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Hemocompatibility improvement of decellularized spleen matrix for constructing transplantable bioartificial liver SCIE PubMed
期刊论文 | 2019 , 14 (2) | BIOMEDICAL MATERIALS
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Abstract :

Thrombogenicity is the predominant obstacle to successful implantation of decellularized spleen matrix (DSM). The aim of this study was to construct a transplantable functional bioartificial liver (BAL) with the use of DSM. This was achieved by layer-by-layer electrostatic immobilization technique by using poly dimethyl diallyl ammonium chloride and heparin. After heparin immobilization, DSM gradually turned from translucent into completely opaque milky white. Toluidine blue staining showed strong positive staining of the entire coated DSM. In vitro diluted blood perfusion test showed that the splenic arterial pressure of the heparin-coated DSM was much lower than that of the non-coated DSM (p < 0.01). Then, we heterotopically transplanted the modified DSM into rat hepatic injury model for 6 h to evaluate the hemocompatibility in vivo. Overall, HE staining and vWF immunohistochemistry all confirmed that heparin-coated DSM has a satisfactory anticoagulant effect. Based on the heparin-coated DSM, BALs were built with the use of rat primary hepatocytes. Our results demonstrate that these heparin-coated BALs satisfied anticoagulant effects even after 6 h. Immunofluorescence of ALB and G6PC also showed that hepatocytes in heparin-coated BAL have significantly higher cell viability and function than the non-coated group. However, serum analysis did not indicate a significant difference between the two groups but a slight trend of improvement with respect to serum albumin (p = 0.156) and aspartate transaminase (p = 0.140). In conclusion, we demonstrated that the BAL constructed by heparin-coated DSM can exert satisfactory short-term anticoagulant effects and can compensate for a certain degree of liver function.

Keyword :

heparin bioartificial liver hemocompatibility PDADMAC decellularized spleen matrix

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GB/T 7714 Liu, Peng , Tian, Boyan , Yang, Lifei et al. Hemocompatibility improvement of decellularized spleen matrix for constructing transplantable bioartificial liver [J]. | BIOMEDICAL MATERIALS , 2019 , 14 (2) .
MLA Liu, Peng et al. "Hemocompatibility improvement of decellularized spleen matrix for constructing transplantable bioartificial liver" . | BIOMEDICAL MATERIALS 14 . 2 (2019) .
APA Liu, Peng , Tian, Boyan , Yang, Lifei , Zheng, Xinglong , Zhang, Xufeng , Li, Jianhui et al. Hemocompatibility improvement of decellularized spleen matrix for constructing transplantable bioartificial liver . | BIOMEDICAL MATERIALS , 2019 , 14 (2) .
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Advanced Roux-en-Y hepaticojejunostomy with magnetic compressive anastomats in obstructive jaundice dog models SCIE PubMed Scopus
期刊论文 | 2018 , 32 (2) , 779-789 | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
WoS CC Cited Count: 3 SCOPUS Cited Count: 5
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Abstract :

Background Although commonly used procedure, Roux-en-Y hepaticojejunostomy (RYHJ) remains to be complicated, time consuming, and has a relatively poor prognosis. We designed the magnetic compressive anastomats (MCAs) to perform RYHJ more efficiently and safely. Materials and methods 36 dogs were divided into two groups randomly. After obstructive jaundice model construction, RYHJ was performed with MCAs in study group or by hand-sewn in control group. Both groups were followed for 1, 3, and 6 months after RYHJ. The liver function and postoperative complications were recorded throughout the follow-up. At the end of each time point, dogs were sent for magnetic resonance imaging (MRI) and sacrificed. Anastomotic samples were taken for anastomotic narrowing rate calculation, histological analyses, tensile strength testing, and hydroxyproline content testing. Results The anastomotic construction times were 44.20 +/- 23.02 min in study group, compared of 60.53 +/- 11.89 min in control group (p < 0.05). The liver function recovered gradually after RYHJ in both groups (p > 0.05). All anastomats were expelled out of the body in 8.81 +/- 2.01 days. The gross incidence of morbidity and mortality was 33.3% (6/18) and 16.7% (3/18) in study group compared with 38.9% (7/18) and 22.2% (4/18) in control group (p > 0.05), and there is no single case of anastomotic-specific complications happened in study group. The narrowing rates of anastomosis were 14.6, 18.5, and 18.7% in study group compared with 35.4, 36.9, and 34% in control group at 1st, 3rd, and 6th month after RYHJ (p < 0.05). In study group, preciser alignment of tissue layers and milder inflammatory reaction contributed to the fast and better wound healing process. Conclusion Perform RYHJ with MCAs is safer, more efficient than by hand-sewn method in obstructive jaundice dog models.

