Background:　To　compare　the　clinicopathological　features　and　prognosis　between　younger　and　aged　patients　with　hepatocellular　carcinoma　(HCC).　Methods:　We　analyzed　the　outcome　of　451　HCC　patients　underwent　liver　resection,　transcatheter　arterial　chemoembolization　and　radiofrequency　ablation,　respectively.　Then　risk　factors　for　aged　and　younger　patients＇　survival　were　evaluated　by　multivariate　analysis,　respectively.　Results:　The　patients　who　were　older　than　55　years　old　were　defined　as　the　older　group.　The　overall　survival　for　aged　patients　was　significantly　worse　than　those　younger　patients.　The　younger　patients　had　similar　liver　functional　reserve　but　more　aggressive　tumor　factors　than　aged　patients.　Cox　regression　analysis　showed　that　the　elevated　levels　of　aspartate　aminotransferase　(AST)　(Wald　chi(2)　=　3.963,　P　=　0.047,　hazard　ratio　[HR]　=　1.453,　95%　confidence　interval　[CI]:　1.006-2.098),　lower　albumin　(Wald　chi(2)　=　12.213,　P　＜　0.001,　HR　=　1.982,　95%　CI:　1.351-2.910),　tumor　size　(Wald　chi(2)　=　8.179,　P　=　0.004,　HR　=　1.841,　95%　CI:　1.212-2.797),　and　higher　alpha-fetoprotein　level　(Wald　chi(2)　=　4.044,　P　=　0.044,　HR　=　1.465,　95%　CI:　1.010-2.126)　were　independent　prognostic　factors　for　aged　patients,　while　only　elevated　levels　of　AST　(Wald　chi(2)　=　14.491,　P　＜　0.001,　HR　=　2.285,　95%　CI:　1.493-3.496)　and　tumor　size　(Wald　chi(2)　=　21.662,　P　＜　0.001,　HR　=　2.928,　95%　CI:　1.863-4.604)　were　independent　prognostic　factors　for　younger　patients.　Conclusions:　Age　is　a　risk　factor　to　determine　the　prognosis　of　patients　with　HCC.　Aged　patients　who　have　good　liver　functional　reserve　are　still　encouraged　to　receive　curative　therapy.