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学者姓名：闫剑群
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Abstract ：
Dopamine plays a key role in food rewards and sweet-taste stimulation. We examined the basis for behavioral responses to sweet taste in dopamine D3 receptor-deficient (D3(-/-)) mice by determining whether the absence of D3 receptors affects the sensitivity to dilute sucrose solutions. In experiment 1, we measured the intensity generalization threshold of conditioned taste aversion (CTA) to a 0.2 M sucrose solution. Results showed that the generalization thresholds were 0.025-0.05 M in D3(-/-) mice and 0.0025-0.005 M in wild-type (WT) mice. In experiment 2, we found that D3(-/-) and WT mice had similar capabilities to form and extinguish CTAs. Since the intensity generalization threshold is mainly due to a combination of sweet-taste sensitivity and the robust nature of CTA formation, the results showed that taste sensitivity to sucrose in D3(-/-) mice was lower than that in WT mice. In experiment 3, to test whether the peripheral sensory signaling may also be affected by the disruption of the dopamine D3 receptors, the mRNA expression levels of sweet-taste-related proteins in taste buds of D3(-/-) mice were determined. The T1R1 and BDNF mRNA expression levels in D3(-/-) mice were higher than the controls, whereas T1R2, T1R3, alpha-gustducin, and TRPM5 mRNA were similar. These findings suggest that disruption of dopamine D3 receptor-mediated signaling decreases the sweet-taste sensitivity and alters the mRNA expression levels of some taste-related molecules.
Keyword ：
BDNF conditioned taste aversion dopamine D3 receptor sweet taste taste buds
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| GB/T 7714 | Sun, Huiling , Li, Jinrong , Yan, Junbao et al. Decreased taste sensitivity to sucrose in dopamine D3 receptor mutant mice [J]. | CHEMICAL SENSES , 2022 , 47 . |
| MLA | Sun, Huiling et al. "Decreased taste sensitivity to sucrose in dopamine D3 receptor mutant mice" . | CHEMICAL SENSES 47 (2022) . |
| APA | Sun, Huiling , Li, Jinrong , Yan, Junbao , Sun, Bo , Wei, Xiaojing , Song, Lin et al. Decreased taste sensitivity to sucrose in dopamine D3 receptor mutant mice . | CHEMICAL SENSES , 2022 , 47 . |
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Abstract ：
Glucagon-like peptide-2 (GLP-2) is secreted from enteroendocrine L-type cells of the gut and also released from preproglucagonergic (PPG) neurons in the nucleus tractus solitarius (NTS) and adjacent medial reticular nucleus of the brain stem. The neurons in the NTS express GLP-2, and the neurons send extensive projections to the hypothalamus. Recent studies show that the intracerebroventricular administration of GLP-2 significantly suppresses food intake in animals and some evidence suggest that the melanocortin receptor-4 (MC4-R) signaling in the hypothalamus is required for intracerebroventricular GLP-2-mediated inhibition of feeding. There is proopiomelanocortin (POMC) positive neurons expressing MC4-R in the NTS. Suppression of MC4-R expressing neurons in the brain stem inhibits gastric emptying. In this study, we tested the effects of NTS GLP-2R activation and blockade on feeding behavior and evaluated the endogenous melanocortin system's role in the NTS in mediating effects of GLP-2 on feeding behavior in fed and fasted rats. Our results demonstrated that microinjection of GLP-2 into the NTS suppressed food intake in fasted-refeeding rats but did not affect food intake in freefeeding rats, and this inhibition was blocked by pretreatment of either Exendin (9-39) or SHU 9119, suggesting the GLP-2 system in the NTS exerts an inhibitory action on food intake. MC4-R mediates this action in the NTS.
