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Author:

Sui Fang (Sui Fang.) | Ji Meiju (Ji Meiju.) | Hou Peng (Hou Peng.)

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Abstract:

Thyroid cancer is the most common endocrine malignant tumor with rapidly increasing incidence in recent decades. Although the majority of thyroid cancers are relatively indolent, some cases still have a risk of developing into more aggressive and lethal forms of thyroid cancers. Similar to other malignancies, thyroid tumorigenesis is a multistep process involving the accumulation of a large number of genetic and epigenetic alterations. Thus, determination of the mechanisms of tumorigenesis is an urgent need for thyroid cancer treatment. Long noncoding RNAs (LncRNAs) have recently been demonstrated to participate in cancer progression. However, their role and molecular mechanism in thyroid cancer remain largely unclear. In this review, we focus on the dysregulation of lncRNAs in thyroid cancer, summarize the latest findings regarding the functions and mechanism of lncRNAs in thyroid cancer, and discuss their potential clinical significance in diagnosis and prognosis of thyroid cancer.

Keyword:

Biomarkers Diagnosis LncRNAs Prognosis Thyroid cancer

Author Community:

  • [ 1 ] [Hou Peng]Key Laboratory for Tumor Precision Medicine of Shanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic address: phou@xjtu.edu.cn.
  • [ 2 ] [Hou Peng]Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China
  • [ 3 ] [Ji Meiju]Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China.
  • [ 4 ] [Sui Fang]Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China.
  • [ 5 ] [Sui, Fang; Hou, Peng] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Shaanxi, Peoples R China
  • [ 6 ] [Ji, Meiju] Xi An Jiao Tong Univ, Affiliated Hosp 1, Ctr Translat Med, Xian 710061, Shaanxi, Peoples R China
  • [ 7 ] [Hou, Peng] Xi An Jiao Tong Univ, Affiliated Hosp 1, Key Lab Tumor Precis Med Shanxi Prov, Xian 710061, Shaanxi, Peoples R China
  • [ 8 ] [Sui, Fang]Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Shaanxi, Peoples R China
  • [ 9 ] [Hou, Peng]Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Shaanxi, Peoples R China
  • [ 10 ] [Ji, Meiju]Xi An Jiao Tong Univ, Affiliated Hosp 1, Ctr Translat Med, Xian 710061, Shaanxi, Peoples R China
  • [ 11 ] [Hou, Peng]Xi An Jiao Tong Univ, Affiliated Hosp 1, Key Lab Tumor Precis Med Shanxi Prov, Xian 710061, Shaanxi, Peoples R China

Reprint Author's Address:

  • Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Shaanxi, Peoples R China.; Hou, P (reprint author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Key Lab Tumor Precis Med Shanxi Prov, Xian 710061, Shaanxi, Peoples R China.

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Source :

Molecular and cellular endocrinology

ISSN: 1872-8057

Year: 2018

Volume: 469

Page: 11-22

3 . 6 9 3

JCR@2018

4 . 1 0 2

JCR@2020

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:130

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 30

SCOPUS Cited Count: 38

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 4

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