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学者姓名：袁祖贻
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Abstract ：
BackgroundThe current burden of dyslipidemia, the pre-hospital application of statins and the association of pre-hospital statins with the severity of coronary artery disease (CAD) and in-hospital outcomes in Chinese patients with first acute coronary syndrome (ACS) are very significant and remain unclear. MethodsA total of 41,183 patients who underwent coronary angiography and were diagnosed with ACS for the first time from a nationwide registry study (CCC-ACS) were enrolled. The severity of CAD was assessed using the CAD prognostic index (CADPI). The patients were classified into statin and non-statin groups according to their pre-hospital statin treatment status. Clinical characteristics, CADPI and in-hospital outcomes were compared, and a logistic regression analysis was performed to determine whether pre-hospital statin therapy is associated with in-hospital outcomes and CADPI. A sensitivity analysis was used to further explore the issues above. ResultsThe non-statin group had more in-hospital all-cause deaths (1.2 vs. 0.8%, P = 0.010). However, no association exists between statin pretreatment and in-hospital major adverse cardiovascular events (MACEs) or all-cause deaths in the entire population and subgroups (all P > 0.05). Surprisingly, statin pretreatment was associated with an 8.9% higher risk of severely obstructive CAD (CADPI >= 37) (OR, 1.089; 95% CI, 1.010-1.175, P = 0.028), and similar results were observed in subgroups of females, those aged 50 to 75 years, and patients with hypertension. ConclusionStatin pretreatment was not related to MACEs or all-cause death during hospital stay, but it was associated with a higher risk of increased angiographic severity in patients with first ACS.
Keyword ：
acute coronary syndrome coronary artery disease prognostic index in-hospital major adverse cardiovascular event low-density lipoprotein cholesterol pre-hospital statin treatment
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| GB/T 7714 | Zhang, Lisha , Zhang, Yan , Chu, Chao et al. Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project [J]. | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2023 , 9 . |
| MLA | Zhang, Lisha et al. "Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project" . | FRONTIERS IN CARDIOVASCULAR MEDICINE 9 (2023) . |
| APA | Zhang, Lisha , Zhang, Yan , Chu, Chao , Deng, Fuxue , Zhou, Juan , Yuan, Zuyi et al. Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project . | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2023 , 9 . |
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Background. Acute myocardial infarction (AMI), as well as its long-term and short-term complications, is known to present with high morbidity and mortality. Cardiac function deterioration and ventricular remodelling after AMI are known to be correlated to worse long-term outcomes. However, the underlying mechanism remains elusive and there is a shortage of serum prediction markers. This study investigates the relationship between in-hospital Cystatin C (CysC) and cardiac function and subsequent prognosis among AMI patients. Research Design and Methods. We measured admission CysC and cardiac function parameters, including ejection fraction (EF) and pro-BNP value in 5956 patients diagnosed with AMI. Simple and multiregression analyses were performed to investigate the correlation between CysC and cardiac function in AMI patients. Major adverse cardiovascular events (MACE), cardiovascular, and all-cause mortality were documented, and 351 participants with high cystatin (>= 1.09 mg/L) and 714 low cystatin (<1.09 mg/L) were investigated for survival analysis during a 48-month follow-up. Results. 5956 patients with AMI were enrolled in the initial observational analysis, and 1065 patients of the whole cohort were included in the follow-up survival analysis. The admission CysC level was found to be significantly positively correlated to the pro-BNP level (R square = 0:2142, 95% CI 4758 to 5265, p < 0:0001) and negatively correlated to the EF value (R square = 0:0095, 95% CI -3.503 to -1.605, p < 0:0001). Kaplan-Meier survival analysis revealed significantly increased MACE incidence (HR = 2:293, 95% CI 1.400 to 3.755, p < 0:0001), cardiovascular mortality (HR = 3:016, 95% CI 1.694 to 5.371, p = 0:0002), and all-cause mortality (HR = 3:424, 95% CI 2.010 to 5.835, p < 0:0001) in high-admission CysC cohort with AMI at the end of 4-year follow-up. Conclusions. Admission CysC is negatively correlated with cardiac function in AMI patients and acts as a novel predictor for MACE incidence in the whole population. Further studies are needed to investigate the specific mechanism of CysC in the cardiac function deterioration among AMI patients.
