Purpose:The　aim　of　this　study　was　to　assess　quality　of　life　(QoL)　and　obturator　functioning　in　patients　having　undergone　a　maxillectomy　as　a　tumor　ablative　resection　and　rehabilitation　with　a　prosthetic　obturator.　Materials　and　Methods:　The　University　of　Washington　Quality　of　Life　scale　version　4　(UVV-QoLv4)　and　the　Obturator　Functioning　Scale　(OFS)　were　used　to　evaluate　the　self-reported　QoL　and　obturator　functioning.　The　effects　of　demographic　and　treatment　variables　on　QoL　were　assessed　using　age,　defect　size,　postoperative　radiotherapy　(RT),　neck　dissection,　and　dentition.　Results:　The　study　included　16　men　and　13　women　with　a　mean　age　of　48.8　years.　Of　the　29　patients,　16　had　a　Brown　Class　2a　or　smaller　defect　and　13　had　a　Brown　Class　2b　or　larger　defect.　The　mean　OFS　score　(P　=　.004)　and　the　physical　(P　=　.001)　and　social-emotional　function　scores　(P　=　.001)　of　the　patients　who　received　postoperative　RT　were　significantly　lower　than　those　who　did　not　receive　postoperative　RT.　The　subscales　for　swallowing　(P　=　.008),　saliva　(P　=　.001),　pain　(P　=　.001),　and　shoulder　function　(P　=　.002)　correlated　strongly　with　postoperative　RT　on　the　UW-QoL.　The　subscales　for　pronunciation　(P　=　.007)　and　saliva　(P　=　.002)　correlated　significantly　with　RT　on　the　OFS.　The　mean　OFS　scores　were　significantly　lower　for　the　patients　with　a　Brown　Class　2a　or　smaller　defect　than　for　Brown　Class　2b　or　larger　(P　=　.005).　Conclusion:　Postoperative　RT　was　the　strongest　variable　affecting　QoL　in　patients　with　maxillectomy　and　prosthetic　obturator　reconstruction.　The　size　of　the　defect　slightly　influenced　the　obturator　function:　however,　it　did　not　influence　the　overall　QoL.