Voltage-gated　L-type　calcium　channels　(VLCC)　are　distributed　widely　throughout　the　brain.　Among　the　genes　involved　in　schizophrenia　(SCZ),　genes　encoding　VLCC　subunits　have　attracted　widespread　attention.　Among　the　four　subunits　comprising　the　VLCC　(alpha　-　1,　alpha　-　2/d,　beta,　and　gamma),　the.　subunit　that　comprises　an　eight-member　protein　family　is　the　least　well　understood.　In　our　study,　to　further　investigate　the　risk　susceptibility　by　the　gamma　subunit　gene　family　to　SCZ,　we　conducted　a　large-scale　association　study　in　Han　Chinese　individuals.　The　SNP　rs17645023　located　in　the　intergenic　region　of　CACNG4　and　CACNG5　was　identified　to　be　significantly　associated　with　SCZ　(OR　=　0.856,　P　=　5.43　x　10(-5)).　Similar　results　were　obtained　in　the　meta-analysis　with　the　current　SCZ　PGC　data　(OR　=　0.8853).　We　also　identified　a　two-SNP　haplotype　(rs10420331-rs11084307,　P　=　1.4　x　10(-6))　covering　the　intronic　region　of　CACNG8　to　be　significantly　associated　with　SCZ.　Epistasis　analyses　were　conducted,　and　significant　statistical　interaction　(OR　=　0.622,　P　=　2.93　x　10(-6),　P-perm　＜　0.001)　was　observed　between　rs192808　(CACNG6)　and　rs2048137　(CACNG5).　Our　results　indicate　that　CACNG4,　CACNG5,　CACNG6　and　CACNG8　may　contribute　to　the　risk　of　SCZ.　The　statistical　epistasis　identified　between　CACNG5　and　CACNG6　suggests　that　there　may　be　an　underlying　biological　interaction　between　the　two　genes.