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Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury SCIE PubMed Scopus
期刊论文 | 2018 , 22 (3) , 748-759 | CELL REPORTS
WoS CC Cited Count: 3 SCOPUS Cited Count: 4
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Abstract :

Peripheral nerve injury can induce pathological conditions that lead to persistent sensitized nociception. Although there is evidence that plastic changes in the cortex contribute to this process, the underlying molecular mechanisms are unclear. Here, we find that activation of the anterior cingulate cortex (ACC) induced by peripheral nerve injury increases the turnover of specific synaptic proteins in a persistent manner. We demonstrate that neural cell adhesion molecule 1 (NCAM1) is one of the molecules involved and show that it mediates spine reorganization and contributes to the behavioral sensitization. We show striking parallels in the underlying mechanism with the maintenance of NMDA-receptor- and protein-synthesis-dependent long-term potentiation (LTP) in the ACC. Our results, therefore, demonstrate a synaptic mechanism for cortical reorganization and suggest potential avenues for neuropathic pain treatment.

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GB/T 7714 Ko, Hyoung-Gon , Choi, Jun-Hyeok , Park, Dong Ik et al. Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury [J]. | CELL REPORTS , 2018 , 22 (3) : 748-759 .
MLA Ko, Hyoung-Gon et al. "Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury" . | CELL REPORTS 22 . 3 (2018) : 748-759 .
APA Ko, Hyoung-Gon , Choi, Jun-Hyeok , Park, Dong Ik , Kang, SukJae Joshua , Lim, Chae-Seok , Sim, Su-Eon et al. Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury . | CELL REPORTS , 2018 , 22 (3) , 748-759 .
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Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice SCIE PubMed
期刊论文 | 2018 , 11 | MOLECULAR BRAIN
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Abstract :

Human and animal studies indicate that some brain regions are activated during painful and pleasant situations, such as the anterior cingulate cortex (ACC). In the present study, we wanted to determine if some of the same neurons in the ACC may be activated by both pain and pleasure. We labeled neurons activated by two stimuli by using two immediate early genes (IEGs), Arc and Homer1a, and detected the intranuclear transcription of the IEG mRNA in situ. We found that there are double-labeling neurons in the ACC after the mice received pain and sexual attraction stimulation. The double-labeling ACC neurons were higher in male mice exposed to female mice (attractive stimulus) than the group exposed to male mice (normal stimulus). The IEG, which indicates the sexual attraction, were also higher in the female exposing group, while the IEG indicating pain showed no significant variance between two groups. Our findings suggest that ACC neurons play important roles in the process of both pain and pleasure.

Keyword :

ACC Pain Arc Sexual attraction Homer1a IEG

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GB/T 7714 Lu, Jing-Shan , Chen, Qi-Yu , Zhou, Sibo et al. Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice [J]. | MOLECULAR BRAIN , 2018 , 11 .
MLA Lu, Jing-Shan et al. "Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice" . | MOLECULAR BRAIN 11 (2018) .
APA Lu, Jing-Shan , Chen, Qi-Yu , Zhou, Sibo , Inokuchi, Kaoru , Zhuo, Min . Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice . | MOLECULAR BRAIN , 2018 , 11 .
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Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice SCIE PubMed Scopus
期刊论文 | 2018 , 11 | MOLECULAR BRAIN
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Abstract :

Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. However, little is known about the changes of synaptic KAR in the cortical area of Fmr1 KO mice. In this study, we performed whole-cell patch-clamp recordings from layer II/III pyramidal neurons in the insular cortex of Fmr1 KO mice. We found that KARs mediated currents were reduced in Fmr1 KO mice. KARs were mainly located in the synaptosomal fraction of the insular cortex. The abundance of KAR subunit GluK1 and GluK2/3 in the synaptosome was reduced in Fmr1 KO mice, whereas the total expressions of these KARs subunits were not changed. Finally, lack of FMRP impairs subsequent internalization of surface GluK2 after KAR activation, while having no effect on the surface GluK2 expression. Our studies provide evidence indicating that loss of FMRP leads to the abnormal function and localization of KARs. This finding implies a new molecular mechanism for Fragile X syndrome.