Keyword ：
Food intake Neurotransmitter Nucleus tractus solitarius (NTS)
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| GB/T 7714 | Sun, Huiling , Meng, Kai , Hou, Lin et al. Melanocortin receptor-4 mediates the anorectic effect induced by the nucleus tractus solitarius injection of glucagon-like Peptide-2 in fasted rats [J]. | EUROPEAN JOURNAL OF PHARMACOLOGY , 2021 , 901 . |
| MLA | Sun, Huiling et al. "Melanocortin receptor-4 mediates the anorectic effect induced by the nucleus tractus solitarius injection of glucagon-like Peptide-2 in fasted rats" . | EUROPEAN JOURNAL OF PHARMACOLOGY 901 (2021) . |
| APA | Sun, Huiling , Meng, Kai , Hou, Lin , Shang, Lijun , Yan, Jianqun . Melanocortin receptor-4 mediates the anorectic effect induced by the nucleus tractus solitarius injection of glucagon-like Peptide-2 in fasted rats . | EUROPEAN JOURNAL OF PHARMACOLOGY , 2021 , 901 . |
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Abstract ：
Nicotinamide N-methyltransferase (NNMT) is a novel regulator, shown recently to regulate adipose tissue energy expenditure partly through changing NAD + content, which is essential for mitochondrial. We determine whether NNMT plays important role in energy metabolism during the beige adipogenesis in vivo and in vitro. Male C57BL/6 mice at 8 weeks old were exposed to 4 celcius for 1, 2, 3, 4, and 5 days, respectively. Interscapular brown adipose tissue (iBAT), inguinal subcutaneous WAT (sWAT), and epididymal WAT (eWAT) were harvested for gene and protein expression analysis and the correlation analysis. In addition, cultured primary mice brown adipocyte (BA) and white adipocyte (WA) treated with or without beta 3-adrenoceptor agonist (CL316, 243) were also harvested for these analyses. A combination of NNMT and its related genetic (Nmnat1, Nampt, Cyp2e1, Nrk1, Cd38) and proteic analyses and also the NAD + levels demonstrated the dynamical and depot-specific remodeling of NAD metabolism in different adipose tissues in response to cold exposure. While upon CL316, 243 treatment, gene expression of Nnmt, Nampt, Cyp2e1, and Nrk1 was all significantly decreased in WA but not in BA. The increased NAD + amount in BA and WA during the beige adipogenesis was observed. Besides, it is demonstrated that the expression of NNMT both in sWAT and WA showed significant negative correlation with browning markers UCP-1 and PGC-1 alpha at protein levels. Above all, NNMT was induced in WAT during the 'cold remodeling' phase and correlated negatively with the process of browning in sWAT and WA, indicating the specific role of NNMT in the regulation of energy homeostasis during the process of beige adipogenesis.
Keyword ：
Adipose tissue Beige cells NAD plus metabolism NNMT Obesity
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| GB/T 7714 | Jia, Ru , Wei, Xiaojing , Jiang, Jianan et al. NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner [J]. | JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY , 2021 , 78 (1) : 169-183 . |
| MLA | Jia, Ru et al. "NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner" . | JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY 78 . 1 (2021) : 169-183 . |
| APA | Jia, Ru , Wei, Xiaojing , Jiang, Jianan , Yang, Zhao , Huang, Jiaqi , Liu, Jing et al. NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner . | JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY , 2021 , 78 (1) , 169-183 . |
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Abstract ：
Aims: Maternal protein malnutrition during perinatal period has long-term consequences on the offspring's metabolic phenotype. Here we determined the effects of maternal protein-restricted (PR) diet on offspring's metabolism in 3- and 12-week-old. Main methods: Sprague-Dawley rats were fed with standard chow diet or PR diet during pregnancy and lactation. Food intake and body weight of offspring were measured weekly. The oral glucose tolerance tests were underwent, the pancreases were collected for histochemical staining, and the duodenum, jejunum and ileum were collected for gene and protein expression analysis in 3- and 12-week-old offspring. Key findings: PR offspring had significant lower body weight and persisted till 12-week-old. From 3- to 12-week-old, PR offspring presented considerably impaired glucose tolerance, while no marked change was shown in control rats. Additionally, the average islet size of PR offspring decreased significantly in 12-week-old. The mRNA and protein expression of nutrient-responsive receptors and transporters T1R3, SGLT1 and GLUT2 increased significantly in the intestine of 3-week-old PR offspring. And from 3- and 12-week-old, the increase tendency of expression subdued. Significance: These results suggest that maternal PR diet during critical developmental windows influences offspring metabolism, which may be subdued partially, but not be reversed completely by chow diet after weaning.
