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Author:

Li, Xiaojun (Li, Xiaojun.) | Cai, Hui (Cai, Hui.) | Cui, Xiaohai (Cui, Xiaohai.) | Cao, Peilong (Cao, Peilong.) | Zhang, Jing (Zhang, Jing.) | Li, Gang (Li, Gang.) | Zhang, Jia (Zhang, Jia.)

Indexed by:

SCIE PubMed Scopus

Abstract:

Repositioning of the mediastinum with implantation of a prosthesis seems the favoured approach to treat late complications of pneumonectomy caused by mediastinal shift. However, the traditional prostheses are not designed speciinot signcally for use in the thoracic cavity, sometimes resulting in failure of treatment for many reasons. The aim of our study was to develop a novel prosthesis to promote prevention or treatment of late postpneumonectomy complications. Using 3D printing technology, we created a novel mimetic lung model replicating the native one and then transplanted it into the thoracic cavity of postpneumonectomy dogs to maintain the original position of the mediastinum. Postoperative morbidity and mortality of late complications were compared between transplanted and non-transplanted groups. The safety and feasibility of implanting a 3D printed prosthesis were also evaluated by chest computed tomography (CT) scan and pathological examination. At the 1-year follow-up, pneumonectomy dogs with 3D printed lungs showed less morbidity and mortality of late complications. CT images indicated dynamic mediastinal shift in pneumonectomy-only dogs with enlarged contralateral lungs. Nevertheless, there was no obvious change in the position of the mediastinum in 3D printed lung transplanted individuals. Moreover, the 3D printed lungs did not cause any additional side effects and revealed good histocompatibility and tolerance of recipients. Our experiences indicated the safety, feasibility and efficacy of transplantation with 3D printed lungs for prevention of late postpneumonectomy complications and provided a practical and possibly unique clinical application of 3D printing technology for surgical therapy.

Keyword:

Complications Mediastinum Pneumonectomy Postoperative care Prosthesis

Author Community:

  • [ 1 ] [Li, Xiaojun; Cui, Xiaohai; Zhang, Jing; Li, Gang; Zhang, Jia] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Thorac Surg 2, Xian 710061, Shaanxi, Peoples R China
  • [ 2 ] [Cai, Hui] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anesthesia, Xian 710061, Shaanxi, Peoples R China
  • [ 3 ] [Cao, Peilong] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Pathol, Xian 710061, Shaanxi, Peoples R China

Reprint Author's Address:

  • Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Thorac Surg 2, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.

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Source :

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

ISSN: 1010-7940

Year: 2014

Issue: 5

Volume: 46

Page: E67-E73

3 . 3 0 4

JCR@2014

4 . 1 9 1

JCR@2020

ESI Discipline: CLINICAL MEDICINE;

ESI HC Threshold:188

JCR Journal Grade:2

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 3

SCOPUS Cited Count: 6

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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