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Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice SCIE PubMed Scopus
期刊论文 | 2018 , 11 | MOLECULAR BRAIN
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Abstract :

Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. However, little is known about the changes of synaptic KAR in the cortical area of Fmr1 KO mice. In this study, we performed whole-cell patch-clamp recordings from layer II/III pyramidal neurons in the insular cortex of Fmr1 KO mice. We found that KARs mediated currents were reduced in Fmr1 KO mice. KARs were mainly located in the synaptosomal fraction of the insular cortex. The abundance of KAR subunit GluK1 and GluK2/3 in the synaptosome was reduced in Fmr1 KO mice, whereas the total expressions of these KARs subunits were not changed. Finally, lack of FMRP impairs subsequent internalization of surface GluK2 after KAR activation, while having no effect on the surface GluK2 expression. Our studies provide evidence indicating that loss of FMRP leads to the abnormal function and localization of KARs. This finding implies a new molecular mechanism for Fragile X syndrome.

Keyword :

Internalization Fragile X syndrome GluK2 Kainate receptor GluK1 Insular cortex FMRP

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GB/T 7714 Qiu, Shuang , Wu, Yu , Lv, Xinyou et al. Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice [J]. | MOLECULAR BRAIN , 2018 , 11 .
MLA Qiu, Shuang et al. "Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice" . | MOLECULAR BRAIN 11 (2018) .
APA Qiu, Shuang , Wu, Yu , Lv, Xinyou , Li, Xia , Zhuo, Min , Koga, Kohei . Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice . | MOLECULAR BRAIN , 2018 , 11 .
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Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice SCIE PubMed
期刊论文 | 2018 , 11 | MOLECULAR BRAIN
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Abstract :

Human and animal studies indicate that some brain regions are activated during painful and pleasant situations, such as the anterior cingulate cortex (ACC). In the present study, we wanted to determine if some of the same neurons in the ACC may be activated by both pain and pleasure. We labeled neurons activated by two stimuli by using two immediate early genes (IEGs), Arc and Homer1a, and detected the intranuclear transcription of the IEG mRNA in situ. We found that there are double-labeling neurons in the ACC after the mice received pain and sexual attraction stimulation. The double-labeling ACC neurons were higher in male mice exposed to female mice (attractive stimulus) than the group exposed to male mice (normal stimulus). The IEG, which indicates the sexual attraction, were also higher in the female exposing group, while the IEG indicating pain showed no significant variance between two groups. Our findings suggest that ACC neurons play important roles in the process of both pain and pleasure.

Keyword :

ACC Pain Arc Sexual attraction Homer1a IEG

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GB/T 7714 Lu, Jing-Shan , Chen, Qi-Yu , Zhou, Sibo et al. Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice [J]. | MOLECULAR BRAIN , 2018 , 11 .
MLA Lu, Jing-Shan et al. "Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice" . | MOLECULAR BRAIN 11 (2018) .
APA Lu, Jing-Shan , Chen, Qi-Yu , Zhou, Sibo , Inokuchi, Kaoru , Zhuo, Min . Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice . | MOLECULAR BRAIN , 2018 , 11 .
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Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury SCIE PubMed Scopus
期刊论文 | 2018 , 22 (3) , 748-759 | CELL REPORTS
WoS CC Cited Count: 7 SCOPUS Cited Count: 6
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Abstract :

Peripheral nerve injury can induce pathological conditions that lead to persistent sensitized nociception. Although there is evidence that plastic changes in the cortex contribute to this process, the underlying molecular mechanisms are unclear. Here, we find that activation of the anterior cingulate cortex (ACC) induced by peripheral nerve injury increases the turnover of specific synaptic proteins in a persistent manner. We demonstrate that neural cell adhesion molecule 1 (NCAM1) is one of the molecules involved and show that it mediates spine reorganization and contributes to the behavioral sensitization. We show striking parallels in the underlying mechanism with the maintenance of NMDA-receptor- and protein-synthesis-dependent long-term potentiation (LTP) in the ACC. Our results, therefore, demonstrate a synaptic mechanism for cortical reorganization and suggest potential avenues for neuropathic pain treatment.

