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< Page ,Total 23 >
Criteria of pressure and thermal damage during laser irradiation of port wine stains: Which is dominant to vascular lesions? EI SCIE
期刊论文 | 2019 , 132 , 848-860 | International Journal of Heat and Mass Transfer
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Abstract :

Port wine stains (PWSs) are congenital dermal vessel proliferations mainly treated with laser therapy. The complete removal of the vessel lesions is rarely achieved because of a lack of discriminatory analysis of the two competitive laser damages to blood vessels, namely, pressure damage and thermal damage. Unlike complete vessel constriction, which is caused by thermal damage that can be measured by temperature-related integral Ω, vessel rupture results from pressure damage, which has been seldom studied. In this study, the rupture potential index based on wall pressure (RPIP) was calculated as the ratio of locally acting pressure to the pressure threshold. RPIP > 1 and Ω > 103 were adopted as benchmarks to judge pressure damage (vessel rupture) and thermal damage (complete vessel constriction), respectively. A computational fluid dynamics simulation was carried out to provide the temperature and pressure field in the PWS vessel model during irradiation by 595 nm pulsed dye laser (PDL) or 1064 nm Nd:YAG laser. Numerical results showed that for the 595 nm laser, vessels constantly underwent rupture. The area of high RPIP determined the degree of rupture by predicting the large and multiple rupture locations of the vessel. By contrast, for the 1064 nm laser, complete constriction was the main damage type. To a single vessel of 100 μm diameter, the optimized laser parameters were E = 10 J/cm2 with tp = 6 ms for 595 nm PDL and E = 180 J/cm2 with tp = 6 ms 1064 nm for Nd:YAG laser. © 2018 Elsevier Ltd

Keyword :

Computational fluid dynamics simulations Discriminatory analysis Laser treatment Port wine stains Pulsed dye lasers Temperature and pressures Vessel constriction Vessel rupture

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GB/T 7714 Jia, Hao , Chen, Bin , Li, Dong . Criteria of pressure and thermal damage during laser irradiation of port wine stains: Which is dominant to vascular lesions? [J]. | International Journal of Heat and Mass Transfer , 2019 , 132 : 848-860 .
MLA Jia, Hao 等. "Criteria of pressure and thermal damage during laser irradiation of port wine stains: Which is dominant to vascular lesions?" . | International Journal of Heat and Mass Transfer 132 (2019) : 848-860 .
APA Jia, Hao , Chen, Bin , Li, Dong . Criteria of pressure and thermal damage during laser irradiation of port wine stains: Which is dominant to vascular lesions? . | International Journal of Heat and Mass Transfer , 2019 , 132 , 848-860 .
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In Vivo Experimental Study on the Enhancement of Optical Clearing Effect by Laser Irradiation in Conjunction with a Chemical Penetration Enhancer SCIE
期刊论文 | 2019 , 9 (3) | APPLIED SCIENCES-BASEL
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Abstract :

The penetration of optical clearing agents (OCAs) is restricted by the natural barrier function of the stratum corneum (SC) of the skin, which can be breached by physical and chemical methods to enhance the transcutaneous delivery of OCAs. To breach the barrier function of SC, we carried out the in vivo experimental study to enhance the optical clearing effect of PEG-400 by laser irradiation in conjunction with a chemical penetration enhancer thiazone. We compared the reflectance spectra of skin without laser irradiation or thiazone. Mono-treatment of thiazone could not significantly enhance the optical clearing efficacy of the skin. After 60 min, the reflectance spectrum decreased by only approximately 10%. With the combined treatment, the reflectance spectrum decreased by approximately 30% after 10 min. Subsequently, the effect of laser dose on the enhancement of optical clearing efficacy was studied. The optimal irradiation dose was determined. The reflectance of skins irradiated by a laser dose at 0.7 J/cm(2) decreased by approximately 10% and were 20% lower than those at 0.5 and 0.9 J/cm(2). The laser at 0.5 J/cm(2) could not damage the SC completely, whereas the laser at 0.9 J/cm(2) influenced the epidermis and dermis; thus, the reflectance of skin samples irradiated by 0.9 J/cm(2) did not decrease.

