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A fast scheme for renal microvascular perfusion functional imaging: Assessed by an imaging quality evaluation model. PubMed SCIE
期刊论文 | 2019 , 46 (2) , 738-745 | Medical physics
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Abstract :

This study aimed to develop a fast scheme of multiparametric perfusion functional imaging (PFI) based on dynamic contrast-enhanced ultrasound (DCEUS) for assessing renal microvascular hemodynamics.The flow process in the DCEUS-based PFI was modified step-by-step to improve its operational efficiency, which was validated through in vivo renal perfusion experiments. A multiparametric model with a comprehensive coefficient of imaging quality (CIQ) was then built on four terms of the average information entropy, contrast, gray, and noise coefficient of PFIs to evaluate the sacrifice of imaging quality during modifications of DCEUS-based PFI.The multiparametric model successfully evaluated modifications of DCEUS-based PFI from multiple perspectives (R<sup>2</sup>  = 0.73, P < 0.01). Compared with the raw scheme in the renal sagittal and coronal planes, the fast PFI scheme significantly improved its operational efficiency by 62.82 ± 1.07% (P < 0.01) and the nine PFIs simultaneously maintained a similar CIQ of 0.26 ± 0.06.The inhomogeneous hemodynamic distributions with a ring-like feature in the renal microvasculature were accurately and efficiently characterized by the fast PFI scheme. The fast PFI scheme can be applied for early diagnosis, follow-up evaluation and monitoring treatment of chronic kidney disease.

Keyword :

modification dynamic contrast-enhanced ultrasound perfusion functional imaging multiparametric model coefficient of imaging quality

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GB/T 7714 Wang Diya , Xu Shanshan , Zhang Kejia et al. A fast scheme for renal microvascular perfusion functional imaging: Assessed by an imaging quality evaluation model. [J]. | Medical physics , 2019 , 46 (2) : 738-745 .
MLA Wang Diya et al. "A fast scheme for renal microvascular perfusion functional imaging: Assessed by an imaging quality evaluation model." . | Medical physics 46 . 2 (2019) : 738-745 .
APA Wang Diya , Xu Shanshan , Zhang Kejia , Zhang Xinyu , Yang Xuan , Xiao Mengnan et al. A fast scheme for renal microvascular perfusion functional imaging: Assessed by an imaging quality evaluation model. . | Medical physics , 2019 , 46 (2) , 738-745 .
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A Parallelizable Framework for Segmenting Piecewise Signals SCIE
期刊论文 | 2019 , 7 , 13217-13229 | IEEE ACCESS
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Abstract :

Piecewise signals appear in many application fields. Here, we propose a framework for segmenting such signals based on the modeling of each piece using a parametric probability distribution. The proposed framework first models the segmentation as an optimization problem with sparsity regularization. Then, an algorithm based on dynamic programming is utilized for finding the optimal solution. However, dynamic programming often suffers from a heavy computational burden. Therefore, we further show that the proposed framework is parallelizable and propose using GPU-based parallel computing to accelerate the computation. This approach is highly desirable for the analysis of large volumes of data that are ubiquitous. The experiments on both the simulated and real genomic datasets from the next-generation sequencing demonstrate an improved performance in terms of both segmentation quality and computational speed.

Keyword :

piecewise distribution dynamic programming Parallel computing next generation sequencing segmentation algorithm

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GB/T 7714 Duan, Junbo , Soussen, Charles , Brie, David et al. A Parallelizable Framework for Segmenting Piecewise Signals [J]. | IEEE ACCESS , 2019 , 7 : 13217-13229 .
MLA Duan, Junbo et al. "A Parallelizable Framework for Segmenting Piecewise Signals" . | IEEE ACCESS 7 (2019) : 13217-13229 .
APA Duan, Junbo , Soussen, Charles , Brie, David , Idier, Jerome , Wang, Yu-Ping , Wan, Mingxi . A Parallelizable Framework for Segmenting Piecewise Signals . | IEEE ACCESS , 2019 , 7 , 13217-13229 .
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Reconstruction of Mandarin Electrolaryngeal Fricatives With Hybrid Noise Source EI SSCI SCIE
期刊论文 | 2019 , 27 (2) , 383-391 | IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING
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Abstract :

