To　observe　the　effects　of　alcohol　intake　at　different　levels　on　acute　myocardial　ischemia　induced　by　pituitrin　in　rats.Forty　SD　male　rats　were　randomly　divided　into　five　groups,　including　model　control　group　(pituitrin,　1U/kg),　positive　control　group　(verapamil,　1　mg/kg),　5%　alcohol　group　(0.4　g/kg),　10%　alcohol　group　(0.8　g/kg)　and　20%　alcohol　group　(1.6　g/kg).　Myocardial　ischemia　model　was　made　in　rats　by　injecting　pituitrin　(1U/kg)　through　sublingual　vein.　The　heart　rate,　incidence　of　arrhythmia,　the　changes　of　ST　segment　and　T　wave　on　electrocardiogram　of　rats　were　observed　and　compared.The　incidence　of　arrhythmia,　the　degree　of　elevated　ST　segment　and　T　wave　amplitude　induced　by　pituitrin　were　remitted　obviously　in　the　5%　alcohol　group　(0.4　g/kg);　The　heart　rate　was　slower　and　the　change　of　ST　segment　and　T　wave　were　not　affected　in　the　10%　alcohol　group　(0.8　g/kg).　The　heart　rate　was　slower　and　the　elevated　ST　segment　and　the　T　wave　amplitude　were　augmented　significantly　in　the　20%　alcohol　group　(1.6　g/kg).A　protective　effect　on　acute　myocardial　ischemia　induced　by　pituitrin　in　rats　was　shown　in　the　5%　alcohol　group　(0.4　g/kg)　and　an　aggravation　of　acute　myocardial　ischemia　induced　by　pituitrin　was　observed　in　the　20%　alcohol　group　(1.6　g/kg).