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| GB/T 7714 | Lou, Bowen , Luo, Yongbai , Zhang, Haoxuan et al. Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis [J]. | DISEASE MARKERS , 2022 , 2022 . |
| MLA | Lou, Bowen et al. "Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis" . | DISEASE MARKERS 2022 (2022) . |
| APA | Lou, Bowen , Luo, Yongbai , Zhang, Haoxuan , Wu, Haoyu , Jiang, Gulinigaer Tuerhong , Liu, Hui et al. Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis . | DISEASE MARKERS , 2022 , 2022 . |
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Background. Previous studies have shown that increased mean corpuscular volume (MCV) is an independent predictor for worse outcomes in coronary artery disease. However, as parameters to classify different types of anemia together with MCV, the relationship between mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and long-term outcomes in acute coronary syndrome (ACS) remains obscure. Moreover, few studies have compared the prognostic value of these red blood cell indices in anemic and nonanemic patients with ACS. Methods and Results. In this single-center observational cohort study, we enrolled 393 patients diagnosed with ACS, including 75 anemic and 318 nonanemic patients. The composite end points were defined as major adverse cardiovascular events (MACEs). After a median follow-up of 31.24 months, Kaplan-Meier survival analysis showed that higher MCV and MCH but not MCHC were significantly associated with increased MACEs in nonanemic ACS patients. Among the enrolled ACS patients without anemia, Cox regression analysis revealed that high MCV and MCH were correlated with increased MACEs after adjustment for cardiovascular risk factors, and receiver operating characteristic (ROC) curve analysis further confirmed the predictive value of high MCV and MCH. In bivariate correlation and linear regression analysis, plasma homocysteine was positively correlated with MCV and MCH but not MCHC in the nonanemic group even after adjusting for age, male sex, BMI, SBP, DBP, smoking, and diabetes. However, MCV, MCH, and MCHC showed no predictive value for MACEs, and no correlation was found between these red blood cell indices and homocysteine in ACS patients with anemia. Conclusion. After adjusting for cardiovascular risk factors, this study showed that higher admission MCV and MCH but not MCHC were independent predictors for long-term MACEs and positively correlated with homocysteine levels in the blood among the nonanemic but not anemic patients with ACS in China.
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| GB/T 7714 | Zhang, Zhanyi , Gao, Shanshan , Dong, Mengya et al. Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome [J]. | DISEASE MARKERS , 2022 , 2022 . |
| MLA | Zhang, Zhanyi et al. "Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome" . | DISEASE MARKERS 2022 (2022) . |
| APA | Zhang, Zhanyi , Gao, Shanshan , Dong, Mengya , Luo, Jian , Xu, Chenbo , Wen, Wen et al. Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome . | DISEASE MARKERS , 2022 , 2022 . |
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Background and Aims. Bile acids, the key products for elimination of cholesterol, play an important role in coronary artery disease (CAD). However, few studies focused on the roles of more accessible serum total bile acids (TBA) in the prediction of adverse cardiovascular events for coronary chronic artery occlusion (CTO). The aim of this study was to explore the potential relationship between serum TBA and long-term prognosis in patients with CTO undergoing percutaneous coronary intervention (PCI). Methods. Baseline TBA was determined in 613 patients with CTO after PCI in the present study. All patients were divided into 3 groups according to the median (3.5 mu mol/l) and the normal upper limit of the TBA (10 mu mol/l). The primary endpoint was all-cause mortality, and the secondary endpoint was major adverse cardiovascular events (MACE). Results. Average age in this study was 65.44 & PLUSMN;9.94 years old. The median of TBA was 3.5 (2.1-6.1) mu mol/l. Over a median follow-up of 33.5 months, compared to those with below 3.5 mu mol/l TBA, 3.5 ~ 10 mu mol/l TBA was associated with significantly reduced risk for the MACE (hazard ratio (HR): 0.59, 95% confidence interval (CI): 0.40 to 0.88; p=0.009) even after adjustment for baseline variables. However, TBA did not predict all-cause mortality and cardiovascular death. Spline analyses showed an L-shaped relationship of the serum TBA with the incidence of MACE. Conclusions. Moderate fasting serum TBA level has a predictive value for MACE even after adjusting for lifestyle and clinical risk factors in CTO patients undergoing PCI.