Keyword ：
Glucose tolerance Glucose transporter Intestine Maternal protein-restricted diet Sweet taste receptor
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| GB/T 7714 | Wang, Nan , Lv, Bo , Guan, Limin et al. Maternal low protein exposure alters glucose tolerance and intestinal nutrient-responsive receptors and transporters expression of rat offspring [J]. | LIFE SCIENCES , 2020 , 243 . |
| MLA | Wang, Nan et al. "Maternal low protein exposure alters glucose tolerance and intestinal nutrient-responsive receptors and transporters expression of rat offspring" . | LIFE SCIENCES 243 (2020) . |
| APA | Wang, Nan , Lv, Bo , Guan, Limin , Qiao, Hu , Sun, Bo , Luo, Xiao et al. Maternal low protein exposure alters glucose tolerance and intestinal nutrient-responsive receptors and transporters expression of rat offspring . | LIFE SCIENCES , 2020 , 243 . |
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Abstract ：
Maternal high-fat (HF) diet negatively affects maternal metabolism and placental function. This study aimed to determine whether gestational exercise prevents the effect of HF diet on placental amino acid transporter expression and nutrient-sensing signaling and the fetal response. Pregnant Sprague-Dawley rats were either fed with a CHOW (13.5% fat) or HF (60% fat) diet during gestation and further divided into two subgroups: voluntary exercised and sedentary. Placentae were collected on gestational day (GD) 14 and GD20, and male placentae were used in this study. We found that gestational exercise ameliorated the detrimental effects of HF diet on dams' adiposity, plasma leptin, and insulin concentrations. Maternal exercise did not influence fetoplacental growth but affected male fetal hypothalamic Leprb, Stat3, Insr, Agrp, and Pomc expressions on GD20. Maternal HF diet decreased placental labyrinth thickness and increased system A amino acid transporter SNAT2 expression, while these changes were normalized by exercise. The activation of placental mechanistic target of rapamycin complex 1/4E-BP1 and LepRb/STAT3 signaling might contribute to the increased placental SNAT2 expression in HF-fed dams, which were reversed by exercise on GD20. These data highlight that gestational exercise reverses HF-diet-induced placental alterations during late gestation without influencing fetal growth. However, maternal exercise altered fetal hypothalamic gene expression, which may affect long-term offspring health.
Keyword ：
fetal development maternal exercise mTORC1 placenta
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| GB/T 7714 | Song Lin , Yan Jianqun , Wang Nan et al. Prenatal exercise reverses high-fat-diet-induced placental alterations and alters male fetal hypothalamus during late gestation in rats†. [J]. | Biology of reproduction , 2020 , 102 (3) : 705-716 . |
| MLA | Song Lin et al. "Prenatal exercise reverses high-fat-diet-induced placental alterations and alters male fetal hypothalamus during late gestation in rats†." . | Biology of reproduction 102 . 3 (2020) : 705-716 . |
| APA | Song Lin , Yan Jianqun , Wang Nan , Wei Xiaojing , Luo Xiao , Meng Kai et al. Prenatal exercise reverses high-fat-diet-induced placental alterations and alters male fetal hypothalamus during late gestation in rats†. . | Biology of reproduction , 2020 , 102 (3) , 705-716 . |
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Abstract ：
The nicotinamide adenine dinucleotide (NAD<sup>+</sup> )/Sirtuin (SIRT) system is linked to metabolic adaptation. This study aimed to determine the temporal profile of metabolic responses of the liver to cold exposure and changes in the hepatic NAD<sup>+</sup> /SIRT system. Eight-week-old male C57BL/6 mice were individually housed in conventional cages under cold exposure (4 °C) for up to 5 days. Cold exposure decreased the hepatic triglyceride level and cholesterol level in mice by 1.7- and 1.6-fold, respectively. Lipogenic gene expression was persistently reduced, while gluconeogenic gene expression was transiently increased. Hepatic NAD<sup>+</sup> /SIRT metabolism was induced during the 'cold remodeling' phase (days 1-3) and correlated with decreasing lipogenic and increasing gluconeogenic gene expression, contributing to the maintenance of whole-body lipid and glucose homeostasis.
Keyword ：
cold exposure lipid liver NAD+ sirtuin
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| GB/T 7714 | Wei Xiaojing , Jia Ru , Yang Zhao et al. NAD+ /sirtuin metabolism is enhanced in response to cold-induced changes in lipid metabolism in mouse liver. [J]. | FEBS letters , 2020 , 594 (11) : 1711-1725 . |
| MLA | Wei Xiaojing et al. "NAD+ /sirtuin metabolism is enhanced in response to cold-induced changes in lipid metabolism in mouse liver." . | FEBS letters 594 . 11 (2020) : 1711-1725 . |
| APA | Wei Xiaojing , Jia Ru , Yang Zhao , Jiang Jianan , Huang Jiaqi , Yan Jianqun et al. NAD+ /sirtuin metabolism is enhanced in response to cold-induced changes in lipid metabolism in mouse liver. . | FEBS letters , 2020 , 594 (11) , 1711-1725 . |
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Abstract ：
Exposure to maternal high-fat (HF) diet during gestation and lactation alters adult offspring's feeding behavior and diet preference. However, the impact of maternal exercise on offspring's diet preference and reward system development is less studied. In this study, we investigate the effect of perinatal maternal exercise on the development of diet preference, dopamine- and opioid-related gene expression in the central reward system in female offspring from HF-fed Sprague-Dawley rat dams. We found maternal HF diet did not alter adult offspring HF preference, but influenced offspring's dopamine and opioid system both at weaning and in adulthood, and these offspring retained higher body weight in adulthood. However, offspring from dams exposed to both HF diet and exercise during gestation and lactation had normalized body weight, decreased fat mass and lower HF-diet preference but increased energy intake in adulthood. The dopamine- and opioid-related gene expression in central reward system and POMC expression in hypothalamus was elevated in these adult offspring. We conclude that maternal exercise during gestation and lactation can potentially overcome the negative effects of perinatal exposure to HF diet in female offspring by altering their diet preference, central reward system signaling and hypothalamus neuropeptide expression.
