Measurements　of　transepidermal　water　loss　(TEWL)　and　stratum　corneum　(SC)　hydration　are　important　for　assessing　epidermal　functions.　However,　the　availability　of　reliable　and　user-friendly　devices,　which　can　simultaneously　measure　both　TEWL　and　SC　hydration　and　can　allow　health　providers　to　remotely　access　data　in　time,　is　limited.GPSkin　Barrier＜sup＞®＜/sup＞　was　compared　with　MPA5　system　in　the　measurements　of　TEWL　and　SC　hydration　on　the　cheek,　the　dorsal　hand,　and　the　forearm　in　200　normal　volunteers,　including　126　females　and　74　males,　aged　1-78 years　with　an　average　age　of　45.24 ± 1.04 years.　Correlation　of　data　measured　with　MPA5　system　and　GPSkin　Barrier＜sup＞®＜/sup＞　was　determined.Levels　of　both　TEWL　and　SC　hydration　measured　with　the　Barrie　GPSkin　Barrier＜sup＞®＜/sup＞　were　lower　than　that　with　MPA5　system　on　all　3　body　sites　except　for　hydration　on　the　cheek.　The　levels　of　both　TEWL　and　SC　hydration　measured　with　GpSkin　Barrier＜sup＞®＜/sup＞　were　correlated　well　with　that　measured　with　MPA5　system　on　all　3　body　sites　CONCLUSIONS:　GPSkin　Barrier＜sup＞®＜/sup＞　is　a　reliable,　affordable,　and　versatile　device　for　assessing　epidermal　permeability　barrier　function　and　SC　hydration.