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| GB/T 7714 | Zeng, Xinchun , Jian, Zhijie , Li, Shanshan et al. The Association between Serum Total Bile Acid Level and Long-Term Prognosis in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention [J]. | DISEASE MARKERS , 2022 , 2022 . |
| MLA | Zeng, Xinchun et al. "The Association between Serum Total Bile Acid Level and Long-Term Prognosis in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention" . | DISEASE MARKERS 2022 (2022) . |
| APA | Zeng, Xinchun , Jian, Zhijie , Li, Shanshan , Xu, Yu , Li, Bolin , Ding, Ning et al. The Association between Serum Total Bile Acid Level and Long-Term Prognosis in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention . | DISEASE MARKERS , 2022 , 2022 . |
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Background: Circadian system plays an important role in cardiovascular health. Experimental studies have also identified sex differences in circadian system. We aim to explore the impact of sex on the association between symptom-onset pattern of STEMI and in-hospital adverse outcomes in Chinese population. Methods: Data were used from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project. 18271 STEMI patients undergoing primary percutaneous coronary intervention entered the study, including 14785 (80.9%) men and 3486 (19.1%) women. The outcomes included allcause mortality and a composite of major adverse cardiovascular and cerebrovascular events (MACCE) during hospitalization. Results: Most participants experienced STEMI onset during 06:00 h to noon, and there was no difference in onset pattern between men and women (p 1/4 0.582). Logistic regression showed that, after adjustment for cardiovascular risk factors, symptom onset time was significantly associated with in-hospital mortality in men, but not in women or the total population. The odds ratios (ORs) for male patients were 1.86 (95% CI 1.05 to 3.27) for midnight to 06:00 h, 1.58 (95% CI 0.95 to 2.64) for 06:00 h to noon, and 0.80 (95% CI 0.49 to 1.73) for 18:00 h to midnight as compared with STEMI presenting during noon to 18:00 h. But symptom onset time was not associated with MACCE in both sexes or the entire cohort. Conclusions: These findings show that STEMI onset time was independently associated with in-hospital mortality in male Chinese patients, indicating that sex should be taken into account in studying impact of circadian system on myocardial infarction. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
Circadian rhythm Myocardial infarction Outcomes Sex differences
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| GB/T 7714 | Xu, Chenbo , Dong, Mengya , Sun, Lizhe et al. Sex differences in the impact of day/night distribution of ST-segment elevation myocardial infarction onset on in-hospital outcomes: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project [J]. | SLEEP MEDICINE , 2022 , 95 : 112-119 . |
| MLA | Xu, Chenbo et al. "Sex differences in the impact of day/night distribution of ST-segment elevation myocardial infarction onset on in-hospital outcomes: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project" . | SLEEP MEDICINE 95 (2022) : 112-119 . |
| APA | Xu, Chenbo , Dong, Mengya , Sun, Lizhe , Deng, Yangyang , Zhou, Juan , Yuan, Zuyi . Sex differences in the impact of day/night distribution of ST-segment elevation myocardial infarction onset on in-hospital outcomes: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project . | SLEEP MEDICINE , 2022 , 95 , 112-119 . |
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Several leukocyte to high-density lipoprotein cholesterol (HDL-C) ratios, including monocyte to HDL-C ratio (MHR), neutrophil to HDL-C ratio (NHR) and lymphocyte to HDL-C ratio (LHR), have been proposed as novel inflammatory indicators. We performed a cross-sectional study to investigate the relationships between these leukocyte to HDL-C ratios and coronary artery disease (CAD) in patients with chest pain with controlled low-density lipoprotein cholesterol (LDL-C). A total of 3482 patients with chest pain with LDL-C <1.8 mmol/L were enrolled. We evaluated the relationships between MHR, NHR, LHR and HDL-C and the occurrence of CAD as well as severe stenosis. We found that in patients with chest pain, higher MHR (adjusted OR=2.83, 95% CI 1.61 to 4.99, p<0.001) and NHR (adjusted OR=1.08, 95% CI 1.04 to 1.13, p<0.001), as well as lower HDL-C (adjusted OR=0.53, 95% CI 0.36 to 0.78, p=0.001), but not higher LHR (adjusted OR=1.06, 95% CI 0.94 to 1.20, p=0.341), had a stronger association with the occurrence of CAD. Moreover, unlike LHR (adjusted OR=1.02, 95% CI 0.93 to 1.13, p=0.654), higher MHR (adjusted OR=2.10, 95% CI 1.43 to 3.07, p<0.001) and NHR (adjusted OR=1.06, 95% CI 1.04 to 1.09, p<0.001) and lower HDL-C (adjusted OR=0.38, 95% CI 0.26 to 0.56, p<0.001) were risk factors for severe stenosis. A receiver operating characteristic curve analysis exhibited comparable abilities between MHR and NHR in predicting the presence and severity of CAD. In conclusion, even though patients with chest pain have achieved LDL-C <1.8 mmol/L, the inflammatory indicators MHR and NHR maintained their predictive abilities and remained associated with the occurrence and severity of CAD.
