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学者姓名:袁祖贻

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Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project SCIE
期刊论文 | 2023 , 9 | FRONTIERS IN CARDIOVASCULAR MEDICINE
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BackgroundThe current burden of dyslipidemia, the pre-hospital application of statins and the association of pre-hospital statins with the severity of coronary artery disease (CAD) and in-hospital outcomes in Chinese patients with first acute coronary syndrome (ACS) are very significant and remain unclear. MethodsA total of 41,183 patients who underwent coronary angiography and were diagnosed with ACS for the first time from a nationwide registry study (CCC-ACS) were enrolled. The severity of CAD was assessed using the CAD prognostic index (CADPI). The patients were classified into statin and non-statin groups according to their pre-hospital statin treatment status. Clinical characteristics, CADPI and in-hospital outcomes were compared, and a logistic regression analysis was performed to determine whether pre-hospital statin therapy is associated with in-hospital outcomes and CADPI. A sensitivity analysis was used to further explore the issues above. ResultsThe non-statin group had more in-hospital all-cause deaths (1.2 vs. 0.8%, P = 0.010). However, no association exists between statin pretreatment and in-hospital major adverse cardiovascular events (MACEs) or all-cause deaths in the entire population and subgroups (all P > 0.05). Surprisingly, statin pretreatment was associated with an 8.9% higher risk of severely obstructive CAD (CADPI >= 37) (OR, 1.089; 95% CI, 1.010-1.175, P = 0.028), and similar results were observed in subgroups of females, those aged 50 to 75 years, and patients with hypertension. ConclusionStatin pretreatment was not related to MACEs or all-cause death during hospital stay, but it was associated with a higher risk of increased angiographic severity in patients with first ACS.

Keyword :

acute coronary syndrome coronary artery disease prognostic index in-hospital major adverse cardiovascular event low-density lipoprotein cholesterol pre-hospital statin treatment

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GB/T 7714 Zhang, Lisha , Zhang, Yan , Chu, Chao et al. Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project [J]. | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2023 , 9 .
MLA Zhang, Lisha et al. "Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project" . | FRONTIERS IN CARDIOVASCULAR MEDICINE 9 (2023) .
APA Zhang, Lisha , Zhang, Yan , Chu, Chao , Deng, Fuxue , Zhou, Juan , Yuan, Zuyi et al. Associations of pre-hospital statin treatment with in-hospital outcomes and severity of coronary artery disease in patients with first acute coronary syndrome-findings from the CCC-ACS project . | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2023 , 9 .
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Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis SCIE
期刊论文 | 2022 , 2022 | DISEASE MARKERS
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Background. Acute myocardial infarction (AMI), as well as its long-term and short-term complications, is known to present with high morbidity and mortality. Cardiac function deterioration and ventricular remodelling after AMI are known to be correlated to worse long-term outcomes. However, the underlying mechanism remains elusive and there is a shortage of serum prediction markers. This study investigates the relationship between in-hospital Cystatin C (CysC) and cardiac function and subsequent prognosis among AMI patients. Research Design and Methods. We measured admission CysC and cardiac function parameters, including ejection fraction (EF) and pro-BNP value in 5956 patients diagnosed with AMI. Simple and multiregression analyses were performed to investigate the correlation between CysC and cardiac function in AMI patients. Major adverse cardiovascular events (MACE), cardiovascular, and all-cause mortality were documented, and 351 participants with high cystatin (>= 1.09 mg/L) and 714 low cystatin (<1.09 mg/L) were investigated for survival analysis during a 48-month follow-up. Results. 5956 patients with AMI were enrolled in the initial observational analysis, and 1065 patients of the whole cohort were included in the follow-up survival analysis. The admission CysC level was found to be significantly positively correlated to the pro-BNP level (R square = 0:2142, 95% CI 4758 to 5265, p < 0:0001) and negatively correlated to the EF value (R square = 0:0095, 95% CI -3.503 to -1.605, p < 0:0001). Kaplan-Meier survival analysis revealed significantly increased MACE incidence (HR = 2:293, 95% CI 1.400 to 3.755, p < 0:0001), cardiovascular mortality (HR = 3:016, 95% CI 1.694 to 5.371, p = 0:0002), and all-cause mortality (HR = 3:424, 95% CI 2.010 to 5.835, p < 0:0001) in high-admission CysC cohort with AMI at the end of 4-year follow-up. Conclusions. Admission CysC is negatively correlated with cardiac function in AMI patients and acts as a novel predictor for MACE incidence in the whole population. Further studies are needed to investigate the specific mechanism of CysC in the cardiac function deterioration among AMI patients.