Keyword :

Internalization Fragile X syndrome GluK2 Kainate receptor GluK1 Insular cortex FMRP

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GB/T 7714 Qiu, Shuang , Wu, Yu , Lv, Xinyou et al. Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice [J]. | MOLECULAR BRAIN , 2018 , 11 .
MLA Qiu, Shuang et al. "Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice" . | MOLECULAR BRAIN 11 (2018) .
APA Qiu, Shuang , Wu, Yu , Lv, Xinyou , Li, Xia , Zhuo, Min , Koga, Kohei . Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice . | MOLECULAR BRAIN , 2018 , 11 .
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Descending facilitation: From basic science to the treatment of chronic pain SCIE PubMed Scopus
期刊论文 | 2017 , 13 | MOLECULAR PAIN | IF: 3.205
WoS CC Cited Count: 6 SCOPUS Cited Count: 9
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Abstract :

It is documented that sensory transmission, including pain, is subject to endogenous inhibitory and facilitatory modulation at the dorsal horn of the spinal cord. Descending facilitation has received a lot of attention, due to its potentially important roles in chronic pain. Recent investigation using neurobiological approaches has further revealed the link between cortical potentiation and descending facilitation. Cortical-spinal top-down facilitation, including those relayed through brainstem neurons, provides powerful control for pain transmission at the level of the spinal cord. It also provides the neuronal basis to link emotional disorders such as anxiety, depression, and loss of hope to somatosensory pain and sufferings. In this review, I will review a brief history of the discovery of brainstem-spinal descending facilitation and explore new information and hypothesis for descending facilitation in chronic pain.

Keyword :

Descending facilitation chronic pain pain serotonin anterior cingulate cortex mice rostroventral medial medulla

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GB/T 7714 Zhuo, Min . Descending facilitation: From basic science to the treatment of chronic pain [J]. | MOLECULAR PAIN , 2017 , 13 .
MLA Zhuo, Min . "Descending facilitation: From basic science to the treatment of chronic pain" . | MOLECULAR PAIN 13 (2017) .
APA Zhuo, Min . Descending facilitation: From basic science to the treatment of chronic pain . | MOLECULAR PAIN , 2017 , 13 .
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SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex SCIE PubMed Scopus
期刊论文 | 2017 , 37 (14) , 3887-3895 | JOURNAL OF NEUROSCIENCE | IF: 5.97
WoS CC Cited Count: 5 SCOPUS Cited Count: 6
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Abstract :

SCRAPPER is an E3 ubiquitin ligase expressed in presynaptic terminals, neural cell body, and dendrites of the hippocampus and cortex, which is coded by the FBXL20 gene. SCRAPPER is known to regulate synaptic transmissions and long-term potentiation (LTP) in the hippocampus, but no report is available for the cortex. Here we show genetic evidence for critical roles of SCRAPPER in excitatory transmission and presynaptic LTP (pre-LTP) of the anterior cingulate cortex (ACC), a critical cortical region for pain, anxiety, and fear. Miniature and spontaneous releases, but not evoked release, of glutamate were significantly increased in SCRAPPER knock-out (SCR-KO) mice. Interestingly, SCRAPPER selectively contributes to the increases of frequency and amplitude. The pre-LTP in the ACC was completely blocked in SCR-KO mice. Our results thus provide direct evidence for SCRAPPER in both spontaneous release and pre-LTP in the ACC and reveal a potential novel target for treating anxiety-related disease.

Keyword :

LTP presynaptic scrapper spontaneous release knock-out mice cortex

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GB/T 7714 Koga, Kohei , Yao, Ikuko , Setou, Mitsutoshi et al. SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex [J]. | JOURNAL OF NEUROSCIENCE , 2017 , 37 (14) : 3887-3895 .
MLA Koga, Kohei et al. "SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex" . | JOURNAL OF NEUROSCIENCE 37 . 14 (2017) : 3887-3895 .
APA Koga, Kohei , Yao, Ikuko , Setou, Mitsutoshi , Zhuo, Min . SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex . | JOURNAL OF NEUROSCIENCE , 2017 , 37 (14) , 3887-3895 .
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Ionotropic glutamate receptors contribute to pain transmission and chronic pain SCIE PubMed Scopus
期刊论文 | 2017 , 112 , 228-234 | NEUROPHARMACOLOGY | IF: 4.249
WoS CC Cited Count: 15 SCOPUS Cited Count: 18
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Abstract :