Keyword ：
Coronary Artery Disease HDL LDL Lipoproteins
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| GB/T 7714 | Liu, Mengping , Liu, Xiaojun , Wei, Zhen et al. MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C [J]. | JOURNAL OF INVESTIGATIVE MEDICINE , 2022 , 70 (7) : 1501-1507 . |
| MLA | Liu, Mengping et al. "MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C" . | JOURNAL OF INVESTIGATIVE MEDICINE 70 . 7 (2022) : 1501-1507 . |
| APA | Liu, Mengping , Liu, Xiaojun , Wei, Zhen , Hua, Rui , Huang, Yuzhi , Hao, Xiang et al. MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C . | JOURNAL OF INVESTIGATIVE MEDICINE , 2022 , 70 (7) , 1501-1507 . |
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Purpose: Anion gap (AG) is a valuable and easily obtained clinical tool for differentially diagnosis of acid-base disorders. Current understanding of the prognostic impact of AG on mortality after acute myocardial infarction (AMI) is limited. We aimed to investigate whether AG is a predictor of short-term and long-term all-cause mortality after AMI. Patients and Methods: We examined 1806 patients diagnosed with AMI in intensive care unit from the Medical Information Mart for Intensive Care III (MIMIC-III) database. We analyzed the association of AG with 30-day, 180-day and 1-year all-cause mortality on a continuous scale and in categories, using multivariable Cox regression. We utilized restricted cubic splines to evaluate the linearity between hazard ratio (HR) and AG concentrations. Results: AG was associated with a higher risk of 30-day, 180-day and 1-year all-cause mortality, with adjusted HRs of 1.083 (95% CI 1.051 to 1.117), 1.077 (95% CI 1.049 to 1.105), and 1.074 (95% CI 1.047 to 1.101), respectively. The results were consistent in subgroup analyses. The association between AG and all-cause mortality was linear for 180-day and 1-year mortality, and near linear for 30-day mortality, as higher concentrations were associated with high all-cause mortality. When stratified according to quartiles, AG was associated with 30-day mortality (HR[95% CI]: second quartile, 2.243[1.273, 3.955]; third quartile, 3.026[1.763, 5.194]; top quartile, 4.402[2.573, 7.531]), 180-day mortality (HR[95% CI]: second quartile, 1.719[1.118, 2.645]; third quartile, 2.362[1.575, 3.542]; top quartile, 3.116[2.077, 4.676]), and 1-year mortality (HR[95% CI]: second quartile, 1.700[1.143, 2.528]; third quartile, 2.239[1.536, 3.264]; top quartile, 2.876[1.969, 4.201]) using bottom quartile as reference. Conclusion: We firstly demonstrated that higher AG was significantly associated with increased 30-day, 180-day and 1-year all-cause mortality in AMI patients. AG as an easily obtained marker is of strong and reliable predictive value for AMI mortality during follow-up.
