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Author:

Yang, Jinru (Yang, Jinru.) | Wang, Feiqian (Wang, Feiqian.) | Pan, Wenqian (Pan, Wenqian.) | Ruan, Litao (Ruan, Litao.) | Ai, Hong (Ai, Hong.)

Indexed by:

SCIE Scopus

Abstract:

Background: Conventional B-mode and Doppler ultrasound are inefficient at showing increased stiffness resulting from the fibrosis developing during kidney transplant rejection. Objectives: This study aims to assess the correlation between ultrasound elastography (UE) and renal function after kidney transplantation. Methods: Patients who underwent UE after renal allotransplantation at the First Affiliated Hospital of Xi'an Jiaotong University Medical School between October 2014 and March 2015 were grouped according to their serum creatinine levels: normal group (serum creatinine level < 134 mu mol/L), acute rejection group (serum creatinine level > 134 mu mol/L that recovered in three months), and chronic allograft nephropathy (CAN) group (serum creatinine level > 134 mu mol/L sustained for > 3 months). UE was scored 1-5 points according to the kidney stiffness, and parameters were compared between groups. Results: All patients in the acute rejection and CAN groups scored at least 2 points, while 80% of the remaining patients scored >= 3 points. In the normal group, 93% of patients scored 1 point (the normal group vs. the acute rejection and CAN groups, P < 0.05). In the acute rejection group, the average relative strain value (MEAN) and the area ratio of low-strain ratio decreased with increasing serum creatinine levels. MEAN was highly predictive of postoperative renal function, with a sensitivity, specificity and area under the curve of 80%, 80% and 0.868, respectively; using a cut off value of 100. Conclusion: UE may reflect renal function and can be a non-invasive method for the evaluation of renal function after kidney transplantation.

Keyword:

elastography imaging technique renal transplantation Ultrasonography

Author Community:

  • [ 1 ] [Yang, Jinru; Wang, Feiqian; Pan, Wenqian; Ruan, Litao; Ai, Hong] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Ultrason, 277 Yanta Rd, Xian 710061, Peoples R China
  • [ 2 ] [Yang, Jinru]Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Ultrason, 277 Yanta Rd, Xian 710061, Peoples R China
  • [ 3 ] [Wang, Feiqian]Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Ultrason, 277 Yanta Rd, Xian 710061, Peoples R China
  • [ 4 ] [Pan, Wenqian]Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Ultrason, 277 Yanta Rd, Xian 710061, Peoples R China
  • [ 5 ] [Ruan, Litao]Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Ultrason, 277 Yanta Rd, Xian 710061, Peoples R China
  • [ 6 ] [Ai, Hong]Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Ultrason, 277 Yanta Rd, Xian 710061, Peoples R China

Reprint Author's Address:

  • Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Ultrason, 277 Yanta Rd, Xian 710061, Peoples R China.

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Source :

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

ISSN: 1940-5901

Year: 2017

Issue: 2

Volume: 10

Page: 3211-3217

0 . 8 3 3

JCR@2017

0 . 1 6 6

JCR@2019

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:157

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 2

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

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