Keyword :

Bilioenteric anastomosis Wound healing Obstructive jaundice Sutureless Anastomat Magnetic compression anastomosis Hepaticojejunostomy

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GB/T 7714 Fan, Chao , Zhang, Hongke , Yan, Xiaopeng et al. Advanced Roux-en-Y hepaticojejunostomy with magnetic compressive anastomats in obstructive jaundice dog models [J]. | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES , 2018 , 32 (2) : 779-789 .
MLA Fan, Chao et al. "Advanced Roux-en-Y hepaticojejunostomy with magnetic compressive anastomats in obstructive jaundice dog models" . | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 32 . 2 (2018) : 779-789 .
APA Fan, Chao , Zhang, Hongke , Yan, Xiaopeng , Ma, Jia , Wang, Chunbao , Lv, Yi . Advanced Roux-en-Y hepaticojejunostomy with magnetic compressive anastomats in obstructive jaundice dog models . | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES , 2018 , 32 (2) , 779-789 .
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Novel laparoscopic training system with continuously perfused ex-vivo porcine liver for hepatobiliary surgery SCIE PubMed Scopus
期刊论文 | 2018 , 32 (2) , 743-750 | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
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Objective To introduce a novel laparoscopic training system with a continuously perfused ex-vivo porcine liver for hepatobiliary surgery. Background Existing models for laparoscopic training, such as box trainers and virtual reality simulators, often fail to provide holistic training and real haptic feedback. We have formulated a new training system that addresses these problems. Methods Real-Liver Laptrainer consists of a porcine liver, customized mannequin, ex-vivo machine perfusion system, and monitoring software. We made a detailed comparison of Real-Liver Laptrainer with the LapSim virtual reality simulator and the FLS Trainer Box systems. Five laparoscopic surgeons assessed the new system on multiple features. We assessed the performances of 43 trainees who used the new system to perform laparoscopic cholecystectomy (LC) three times. Results Real-Liver Laptrainer offered more functions and better tactile feedback than the FLS or LapSim system. All five surgeons graded the quality of the new system as realistic. The utility of the system for training was scored as 3.6 +/- 1.1 on a scale of 1-5. Between the first and third attempts, the number of successfully performed LCs increased (9 vs 14 vs 23; P = .011), while the numbers of liver damage incidents (25 vs. 21 vs. 18, P = .303) and gallbladder perforations decreased (17 vs. 12 vs. 9, P = .163). The mean LC operation time significantly decreased (63 vs. 50 vs. 44, P < .0001). Conclusion Real-Liver Laptrainer is a feasible, stable, and practical training model that has potential for improving the laparoscopic skills of surgeons.

Keyword :

Ex-vivo perfusion Laparoscopic surgery Porcine liver Simulation education

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GB/T 7714 Liu, Wenyan , Zheng, Xinglong , Wu, Rongqian et al. Novel laparoscopic training system with continuously perfused ex-vivo porcine liver for hepatobiliary surgery [J]. | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES , 2018 , 32 (2) : 743-750 .
MLA Liu, Wenyan et al. "Novel laparoscopic training system with continuously perfused ex-vivo porcine liver for hepatobiliary surgery" . | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 32 . 2 (2018) : 743-750 .
APA Liu, Wenyan , Zheng, Xinglong , Wu, Rongqian , Jin, Yinbin , Kong, Shu , Li, Jianpeng et al. Novel laparoscopic training system with continuously perfused ex-vivo porcine liver for hepatobiliary surgery . | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES , 2018 , 32 (2) , 743-750 .
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Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death SCIE PubMed Scopus
期刊论文 | 2018 , 13 (5) | PLOS ONE
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Hypoxia-mediated pancreatic beta cell death is one of the main causes of pancreatic beta celldeath, which leads to the loss of functional pancreatic beta cell mass and type 1 diabetes andtype 2 diabetes. However, the molecular mechanisms that control life and death of pancreatic beta cells remain poorly understood. Here we showed that mitochondrial fission was strongly induced in pancreatic beta cellsmainly due to an elevation of DRP1(S616) phosphorylation through HIF-1 alpha activation and subsequent DRP1 mitochondrial translocation. Hypoxia-induced pancreatic beta cell death can be reversed by the inhibition of mitochondrial fission viaDRP1 knockdown. We further demonstrated that hypoxia-induced mitochondrial fission untightened the cristae formation, which subsequently triggers mitochondrial cytochrome c release and consequent caspase activation. Moreover, treatment with mitochondrial division inhibitor-1 (Mdivi-1), a specific inhibitor of DRP1-mediated mitochondrial fission, significantly suppressedbeta cell death in vitro, indicating a promising therapeutic strategy for treatment of diabetes. Taken together, our results reveal a crucial role for the DRP1-mediated mitochondrial fission in hypoxia-induced beta cell death, which provides a strong evidence for thisprocessas drug target indiabetestreatment.