Keyword ：
acute myocardial infarction all-cause mortality anion gap
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| GB/T 7714 | Xu, Chenbo , Sun, Lizhe , Dong, Mengya et al. Serum Anion Gap is Associated with Risk of All-Cause Mortality in Critically III Patients with Acute Myocardial Infarction [J]. | INTERNATIONAL JOURNAL OF GENERAL MEDICINE , 2022 , 15 : 223-231 . |
| MLA | Xu, Chenbo et al. "Serum Anion Gap is Associated with Risk of All-Cause Mortality in Critically III Patients with Acute Myocardial Infarction" . | INTERNATIONAL JOURNAL OF GENERAL MEDICINE 15 (2022) : 223-231 . |
| APA | Xu, Chenbo , Sun, Lizhe , Dong, Mengya , Ullah, Habib , Ullah, Hameed , Zhou, Juan et al. Serum Anion Gap is Associated with Risk of All-Cause Mortality in Critically III Patients with Acute Myocardial Infarction . | INTERNATIONAL JOURNAL OF GENERAL MEDICINE , 2022 , 15 , 223-231 . |
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Background and AimsMalnutrition is a well known risk factor for adverse outcomes in patients with cancer, cardiovascular disease (CVD) and chronic kidney disease, but epidemiological evidence on its relationship with the long-term risk of all-cause mortality and cardiovascular death is limited. MethodsA total of 20,116 adults from the United States National Health and Nutrition Examination Survey 2007-2014 were enrolled. The Geriatric Nutritional Risk Index (GNRI), Prognostic Nutritional Index (PNI), Controlling Nutritional Status (CONUT) score, and Triglycerides (TG) x Total Cholesterol (TC) x Body Weight (BW) Index (TCBI) were calculated at baseline. Cox regression and the Kaplan-Meier analysis were conducted when participants were divided into three groups according to the tertiles of objective nutritional scores. Restricted cubic spline was performed to further explore the shape of the relationship between all-cause mortality, cardiovascular death, and nutritional scores. In addition, the area under the curve (AUC), continuous net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were conducted to assess which nutritional scores have the greatest predictive value for all-cause death and cardiovascular death in the general population. ResultsThe cumulative incidence of all-cause death and cardiovascular death was significantly higher in participants with a higher CONUT score, lower GNRI, and lower PNI. TCBI showed the worst performance on grading and risk assessment. After adjusting confounding factors, the lowest PNI and GNRI tertile and highest COUNT score were independently and significantly associated with increased risk of all-cause death (all P < 0.01) and cardiovascular death (all P < 0.05) analyzed by a multivariate Cox regression model. An L-shaped association between the HR (hazard ratio) of all-cause mortality and nutritional scores (GNRI, PNI and TCBI) was observed in the overall populations. In addition, the PNI had the highest predictive value for all-cause mortality [AUC: 0.684, 95% confidence interval (CI): 0.667-0.701] and cardiovascular death (AUC: 0.710, 95% CI: 0.672-0.749) in the general population compared with other nutritional scores. ConclusionThe poorer the nutritional status of the general population, the higher the all-cause mortality and cardiovascular mortality. The PNI score may provide more useful predictive values than other nutritional scores.
Keyword ：
all-cause death cardiovascular death general population malnutrition nutritional scores
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| GB/T 7714 | Fan, Heze , Huang, Yuzhi , Zhang, Haoxuan et al. Association of Four Nutritional Scores With All-Cause and Cardiovascular Mortality in the General Population [J]. | FRONTIERS IN NUTRITION , 2022 , 9 . |
| MLA | Fan, Heze et al. "Association of Four Nutritional Scores With All-Cause and Cardiovascular Mortality in the General Population" . | FRONTIERS IN NUTRITION 9 (2022) . |
| APA | Fan, Heze , Huang, Yuzhi , Zhang, Haoxuan , Feng, Xueying , Yuan, Zuyi , Zhou, Juan . Association of Four Nutritional Scores With All-Cause and Cardiovascular Mortality in the General Population . | FRONTIERS IN NUTRITION , 2022 , 9 . |
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BackgroundContrast-induced acute kidney injury (CI-AKI) is a common complication of patients undergoing percutaneous coronary intervention (PCI). Data regarding the influence of sodium-glucose cotransporter-2 (SGLT2) inhibitor on the CI-AKI incidence and renal outcomes of patients undergoing PCI are limited. This study aimed to examine the real-world risk of CI-AKI in SGLT2 inhibitor users undergoing PCI. MethodsWe used longitudinal data from the medical records of the First Affiliated Hospital of Xi'an Jiaotong University. We selected SGLT inhibitor users and nonusers [patients with type 2 diabetes (T2D) without SGLT2 inhibitor prescription] undergoing PCI. We determined CI-AKI by the ESUR (European Society of Urogenital Radiology, AKI(ESUR)) and KDIGO definition (Kidney Disease: Improving Global Outcomes, AKI(KDIGO)). We performed 1:1 nearest-neighbor propensity matching and calculated unadjusted odds ratios (ORs) and adjusted ORs (aORs; accounting for covariates poorly balanced) for AKI in primary and sensitivity analyses. We compared the renal function indicators in users and nonusers at 24, 48, and 72 h post-PCI. ResultsWe identified 242 SGLT2 inhibitor users and 242 nonusers in the cohort. The unadjusted ORs of CI-AKI(ESUR) were 63% lower in users [OR: 0.37 (95% CI: 0.18-0.68); P = 0.01], which was unchanged [aOR: 0.37 (95% CI: 0.19-0.67); P < 0.01] post adjustment. These estimates did not qualitatively change across several sensitivity analyses. There was no significant difference in urea nitrogen, creatinine, and estimated glomerular filtration rate (eGFR) values between the two groups before PCI, and at 24 h, while the creatinine (48 and 72 h post-PCI) and CyC (24 and 48 h post-PCI) were significantly lower than those in the nonuser group (P < 0.05). ConclusionOur findings do not suggest an increased risk of CI-AKI associated with SGLT2 inhibitor use in patients with CAD and T2D undergoing PCI.
