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Abstract:
This study used high-performance liquid chromatography to measure 202 teicoplanin plasma trough concentrations (C-min) in 114 haematological malignancy patients with febrile neutropenia. Patients were divided into two groups according to the mean initial dose (MID) over the first 3 days of treatment: (i) MID = 533.33 mg/day (loading dose group, 400 mg q12h for three doses followed by 400 mg qd, n = 62) and (ii) MID < 533.33 mg/day (unloaded or underloaded group, n = 52). During the first 3 days after treatment, the overall C-min was higher in group 1 than in group 2 (10.96 +/- 5.44 mg/L versus 6.31 +/- 3.73 mg/L, mean +/- S.D.; p = 0.002), as was the qualifying rate of C-min > 10 mg/L (54.5% versus 11.1%, p = 0.001), and the probability of C-min < 5 mg/L was lower in group 1 than in group 2 (13.6% versus 40.7%, p = 0.037). After 3 days, the average C-min and qualifying rates did not differ significantly between the two groups, and the average C-min was <10 mg/L in both groups. Binary logistic regression analysis revealed that creatinine clearance (p = 0.004) and MID (p = 0.010) could affect C-min during the first 3 days of treatment and that age (p = 0.022) only could affect C-min after 3 days. In conclusion, it is necessary to apply loading dose to achieve teicoplanin C-min > 10 mg/L rapidly and, from a pharmacokinetic/pharmacodynamic perspective, 600 mg is recommended as loading and maintenance dose for these patients when AUC(24)/minimum inhibitory concentration > 345.
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BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
ISSN: 1742-7835
Year: 2018
Issue: 5
Volume: 123
Page: 594-601
2 . 4 5 2
JCR@2018
4 . 0 8 0
JCR@2020
ESI Discipline: PHARMACOLOGY & TOXICOLOGY;
ESI HC Threshold:100
JCR Journal Grade:3
CAS Journal Grade:3
Cited Count:
WoS CC Cited Count: 4
SCOPUS Cited Count: 3
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 1
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