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GB/T 7714 Zhang, Da , Liu, Yanfang , Tang, Yao et al. Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death [J]. | PLOS ONE , 2018 , 13 (5) .
MLA Zhang, Da et al. "Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death" . | PLOS ONE 13 . 5 (2018) .
APA Zhang, Da , Liu, Yanfang , Tang, Yao , Wang, Xiaofeng , Li, Zhichao , Li, Rui et al. Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death . | PLOS ONE , 2018 , 13 (5) .
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Transfusion of Older Red Blood Cells Increases the Risk of Acute Kidney Injury After Orthotopic Liver Transplantation: A Propensity Score Analysis SCIE PubMed Scopus
期刊论文 | 2018 , 127 (1) , 202-209 | ANESTHESIA AND ANALGESIA
WoS CC Cited Count: 5 SCOPUS Cited Count: 5
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BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of orthotopic liver transplantation (OLT). Transfusion of older red blood cells (RBCs) has been implicated in poor outcomes in trauma, cardiac surgery, and critically ill patients. However, whether transfusion of older RBCs plays any role in post-OLT AKI remained unknown. The aim of this study was to investigate the effect of the age of transfused RBCs on post-OLT AKI. METHODS: The clinical data of consecutive adult patients who received donation after cardiac death and underwent OLT from December 2011 to December 2015 were analyzed. These patients were divided into 2 groups: the newer blood group, who received exclusively RBCs that had been stored for <14 days; and the older blood group, who received RBCs that had been stored for 14 days or more. The incidence of post-OLT AKI, severe AKI, lengths of intensive care unit and hospital stay, and in-hospital mortality after OLT were analyzed. RESULTS: Postoperative AKI occurred in 65.1% of patients in the older blood group and 40.5% of patients in the newer blood group (P < .01). The incidence of severe AKI after OLT was significantly higher, and the duration of intensive care unit stay was significantly longer, in the older blood group. After adjustment by the multivariable regression logistic analysis, transfusion of older blood was independently associated with post-OLT AKI (odds ratio [OR] = 2.47 [95% confidence interval {CI}, 1.13-5.41]; P = .024) and severe AKI (OR = 5.88 [95% CI, 2.06-16.80]; P = .001). After adjustment by the inverse probability of treatment weighting analysis, patients in the older blood group still had significantly higher incidences of postoperative AKI (OR = 2.13 [95% CI, 1.07-4.22]; P = .030) and severe AKI (OR = 3.34 [95% CI, 1.47-7.60]; P = .003) than those in the newer blood group. CONCLUSIONS: Transfusion of older RBCs significantly increased the risk of postoperative AKI in liver transplant recipients.