Keyword ：
Diet preference High-fat diet Maternal exercise Reward system
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| GB/T 7714 | Song, Lin , Cui, Jiaqi , Wang, Ning et al. Maternal exercise during gestation and lactation decreases high-fat diet preference by altering central reward system gene expression in adult female offspring from high-fat fed dams [J]. | BEHAVIOURAL BRAIN RESEARCH , 2020 , 390 . |
| MLA | Song, Lin et al. "Maternal exercise during gestation and lactation decreases high-fat diet preference by altering central reward system gene expression in adult female offspring from high-fat fed dams" . | BEHAVIOURAL BRAIN RESEARCH 390 (2020) . |
| APA | Song, Lin , Cui, Jiaqi , Wang, Ning , Wang, Rui , Yan, Jianqun , Sun, Bo . Maternal exercise during gestation and lactation decreases high-fat diet preference by altering central reward system gene expression in adult female offspring from high-fat fed dams . | BEHAVIOURAL BRAIN RESEARCH , 2020 , 390 . |
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Abstract ：
The prevalence of obesity is growing, and high fat diet (HFD)-induced obesity can alter the brain and cognition. However, the link between HFD, hippocampal function, and inflammation is still not fully understood. Tripartite motif (TRIM) family has been implicated in various cellular processes, such as apoptosis, neurogenesis, and innate immune responses. Trim69, a member of TRIM family, was investigated in the present study to determine its role in HFD-induced hippocampal damage. Here, we first found that hippocampal Trim69 expression was markedly down-regulated in wild-type (WT) mice challenged with HFD. Trim69 knockout (KO) mice exhibited an exaggerated version of the metabolic disorder after HFD challenge, as evidenced by their increased body weight and elevated insulin resistance. HFD-induced hippocampal injury was further aggravated by Trim69 deletion, as confirmed by the reduced survival of neurons and increased level of apoptotic cell death. In addition, the inflammatory response triggered by HFD was more pronounced in the hippocampi of Trim69-KO mice after blockage of the activation of the nuclear factor kappa B (NF-kappa B) signaling pathway. Phosphorylation of mitogen-activated protein kinase (MAPK) kinase 4 (MKK4), MKK7, and c-Jun N-terminal kinase (INK) in the hippocampi of HFD-challenged mice was intensified by the loss of Trim69. Hippocampal-apoptosis-signal-regulating kinase 1 (ASK1) phosphorylation was also found to be up -regulated by HFD, especially in mice with Trim69 deletion. Of note, we found that Trim69 directly interacted with and deubi-quitinated ASK1 in microglial cells. Microglial cell-specific suppression of Trim69 exacerbated inflammation and apoptosis in response to lipopolysaccharide (LPS). Trim69 over-expression markedly alleviated LPS-induced inflammatory response and apoptotic cell death in microglial cells. Together, these results indicated that Trim69 might be a functionally essential inhibitor of ASK1 activation during the pathogenesis of hippocampal inflammation and apoptosis, and it could serve as a novel molecular target for obesity-associated brain damage. (C) 2019 Published by Elsevier Inc.
