Novel　Pt(II)　complexes,　(TFPPy)PtPic　and　(TFPQ)PtPic,　containing　fluorinated　phenylpyridine　or　phenylquinoline　with　pyridine-2-carboxylate　as　chelating　ligands　were　synthesized　according　to　rational　design,　their　therapeutical　activities　examined.　Remarkable　radiosensitization　SER　values　were　observed　even　in　radio-resistant　cell　line　after　treated　with　these　complexes.　Furthermore,　the　two　complexes　have　shown　antiviral　activity　against　DNA　virus　HSV-1.　Comply　with　live　cell　imaging　results,　molecular　docking　have　revealed　the　complexes　forms　stable　hydrogen　bond　and　hydrophobic　interactions　to　the　minor　groove　of　target　DNA　double　helix.　These　findings　demonstrate　the　non-classical　structure　complexes　are　promising　for　further　evaluation　as　a　new　type　of　prodrug　radiochemotherapy　and　antiviral　treatment.