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GB/T 7714 Lou, Bowen , Luo, Yongbai , Zhang, Haoxuan et al. Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis [J]. | DISEASE MARKERS , 2022 , 2022 .
MLA Lou, Bowen et al. "Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis" . | DISEASE MARKERS 2022 (2022) .
APA Lou, Bowen , Luo, Yongbai , Zhang, Haoxuan , Wu, Haoyu , Jiang, Gulinigaer Tuerhong , Liu, Hui et al. Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis . | DISEASE MARKERS , 2022 , 2022 .
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Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome SCIE Scopus
期刊论文 | 2022 , 2022 | DISEASE MARKERS
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Background. Previous studies have shown that increased mean corpuscular volume (MCV) is an independent predictor for worse outcomes in coronary artery disease. However, as parameters to classify different types of anemia together with MCV, the relationship between mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and long-term outcomes in acute coronary syndrome (ACS) remains obscure. Moreover, few studies have compared the prognostic value of these red blood cell indices in anemic and nonanemic patients with ACS. Methods and Results. In this single-center observational cohort study, we enrolled 393 patients diagnosed with ACS, including 75 anemic and 318 nonanemic patients. The composite end points were defined as major adverse cardiovascular events (MACEs). After a median follow-up of 31.24 months, Kaplan-Meier survival analysis showed that higher MCV and MCH but not MCHC were significantly associated with increased MACEs in nonanemic ACS patients. Among the enrolled ACS patients without anemia, Cox regression analysis revealed that high MCV and MCH were correlated with increased MACEs after adjustment for cardiovascular risk factors, and receiver operating characteristic (ROC) curve analysis further confirmed the predictive value of high MCV and MCH. In bivariate correlation and linear regression analysis, plasma homocysteine was positively correlated with MCV and MCH but not MCHC in the nonanemic group even after adjusting for age, male sex, BMI, SBP, DBP, smoking, and diabetes. However, MCV, MCH, and MCHC showed no predictive value for MACEs, and no correlation was found between these red blood cell indices and homocysteine in ACS patients with anemia. Conclusion. After adjusting for cardiovascular risk factors, this study showed that higher admission MCV and MCH but not MCHC were independent predictors for long-term MACEs and positively correlated with homocysteine levels in the blood among the nonanemic but not anemic patients with ACS in China.

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GB/T 7714 Zhang, Zhanyi , Gao, Shanshan , Dong, Mengya et al. Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome [J]. | DISEASE MARKERS , 2022 , 2022 .
MLA Zhang, Zhanyi et al. "Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome" . | DISEASE MARKERS 2022 (2022) .
APA Zhang, Zhanyi , Gao, Shanshan , Dong, Mengya , Luo, Jian , Xu, Chenbo , Wen, Wen et al. Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome . | DISEASE MARKERS , 2022 , 2022 .
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The Association between Serum Total Bile Acid Level and Long-Term Prognosis in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention SCIE Scopus
期刊论文 | 2022 , 2022 | DISEASE MARKERS
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Background and Aims. Bile acids, the key products for elimination of cholesterol, play an important role in coronary artery disease (CAD). However, few studies focused on the roles of more accessible serum total bile acids (TBA) in the prediction of adverse cardiovascular events for coronary chronic artery occlusion (CTO). The aim of this study was to explore the potential relationship between serum TBA and long-term prognosis in patients with CTO undergoing percutaneous coronary intervention (PCI). Methods. Baseline TBA was determined in 613 patients with CTO after PCI in the present study. All patients were divided into 3 groups according to the median (3.5 mu mol/l) and the normal upper limit of the TBA (10 mu mol/l). The primary endpoint was all-cause mortality, and the secondary endpoint was major adverse cardiovascular events (MACE). Results. Average age in this study was 65.44 & PLUSMN;9.94 years old. The median of TBA was 3.5 (2.1-6.1) mu mol/l. Over a median follow-up of 33.5 months, compared to those with below 3.5 mu mol/l TBA, 3.5 ~ 10 mu mol/l TBA was associated with significantly reduced risk for the MACE (hazard ratio (HR): 0.59, 95% confidence interval (CI): 0.40 to 0.88; p=0.009) even after adjustment for baseline variables. However, TBA did not predict all-cause mortality and cardiovascular death. Spline analyses showed an L-shaped relationship of the serum TBA with the incidence of MACE. Conclusions. Moderate fasting serum TBA level has a predictive value for MACE even after adjusting for lifestyle and clinical risk factors in CTO patients undergoing PCI.