Investigation of the synaptic mechanisms for sensory transmission and modulation provide us with critical information about the transmission of painful sensation as well as the basic mechanisms of chronic pain. Recent studies consistently demonstrate that glutamatergic synapses not only play an important role in sensory transmission, including pain and itch transmission, but also contribute to nociceptive sensitization at different levels of the brain. Different subtypes of glutamate receptors play selective roles in synaptic transmission and long-term potentiation (LTP), as well as synaptic modulation. Understanding the contribution of each subtype of glutamate receptors, and related downstream signaling pathways may provide a new opportunity to design better medicine for the treatment of different forms of chronic pain. This article is part of the Special Issue entitled 'Ionotropic glutamate receptors'. (C) 2016 Elsevier Ltd. All rights reserved.

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GB/T 7714 Zhuo, Min . Ionotropic glutamate receptors contribute to pain transmission and chronic pain [J]. | NEUROPHARMACOLOGY , 2017 , 112 : 228-234 .
MLA Zhuo, Min . "Ionotropic glutamate receptors contribute to pain transmission and chronic pain" . | NEUROPHARMACOLOGY 112 (2017) : 228-234 .
APA Zhuo, Min . Ionotropic glutamate receptors contribute to pain transmission and chronic pain . | NEUROPHARMACOLOGY , 2017 , 112 , 228-234 .
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Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex SCIE PubMed Scopus
期刊论文 | 2017 , 13 | MOLECULAR PAIN | IF: 3.205
WoS CC Cited Count: 1 SCOPUS Cited Count: 2
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Calcium signaling is critical for synaptic transmission and plasticity. N-methyl-D-aspartic acid (NMDA) receptors play a key role in synaptic potentiation in the anterior cingulate cortex. Most previous studies of calcium signaling focus on hippocampal neurons, little is known about the activity-induced calcium signals in the anterior cingulate cortex. In the present study, we show that NMDA receptor-mediated postsynaptic calcium signals induced by different synaptic stimulation in anterior cingulate cortex pyramidal neurons. Single and multi-action potentials evoked significant suprathreshold Ca2+ increases in somas and spines. Both NMDA receptors and voltage-gated calcium channels contributed to this increase. Postsynaptic Ca2+ signals were induced by puff-application of glutamate, and a NMDA receptor antagonist AP5 blocked these signals in both somas and spines. Finally, long-term potentiation inducing protocols triggered postsynaptic Ca2+ influx, and these influx were NMDA receptor dependent. Our results provide the first study of calcium signals in the anterior cingulate cortex and demonstrate that NMDA receptors play important roles in postsynaptic calcium signals in anterior cingulate cortex pyramidal neurons.

Keyword :

two-photon microscopy calcium imaging Synaptic plasticity NMDA receptors long-term potentiation anterior cingulate cortex

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GB/T 7714 Li, Xu-Hui , Song, Qian , Chen, Tao et al. Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex [J]. | MOLECULAR PAIN , 2017 , 13 .
MLA Li, Xu-Hui et al. "Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex" . | MOLECULAR PAIN 13 (2017) .
APA Li, Xu-Hui , Song, Qian , Chen, Tao , Zhuo, Min . Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex . | MOLECULAR PAIN , 2017 , 13 .
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Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex SCIE PubMed Scopus
期刊论文 | 2017 , 37 (35) , 8534-8548 | JOURNAL OF NEUROSCIENCE | IF: 5.97
WoS CC Cited Count: 7 SCOPUS Cited Count: 9
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Phosphorylation of AMPA receptor GluA1 plays important roles in synaptic potentiation. Most previous studies have been performed in the hippocampus, while the roles of GluA1 phosphorylation in the cortex remain unknown. Here we investigated the involvement of the phosphorylation of GluA1 in the LTP in the anterior cingulate cortex (ACC) using mice with a GluA1 knock-in mutation at the PKA phosphorylation site serine 845 (s845A) or CaMKII/PKC phosphorylation site serine 831 (s831A). The network LTP, which is constructed by multiple recordings of LTP at different locations within the ACC, was also investigated. We found that the expression of LTP and network LTP was significantly impaired in the s845A mice, but not in the s831A mice. By contrast, basal synaptic transmission and NMDA receptor-mediated responses were not affected. Furthermore, to uncover potential information under the current acquired data, a new method for reconstruction and better visualization of the signals was developed to observe the spatial localizations and dynamic temporal changes of fEPSP signals and multiple LTP responses within the ACC circuit. Our results provide strong evidence that PKA phosphorylation of the GluA1 is important for the network LTP expression in the ACC.

