Background/Aims:　The　aim　of　our　study　was　to　investigate　the　effect　of　high-salt　diet　on　the　renal　expression　of　renalase　and　the　potential　role　of　the　local　renin-angiotensin　system　in　this　process.　Methods:　Sprague-Dawley　(SD)　rats　were　divided　into　groups　according　to　salt　content　in　diet　and　drug　treatment　as　follows:　normal-salt　diet　(NS),　high-salt　diet　(HS),　high-salt　intake　with　hydralazine　(HS+H),　high-salt　diet　with　enalapril　(HS+E),　and　high-salt　diet　with　valsartan　(HS+V).　The　dietary　intervention　and　drugs　were　given　for　four　weeks.　Renin　activity　and　angiotensin　II　type　1　receptor　(AT1R)　levels　were　detected　by　real-time　PCR.　Renalase　mRNA　and　protein　were　also　measured.　Results:　After　four　weeks,　systolic　blood　pressure　and　proteinuria　were　significantly　increased　in　the　HS　group　with　respect　to　the　NS　group.　Dietary　salt　intake　caused　a　dramatic　decrease　in　renalase　expression　in　the　rat　kidneys.　Renal　cortex　renin　and　AT1R　increased　significantly　in　the　HS　and　HS+H　groups.　Urinary　protein　was　positively　correlated　with　renal　renin　and　AT1R　levels.　However,　in　the　HS+E　and　HS+V　groups,　enalapril　and　valsartan　failed　to　influence　renal　renalase　expression　but　abolished　the　increase　in　proteinuria,　renal　cortex　renin,　and　AT1R　levels　with　respect　to　the　HS　group.　Conclusion:　This　study　indicates　that　high　salt　intake　reduces　renal　expression,　and　renal　RAS　may　be　not　involved　in　the　regulation　of　renalase　in　SD　rats　fed　with　high-salt　diet.　(C)　2015　The　Author(s)　Published　by　S.　Karger　AG,　Basel