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GB/T 7714 Zeng, Xinchun , Jian, Zhijie , Li, Shanshan et al. The Association between Serum Total Bile Acid Level and Long-Term Prognosis in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention [J]. | DISEASE MARKERS , 2022 , 2022 .
MLA Zeng, Xinchun et al. "The Association between Serum Total Bile Acid Level and Long-Term Prognosis in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention" . | DISEASE MARKERS 2022 (2022) .
APA Zeng, Xinchun , Jian, Zhijie , Li, Shanshan , Xu, Yu , Li, Bolin , Ding, Ning et al. The Association between Serum Total Bile Acid Level and Long-Term Prognosis in Patients with Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention . | DISEASE MARKERS , 2022 , 2022 .
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Sex differences in the impact of day/night distribution of ST-segment elevation myocardial infarction onset on in-hospital outcomes: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project SCIE Scopus
期刊论文 | 2022 , 95 , 112-119 | SLEEP MEDICINE
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Background: Circadian system plays an important role in cardiovascular health. Experimental studies have also identified sex differences in circadian system. We aim to explore the impact of sex on the association between symptom-onset pattern of STEMI and in-hospital adverse outcomes in Chinese population. Methods: Data were used from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project. 18271 STEMI patients undergoing primary percutaneous coronary intervention entered the study, including 14785 (80.9%) men and 3486 (19.1%) women. The outcomes included allcause mortality and a composite of major adverse cardiovascular and cerebrovascular events (MACCE) during hospitalization. Results: Most participants experienced STEMI onset during 06:00 h to noon, and there was no difference in onset pattern between men and women (p 1/4 0.582). Logistic regression showed that, after adjustment for cardiovascular risk factors, symptom onset time was significantly associated with in-hospital mortality in men, but not in women or the total population. The odds ratios (ORs) for male patients were 1.86 (95% CI 1.05 to 3.27) for midnight to 06:00 h, 1.58 (95% CI 0.95 to 2.64) for 06:00 h to noon, and 0.80 (95% CI 0.49 to 1.73) for 18:00 h to midnight as compared with STEMI presenting during noon to 18:00 h. But symptom onset time was not associated with MACCE in both sexes or the entire cohort. Conclusions: These findings show that STEMI onset time was independently associated with in-hospital mortality in male Chinese patients, indicating that sex should be taken into account in studying impact of circadian system on myocardial infarction. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keyword :

Circadian rhythm Myocardial infarction Outcomes Sex differences

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GB/T 7714 Xu, Chenbo , Dong, Mengya , Sun, Lizhe et al. Sex differences in the impact of day/night distribution of ST-segment elevation myocardial infarction onset on in-hospital outcomes: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project [J]. | SLEEP MEDICINE , 2022 , 95 : 112-119 .
MLA Xu, Chenbo et al. "Sex differences in the impact of day/night distribution of ST-segment elevation myocardial infarction onset on in-hospital outcomes: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project" . | SLEEP MEDICINE 95 (2022) : 112-119 .
APA Xu, Chenbo , Dong, Mengya , Sun, Lizhe , Deng, Yangyang , Zhou, Juan , Yuan, Zuyi . Sex differences in the impact of day/night distribution of ST-segment elevation myocardial infarction onset on in-hospital outcomes: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project . | SLEEP MEDICINE , 2022 , 95 , 112-119 .
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Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis SCIE
期刊论文 | 2022 , 9 | FRONTIERS IN CARDIOVASCULAR MEDICINE
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BackgroundContrast-induced acute kidney injury (CI-AKI) is a common complication of patients undergoing percutaneous coronary intervention (PCI). Data regarding the influence of sodium-glucose cotransporter-2 (SGLT2) inhibitor on the CI-AKI incidence and renal outcomes of patients undergoing PCI are limited. This study aimed to examine the real-world risk of CI-AKI in SGLT2 inhibitor users undergoing PCI. MethodsWe used longitudinal data from the medical records of the First Affiliated Hospital of Xi'an Jiaotong University. We selected SGLT inhibitor users and nonusers [patients with type 2 diabetes (T2D) without SGLT2 inhibitor prescription] undergoing PCI. We determined CI-AKI by the ESUR (European Society of Urogenital Radiology, AKI(ESUR)) and KDIGO definition (Kidney Disease: Improving Global Outcomes, AKI(KDIGO)). We performed 1:1 nearest-neighbor propensity matching and calculated unadjusted odds ratios (ORs) and adjusted ORs (aORs; accounting for covariates poorly balanced) for AKI in primary and sensitivity analyses. We compared the renal function indicators in users and nonusers at 24, 48, and 72 h post-PCI. ResultsWe identified 242 SGLT2 inhibitor users and 242 nonusers in the cohort. The unadjusted ORs of CI-AKI(ESUR) were 63% lower in users [OR: 0.37 (95% CI: 0.18-0.68); P = 0.01], which was unchanged [aOR: 0.37 (95% CI: 0.19-0.67); P < 0.01] post adjustment. These estimates did not qualitatively change across several sensitivity analyses. There was no significant difference in urea nitrogen, creatinine, and estimated glomerular filtration rate (eGFR) values between the two groups before PCI, and at 24 h, while the creatinine (48 and 72 h post-PCI) and CyC (24 and 48 h post-PCI) were significantly lower than those in the nonuser group (P < 0.05). ConclusionOur findings do not suggest an increased risk of CI-AKI associated with SGLT2 inhibitor use in patients with CAD and T2D undergoing PCI.