Keyword :

thiazone tissue optical clearing technique in vivo skin combined penetration enhancement optical clearing laser irradiation

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GB/T 7714 Liu, Xinyi , Chen, Bin . In Vivo Experimental Study on the Enhancement of Optical Clearing Effect by Laser Irradiation in Conjunction with a Chemical Penetration Enhancer [J]. | APPLIED SCIENCES-BASEL , 2019 , 9 (3) .
MLA Liu, Xinyi 等. "In Vivo Experimental Study on the Enhancement of Optical Clearing Effect by Laser Irradiation in Conjunction with a Chemical Penetration Enhancer" . | APPLIED SCIENCES-BASEL 9 . 3 (2019) .
APA Liu, Xinyi , Chen, Bin . In Vivo Experimental Study on the Enhancement of Optical Clearing Effect by Laser Irradiation in Conjunction with a Chemical Penetration Enhancer . | APPLIED SCIENCES-BASEL , 2019 , 9 (3) .
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Theoretical study of cryogen spray cooling with R134a, R404A and R1234yf: Comparison and clinical potential application EI SCIE
期刊论文 | 2019 , 148 , 1058-1067 | Applied Thermal Engineering
WoS CC Cited Count: 1
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Abstract :

In laser dermatology, cryogen spray cooling has been used to protect the epidermis from unwanted thermal damage. In this work, spray characteristics and surface heat transfer dynamics were simulated by two-way coupling hybrid vortex method to evaluate the surface cooling capacity of R134a, R404A and R1234yf in terms of cooling density and effective heat flux. Simulation results reveal that R404A has the largest cooling capacity and smallest dispersion. R1234yf has similar spray characteristics but smaller dispersion compared with R134a. The maximum effective heat flux for R134a, R404A and R1234yf was determined as 262.1, 407.5 and 225.8 kW/m2 at the spray distances of 25.6, 30.8 and 25.1 mm, respectively. Substituting the environment friendly R1234yf for R134a can remarkably reduce global warming potential by over 1430 times and increase cooling density but insufficient cooling capacity. The effective heat flux of R1234yf can be enhanced by 18.8% by reducing the nozzle diameter and decreasing the back pressure (D = 0.4 mm, Pb = 0.01 MPa). This result is comparable with that of R134a under 1 atm and provides a theoretical basis for R1234yf potential application in clinics. © 2018 Elsevier Ltd

Keyword :

Cryogen spray cooling Environment friendly Global warming potential Heat Transfer enhancement R1234yf Spray characteristics Surface heat transfer Theoretical study

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GB/T 7714 Chen, Bin , Tian, Jiameng , Wang, Rui et al. Theoretical study of cryogen spray cooling with R134a, R404A and R1234yf: Comparison and clinical potential application [J]. | Applied Thermal Engineering , 2019 , 148 : 1058-1067 .
MLA Chen, Bin et al. "Theoretical study of cryogen spray cooling with R134a, R404A and R1234yf: Comparison and clinical potential application" . | Applied Thermal Engineering 148 (2019) : 1058-1067 .
APA Chen, Bin , Tian, Jiameng , Wang, Rui , Zhou, Zhifu . Theoretical study of cryogen spray cooling with R134a, R404A and R1234yf: Comparison and clinical potential application . | Applied Thermal Engineering , 2019 , 148 , 1058-1067 .
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Numerical Investigation of the Thermal Response to Skin Tissue during Laser Lipolysis EI SCIE Scopus CSCD
期刊论文 | 2018 , 27 (5) , 470-478 | JOURNAL OF THERMAL SCIENCE
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Abstract :