The Mandarin electrolaryngeal (EL) speech is suffering from severe fricative confusion due to improper EL source in EL speech production and abnormal physiological structure of vocal tract in the laryngectomized condition. To reduce the fricative confusions, this paper proposes a hybrid noise source by combining the typical natural fricative sources and compensation sources that consider the acoustic defects in the frequency domain caused by the truncated vocal tract and abnormal source location in EL speech production. All parameters of the model are fricative-specific and the parameters of the compensation sources are determined by analyzing the vocal tract transfer functions before and after the laryngectomy. All five Mandarin fricatives are produced by laryngectomized subjects with an experimental EL system loading the hybrid noise source and the wideband noise source. The acoustic and perceptual features of these reconstructed EL fricatives are analyzed and evaluated by comparing with the conventional EL fricatives and normal fricatives. The results indicate that the hybrid noise source successfully improves the acoustic properties of the EL fricatives by forming better spectral shapes, raising the frequencies of average energy concentration, and producing better spectral skewness and kurtosis. Finally, due to these improvements of acoustic properties, the hybrid noise sources achieve much larger intelligibility for EL fricatives than the wideband noise source and the conventional EL source. Thus, the hybrid noise source is an effective, feasible, and promising method of reducing the severe fricative confusions and improving the intelligibility of EL speech.

Keyword :

intelligibility voice source Acoustic analysis electrolarynx fricative reconstruction

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GB/T 7714 Xiao, Ke , Wang, Supin , Wan, Mingxi et al. Reconstruction of Mandarin Electrolaryngeal Fricatives With Hybrid Noise Source [J]. | IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING , 2019 , 27 (2) : 383-391 .
MLA Xiao, Ke et al. "Reconstruction of Mandarin Electrolaryngeal Fricatives With Hybrid Noise Source" . | IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING 27 . 2 (2019) : 383-391 .
APA Xiao, Ke , Wang, Supin , Wan, Mingxi , Wu, Liang . Reconstruction of Mandarin Electrolaryngeal Fricatives With Hybrid Noise Source . | IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING , 2019 , 27 (2) , 383-391 .
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A Joint Least Squares and Least Absolute Deviation Model SCIE
期刊论文 | 2019 , 26 (4) , 543-547 | IEEE SIGNAL PROCESSING LETTERS
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Abstract :

We propose a joint least squares and least absolute deviations (JOLESALAD) model, show that the proposed model can cover least absolute shrinkage and selection operator (LASSO) and two of its variants, namely the generalized LASSO (gLASSO) and the constrained LASSO (cLASSO), and prove that under a full rank condition, the JOLESALAD can be transformed into cLASSO. Based on this equivalency, rich tools currently available for LASSO models can be applied to solve gLASSO and cLASSO. As an example of illustration, we demonstrate an application of the proposed model to the restoration of a noisy ramp signal that needs proper use of penalty term.

Keyword :

constrained LASSO generalized LASSO ramp signal restoration LASSO

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GB/T 7714 Duan, Junbo , Idier, Jerome , Wang, Yu-Ping et al. A Joint Least Squares and Least Absolute Deviation Model [J]. | IEEE SIGNAL PROCESSING LETTERS , 2019 , 26 (4) : 543-547 .
MLA Duan, Junbo et al. "A Joint Least Squares and Least Absolute Deviation Model" . | IEEE SIGNAL PROCESSING LETTERS 26 . 4 (2019) : 543-547 .
APA Duan, Junbo , Idier, Jerome , Wang, Yu-Ping , Wan, Mingxi . A Joint Least Squares and Least Absolute Deviation Model . | IEEE SIGNAL PROCESSING LETTERS , 2019 , 26 (4) , 543-547 .
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IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound EI PubMed
期刊论文 | 2018 | Ultrasonics Sonochemistry
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Abstract :

Inertial cavitation is crucial for the therapeutic effects of sonodynamic. Therefore, approaches that can induce highly efficient inertial cavitation should be of benefit for sonodynamic effect. Our previous study demonstrated that highly efficient inertial cavitation activity can be achieved through the combinatorial use of a short-pulsed focused ultrasound (SPFU) sequence and perfluorohexane (PFH) nanodroplets. Herein, we applied the SPFU sequence and PFH nanodroplets in sonodynamic. A hydrophobic sonosensitizer, IR780 iodine, was loaded inside denatured bovine serum albumin-shelled PFH (PFH@BSA-IR780) nanodroplets. The sonodynamic efficacy was validated by treating HeLa cervical cancer cells. Under SPFU exposure, PFH@BSA-IR780 nanodroplets were highly effective in promoting reactive oxygen species generation and inducing cancer cell death. A significant decrease in cell viability was achieved within just 10 s. Besides the cytotoxicity of ROS, the mechanical bioeffects of inertial cavitation also led to severe cell death resulting from higher acoustic power or the longer treatment time. The application of the SPFU sequence coupled with PFH@BSA-IR780 nanodroplets is a promising strategy for efficient sonodynamic. © 2018 Elsevier B.V.

