Natriuretic　peptide　receptor　A　(NPR-A)　is　the　receptor　for　atrial　natriuretic　peptide　(ANP)　and　brain　natriuretic　peptide　(BNP).　NPR-A　plays　critical　physiological　and　pathophysiological　roles　in　several　target　cell　and　tissue　system　processes,　such　as　cell　growth,　apoptosis,　proliferation,　and　inflammation.　Accumulating　data　demonstrate　that　NPR-A　is　involved　in　immune　and　inflammatory　reactions　and　is　a　potential　target　in　inflammation　treatment.　It　is　expressed　in　various　cancer　cells　and　is　important　for　tumor　growth.　A　recent　study　indicated　that　NPR-A　signaling　can　regulate　stem　cell　recruitment　and　angiogenesis.　This　signaling　can　serve　as　a　model　for　studying　the　linkage　between　inflammation　and　tumorigenesis.　In　this　review　we　highlight　the　mechanisms　by　which　NPR-A　affects　signaling　pathways　involved　in　inflammation　and　cancer,　and　we　discuss　its　potential　as　a　novel　target　in　inflammation,　cancer,　and　cancer-related　inflammation.