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GB/T 7714 Wang, Yue , Li, Qingshan , Ma, Tao et al. Transfusion of Older Red Blood Cells Increases the Risk of Acute Kidney Injury After Orthotopic Liver Transplantation: A Propensity Score Analysis [J]. | ANESTHESIA AND ANALGESIA , 2018 , 127 (1) : 202-209 .
MLA Wang, Yue et al. "Transfusion of Older Red Blood Cells Increases the Risk of Acute Kidney Injury After Orthotopic Liver Transplantation: A Propensity Score Analysis" . | ANESTHESIA AND ANALGESIA 127 . 1 (2018) : 202-209 .
APA Wang, Yue , Li, Qingshan , Ma, Tao , Liu, Xuemin , Wang, Bo , Wu, Zheng et al. Transfusion of Older Red Blood Cells Increases the Risk of Acute Kidney Injury After Orthotopic Liver Transplantation: A Propensity Score Analysis . | ANESTHESIA AND ANALGESIA , 2018 , 127 (1) , 202-209 .
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MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells SCIE PubMed Scopus
期刊论文 | 2018 , 101 , 39-48 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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Chemotherapy resistance represents a major obstacle in the treatment of patients with hepatocellular carcinoma (HCC). The purpose of this study was to investigate the anti-cancer effect of MEL-pep, a novel analog of the natural antibacterial peptide melittin (MEL), on human 5-fluorouracil-resistant HCC cells (BEL-7402/5-FU) and to clarify the molecular mechanisms involved in these effects. We found that MEL-pep inhibited the proliferation of BEL-7402/5-FU cells and reversed 5-FU resistance in vitro. MEL-pep directly bound to BEL-7402/5-FU cells and disrupted the cell membrane P-glycoprotein (P-gp) plays an important role in the development of resistance to anticancer drugs. We found that MEL-pep inhibited P-gp expression and increased the intracellular accumulation of the P-gp substrate rhodamine-123 in BEL-7402/5-FU cells. Additionally, the phosphorylation of Akt and NF-kappa B/p65 nuclear translocation was all inhibited by MEL-pep. Insulin like growth factor I, a phosphatidylinositol 3 kinase(PI3K) /protein kinase B(AKT) agonist, reversed MEL-pep induced P-gp suppression. Therefore, MEL-pep inhibited P-gp expression by deactivating the PI3K/Akt signaling pathway. Finally, in a BEL-7402/5-FU cell-derived xenograft tumor model in mice, we found that the intratumoral administration of MEL-pep inhibited tumor growth in a dose-dependent manner. Thus, MEL-pep could be a promising candidate in the treatment of chemotherapy resistant HCC.

Keyword :

Cell membrane P-glycoprotein MEL-pep 5-Fluorouracil-resistant hepatocellular carcinoma

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GB/T 7714 Ke, Mengyun , Dong, Jian , Wang, Yue et al. MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells [J]. | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY , 2018 , 101 : 39-48 .
MLA Ke, Mengyun et al. "MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells" . | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 101 (2018) : 39-48 .
APA Ke, Mengyun , Dong, Jian , Wang, Yue , Zhang, Jia , Zhang, Mei , Wu, Zheng et al. MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells . | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY , 2018 , 101 , 39-48 .
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Gastrojejunal anastomosis in rats using the magnetic compression technique SCIE PubMed Scopus
期刊论文 | 2018 , 8 | SCIENTIFIC REPORTS
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Rats are suitable animal models in which to study the effects of gastric bypass surgery. However, construction of gastrojejunal anastomosis in the rat is technically demanding and is associated with high rate of postoperative complications. The aim of this study was to explore the feasibility and efficacy of the magnetic compression technique (MCT) in side-to-side gastrojejunal anastomosis in rats. Thirty male rats underwent gastrojejunal anastomosis using one of three techniques: hand-sewn, magnetic compression using cuboid magnets, and magnetic compression using magnetic rings. The mean anastomosis time using the magnetic compression technique was significantly less than that of the hand-sewn technique (3.6 +/- 0.96 and 6.50 +/- 1.58 vs. 14.40 +/- 2.37 minutes,). The survival rate was highest in animals treated with magnetic compression using cuboid magnets (100%), followed by animals treated with magnetic compression using magnetic rings (90%) and then hand sewing (70%). The mean burst pressure did not differ significantly between the magnetic compression and hand-sewn anastomoses. Anastomoses constructed by magnetic compression were smoother and flatter than hand-sewn anastomoses. The results showed that MCT is a simple and feasible method for gastrojejunal anastomosis in the rat.