Keyword ：
contrast-induced AKI coronary artery disease diabetes mellitus percutaneous coronary intervention SGLT2 inhibitor
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| GB/T 7714 | Hua, Rui , Ding, Ning , Guo, Hanqing et al. Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis [J]. | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2022 , 9 . |
| MLA | Hua, Rui et al. "Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis" . | FRONTIERS IN CARDIOVASCULAR MEDICINE 9 (2022) . |
| APA | Hua, Rui , Ding, Ning , Guo, Hanqing , Wu, Yue , Yuan, Zuyi , Li, Ting . Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis . | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2022 , 9 . |
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Purpose: Left ventricular aneurysm (LVA) is a severe and common mechanical comorbidity with acute myocardial infarction (AMI) that can present high mortality and serious adverse outcomes. Accordingly, there is a need for early identification and prevention of patients at risk of LVA. The aim of this study was to develop and validate a risk prediction model for LVA among AMI patients in Methods: A total of 509 patients with AMI were retrospectively collected between January 2018 and August 2021. All patients were randomly divided into a training group (n=356) and a validation group (n=153). Potential risk factors for LVA were screened for predictive modelling using least absolute shrinkage and selection operator regression, multivariate logistic regression, clinical relevance, and represented by a comprehensive nomogram. Receiver operating characteristic curve, calibration curve, and decisioncurve analysis (DCA) were used to assess the discrimination capacity, calibration, and clinical validity, respectively.Results: Seven predictors were finally identified for the establishment of prediction model, including age, cardiovascular disease and aspartate aminotransferase. The prediction model achieved acceptable areas under the curves of 0.901 (95% confidence interval [CI]=0.868-0.933) and 0.908 (95% CI=0.861-0.956) in the training and validation groups, respectively, and the calibration curves fit well in our model. The DCA result indicated that this nomogram exhibited a favorable performance in terms of clinical utility.Conclusion: An accurate prediction model for LVA development established, which can be applied to rapidly assess the risk of LVA in patients with AMI. Our findings will aid clinical decision-making to reduce the incidence of LVA in high-risk patients, and counteract adverse cardiovascular outcomes.
Keyword ：
acute myocardial infarction adverse cardiovascular outcomes cardiovascular disease left ventricular aneurysm risk prediction model
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| GB/T 7714 | Xing, Yuanming , Wang, Chen , Wu, Haoyu et al. Development and Evaluation of a Risk Prediction Model for Left Ventricular Aneurysm in Patients with Acute Myocardial Infarction in Northwest China [J]. | INTERNATIONAL JOURNAL OF GENERAL MEDICINE , 2022 , 15 . |
| MLA | Xing, Yuanming et al. "Development and Evaluation of a Risk Prediction Model for Left Ventricular Aneurysm in Patients with Acute Myocardial Infarction in Northwest China" . | INTERNATIONAL JOURNAL OF GENERAL MEDICINE 15 (2022) . |
| APA | Xing, Yuanming , Wang, Chen , Wu, Haoyu , Ding, Yiming , Chen, Siying , Yuan, Zuyi . Development and Evaluation of a Risk Prediction Model for Left Ventricular Aneurysm in Patients with Acute Myocardial Infarction in Northwest China . | INTERNATIONAL JOURNAL OF GENERAL MEDICINE , 2022 , 15 . |
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