The　etiology　of　chronic　prostatitis/chronic　pelvic　pain　syndrome　(CP/CPPS)　is　unknown,　which　might　associate　with　substantial　morbidity　and　a　greatly　reduced　quality　of　life　(QOL),　and　significant　healthcare　cost.　In　this　study,　we　investigated　the　symptoms,　psychological　burden　and　sexual　dysfunction　in　men　with　chronic　prostatitis/chronic　pelvic　pain　syndrome.　A　cross-sectional　and　multicenter　survey　was　conducted　from　July　2012　to　January　2014.　Male　participants　were　recruited　from　urology　clinics　in　five　cities　in　China.　Patients　were　asked　to　participate　the　survey　by　completing　a　verbal　questionnaire,　which　consisted　of　social-demographics,　sexual　history,　expressed　prostatic　secretions　evaluation　and　score　of　the　National　Institute　of　Health　Chronic　Prostatitis　Symptom　Index　(NIH-CPSI).　Finally,　a　total　of　1,280　men　completed　the　survey.　The　incidences　of　CP/CPPS　type　III　a　and　III　b　in　men　with　CP/CPPS　(N=801)　were　31.71%　and　68.29%,　respectively.　Significantly　differences　on　NIH-CPSI　scores,　and　the　incidence　of　psychological　burden　and　sexual　dysfunction　were　observed　between　CP/CPPS　and　control　groups.　Similarly,　men　with　the　CP/CPPS　type　III　a　vs.　type　III　b　reported　higher　scores　of　NIH-CPSI,　and　higher　incidence　of　psychological　burden　and　sexual　dysfunction　(P＜0.001　for　all).　Logistic　regression　analyses　showed　that　CP/CPPS　was　significantly　associated　with　NIH-CPSI　scores,　including　total　scores　＞20,　pain　symptoms　＞10,　urinary　symptoms　and　QOL　impact.　In　addition,　CP/CPPS　associated　with　psychological　burden　(Anxiety;　Depression;　Loss　of　sleep;　Decline　in　memory　and　sexual　dysfunction　(PE;　ED;　Decline　in　sexual　desire).　In　conclusion,　CP/CPPS　was　significantly　associated　with　NIH-CPSI,　psychological　burden　and　sexual　dysfunction.