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GB/T 7714 An, Yingfeng , Zhang, Yanchao , Liu, Hao et al. Gastrojejunal anastomosis in rats using the magnetic compression technique [J]. | SCIENTIFIC REPORTS , 2018 , 8 .
MLA An, Yingfeng et al. "Gastrojejunal anastomosis in rats using the magnetic compression technique" . | SCIENTIFIC REPORTS 8 (2018) .
APA An, Yingfeng , Zhang, Yanchao , Liu, Hao , Ma, Sijie , Fu, Shan , Lv, Yi et al. Gastrojejunal anastomosis in rats using the magnetic compression technique . | SCIENTIFIC REPORTS , 2018 , 8 .
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Gamma-glutamyl transpeptidase to platelet ratio predicts short-term outcomes in hepatocellular carcinoma patients undergoing minor liver resection SCIE PubMed Scopus
期刊论文 | 2018 , 231 , 403-410 | JOURNAL OF SURGICAL RESEARCH
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Background: There is a strong correlation between liver fibrosis and postoperative morbidity after hepatectomy in hepatocellular carcinoma (HCC) patients. The aim of this study was to evaluate which noninvasive fibrosis index (gamma-glutamyl transpeptidase to platelet ratio [GPR], aspartate aminotransferase to platelet ratio index, fibrosis-4 index, or Forns index) was best able to predict complications in patients undergoing hepatectomy for HCC. Materials and methods: This retrospective analysis included 275 patients who underwent hepatectomy for HCC from January 2008 to December 2012. Postoperative mortality was defined as death within 90 d after surgery. Complications were grouped into seven grades on the basis of the modified Clavien classification, and major postoperative complications were defined as grade 3 or above. The influence of noninvasive fibrosis indices on postoperative outcomes was assessed by receiver operating characteristic analysis. The primary outcomes were overall complications and major complications, estimated by univariate and multivariate analysis. Results: Patients with HCC undergoing anatomical liver resection in the authors' department were evaluated for this study. Finally, 275 patients who underwent minor liver resection (<= 2 liver segments) were included. Of these, 231 (84%) were male. The multivariate analysis indicated that the GPR index was not only independently associated with overall complications (hazard ratio, 2.692; 95% confidence interval [CI], 1.626-4.250; P < 0.001) but also independently predictive of major complications (hazard ratio, 1.143; 95% CI, 1.046-1.249; P = 0.03). The areas under the receiver operating characteristic curve for predicting overall complications and major complications for the GPR index were 0.704 (95% CI, 0.643-0.765; P < 0.001) and 0.752 (95% CI, 0.638-0.865; P < 0.001), respectively. Conclusions: The data suggested that the GPR index could be a promising predictor of overall postoperative complications and major complications after minor hepatectomy for HCC. (C) 2018 Elsevier Inc. All rights reserved.

Keyword :

Gamma-glutamyl transpeptidase to platelet ratio Short-term outcomes Hepatocellular carcinoma Noninvasive fibrosis indices

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GB/T 7714 Ke, Meng-yun , Zhang, Mei , Su, Qing et al. Gamma-glutamyl transpeptidase to platelet ratio predicts short-term outcomes in hepatocellular carcinoma patients undergoing minor liver resection [J]. | JOURNAL OF SURGICAL RESEARCH , 2018 , 231 : 403-410 .
MLA Ke, Meng-yun et al. "Gamma-glutamyl transpeptidase to platelet ratio predicts short-term outcomes in hepatocellular carcinoma patients undergoing minor liver resection" . | JOURNAL OF SURGICAL RESEARCH 231 (2018) : 403-410 .
APA Ke, Meng-yun , Zhang, Mei , Su, Qing , Wei, Shasha , Zhang, Jia , Wang, Yue et al. Gamma-glutamyl transpeptidase to platelet ratio predicts short-term outcomes in hepatocellular carcinoma patients undergoing minor liver resection . | JOURNAL OF SURGICAL RESEARCH , 2018 , 231 , 403-410 .
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Magnetic compression technique for colonic anastomosis in rats SCIE PubMed Scopus
期刊论文 | 2018 , 231 , 24-29 | JOURNAL OF SURGICAL RESEARCH
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Background: Magnetic compression technique (MCT) is useful for construction of digestive tract anastomoses in pigs and dogs. This study determined the efficacy of MCT for performing colonic anastomosis in rats. Methods: Twenty male Sprague-Dawley rats (230-280 g) were randomly apportioned to a study group that underwent colonic anastomosis with MCT or a control group subjected to hand-sewn colonic anastomosis. The groups were compared for time to construct the anastomosis, survival rate, and postoperative complications. Animals were euthanized at 1 mo postsurgery to study the burst pressure and histology of the anastomoses. Results: The study group required significantly less time to construct the anastomosis (6.50 +/- 1.58 min) than did the control (15.6 +/- 2.22 min). The survival rate of the study group (100%) was significantly higher than that of the control group (60%). In the control group, three rats developed anastomotic leakage and one rat developed anastomotic obstruction. No anastomotic leakage or obstruction was observed in the study group. The burst pressures of the two groups were similar. Histology showed that the study group had better alignment of the tissue layers and less inflammation compared with the control group. Conclusions: MCT is a safe and feasible technique for colonic anastomosis in rats, with better postoperative outcomes compared with hand-sewn anastomosis. (C) 2018 Elsevier Inc. All rights reserved.