Keyword ：
ASK1 Hippocampus Inflammation and apoptosis Obesity Trim69
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| GB/T 7714 | Li, Lin-Juan , Zheng, Jun-Chen , Kang, Rui et al. Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation [J]. | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , 2019 , 515 (4) : 658-664 . |
| MLA | Li, Lin-Juan et al. "Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation" . | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 515 . 4 (2019) : 658-664 . |
| APA | Li, Lin-Juan , Zheng, Jun-Chen , Kang, Rui , Yan, Jian-Qun . Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation . | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , 2019 , 515 (4) , 658-664 . |
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Abstract ：
Maternal high-fat (HF) diet affects offspring's metabolic phenotype. Sweet taste is an important factor in promoting appetite. In order to determine the effects of maternal HF diet throughout gestation and lactation on taste sensitivity to sucrose in rat offspring, we measured conditioned aversion threshold for sucrose by conditioned taste aversion (CTA) associated with two-bottle choice tests, and measured mRNA expression of sweet taste receptors in taste buds. In male offspring, conditioned aversion threshold for sucrose lay between 0.007 M and 0.009 M in control group, while in those with HF dams, the threshold significantly increased to be between 0.011 M and 0.02 M. In female offspring, conditioned aversion threshold for sucrose lay between 0.003 M and 0.005 M in control group, whereas maternal HF diet increased it to be between 0.007 M and 0.009 M. Maternal HF diet increased T1R2 and T1R3 mRNA expression in taste buds of male offspring, while only increased T1R2 mRNA expression in female offspring. Both male and female offspring with HF dams had lower a-gustducin mRNA expression, whereas only male offspring with HF darns had lower OB-Rb mRNA expression in taste buds. Our data suggest that maternal HF diet decreased taste sensitivity to sucrose in both male and female offspring, which may be partly due to altered expression of sweet taste receptors and related downstream pathways in taste buds.
Keyword ：
Conditioned aversion threshold Conditioned taste aversion Maternal diet Sweet taste receptor Two-bottle choice test
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| GB/T 7714 | Song, Lin , Chen, Ke , Yan, Jianqun et al. Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring [J]. | PHYSIOLOGY & BEHAVIOR , 2019 , 212 . |
| MLA | Song, Lin et al. "Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring" . | PHYSIOLOGY & BEHAVIOR 212 (2019) . |
| APA | Song, Lin , Chen, Ke , Yan, Jianqun , Zhang, Yingfei , Mao, Xiwei , Lu, Bo et al. Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring . | PHYSIOLOGY & BEHAVIOR , 2019 , 212 . |
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Abstract ：
To reveal the nongenomic effect of aldosterone on the regulation of sodium intake in the nucleus tractus solitarius (NTS) and the role of central nucleus of the amygdala (CeA) in regulating this effect.Adult male SD rats were divided into four groups and underwent operations to induce bilateral CeA electrolytic lesions (400 μA, 25 s; <i>n</i>=28), bilateral sham CeA lesions (<i>n</i>=28), unilateral CeA lesions (<i>n</i>=28), or unilateral sham CeA lesions (<i>n</i>=26). After 3 days of recovery, the rats received implantation of a stainless steel 23-gauge cannula wih two tubes into the NTS followed by a recovery period of 7 days. The rats in each group were then divided into two subgroups for microinjection of aldosterone (50 ng/μL) or control solution in the NTS, and the cumulative intake within 30 min of 0.3 mol/L NaCl solution was recorded for each rat.Bilateral CeA lesions (3 days) eliminated the increased 0.3 mol/L NaCl intake induced by aldosterone microinjected into the NTS (0.3±0.04 mL in CeA lesion group <i>vs</i> 1.3±0.3 mL in sham lesion group). Unilateral CeA lesion (3 days) reduced aldosterone-induced increase of NaCl intake in the first 15 min (<i>P</i> < 0.05) but not in 15-30 min (<i>P</i> > 0.05). In rats with sham lesions, aldosterone (50 ng/μL) still induced a significant increase in NaCl intake[1.3±0.3 mL <i>vs</i> 0.25±0.02 mL in the control group; F (3, 224)=24.0, <i>P</i> < 0.05].The regulation of sodium intake by aldosterone is subjected to descending facilitatory modulation by the bilateral CeA, and CeA integrity is essential for aldosterone to execute the nongenomic effect in regulating rapid sodium intake.
Keyword ：
aldosterone central nucleus of the amygdala nongenomic effect sodium intake
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| GB/T 7714 | Qiao Hu , Wang Nan , Yan Jianqun . Role of the central nucleus of the amygdala in regulating the nongenomic effect of aldosterone on sodium intake in rat nucleus tractus solitarius]. [J]. | Journal of Southern Medical University , 2018 , 38 (10) : 1159-1164 . |
| MLA | Qiao Hu et al. "Role of the central nucleus of the amygdala in regulating the nongenomic effect of aldosterone on sodium intake in rat nucleus tractus solitarius]." . | Journal of Southern Medical University 38 . 10 (2018) : 1159-1164 . |
| APA | Qiao Hu , Wang Nan , Yan Jianqun . Role of the central nucleus of the amygdala in regulating the nongenomic effect of aldosterone on sodium intake in rat nucleus tractus solitarius]. . | Journal of Southern Medical University , 2018 , 38 (10) , 1159-1164 . |
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