Laser lipolysis can effectively treat obesity and its associated diseases, such as hypertension, fatty liver, and hyperlipidemia. However, currently available invasive laser lipolysis, which transmits laser to a fiber-optic catheter inserted into the subcutaneous tissue for irradiation through an incision, may cause hematomas, infections, and empyrosis. The current study presents a novel, noninvasive approach for laser lipolysis, which directly irradiates the intact skin surface without an incision and preferentially targets adipose tissue at the near-infrared band. High laser energy is necessary to damage adipocytes; however, this may carbonate and burn the dermis. Therefore, the introduction of skin cooling is essential to avoid unwanted hyperthermal injury and improve the threshold of radiant exposure. In the current study, we investigated a novel noninvasive approach assisted with skin cooling by establishing a homogeneous multi-layer skin model. In this method, light propagation in the skin was simulated by using the Monte Carlo method. Skin cooling was employed before laser irradiation to protect the epidermis from thermal damage, which was treated as a boundary condition based on Newton's law. The numerical results showed that the photons were deposited in the adipose layer more than in the other layers. Laser can effectively destroy adipose tissue at an energy density of >200 J/cm(2) at 1210 nm wavelength, whereas at least 300 J/cm(2) is required at 1064 nm to achieve the same effect. In this experiment, at >5 s pulse width, the selectivity of adipose was not obvious. Moreover, the results indicated that 60 ms R134a or R404a spray can effectively reduce the temperature of the epidermis. R404a exhibited a stronger cooling effect than R134a. Cold air cooling at -10 degrees C for 10 s could effectively decrease the skin temperature, and deeper cooling could be achieved by cold air cooling compared with cryogen spray cooling.

Keyword :

laser lipolysis skin cooling multi-layer skin model Nd:YAG laser

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GB/T 7714 Chen, Bin , Zhang, Yue , Li, Dong . Numerical Investigation of the Thermal Response to Skin Tissue during Laser Lipolysis [J]. | JOURNAL OF THERMAL SCIENCE , 2018 , 27 (5) : 470-478 .
MLA Chen, Bin et al. "Numerical Investigation of the Thermal Response to Skin Tissue during Laser Lipolysis" . | JOURNAL OF THERMAL SCIENCE 27 . 5 (2018) : 470-478 .
APA Chen, Bin , Zhang, Yue , Li, Dong . Numerical Investigation of the Thermal Response to Skin Tissue during Laser Lipolysis . | JOURNAL OF THERMAL SCIENCE , 2018 , 27 (5) , 470-478 .
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Multiple laser pulses in conjunction with an optical clearing agent to improve the curative effect of cutaneous vascular lesions SCIE PubMed Scopus
期刊论文 | 2018 , 33 (6) , 1295-1306 | LASERS IN MEDICAL SCIENCE
WoS CC Cited Count: 1
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Abstract :

Port-wine stain (PWS) birthmark is a congenital microvascular malformation of the skin. A 1064-nm Nd:YAG laser can achieve a deeper treatment, but the weak absorption by blood limits its clinical application. Multiple laser pulses (MLPs) are a potential solution to enhance the curative effect of a Nd:YAG laser. To reduce the pulse number (p (n)) required for the thermal destruction of the blood vessel, the effect of glucose in conjunction with MLP was investigated. In vivo experiments were performed on a dorsal skin chamber model. Different concentrations (20, 25, 30, and 40%) of glucose were applied to the sub-dermal side of the hamster skin before laser irradiation. Identical vessels with diameters of 200 +/- 30 and 110 +/- 20 mu m were chosen as representatives of typical PWS vessels. Instant thermal responses of the blood vessel were recorded by a high-speed camera. The required p (n) for blood vessel damage was compared with that without glucose pretreatment. Results showed that the use of glucose with a concentration of 20% combined with MLP Nd:YAG laser to damage blood vessels is more appropriate because severe hemorrhage or carbonization easily appeared in blood vessels at higher glucose concentration of 25, 30, and 40%. When 20% glycerol is pretreated on the sub-dermal hamster skin, the required p (n) for blood vessel damage can be significantly decreased for different power densities. For example, p (n) can be reduced by 40% when the power density is 57 J/cm(2). In addition, generation of cavitation and bubbles in blood vessels is difficult upon pretreatment with glucose. The combination of glucose with MLP Nd:YAG laser could be an effective protocol for reducing the p (n) required for blood vessel damage. Randomized controlled trial (RCT) and human trials will be conducted in the future.