Keyword :

Cervical cancer cells Denatured bovine serum albumins Focused ultrasound Inertial cavitation Inertial cavitation activity Nanodroplet Reactive oxygen species Sonodynamic effect

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GB/T 7714 Chang, Nan , Qin, Dui , Wu, Pengying et al. IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound [J]. | Ultrasonics Sonochemistry , 2018 .
MLA Chang, Nan et al. "IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound" . | Ultrasonics Sonochemistry (2018) .
APA Chang, Nan , Qin, Dui , Wu, Pengying , Xu, Shanshan , Wang, Supin , Wan, Mingxi . IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound . | Ultrasonics Sonochemistry , 2018 .
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Passive acoustic mapping of cavitation using eigenspace-based robust Capon beamformer in ultrasound therapy EI SCIE PubMed Scopus
期刊论文 | 2018 , 41 , 670-679 | ULTRASONICS SONOCHEMISTRY
SCOPUS Cited Count: 1
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Abstract :

Pulse-echo imaging technique can only play a role when high intensity focused ultrasound (HIFU) is turned off due to the interference between the primary HIFU signal and the transmission pulse. Passive acoustic mapping (PAM) has been proposed as a tool for true real-time monitoring of HIFU therapy. However, the most-used PAM algorithm based on time exposure acoustic (TEA) limits the quality of cavitation image. Recently, robust Capon beamformer (RCB) has been used in PAM to provide improved resolution and reduced artifacts over TEA-based PAM, but the presented results have not been satisfactory. In the present study, we applied an eigenspace-based RCB (EISRCB) method to further improve the PAM image quality. The optimal weighting vector of the proposed method was found by projecting the RCB weighting vector onto the desired vector subspace constructed from the eigenstructure of the covariance matrix. The performance of the proposed PAM was validated by both simulations and in vitro histotripsy experiments. The results suggested that the proposed PAM significantly outperformed the conventionally used TEA and RCB-based PAM. The comparison results between pulse-echo images of the residual bubbles and cavitation images showed the potential of our proposed PAM in accurate localization of cavitation activity during HIFU therapy.

Keyword :

Eigenspace-based robust Capon beamformer Real-time monitoring Passive acoustic mapping Cavitation

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GB/T 7714 Lu, Shukuan , Hu, Hong , Yu, Xianbo et al. Passive acoustic mapping of cavitation using eigenspace-based robust Capon beamformer in ultrasound therapy [J]. | ULTRASONICS SONOCHEMISTRY , 2018 , 41 : 670-679 .
MLA Lu, Shukuan et al. "Passive acoustic mapping of cavitation using eigenspace-based robust Capon beamformer in ultrasound therapy" . | ULTRASONICS SONOCHEMISTRY 41 (2018) : 670-679 .
APA Lu, Shukuan , Hu, Hong , Yu, Xianbo , Long, Jiangying , Jing, Bowen , Zong, Yujin et al. Passive acoustic mapping of cavitation using eigenspace-based robust Capon beamformer in ultrasound therapy . | ULTRASONICS SONOCHEMISTRY , 2018 , 41 , 670-679 .
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Occlusion and rupture of ex vivo capillary bifurcation due to acoustic droplet vaporization EI SCIE Scopus
期刊论文 | 2018 , 112 (23) | APPLIED PHYSICS LETTERS
SCOPUS Cited Count: 1
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Abstract :

Gas embolotherapy (GE) consists in the occlusion of tumor blood vessels using gas emboli induced by acoustic droplet vaporization (ADV), to create tumor starvation and localized drug delivery. Therefore, the occlusion and rupture of capillary bifurcation due to ADV was investigated in an ex vivo rat mesentery model using a confocal acousto-optical high-speed microscope system. Following ADV bubble formation, coalescence, and translational movement, the growing bubbles lodged in and then occluded two different capillary bifurcations. Capillary rupture was induced at the bubble lodging area, immediately followed by gas extravasation and bubble dislodging. Before and after bubble lodgment/occlusion, a local microvessel invagination was observed due to the interactions between ADV bubbles and the microvessel itself, indicating a contribution to the capillary rupture. Understanding the transient dynamics of ADV bubble, the bubble-microvessel interaction and the consequent mechanical bio-effects in GE is of the paramount importance for developing and applying this approach in clinical practice. Published by AIP Publishing.

