High　uric　acid　(UA)　level　and　high　salt　intake　are　reportedly　associated　with　cardiovascular　disease.　This　study　investigated　the　association　between　UA　and　urinary　sodium　excretion,　as　well　as　its　interaction　on　the　risk　of　prehypertension.　A　total　of　1869　participants　without　hypertension　were　recruited　from　a　previously　established　cohort　in　Shaanxi　Province,　China.　The　participants　were　classified　as　normotensive　or　prehypertensive　on　the　basis　of　their　blood　pressure.　Increasing　quartiles　of　sodium　excretion　were　associated　with　high　urinary　UA/creatinine　levels　in　prehypertensive　participants.　Estimated　sodium　excretion　positively　correlated　with　urinary　UA/creatinine　excretions　in　the　prehypertensive　group.　In　addition,　the　multivariate-adjusted　odds　ratios　for　prehypertension　compared　with　normotension　were　1.68　(1.27-2.22)　for　sodium　excretion　and　1.71　(1.21-2.42)　for　serum　UA.　Increasing　sodium　excretion　and　serum　UA　were　associated　with　higher　risk　of　prehypertension.　Compared　with　the　lowest　quartiles,　the　highest　sodium　excretion　and　serum　UA　quartiles　entailed　3.48　times　greater　risk　of　prehypertension.　Sodium　excretion　is　associated　with　urinary　UA　excretion　in　prehypertensive　participants.　The　present　study　shows　that　high　levels　of　salt　intake　and　serum　UA　simultaneously　are　associated　with　a　higher　risk　of　prehypertension.