Keyword :

Multiple laser pulses Optical cleaning agent Laser therapy Port-wine stain Glucose

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GB/T 7714 Ma, Jun , Chen, Bin , Li, Dong et al. Multiple laser pulses in conjunction with an optical clearing agent to improve the curative effect of cutaneous vascular lesions [J]. | LASERS IN MEDICAL SCIENCE , 2018 , 33 (6) : 1295-1306 .
MLA Ma, Jun et al. "Multiple laser pulses in conjunction with an optical clearing agent to improve the curative effect of cutaneous vascular lesions" . | LASERS IN MEDICAL SCIENCE 33 . 6 (2018) : 1295-1306 .
APA Ma, Jun , Chen, Bin , Li, Dong , Zhang, Yue , Ying, Zhaoxia . Multiple laser pulses in conjunction with an optical clearing agent to improve the curative effect of cutaneous vascular lesions . | LASERS IN MEDICAL SCIENCE , 2018 , 33 (6) , 1295-1306 .
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Correction to: Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study. PubMed Scopus SCIE
期刊论文 | 2018 , 33 (9) , 2015-2015 | Lasers in medical science
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In the originally published article, the title was incorrectly copied from another article. The correct title is "Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study", which is also shown above.

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GB/T 7714 Ma Jun , Chen Bin , Li Dong et al. Correction to: Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study. [J]. | Lasers in medical science , 2018 , 33 (9) : 2015-2015 .
MLA Ma Jun et al. "Correction to: Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study." . | Lasers in medical science 33 . 9 (2018) : 2015-2015 .
APA Ma Jun , Chen Bin , Li Dong , Zhang Yue , Ying Zhaoxia . Correction to: Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study. . | Lasers in medical science , 2018 , 33 (9) , 2015-2015 .
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制冷剂瞬态闪蒸喷雾冷却研究进展 CSCD PKU
期刊论文 | 2018 , (1) , 57-68 | 化工学报
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Abstract :

随着皮肤激光医学的高速发展,与之配合的表皮冷却技术日益重要,具有极大的市场应用前景.制冷剂瞬态闪蒸喷雾冷却(CSC)已经成为激光治疗血管性皮肤病的重要辅助冷却手段,可以有效减小黑色素吸收激光能量导致的表皮热损伤,从而提高入射激光能量、改善治疗效果.CSC涉及到低沸点高挥发性介质的闪蒸雾化、冷却表面沸腾相变传热等多相流与传热复杂科学问题,已有研究大部分是以实验的方式进行.本文从闪蒸喷雾机理、闪蒸喷雾特性、表面动态传热规律与传热强化4个方面对CSC在近二十年的研究进展进行综述,对比分析了典型研究方法与研究结果,并对其影响因素进行了探讨,使用更低沸点的新制冷剂与背压/距离耦合的喷雾新技术可以极大提高冷却能力.最后,指出了当前研究的难点以及后续研究方向.

Keyword :

制冷剂闪蒸喷雾冷却 传热 生物医学工程 激光皮肤医学 气液两相流

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GB/T 7714 陈斌 , 周致富 , 辛慧 . 制冷剂瞬态闪蒸喷雾冷却研究进展 [J]. | 化工学报 , 2018 , (1) : 57-68 .
MLA 陈斌 et al. "制冷剂瞬态闪蒸喷雾冷却研究进展" . | 化工学报 1 (2018) : 57-68 .
APA 陈斌 , 周致富 , 辛慧 . 制冷剂瞬态闪蒸喷雾冷却研究进展 . | 化工学报 , 2018 , (1) , 57-68 .
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R1234yf瞬态喷雾冷却及过热度影响的实验研究 CSCD PKU
期刊论文 | 2018 , (2) , 595-601 | 化工学报
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Abstract :

制冷剂瞬态喷雾冷却是临床激光治疗的重要辅助手段.当前临床应用及实验研究均采用R134a或R404A进行喷雾冷却,但这两种制冷剂具有极高的温室效应潜能(GWP)值,对环境产生严重威胁.以热物性与R134a相似、而GWP值仅为4的R1234yf作为喷雾冷却的替代制冷剂,对其临床应用进行了探索性研究.表面传热的研究结果显示R1234f的冷却能力略低于R134a与R404A.通过降低制冷剂过热度的方式,可以有效提高喷雾集中程度,在保证闪蒸雾化的前提下显著提高表面热通量,提高R1234yf喷雾临床应用的可行性.