Keyword :

contrast-induced AKI coronary artery disease diabetes mellitus percutaneous coronary intervention SGLT2 inhibitor

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GB/T 7714 Hua, Rui , Ding, Ning , Guo, Hanqing et al. Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis [J]. | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2022 , 9 .
MLA Hua, Rui et al. "Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis" . | FRONTIERS IN CARDIOVASCULAR MEDICINE 9 (2022) .
APA Hua, Rui , Ding, Ning , Guo, Hanqing , Wu, Yue , Yuan, Zuyi , Li, Ting . Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis . | FRONTIERS IN CARDIOVASCULAR MEDICINE , 2022 , 9 .
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Development and Evaluation of a Risk Prediction Model for Left Ventricular Aneurysm in Patients with Acute Myocardial Infarction in Northwest China SCIE
期刊论文 | 2022 , 15 | INTERNATIONAL JOURNAL OF GENERAL MEDICINE
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Purpose: Left ventricular aneurysm (LVA) is a severe and common mechanical comorbidity with acute myocardial infarction (AMI) that can present high mortality and serious adverse outcomes. Accordingly, there is a need for early identification and prevention of patients at risk of LVA. The aim of this study was to develop and validate a risk prediction model for LVA among AMI patients in Methods: A total of 509 patients with AMI were retrospectively collected between January 2018 and August 2021. All patients were randomly divided into a training group (n=356) and a validation group (n=153). Potential risk factors for LVA were screened for predictive modelling using least absolute shrinkage and selection operator regression, multivariate logistic regression, clinical relevance, and represented by a comprehensive nomogram. Receiver operating characteristic curve, calibration curve, and decisioncurve analysis (DCA) were used to assess the discrimination capacity, calibration, and clinical validity, respectively.Results: Seven predictors were finally identified for the establishment of prediction model, including age, cardiovascular disease and aspartate aminotransferase. The prediction model achieved acceptable areas under the curves of 0.901 (95% confidence interval [CI]=0.868-0.933) and 0.908 (95% CI=0.861-0.956) in the training and validation groups, respectively, and the calibration curves fit well in our model. The DCA result indicated that this nomogram exhibited a favorable performance in terms of clinical utility.Conclusion: An accurate prediction model for LVA development established, which can be applied to rapidly assess the risk of LVA in patients with AMI. Our findings will aid clinical decision-making to reduce the incidence of LVA in high-risk patients, and counteract adverse cardiovascular outcomes.

Keyword :

acute myocardial infarction adverse cardiovascular outcomes cardiovascular disease left ventricular aneurysm risk prediction model

