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学者姓名：卓敏
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| GB/T 7714 | Zhou, Zhaoxiang , Chen, Qiyu , Liu, Qin et al. Cortical synaptic mechanism for chronic pain and anxiety in Parkinson's disease [J]. | JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE , 2023 , 10 (4) : 300-303 . |
| MLA | Zhou, Zhaoxiang et al. "Cortical synaptic mechanism for chronic pain and anxiety in Parkinson's disease" . | JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE 10 . 4 (2023) : 300-303 . |
| APA | Zhou, Zhaoxiang , Chen, Qiyu , Liu, Qin , Xu, Pingyi , Lu, Jingshan , Zhuo, Min . Cortical synaptic mechanism for chronic pain and anxiety in Parkinson's disease . | JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE , 2023 , 10 (4) , 300-303 . |
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Abstract ：
Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focused primarily on the homosynaptic plasticity in adult mice, while fewer studies have looked at heterosynaptic plasticity-such as synaptic tagging in aged mice. In the present study, we investigated synaptic tagging in adult and middle-aged mice's anterior cingulate cortex (ACC) using the 64-channel multielectrode dish (MED64) recording system. We found that synaptic tagging was impaired in the ACC of middle-aged male mice as compared to adult mice. Both the network late-phase LTP (L-LTP) and the recruitment of inactive responses were reduced in the ACC of middle-aged male mice. Similar results were found in female middle-aged mice, indicating that there is no gender difference. Furthermore, bath application of brain-derived neurotrophic factor (BDNF) or systemic treatment with newly developed TrkB receptor agonists R13, was shown to rescue both synaptic tagging, and L-LTP, in middle-aged mice. To determine the distribution of synaptic LTP within the ACC, a new visualization method was developed to map the Spatio-temporal variation of LTP in the ACC. Our results provide strong evidence that cortical potentiation and synaptic tagging show an age-dependent reduction, and point to the TrkB receptor as a potential drug target for the treatment of memory decline.
Keyword ：
ACC BDNF LTP Middle-aged mice R13 Synaptic tagging
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| GB/T 7714 | Zhou, Si-Bo , Xue, Man , Liu, Weiqi et al. Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice [J]. | MOLECULAR BRAIN , 2023 , 16 (1) . |
| MLA | Zhou, Si-Bo et al. "Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice" . | MOLECULAR BRAIN 16 . 1 (2023) . |
| APA | Zhou, Si-Bo , Xue, Man , Liu, Weiqi , Chen, Yu-Xin , Chen, Qi-Yu , Lu, Jing-Shan et al. Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice . | MOLECULAR BRAIN , 2023 , 16 (1) . |
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| GB/T 7714 | Zhou, Zhaoxiang , Ye, Penghai , Li, Xu-Hui et al. Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson's disease (vol 14, 161, 2021) [J]. | MOLECULAR BRAIN , 2022 , 15 (1) . |
| MLA | Zhou, Zhaoxiang et al. "Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson's disease (vol 14, 161, 2021)" . | MOLECULAR BRAIN 15 . 1 (2022) . |
| APA | Zhou, Zhaoxiang , Ye, Penghai , Li, Xu-Hui , Zhang, Yuxiang , Li, Muhang , Chen, Qi-Yu et al. Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson's disease (vol 14, 161, 2021) . | MOLECULAR BRAIN , 2022 , 15 (1) . |
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Abstract ：
Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals are highly plastic and can undergo long-term potentiation (LTP), a phenomenon that is also reported in brain areas for learning and memory (such as the hippocampus). Genetic and pharmacological studies show that inhibiting such cortical LTP can help to reduce behavioral sensitization caused by injury as well as injury-induced emotional changes. In this review, we will summarize recent progress related to synaptic mechanisms for different forms of cortical LTP and their possible contribution to behavioral pain and emotional changes. © 2022 by the authors.
