It　has　been　suggested　that　combined　effect　of　natural　products　may　improve　the　treatment　effectiveness　in　combating　proliferation　of　cancer　cells.　Here,　we　examined　the　combined　anticancer　activities　of　compounds　of　three　natural　origin　including　baicalein,　curcumin,　and　resveratrol　with　chemotherapy　drug　paclitaxel　respectively,　which　showed　that　combination　of　paclitaxel　with　curcumin　exhibited　synergistic　growth　inhibition　and　induced　significant　apoptosis　in　MCF-7　cell　lines.　Treatment　of　MCF-7　cell　lines　with　paclitaxel　and　curcumin　induced　the　apoptosis　of　regulatory　protein　Bcl-2　but　decreased　Bax　expression.　In　addition,　simultaneous　treatment　with　paclitaxel　and　curcumin　strongly　inhibited　paclitaxel-induced　activities　of　EGFR　signaling.　Furthermore,　the　combination　of　paclitaxel　and　curcumin　exerted　increased　anti-tumor　efficacy　on　mouse　models.　Overall,　our　data　described　the　promising　therapeutic　potential　and　underlying　mechanisms　of　combining　paclitaxel　with　curcumin　in　treating　breast　cancer.