To　test　the　effect　of　resvertrol　on　protecting　the　intestinal　mucosal　barrier　in　rats　with　severe　acute　pancreatitis.Twenty　four　SD　rats　were　randomly　divided　into　three　groups:　severe　acute　pancreatitis　without　treatments　(SAP　group),　severe　acute　pancreatitis　with　sham-operations　(SO　group),　and　severe　acute　pancreatitis　treated　with　resveratrol　(RES　group).　Specimen　were　obtained　6　hours　after　the　severe　acute　pancreatitis　was　induced.　The　endotoxin　level　in　the　blood　taken　from　portal　vein　was　measured　with　turbidimetry.　Apoptosis　of　mucosal　cells　was　detected　by　TUNEL　methods.　The　expressions　of　Bax　and　Bcl-2　mRNA　in　intestinal　mucosal　cells　were　determined　by　semi-quantitative　RT-PCR.　Mitochondrial　membranous　electric　potential　of　intestinal　mucosal　cells　was　measured　by　confocal　microscopy.The　RES　group　had　less　serum　endotoxin　in　portal　vein　than　the　SAP　group　(P　＜　0.01).　The　SAP　group　had　higher　apoptotic　index　of　mucosal　cells　than　the　RES　group　(P　＜　0.01).　The　SAP　group　had　higher　expression　of　Bax　mRNA　in　intestinal　mucosal　cells　and　lower　expression　of　Bcl-2　mRNA　than　the　RES　group　(P　＜　0.01).　The　SAP　group　had　lower　mitochondrial　membranous　electric　potential　of　intestinal　mucosal　cells　than　the　REA　group　(P　＜　0.01).Resvertrol　inhibits　the　apoptosis　of　intestinal　mucosa　cells　and　protects　the　intestinal　barrier　function,　which　might　prevent　the　translocation　of　bacteria　and　endotoxin　in　patients　with　severe　acute　pancreatitis.