Keyword :

ACC LTP network AMPA PKA mice

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GB/T 7714 Song, Qian , Zheng, Hong-Wei , Li, Xu-Hui et al. Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex [J]. | JOURNAL OF NEUROSCIENCE , 2017 , 37 (35) : 8534-8548 .
MLA Song, Qian et al. "Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex" . | JOURNAL OF NEUROSCIENCE 37 . 35 (2017) : 8534-8548 .
APA Song, Qian , Zheng, Hong-Wei , Li, Xu-Hui , Huganir, Richard L. , Kuner, Thomas , Zhuo, Min et al. Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex . | JOURNAL OF NEUROSCIENCE , 2017 , 37 (35) , 8534-8548 .
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Cortical kainate receptors and behavioral anxiety SCIE PubMed Scopus
期刊论文 | 2017 , 10 | MOLECULAR BRAIN | IF: 3.449
WoS CC Cited Count: 3
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The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo long-term plastic changes in adult animals. Long-term potentiation (LTP) of cortical synapses may play important roles in chronic pain and anxiety. In addition to NMDA and AMPA receptors, kainate (KA) receptors have been found to play roles in synaptic transmission, regulation and presynaptic forms of LTP. In this brief review, I will summarize the new progress made on KA receptors, and propose that ACC synapses may provide a good synaptic model for understanding cortical mechanism for behavioral anxiety, and its related emotional disorders.

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GB/T 7714 Zhuo, Min . Cortical kainate receptors and behavioral anxiety [J]. | MOLECULAR BRAIN , 2017 , 10 .
MLA Zhuo, Min . "Cortical kainate receptors and behavioral anxiety" . | MOLECULAR BRAIN 10 (2017) .
APA Zhuo, Min . Cortical kainate receptors and behavioral anxiety . | MOLECULAR BRAIN , 2017 , 10 .
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Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex SCIE PubMed Scopus
期刊论文 | 2017 , 10 | MOLECULAR BRAIN | IF: 3.449
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Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion. ACC neurons receive innervation of projecting serotonergic nerve terminals from raphe nuclei, but the possible effect of 5-HT on excitatory transmission in the ACC has not been investigated. In the present study, we investigated the role of 5-HT on glutamate neurotransmission in the ACC slices of adult mice. Bath application of 5-HT produced dose-dependent inhibition of evoked excitatory postsynaptic currents (eEPSCs). Paired pulse ratio (PPR) was significantly increased, indicating possible presynaptic effects of 5-HT. Consistently, bath application of 5-HT significantly decreased the frequency of spontaneous and miniature excitatory postsynaptic currents (sEPSCs and mEPSCs). By contrast, amplitudes of sEPSCs and mEPSCs were not significantly affected. After postsynaptic application of G protein inhibitor GDP-beta-S, 5-HT produced inhibition of eEPSCs was significantly reduced. Finally, NAN-190, an antagonist of 5-HT1A receptor, significantly reduced postsynaptic inhibition of 5-HT and abolished presynaptic inhibition. Our results strongly suggest that presynaptic as well as postsynaptic 5-HT receptor including 5-HT1A subtype receptor may contribute to inhibitory modulation of glutamate release as well as postsynaptic responses in the ACC.

Keyword :

Anterior cingulate cortex Serotonin Adenylyl cyclase Excitatory postsynaptic currents Glutamatergic neurotransmission

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GB/T 7714 Tian, Zhen , Yamanaka, Manabu , Bernabucci, Matteo et al. Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex [J]. | MOLECULAR BRAIN , 2017 , 10 .
MLA Tian, Zhen et al. "Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex" . | MOLECULAR BRAIN 10 (2017) .
APA Tian, Zhen , Yamanaka, Manabu , Bernabucci, Matteo , Zhao, Ming-gao , Zhuo, Min . Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex . | MOLECULAR BRAIN , 2017 , 10 .
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