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GB/T 7714 Ko, Hyoung-Gon , Choi, Jun-Hyeok , Park, Dong Ik et al. Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury [J]. | CELL REPORTS , 2018 , 22 (3) : 748-759 .
MLA Ko, Hyoung-Gon et al. "Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury" . | CELL REPORTS 22 . 3 (2018) : 748-759 .
APA Ko, Hyoung-Gon , Choi, Jun-Hyeok , Park, Dong Ik , Kang, SukJae Joshua , Lim, Chae-Seok , Sim, Su-Eon et al. Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury . | CELL REPORTS , 2018 , 22 (3) , 748-759 .
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New mechanisms for pain: From neurons to glia; from spinal cord to cortex SCIE PubMed Scopus
期刊论文 | 2017 , 141 (4) , 484-485 | JOURNAL OF NEUROCHEMISTRY | IF: 4.609
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GB/T 7714 Zhuo, Min . New mechanisms for pain: From neurons to glia; from spinal cord to cortex [J]. | JOURNAL OF NEUROCHEMISTRY , 2017 , 141 (4) : 484-485 .
MLA Zhuo, Min . "New mechanisms for pain: From neurons to glia; from spinal cord to cortex" . | JOURNAL OF NEUROCHEMISTRY 141 . 4 (2017) : 484-485 .
APA Zhuo, Min . New mechanisms for pain: From neurons to glia; from spinal cord to cortex . | JOURNAL OF NEUROCHEMISTRY , 2017 , 141 (4) , 484-485 .
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Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice. PubMed
期刊论文 | 2017 , 3 (7) , e00338 | Heliyon
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Long-term potentiation (LTP) of synaptic transmission in the central nervous system is a key form of cortical plasticity. The insular cortex (IC) is known to play important roles in pain perception, aversive memory and mood disorders. LTP has been recently reported in the IC, however, the signaling pathway for IC LTP remains unknown. Here, we investigated the synaptic mechanism of IC LTP. We found that IC LTP induced by the pairing protocol was N-methyl-D-aspartate receptors (NMDARs) dependent, and expressed postsynaptically, since paired-pulse ratio (PPR) was not affected. Postsynaptic calcium is important for the induction of post-LTP, since the postsynaptic application of BAPTA completely blocked the induction of LTP. Calcium-activated adenylyl cyclase subtype 1 (AC1) is required for potentiation. By contrast, AC8 is not required. Inhibition of Ca<sup>2+</sup> permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (CP-AMPARs) or protein kinase M zeta (PKMζ) reduced the expression of LTP. Our results suggest that calcium-stimulated AC1, but not AC8, can be a trigger of the induction and maintenance of LTP in the IC.

Keyword :

Neuroscience

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GB/T 7714 Yamanaka Manabu , Matsuura Takanori , Pan Haili et al. Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice. [J]. | Heliyon , 2017 , 3 (7) : e00338 .
MLA Yamanaka Manabu et al. "Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice." . | Heliyon 3 . 7 (2017) : e00338 .
APA Yamanaka Manabu , Matsuura Takanori , Pan Haili , Zhuo Min . Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice. . | Heliyon , 2017 , 3 (7) , e00338 .
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Descending facilitation: From basic science to the treatment of chronic pain SCIE PubMed Scopus
期刊论文 | 2017 , 13 | MOLECULAR PAIN | IF: 3.205
WoS CC Cited Count: 7 SCOPUS Cited Count: 9
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Abstract :

It is documented that sensory transmission, including pain, is subject to endogenous inhibitory and facilitatory modulation at the dorsal horn of the spinal cord. Descending facilitation has received a lot of attention, due to its potentially important roles in chronic pain. Recent investigation using neurobiological approaches has further revealed the link between cortical potentiation and descending facilitation. Cortical-spinal top-down facilitation, including those relayed through brainstem neurons, provides powerful control for pain transmission at the level of the spinal cord. It also provides the neuronal basis to link emotional disorders such as anxiety, depression, and loss of hope to somatosensory pain and sufferings. In this review, I will review a brief history of the discovery of brainstem-spinal descending facilitation and explore new information and hypothesis for descending facilitation in chronic pain.

