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Craniotomy and membranectomy are widely accepted for the treatment of organized chronic subdural hematoma (CSDH); however, to our knowledge, the efficacy of burr hole irrigation and drainage with urokinase (UK) for organized CSDH has not been previously investigated. This case report describes 4 cases of organized CSDH, which were cured by UK injection into the hematoma cavity after one burr hole surgery. All patients were male (aged 55, 55, 58, and 76 years). One patient underwent an initial single burr hole craniotomy with a partial membranectomy and a burr hole 13 and 21 days after the first procedure. UK was subsequently injected into the hematoma cavity. One patient underwent burr hole surgery twice in 10 days, and UK was injected into the hematoma cavity after the second burr hole operation. Two patients underwent one burr hole operation and UK injection into the hematoma cavity following surgery. Organized hematoma drainage was satisfactory following UK administration. All patients exhibited full recovery without recurrence of the CSDH. There was no morbidity or mortality associated with UK injection. After a follow-up period of two months, a computed tomography (CT) scan indicated complete resolution of the hematoma in all 4 cases. These findings provide preliminary evidence that UK treatment after CSDH is a beneficial, safe, and effective treatment.
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INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
ISSN: 1940-5901
Year: 2017
Issue: 10
Volume: 10
Page: 14834-14840
0 . 8 3 3
JCR@2017
0 . 1 6 6
JCR@2019
ESI Discipline: BIOLOGY & BIOCHEMISTRY;
ESI HC Threshold:157
JCR Journal Grade:4
CAS Journal Grade:4
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WoS CC Cited Count: 0
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ESI Highly Cited Papers on the List: 0 Unfold All
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30 Days PV: 0
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