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GB/T 7714 Feng, Yi , Qin, Dui , Zhang, Jun et al. Occlusion and rupture of ex vivo capillary bifurcation due to acoustic droplet vaporization [J]. | APPLIED PHYSICS LETTERS , 2018 , 112 (23) .
MLA Feng, Yi et al. "Occlusion and rupture of ex vivo capillary bifurcation due to acoustic droplet vaporization" . | APPLIED PHYSICS LETTERS 112 . 23 (2018) .
APA Feng, Yi , Qin, Dui , Zhang, Jun , Zhang, Lei , Bouakaz, Ayache , Wan, Mingxi . Occlusion and rupture of ex vivo capillary bifurcation due to acoustic droplet vaporization . | APPLIED PHYSICS LETTERS , 2018 , 112 (23) .
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Efficient and controllable thermal ablation induced by short-pulsed HIFU sequence assisted with perfluorohexane nanodroplets EI SCIE PubMed Scopus
期刊论文 | 2018 , 45 , 57-64 | ULTRASONICS SONOCHEMISTRY
WoS CC Cited Count: 2 SCOPUS Cited Count: 3
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Abstract :

A HIFU sequence with extremely short pulse duration and high pulse repetition frequency can achieve thermal ablation at a low acoustic power using inertial cavitation. Because of its cavitation-dependent property, the therapeutic outcome is unreliable when the treatment zone lacks cavitation nuclei. To overcome this intrinsic limitation, we introduced perfluorocarbon nanodroplets as extra cavitation nuclei into short-pulsed HIFU-mediated thermal ablation. Two types of nanodroplets were used with perfluorohexane (PFH) as the core material coated with bovine serum albumin (BSA) or an anionic fluorosurfactant (FS) to demonstrate the feasibility of this study. The thermal ablation process was recorded by high-speed photography. The inertial cavitation activity during the ablation was revealed by sonoluminescence (SL). The high-speed photography results show that the thermal ablation volume increased by similar to 643% and 596% with BSA-PFH and FS-PFH, respectively, than the short-pulsed HIFU alone at an acoustic power of 19.5 W. Using nanodroplets, much larger ablation volumes were created even at a much lower acoustic power. Meanwhile, the treatment time for ablating a desired volume significantly reduced in the presence of nanodroplets. Moreover, by adjusting the treatment time, lesion migration towards the HIFU transducer could also be avoided. The SL results show that the thermal lesion shape was significantly dependent on the inertial cavitation in this short-pulsed HIFU-mediated thermal ablation. The inertial cavitation activity became more predictable by using nanodroplets. Therefore, the introduction of PFH nanodroplets as extra cavitation nuclei made the short-pulsed HIFU thermal ablation more efficient by increasing the ablation volume and speed, and more controllable by reducing the acoustic power and preventing lesion migration.

Keyword :

Short-pulsed HIFU sequence Inertial cavitation Pertluorohexane nanodroplets Thermal ablation

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GB/T 7714 Chang, Nan , Lu, Shukuan , Qin, Dui et al. Efficient and controllable thermal ablation induced by short-pulsed HIFU sequence assisted with perfluorohexane nanodroplets [J]. | ULTRASONICS SONOCHEMISTRY , 2018 , 45 : 57-64 .
MLA Chang, Nan et al. "Efficient and controllable thermal ablation induced by short-pulsed HIFU sequence assisted with perfluorohexane nanodroplets" . | ULTRASONICS SONOCHEMISTRY 45 (2018) : 57-64 .
APA Chang, Nan , Lu, Shukuan , Qin, Dui , Xu, Tianqi , Han, Meng , Wang, Supin et al. Efficient and controllable thermal ablation induced by short-pulsed HIFU sequence assisted with perfluorohexane nanodroplets . | ULTRASONICS SONOCHEMISTRY , 2018 , 45 , 57-64 .
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Effects of Vertical Glottal Duct Length on Intraglottal Pressures and Phonation Threshold Pressure in the Uniform Glottis SCIE PubMed Scopus
期刊论文 | 2018 , 32 (1) , 8-22 | JOURNAL OF VOICE
SCOPUS Cited Count: 1
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Abstract :