Keyword :

Magnetic compression technique Rat Colorectal surgery Anastomosis

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GB/T 7714 Bai, Jigang , Huo, Xiongwei , Ma, Jia et al. Magnetic compression technique for colonic anastomosis in rats [J]. | JOURNAL OF SURGICAL RESEARCH , 2018 , 231 : 24-29 .
MLA Bai, Jigang et al. "Magnetic compression technique for colonic anastomosis in rats" . | JOURNAL OF SURGICAL RESEARCH 231 (2018) : 24-29 .
APA Bai, Jigang , Huo, Xiongwei , Ma, Jia , Lv, Yi , Yan, Xiaopeng . Magnetic compression technique for colonic anastomosis in rats . | JOURNAL OF SURGICAL RESEARCH , 2018 , 231 , 24-29 .
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Prognostic value of FOXQ1 in patients with malignant solid tumors: a meta-analysis SCIE PubMed Scopus
期刊论文 | 2017 , 10 , 1777-1781 | ONCOTARGETS AND THERAPY | IF: 2.656
SCOPUS Cited Count: 1
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Background: Forkhead box Q1 ( FOXQ1, also known as HFH1), a member of the forkhead transcription factor family, has been demonstrated to be overexpressed in multiple tumors and is thought to be an indicator of poor clinical outcomes. Methods: A meta-analysis using qualified relevant literature was performed to evaluate the prognostic significance of FOXQ1 in various malignant solid tumors. A search of electronic databases was conducted in MEDLINE, Embase, and the Cochrane Library to identify relevant studies published from 1966 to July 30, 2016, and the studies were identified by further evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for analyses were assessed to investigate the association between FOXQ1 expression and overall survival (OS) of patients with malignant solid tumors. Results: A total of 1,520 patients from six studies (seven cohorts) with multiple malignant solid tumors were included. For OS, high FOXQ1 expression could significantly predict worse outcome with the pooled HR of 1.38 (95% CI: 1.17-1.59; P < 0.001). The subgroup -analysis suggested that the elevated levels of FOXQ1 appear to be associated with worse OS in hepatocellular carcinoma (HR = 1.34; 95% CI: 1.11-1.57; P < 0.001) and other cancers (HR = 1.62; 95% CI: 1.09-2.14; P < 0.001). Conclusion: This meta-analysis indicated that the high expression of FOXQ1 is associated with an adverse OS in malignant solid tumors, suggesting that FOXQ1 may be a predictor of poor prognosis for the development of malignant solid tumors.

Keyword :

FOXQ1 prognosis meta-analysis cancer overall survival

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GB/T 7714 Cui, Xiaohai , Zhang, Jing , Lv, Jiajun et al. Prognostic value of FOXQ1 in patients with malignant solid tumors: a meta-analysis [J]. | ONCOTARGETS AND THERAPY , 2017 , 10 : 1777-1781 .
MLA Cui, Xiaohai et al. "Prognostic value of FOXQ1 in patients with malignant solid tumors: a meta-analysis" . | ONCOTARGETS AND THERAPY 10 (2017) : 1777-1781 .
APA Cui, Xiaohai , Zhang, Jing , Lv, Jiajun , Yan, Yan , Liu, Xu , Wang, Jizhao et al. Prognostic value of FOXQ1 in patients with malignant solid tumors: a meta-analysis . | ONCOTARGETS AND THERAPY , 2017 , 10 , 1777-1781 .
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