Keyword :

R1234yf 喷雾形态 表面 相变 传热

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GB/T 7714 王锐 , 陈斌 , 王嘉丰 et al. R1234yf瞬态喷雾冷却及过热度影响的实验研究 [J]. | 化工学报 , 2018 , (2) : 595-601 .
MLA 王锐 et al. "R1234yf瞬态喷雾冷却及过热度影响的实验研究" . | 化工学报 2 (2018) : 595-601 .
APA 王锐 , 陈斌 , 王嘉丰 , 田加猛 , 周致富 , 应朝霞 . R1234yf瞬态喷雾冷却及过热度影响的实验研究 . | 化工学报 , 2018 , (2) , 595-601 .
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Experimental Study on Laser Induced Bubble Occlusion of Blood Vessels in Treatment of Proliferative Vascular Dermatosis EI
期刊论文 | 2018 , 39 (10) , 2223-2228 | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics
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In order to explore the mechanism of laser induced bubble occlusion of vascular lesions in treating proliferative vascular dermatosis, we established a fluorescence microscopic observation system based on the dorsal skin chamber model. Thermal responses of blood vessel and bubble's generation and development were investigated under multi-pulse 1,064 nm laser irradiation with moderate energy density before and after liposome injection. The results showed that liposomes in blood can be additional nucleation to decrease temperature threshold of bubble formation, thus bubble generation probability increases obviously from 10% to 52% after liposome injection. After produced, bubbles can expand to the maximum volume in 15 min and occlude the blood vessels for a long time, causing the vascular wall necrosis by hypoxia. © 2018, Science Press. All right reserved.

Keyword :

Bubble generation Embolization Laser induced bubbles Microscopic observations Multi-pulse laser Temperature thresholds Thermal response Vascular lesions

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GB/T 7714 Jia, Hao , Chen, Bin , Xing, Lin-Zhuang et al. Experimental Study on Laser Induced Bubble Occlusion of Blood Vessels in Treatment of Proliferative Vascular Dermatosis [J]. | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics , 2018 , 39 (10) : 2223-2228 .
MLA Jia, Hao et al. "Experimental Study on Laser Induced Bubble Occlusion of Blood Vessels in Treatment of Proliferative Vascular Dermatosis" . | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics 39 . 10 (2018) : 2223-2228 .
APA Jia, Hao , Chen, Bin , Xing, Lin-Zhuang , Li, Dong , Ying, Zhao-Xia . Experimental Study on Laser Induced Bubble Occlusion of Blood Vessels in Treatment of Proliferative Vascular Dermatosis . | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics , 2018 , 39 (10) , 2223-2228 .
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Investigation of Non-Fourier Heat Transfer in Biological Tissues Irradiated by Pulsed Laser EI Scopus CSCD PKU
期刊论文 | 2018 , 39 (3) , 598-602 | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics
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Investigation of the heat transfer in biological tissues is of great importance during the laser-mediated thermal therapies of skin diseases. These processes generally feature rapid heating with high heat flux and small temporal scales within extremely heterogeneous tissue media. Under those conditions, the non-Fourier effect should be taken into account. This paper studied the bio-heat transfer in skin tissue model that irradiated by pulsed laser. After optical transmission and energy deposition were obtained by Monte Carlo method, the dual-phase-lag (DPL) model was employed and solved by using a three-level finite difference method to characterize non-Fourier heat conduction by focusing on the thermal lag during the interaction of pulsed laser with biological tissues. It is found that substantial discrepancies exist among the temperature responses of biological tissues with and without considering the non-Fourier effect. The calculated temperature in the nonFourier heat transfer is lower and the appearance of the highest temperature exhibits lagging behaviors. © 2018, Science Press. All right reserved.

Keyword :

Biological tissues Dual-phase-lag models Energy depositions Heterogeneous tissues Highest temperature Non-Fourier effects Non-Fourier heat conduction Temperature response

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GB/T 7714 Zhang, Yong , Chen, Bin , Li, Dong et al. Investigation of Non-Fourier Heat Transfer in Biological Tissues Irradiated by Pulsed Laser [J]. | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics , 2018 , 39 (3) : 598-602 .
MLA Zhang, Yong et al. "Investigation of Non-Fourier Heat Transfer in Biological Tissues Irradiated by Pulsed Laser" . | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics 39 . 3 (2018) : 598-602 .
APA Zhang, Yong , Chen, Bin , Li, Dong , Ying, Zhao-Xia . Investigation of Non-Fourier Heat Transfer in Biological Tissues Irradiated by Pulsed Laser . | Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics , 2018 , 39 (3) , 598-602 .
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