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GB/T 7714 Xing, Yuanming , Wang, Chen , Wu, Haoyu et al. Development and Evaluation of a Risk Prediction Model for Left Ventricular Aneurysm in Patients with Acute Myocardial Infarction in Northwest China [J]. | INTERNATIONAL JOURNAL OF GENERAL MEDICINE , 2022 , 15 .
MLA Xing, Yuanming et al. "Development and Evaluation of a Risk Prediction Model for Left Ventricular Aneurysm in Patients with Acute Myocardial Infarction in Northwest China" . | INTERNATIONAL JOURNAL OF GENERAL MEDICINE 15 (2022) .
APA Xing, Yuanming , Wang, Chen , Wu, Haoyu , Ding, Yiming , Chen, Siying , Yuan, Zuyi . Development and Evaluation of a Risk Prediction Model for Left Ventricular Aneurysm in Patients with Acute Myocardial Infarction in Northwest China . | INTERNATIONAL JOURNAL OF GENERAL MEDICINE , 2022 , 15 .
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Endothelial-derived extracellular microRNA-92a promotes arterial stiffness by regulating phenotype changes of vascular smooth muscle cells SCIE
期刊论文 | 2022 , 12 (1) | SCIENTIFIC REPORTS
WoS CC Cited Count: 2
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Endothelial dysfunction and vascular smooth muscle cell (VSMC) plasticity are critically involved in the pathogenesis of hypertension and arterial stiffness. MicroRNAs can mediate the cellular communication between vascular endothelial cells (ECs) and neighboring cells. Here, we investigated the role of endothelial-derived extracellular microRNA-92a (miR-92a) in promoting arterial stiffness by regulating EC-VSMC communication. Serum miR-92a level was higher in hypertensive patients than controls. Circulating miR-92a level was positively correlated with pulse wave velocity (PWV), systolic blood pressure (SBP), diastolic blood pressure (DBP), and serum endothelin-1 (ET-1) level, but inversely with serum nitric oxide (NO) level. In vitro, angiotensin II (Ang II)-increased miR-92a level in ECs mediated a contractile-to-synthetic phenotype change of co-cultured VSMCs. In Ang II-infused mice, locked nucleic acid-modified antisense miR-92a (LNA-miR-92a) ameliorated PWV, SBP, DBP, and impaired vasodilation induced by Ang II. LNA-miR-92a administration also reversed the increased levels of proliferative genes and decreased levels of contractile genes induced by Ang II in mouse aortas. Circulating serum miR-92a level and PWV were correlated in these mice. These findings indicate that EC miR-92a may be transported to VSMCs via extracellular vesicles to regulate phenotype changes of VSMCs, leading to arterial stiffness.

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GB/T 7714 Wang, Chen , Wu, Haoyu , Xing, Yuanming et al. Endothelial-derived extracellular microRNA-92a promotes arterial stiffness by regulating phenotype changes of vascular smooth muscle cells [J]. | SCIENTIFIC REPORTS , 2022 , 12 (1) .
MLA Wang, Chen et al. "Endothelial-derived extracellular microRNA-92a promotes arterial stiffness by regulating phenotype changes of vascular smooth muscle cells" . | SCIENTIFIC REPORTS 12 . 1 (2022) .
APA Wang, Chen , Wu, Haoyu , Xing, Yuanming , Ye, Yulan , He, Fangzhou , Yin, Qian et al. Endothelial-derived extracellular microRNA-92a promotes arterial stiffness by regulating phenotype changes of vascular smooth muscle cells . | SCIENTIFIC REPORTS , 2022 , 12 (1) .
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Ideal Cardiovascular Health Metrics Are Associated with Reduced Severity of Hepatic Steatosis and Liver Fibrosis Detected by Transient Elastography SCIE
期刊论文 | 2022 , 14 (24) | NUTRIENTS
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Life's Simple 7 (LS7) is the American Heart Association's (AHA) proposal for a healthy lifestyle, also known as cardiovascular health (CVH) metrics. However, the association between CVH metrics and the severity of hepatic steatosis and liver fibrosis detected by transient elastography is unknown. We performed a cross-sectional study using the data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) cycle. The controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were used to evaluate the severity of hepatic steatosis and liver fibrosis and to define NAFLD, advanced liver fibrosis, and cirrhosis. A total of 2679 participants were included. Multivariate linear regression analysis revealed that per 1-unit increase in the CVH metric, CAP and LSM decreased by 8.565 units and 0.274 units, respectively. In the multivariate logistic regression analysis, the risk of NAFLD, advanced liver fibrosis, and cirrhosis were 7, 10, and 6 times higher in the poor CVH group than in the ideal CVH group. Subgroup analysis indicated that CVD patients and non-Hispanic whites could benefit more from ideal CVH. In conclusion, adherence to ideal CVH metrics, as proposed by the AHA, can significantly reduce the risk of hepatic steatosis and liver fibrosis.