Keyword :

Descending facilitation chronic pain pain serotonin anterior cingulate cortex mice rostroventral medial medulla

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GB/T 7714 Zhuo, Min . Descending facilitation: From basic science to the treatment of chronic pain [J]. | MOLECULAR PAIN , 2017 , 13 .
MLA Zhuo, Min . "Descending facilitation: From basic science to the treatment of chronic pain" . | MOLECULAR PAIN 13 (2017) .
APA Zhuo, Min . Descending facilitation: From basic science to the treatment of chronic pain . | MOLECULAR PAIN , 2017 , 13 .
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Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex SCIE PubMed Scopus
期刊论文 | 2017 , 13 | MOLECULAR PAIN | IF: 3.205
WoS CC Cited Count: 4 SCOPUS Cited Count: 4
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Calcium signaling is critical for synaptic transmission and plasticity. N-methyl-D-aspartic acid (NMDA) receptors play a key role in synaptic potentiation in the anterior cingulate cortex. Most previous studies of calcium signaling focus on hippocampal neurons, little is known about the activity-induced calcium signals in the anterior cingulate cortex. In the present study, we show that NMDA receptor-mediated postsynaptic calcium signals induced by different synaptic stimulation in anterior cingulate cortex pyramidal neurons. Single and multi-action potentials evoked significant suprathreshold Ca2+ increases in somas and spines. Both NMDA receptors and voltage-gated calcium channels contributed to this increase. Postsynaptic Ca2+ signals were induced by puff-application of glutamate, and a NMDA receptor antagonist AP5 blocked these signals in both somas and spines. Finally, long-term potentiation inducing protocols triggered postsynaptic Ca2+ influx, and these influx were NMDA receptor dependent. Our results provide the first study of calcium signals in the anterior cingulate cortex and demonstrate that NMDA receptors play important roles in postsynaptic calcium signals in anterior cingulate cortex pyramidal neurons.

Keyword :

two-photon microscopy calcium imaging Synaptic plasticity NMDA receptors long-term potentiation anterior cingulate cortex

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GB/T 7714 Li, Xu-Hui , Song, Qian , Chen, Tao et al. Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex [J]. | MOLECULAR PAIN , 2017 , 13 .
MLA Li, Xu-Hui et al. "Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex" . | MOLECULAR PAIN 13 (2017) .
APA Li, Xu-Hui , Song, Qian , Chen, Tao , Zhuo, Min . Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex . | MOLECULAR PAIN , 2017 , 13 .
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Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain SCIE PubMed Scopus
期刊论文 | 2017 , 21 (5) , 487-493 | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | IF: 1.469
WoS CC Cited Count: 4 SCOPUS Cited Count: 4
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Abstract :

The anterior cingulate cortex (ACC) is known for its role in perception of nociceptive signals and the associated emotional responses. Recent optogenetic studies, involving modulation of neuronal activity in the ACC, show that the ACC can modulate mechanical hyperalgesia. In the present study, we used optogenetic techniques to selectively modulate excitatory pyramidal neurons and inhibitory interneurons in the ACC in a model of chronic inflammatory pain to assess their motivational effect in the conditioned place preference (CPP) test. Selective inhibition of pyramidal neurons induced preference during the CPP test, while activation of parvalbumin (PV)-specific neurons did not. Moreover, chemogenetic inhibition of the excitatory pyramidal neurons alleviated mechanical hyperalgesia, consistent with our previous result. Our results provide evidence for the analgesic effect of inhibition of ACC excitatory pyramidal neurons and a prospective treatment for chronic pain.