Keyword ：
anterior cingulate cortex; chronic pain; long-term potentiation; neuropathic pain; synaptic plasticity
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| GB/T 7714 | Lee, J.-H.A. , Chen, Q. , Zhuo, M. . Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex [J]. | Biomedicines , 2022 , 10 (11) . |
| MLA | Lee, J.-H.A. et al. "Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex" . | Biomedicines 10 . 11 (2022) . |
| APA | Lee, J.-H.A. , Chen, Q. , Zhuo, M. . Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex . | Biomedicines , 2022 , 10 (11) . |
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The anterior cingulate cortex (ACC) is located in the frontal part of the cingulate cortex, and plays important roles in pain perception and emotion. The thalamocortical pathway is the major sensory input to the ACC. Previous studies have show that several different thalamic nuclei receive projection fibers from spinothalamic tract, that in turn send efferents to the ACC by using neural tracers and optical imaging methods. Most of these studies were performed in monkeys, cats, and rats, few studies were reported systematically in adult mice. Adult mice, especially genetically modified mice, have provided molecular and synaptic mechanisms for cortical plasticity and modulation in the ACC. In the present study, we utilized rabies virus-based retrograde tracing system to map thalamic-anterior cingulate monosynaptic inputs in adult mice. We also combined with a new high-throughput VISoR imaging technique to generate a three-dimensional whole-brain reconstruction, especially the thalamus. We found that cortical neurons in the ACC received direct projections from different sub-nuclei in the thalamus, including the anterior, ventral, medial, lateral, midline, and intralaminar thalamic nuclei. These findings provide key anatomic evidences for the connection between the thalamus and ACC.
Keyword ：
anterior cingulate cortex mapping retrograde projection Thalamus volumetric imaging with synchronized on-the-fly-scan and readout
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| GB/T 7714 | Xue, Man , Shi, Wan-Tong , Zhou, Si-Bo et al. Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice [J]. | MOLECULAR PAIN , 2022 , 18 . |
| MLA | Xue, Man et al. "Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice" . | MOLECULAR PAIN 18 (2022) . |
| APA | Xue, Man , Shi, Wan-Tong , Zhou, Si-Bo , Li, Ya-Nan , Wu, Feng-Yi , Chen, Qi-Yu et al. Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice . | MOLECULAR PAIN , 2022 , 18 . |
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| GB/T 7714 | Li, Xu-Hui , Chen, Qi-Yu , Zhuo, Min . Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain (vol 17, pg 861, 2020) [J]. | NEUROTHERAPEUTICS , 2021 , 18 (3) : 2129-2129 . |
| MLA | Li, Xu-Hui et al. "Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain (vol 17, pg 861, 2020)" . | NEUROTHERAPEUTICS 18 . 3 (2021) : 2129-2129 . |
| APA | Li, Xu-Hui , Chen, Qi-Yu , Zhuo, Min . Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain (vol 17, pg 861, 2020) . | NEUROTHERAPEUTICS , 2021 , 18 (3) , 2129-2129 . |
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Introduction N-Methyl-D-aspartate receptors (NMDARs) play a critical role in different forms of plasticity in the central nervous system. NMDARs are always assembled in tetrameric form, in which two GluN1 subunits and two GluN2 and/or GluN3 subunits combine together. Previous studies focused mainly on the hippocampus. The anterior cingulate cortex (ACC) is a key cortical region for sensory and emotional functions. NMDAR GluN2A and GluN2B subunits have been previously investigated, however much less is known about the GluN2C/2D subunits. Results In the present study, we found that the GluN2C/2D subunits are expressed in the pyramidal cells of ACC of adult mice. Application of a selective antagonist of GluN2C/2D, (2R*,3S*)-1-(9-bromophenanthrene-3-carbonyl) piperazine-2,3-dicarboxylic acid (UBP145), significantly reduced NMDAR-mediated currents, while synaptically evoked EPSCs were not affected. UBP145 affected neither the postsynaptic long-term potentiation (post-LTP) nor the presynaptic LTP (pre-LTP). Furthermore, the long-term depression (LTD) was also not affected by UBP145. Finally, both UBP145 decreased the frequency of the miniature EPSCs (mEPSCs) while the amplitude remained intact, suggesting that the GluN2C/2D may be involved in presynaptic regulation of spontaneous glutamate release. Conclusions Our results provide direct evidence that the GluN2C/2D contributes to evoked NMDAR mediated currents and mEPSCs in the ACC, which may have significant physiological implications.
Keyword ：
2D ACC GluN2C LTD LTP NMDAR
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| GB/T 7714 | Chen, Qi-Yu , Li, Xu-Hui , Lu, Jing-Shan et al. NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice [J]. | MOLECULAR BRAIN , 2021 , 14 (1) . |
| MLA | Chen, Qi-Yu et al. "NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice" . | MOLECULAR BRAIN 14 . 1 (2021) . |
| APA | Chen, Qi-Yu , Li, Xu-Hui , Lu, Jing-Shan , Liu, Yinglu , Lee, Jung-Hyun Alex , Chen, Yu-Xin et al. NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice . | MOLECULAR BRAIN , 2021 , 14 (1) . |
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Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and postsynaptic LTP (post-LTP), have been characterized in the anterior cingulate cortex (ACC). Both pre-LTP and post-LTP contribute to chronic-pain-related anxiety and behavioral sensitization. The roles of oxytocin in the ACC have not been studied. Here, we find that microinjections of oxytocin into the ACC attenuate nociceptive responses and anxiety-like behavioral responses in animals with neuropathic pain. Application of oxytocin selectively blocks the maintenance of pre-LTP but not post-LTP. In addition, oxytocin enhances inhibitory transmission and excites ACC interneurons. Similar results are obtained by using selective optical stimulation of oxytocin-containing projecting terminals in the ACC in animals with neuropathic pain. Our results demonstrate that oxytocin acts on central synapses and reduces chronic-pain-induced anxiety by reducing pre-LTP.
