang, Daowen
(Wang, Daowen.)
|
Wang, Zehua
(Wang, Zehua.)
|
Di, Wen
(Di, Wen.)
|
Shen, Keng
(Shen, Keng.)
|
Lin, Dongxin
(Lin, Dongxin.)
|
Shen, Hongbing
(Shen, Hongbing.)
|
Feng, Youji
(Feng, Youji.)
|
Xie, Xing
(Xie, Xing.)
|
Ma, Ding
(Ma, Ding.)
Abstract：
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a ＇stringently matched samples＇ subset (829 cases and 990 controls) from the discovery set on the basis of principal component analysis; the follow-up stages included two independent sample sets (1,824 cases and 3,808 controls for follow-up 1 and 2,343 cases and 3,388 controls for follow-up 2). We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, P-combined,P- stringently matched = 9.69 x 10(-9), per-allele odds ratio (OR)(stringently matched) = 1.26) and 17q12 (rs8067378, P-combined,P- stringently matched = 2.00 x 10(-8), per-allele ORstringently matched = 1.18). We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched = 4.52 x 10(-27), per-allele ORstringently matched = 0.75). Our findings provide new insights into the genetic etiology of cervical cancer.
