Among　the　hydrogen　storage　properties　of　solid　materials,　e.g.,　metal　hydrides,　the　reaction　kinetics　is　of　great　importance　and　is　often　investigated　by　fitting　reaction　rate　curves　to　given　models.　Thanks　to　such　models,　key　parameters　such　as　activation　energies　can　be　found.　However,　it　is　noteworthy　that　the　parameters　thus　obtained　often　show　great　disparities　even　for　the　same　material.　In　addition　to　experimental　inaccuracies,　these　disparities　may　also　be　attributed　to　the　improper　processing　of　the　data　and　to　suboptimal　experimental　design.　In　this　paper,　we　present　some　theoretical　tools　based　on　optimal　experimental　design　(OED)　to　analyze　and　optimize　the　uncertainty　on　the　estimated　parameters.　The　uncertainty　is　derived　from　asymptotic　statistics　and　it　is　shown　to　be　closely　linked　to　the　sensitivity　of　the　experiment　to　the　parameters.　We　found　that　by　applying　a　new　OED-based　procedure,　the　estimate　of　the　kinetic　parameters　can　be　effectively　improved.　Copyright　(C)　2016,　Hydrogen　Energy　Publications,　LLC.　Published　by　Elsevier　Ltd.　All　rights　reserved.