According to Titze's 1988 derivations for phonation threshold pressure (PTP), there are a number of important variables that PTP depends upon. A primary one is the vertical glottal duct length T: PTP decreases if T is increased. Changing the length of T, however, may have a significant effect on other variables that PTP depends upon. This study examined the effects of lengthening the vertical uniform glottal duct on the transglottal and intraglottal pressures, and the derived transglottal pressure coefficients, for five glottal diameters (0.01, 0.02, 0.04, 0.08, and 0.16 cm) and three transglottal pressures (500, 1000, and 1500 Pa) for the uniform glottis by using the computational fluid dynamics code Fluent (for laminar, incompressible, two-dimensional flow). The results suggest the following: A longer vertical glottal duct length increases the intraglottal and transglottal pressures, and more so for smaller glottal diameters, and increases the transglottal pressure coefficient. In addition, unlike the transglottal pressure coefficient, the glottal entrance pressure coefficient is highly dependent on the vertical glottal duct length only for lower flows and Reynolds numbers, but is relatively independent of duct length, glottal diameter, and transglottal pressure above a flow value of approximately 50 cm(3)/s, suggesting that the entrance pressure coefficient is a relatively local phenomenon. These results suggest that the vertical glottal duct length and its effects need to be taken into consideration for vocal fold modeling, aeroacoustics purposes, and the estimation of PTP.

Keyword :

Uniform glottis Length of the glottis Phonation threshold pressure Vertical glottal duct length Intraglottal pressure

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GB/T 7714 Li, Sheng , Scherer, Ronald C. , Fulcher, Lewis P. et al. Effects of Vertical Glottal Duct Length on Intraglottal Pressures and Phonation Threshold Pressure in the Uniform Glottis [J]. | JOURNAL OF VOICE , 2018 , 32 (1) : 8-22 .
MLA Li, Sheng et al. "Effects of Vertical Glottal Duct Length on Intraglottal Pressures and Phonation Threshold Pressure in the Uniform Glottis" . | JOURNAL OF VOICE 32 . 1 (2018) : 8-22 .
APA Li, Sheng , Scherer, Ronald C. , Fulcher, Lewis P. , Wang, Xianbo , Qiu, Lijun , Wan, Mingxi et al. Effects of Vertical Glottal Duct Length on Intraglottal Pressures and Phonation Threshold Pressure in the Uniform Glottis . | JOURNAL OF VOICE , 2018 , 32 (1) , 8-22 .
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DCEUS-based focal parametric perfusion imaging of microvessel with single-pixel resolution and high contrast EI SCIE PubMed Scopus
期刊论文 | 2018 , 84 , 392-403 | ULTRASONICS
WoS CC Cited Count: 3 SCOPUS Cited Count: 4
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This study aimed to develop a focal microvascular contrast-enhanced ultrasonic parametric perfusion imaging (PPI) scheme to overcome the tradeoff between the resolution, contrast, and accuracy of focal PPI in the tumor. Its resolution was limited by the low signal-to-clutter ratio (SCR) of time-intensitycurves (TICs) induced by multiple limitations, which deteriorated the accuracy and contrast of focal PPI. The scheme was verified by the in-vivo perfusion experiments. Single-pixel TICs were first extracted to ensure PPI with the highest resolution. The SCR of focal TICs in the tumor was improved using respiratory motion compensation combined with detrended fluctuation analysis. The entire and focal PPIs of six perfusion parameters were then accurately created after filtrating the valid TICs and targeted perfusion parameters. Compared with those of the conventional PPIs, the axial and lateral resolutions of focal PPIs were improved by 30.29% (p < .05) and 32.77% (p < .05), respectively; the average contrast and accuracy evaluated by SCR improved by 7.24 +/- 4.90 dB (p < .05) and 5.18 +/- 1.28 dB (p < .05), respectively. The edge, morphostructure, inhomogeneous hyper- enhanced distribution, and ring-like perfusion features in intratumoral microvessel were accurately distinguished and highlighted by the focal PPIs. The developed focal PPI can assist clinicians in making confirmed diagnoses and in providing appropriate therapeutic strategies for liver tumor. (C) 2017 Elsevier B.V. All rights reserved.

Keyword :

Contrast-enhanced ultrasound Parametric perfusion imaging Single-pixel resolution Microbubbles High contrast

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GB/T 7714 Wang, Diya , Xiao, Mengnan , Hu, Hong et al. DCEUS-based focal parametric perfusion imaging of microvessel with single-pixel resolution and high contrast [J]. | ULTRASONICS , 2018 , 84 : 392-403 .
MLA Wang, Diya et al. "DCEUS-based focal parametric perfusion imaging of microvessel with single-pixel resolution and high contrast" . | ULTRASONICS 84 (2018) : 392-403 .
APA Wang, Diya , Xiao, Mengnan , Hu, Hong , Zhang, Yu , Su, Zhe , Xu, Shanshan et al. DCEUS-based focal parametric perfusion imaging of microvessel with single-pixel resolution and high contrast . | ULTRASONICS , 2018 , 84 , 392-403 .
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