Keyword :

cardiovascular health metrics controlled attenuation parameter healthy lifestyle liver stiffness measurement National Health and Nutrition Examination Survey

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GB/T 7714 Fan, Heze , Xu, Chenbo , Li, Wenyuan et al. Ideal Cardiovascular Health Metrics Are Associated with Reduced Severity of Hepatic Steatosis and Liver Fibrosis Detected by Transient Elastography [J]. | NUTRIENTS , 2022 , 14 (24) .
MLA Fan, Heze et al. "Ideal Cardiovascular Health Metrics Are Associated with Reduced Severity of Hepatic Steatosis and Liver Fibrosis Detected by Transient Elastography" . | NUTRIENTS 14 . 24 (2022) .
APA Fan, Heze , Xu, Chenbo , Li, Wenyuan , Huang, Yuzhi , Hua, Rui , Xiong, Ying et al. Ideal Cardiovascular Health Metrics Are Associated with Reduced Severity of Hepatic Steatosis and Liver Fibrosis Detected by Transient Elastography . | NUTRIENTS , 2022 , 14 (24) .
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MED1 Regulates BMP/TGF-beta in Endothelium: Implication for Pulmonary Hypertension SCIE
期刊论文 | 2022 , 131 (10) , 828-841 | CIRCULATION RESEARCH
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Background: Dysregulated BMP (bone morphogenetic protein) or TGF-beta (transforming growth factor beta) signaling pathways are imperative in idiopathic and familial pulmonary arterial hypertension (PAH) as well as experimental pulmonary hypertension (PH) in rodent models. MED1 (mediator complex subunit 1) is a key transcriptional co-activator and KLF4 (Kruppel-like factor 4) is a master transcription factor in endothelium. However, MED1 and KLF4 epigenetic and transcriptional regulations of the BMP/TGF-beta axes in pulmonary endothelium and their dysregulations leading to PAH remain elusive. We investigate the MED1/KLF4 co-regulation of the BMP/TGF-beta axes in endothelium by studying the epigenetic regulation of BMPR2 (BMP receptor type II), ETS-related gene (ERG), and TGFBR2 (TGF-beta receptor 2) and their involvement in the PH. Methods: High-throughput screening involving data from RNA-seq, MED1 ChIP-seq, H3K27ac ChIP-seq, ATAC-seq, and high-throughput chromosome conformation capture together with in silico computations were used to explore the epigenetic and transcriptional regulation of BMPR2, ERG, and TGFBR2 by MED1 and KLF4. In vitro experiments with cultured pulmonary arterial endothelial cells (ECs) and bulk assays were used to validate results from these in silico analyses. Lung tissue from patients with idiopathic PAH, animals with experimental PH, and mice with endothelial ablation of MED1 (EC-MED1(-/-)) were used to study the PH-protective effect of MED1. Results: Levels of MED1 were decreased in lung tissue or pulmonary arterial endothelial cells from idiopathic PAH patients and rodent PH models. Mechanistically, MED1 acted synergistically with KLF4 to transactivate BMPR2, ERG, and TGFBR2 via chromatin remodeling and enhancer-promoter interactions. EC-MED1(-/-) mice showed PH susceptibility. In contrast, MED1 overexpression mitigated the PH phenotype in rodents. Conclusions: A homeostatic regulation of BMPR2, ERG, and TGFBR2 in ECs by MED1 synergistic with KLF4 is essential for the normal function of the pulmonary endothelium. Dysregulation of MED1 and the resulting impairment of the BMP/TGF-beta signaling is implicated in the disease progression of PAH in humans and PH in rodent models.

Keyword :

BMP endothelium MED1 pulmonary arterial hypertension TGF-beta

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GB/T 7714 Wang, Chen , Xing, Yuanming , Zhang, Jiao et al. MED1 Regulates BMP/TGF-beta in Endothelium: Implication for Pulmonary Hypertension [J]. | CIRCULATION RESEARCH , 2022 , 131 (10) : 828-841 .
MLA Wang, Chen et al. "MED1 Regulates BMP/TGF-beta in Endothelium: Implication for Pulmonary Hypertension" . | CIRCULATION RESEARCH 131 . 10 (2022) : 828-841 .
APA Wang, Chen , Xing, Yuanming , Zhang, Jiao , He, Ming , Dong, Jianjie , Chen, Shanshan et al. MED1 Regulates BMP/TGF-beta in Endothelium: Implication for Pulmonary Hypertension . | CIRCULATION RESEARCH , 2022 , 131 (10) , 828-841 .
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