Objective:　Polycystic　ovary　syndrome　(PCOS)　is　one　of　the　most　common　endocrinopathies　affecting　5-7%　of　reproductive　age　women　worldwide.　The　aim　of　our　study　was　to　explore　the　PCOS-related　single　nucleotide　polymorphism　(SNP)　associations　between　common　genetic　variants　and　PCOS　risk　in　a　Han　Chinese　women　population.　Methods:　In　this　case-control　study,　285　Chinese　Han　women　aged　28.50　+/-　6.858　years　with　PCOS　and　299　controls　of　a　mean　age　of　32.66　+/-　7.018　years　were　compared.　We　selected　recently　published　genome-wide　association　studies　(GWAS)　which　identified　several　genetic　loci　in　PCOS.　All　the　SNPs　were　genotyped　by　Sequenom　Mass-ARRAY　technology.　Associations　between　the　gene　and　the　risk　of　PCOS　were　tested　using　various　genetic　models　by　Statistical　Package　for　the　Social　Sciences　and　Plink.　Results:　We　found　that　rs705702　in　the　RAB5B/SUOX　was　associated　with　PCOS　(odds　ratio=1.42;　95%　confidence　interval=1.08-1.87,　p=0.011)　and　increased　the　PCOS　risk.　The　genotypic　model　analysis　also　showed　that　rs705702　was　associated　with　PCOS　risk.　Conclusion:　Our　results　suggest　that　SNPs　rs705702　in　gene　RAB5B/SUOX　was　associated　with　PCOS　in　Han　Chinese　women.