Keyword :

Anterior cingulate cortex Conditioned place preference Pain Optogenetics

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GB/T 7714 Kang, Sukjae Joshua , Kim, Siyong , Lee, Jaehyun et al. Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain [J]. | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY , 2017 , 21 (5) : 487-493 .
MLA Kang, Sukjae Joshua et al. "Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain" . | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 21 . 5 (2017) : 487-493 .
APA Kang, Sukjae Joshua , Kim, Siyong , Lee, Jaehyun , Kwak, Chuljung , Lee, Kyungmin , Zhuo, Min et al. Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain . | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY , 2017 , 21 (5) , 487-493 .
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Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex SCIE PubMed Scopus
期刊论文 | 2017 , 10 | MOLECULAR BRAIN | IF: 3.449
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion. ACC neurons receive innervation of projecting serotonergic nerve terminals from raphe nuclei, but the possible effect of 5-HT on excitatory transmission in the ACC has not been investigated. In the present study, we investigated the role of 5-HT on glutamate neurotransmission in the ACC slices of adult mice. Bath application of 5-HT produced dose-dependent inhibition of evoked excitatory postsynaptic currents (eEPSCs). Paired pulse ratio (PPR) was significantly increased, indicating possible presynaptic effects of 5-HT. Consistently, bath application of 5-HT significantly decreased the frequency of spontaneous and miniature excitatory postsynaptic currents (sEPSCs and mEPSCs). By contrast, amplitudes of sEPSCs and mEPSCs were not significantly affected. After postsynaptic application of G protein inhibitor GDP-beta-S, 5-HT produced inhibition of eEPSCs was significantly reduced. Finally, NAN-190, an antagonist of 5-HT1A receptor, significantly reduced postsynaptic inhibition of 5-HT and abolished presynaptic inhibition. Our results strongly suggest that presynaptic as well as postsynaptic 5-HT receptor including 5-HT1A subtype receptor may contribute to inhibitory modulation of glutamate release as well as postsynaptic responses in the ACC.

Keyword :

Anterior cingulate cortex Serotonin Adenylyl cyclase Excitatory postsynaptic currents Glutamatergic neurotransmission

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GB/T 7714 Tian, Zhen , Yamanaka, Manabu , Bernabucci, Matteo et al. Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex [J]. | MOLECULAR BRAIN , 2017 , 10 .
MLA Tian, Zhen et al. "Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex" . | MOLECULAR BRAIN 10 (2017) .
APA Tian, Zhen , Yamanaka, Manabu , Bernabucci, Matteo , Zhao, Ming-gao , Zhuo, Min . Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex . | MOLECULAR BRAIN , 2017 , 10 .
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Cortical kainate receptors and behavioral anxiety SCIE PubMed Scopus
期刊论文 | 2017 , 10 | MOLECULAR BRAIN | IF: 3.449
WoS CC Cited Count: 3 SCOPUS Cited Count: 5
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The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo long-term plastic changes in adult animals. Long-term potentiation (LTP) of cortical synapses may play important roles in chronic pain and anxiety. In addition to NMDA and AMPA receptors, kainate (KA) receptors have been found to play roles in synaptic transmission, regulation and presynaptic forms of LTP. In this brief review, I will summarize the new progress made on KA receptors, and propose that ACC synapses may provide a good synaptic model for understanding cortical mechanism for behavioral anxiety, and its related emotional disorders.

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GB/T 7714 Zhuo, Min . Cortical kainate receptors and behavioral anxiety [J]. | MOLECULAR BRAIN , 2017 , 10 .
MLA Zhuo, Min . "Cortical kainate receptors and behavioral anxiety" . | MOLECULAR BRAIN 10 (2017) .
APA Zhuo, Min . Cortical kainate receptors and behavioral anxiety . | MOLECULAR BRAIN , 2017 , 10 .
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