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| GB/T 7714 | Li, Xu-Hui , Matsuura, Takanori , Xue, Man et al. Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation [J]. | CELL REPORTS , 2021 , 36 (3) . |
| MLA | Li, Xu-Hui et al. "Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation" . | CELL REPORTS 36 . 3 (2021) . |
| APA | Li, Xu-Hui , Matsuura, Takanori , Xue, Man , Chen, Qi-Yu , Liu, Ren-Hao , Lu, Jing-Shan et al. Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation . | CELL REPORTS , 2021 , 36 (3) . |
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Migraine is the second most prevalent disorder in the world; yet, its underlying mechanisms are still poorly understood. Cumulative studies have revealed pivotal roles of cerebral cortex in the initiation, propagation, and termination of migraine attacks as well as the interictal phase. Investigation of basic mechanisms of the cortex in migraine not only brings insight into the underlying pathophysiology but also provides the basis for designing novel treatments. We aim to summarize the current research literatures and give a brief overview of the cortex and its role in migraine, including the basic structure and function; structural, functional, and biochemical neuroimaging; migraine-related genes; and theories related to cortex in migraine pathophysiology. We propose that long-term plasticity of synaptic transmission in the cortex encodes migraine.
Keyword ：
cerebral cortex cortical spreading depression long-term potentiation migraine pathophysiology
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| GB/T 7714 | Dai, Wei , Liu, Ren-Hao , Qiu, Enchao et al. Cortical mechanisms in migraine [J]. | MOLECULAR PAIN , 2021 , 17 . |
| MLA | Dai, Wei et al. "Cortical mechanisms in migraine" . | MOLECULAR PAIN 17 (2021) . |
| APA | Dai, Wei , Liu, Ren-Hao , Qiu, Enchao , Liu, Yinglu , Chen, Zhiye , Chen, Xiaoyan et al. Cortical mechanisms in migraine . | MOLECULAR PAIN , 2021 , 17 . |
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Abstract ：
Lack of uricase leads to the high incidence of gout in humans and poultry, which is different from rodents. Therefore, chicken is considered to be one of the ideal animal models for the study of gout. Gout-related pain caused by the accumulation of urate in joints is one type of inflammatory pain, which causes damage to joint function. Our previous studies have demonstrated the crucial role of calcium-stimulated adenylyl cyclase subtype 1 (AC1) in inflammatory pain in rodents; however, there is no study in poultry. In the present study, we injected mono-sodium urate (MSU) into the left ankle joint of the chicken to establish a gouty arthritis model, and tested the effect of AC1 inhibitor NB001 on gouty arthritis in chickens. We found that MSU successfully induced spontaneous pain behaviors including sitting, standing on one leg, and limping after 1-3 h of injection into the left ankle of chickens. In addition, edema and mechanical pain hypersensitivity also occurred in the left ankle of chickens with gouty arthritis. After peroral administration of NB001 on chickens with gouty arthritis, both the spontaneous pain behaviors and the mechanical pain hypersensitivity were effectively relieved. The MSU-induced edema in the left ankle of chickens was not affected by NB001, suggesting a central effect of NB001. Our results provide a strong evidence that AC1 is involved in the regulation of inflammatory pain in poultry. A selective AC1 inhibitor NB001 produces an analgesic effect (not anti-inflammatory effect) on gouty pain and may be used for future treatment of gouty pain in both humans and poultry.
Keyword ：
adenylyl cyclase 1 arthritis chicken Gout inflammatory pain NB001 spontaneous pain
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| GB/T 7714 | Liu, Ren-Hao , Shi, Wantong , Zhang, Yu-Xing et al. Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis [J]. | MOLECULAR PAIN , 2021 , 17 . |
| MLA | Liu, Ren-Hao et al. "Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis" . | MOLECULAR PAIN 17 (2021) . |
| APA | Liu, Ren-Hao , Shi, Wantong , Zhang, Yu-Xing , Zhuo, Min , Li, Xu-Hui . Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis . | MOLECULAR PAIN , 2021 , 17 . |
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