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学者姓名:徐峰

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< Page ,Total 26 >
Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. PubMed Scopus SCIE
期刊论文 | 2019 , 120 (4) , 5644-5651 | Journal of cellular biochemistry
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Abstract :

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus and is considered as a leading cause of blindness. Oxidative stress and inflammation are significant drivers for the development of DR. Eriodictyol, a flavonoid compound, was proved to possess anti-inflammatory, antioxidative, and antidiabetic activities. However, the role of eriodictyol in DR has not been unveiled. In the current study, we explored the protective effects of eriodictyol on high glucose (HG)-induced rat retinal ganglial cells (RGCs). The results suggested that eriodictyol improved cell viability of HG-induced rat RGC-5 cells in a dose-dependent manner. Eriodictyol reduced the reactive oxygen species production and increased the activities of superoxide dismutase, glutathione peroxidase and catalase in rat RGC-5 cells in response to HG stimulation. The production of proinflammatory cytokines including tumor necrosis factor alpha and interleukin-8 was diminished after eriodictyol treatment. Eriodictyol also suppressed cell apoptosis induced HG in rat RGC-5 cells. Furthermore, eriodictyol enhanced the nuclear translocation of nuclear factor erythroid-2 (E2)-related factor 2 (Nrf2) and elevated the expression of antioxidant enzyme heme-oxygenase-1 (HO-1). These findings suggested that eriodictyol protects the RGC-5 cells from HG-induced oxidative stress, inflammation, and cell apoptosis through regulating the activation of Nrf2/HO-1 pathway.

Keyword :

eriodictyol oxidative stress diabetic retinopathy (DR) nuclear factor erythroid-2 (E2)-related factor 2/heme-oxygenase-1 (Nrf2/HO-1) pathway inflammation

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GB/T 7714 Lv Peilin , Yu Jingni , Xu Xiayu et al. Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. [J]. | Journal of cellular biochemistry , 2019 , 120 (4) : 5644-5651 .
MLA Lv Peilin et al. "Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells." . | Journal of cellular biochemistry 120 . 4 (2019) : 5644-5651 .
APA Lv Peilin , Yu Jingni , Xu Xiayu , Lu Tianjian , Xu Feng . Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells. . | Journal of cellular biochemistry , 2019 , 120 (4) , 5644-5651 .
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Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles SCIE PubMed
期刊论文 | 2019 , 9 (1) , 246-264 | THERANOSTICS
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Abstract :

Photodynamic therapy (PDT) has been widely applied in the clinic for the treatment of various types of cancer due to its precise controllability, minimally invasive approach and high spatiotemporal accuracy as compared with conventional chemotherapy. However, the porphyrin-based photosensitizers (PSs) used in clinics generally suffer from aggregation-caused reductions in the generation of reactive oxygen species (ROS) and limited tissue penetration because of visible light activation, which greatly hampers their applications for the treatment of deep-seated tumors. Methods: We present a facile strategy for constructing a NIR-regulated cancer theranostic nanoplatform by encapsulating upconversion nanoparticles (UCNPs) and a luminogen (2-(2,6-bis((E)-4-(phenyl(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene)malononitrile, TTD) with aggregation-induced emission (AIEgen) characteristics using an amphiphilic polymer, and further conjugating cyclic arginine-glycine-aspartic acid (cRGD) peptide to yield UCNP@TTD-cRGD NPs. We then evaluated the bioimaging and anti-tumor capability of the UCNP@TTD-cRGD NPs under NIR light illumination in an in vitro three-dimensional (3D) cancer spheroid and in a murine tumor model, respectively. Results: With a close match between the UCNP emission and absorption of the AIEgen, the synthesized NPs could efficiently generate ROS, even under excitation through thick tissues. The NIR-regulated UCNP@TTD-cRGD NPs that were developed could selectively light up the targeted cancer cells and significantly inhibit tumor growth during the NIR-regulated PDT treatment as compared with the cells under white light excitation. Conclusion: In summary, the synthesized UCNP@TTD-cRGD NPs showed great potential in NIR light-regulated photodynamic therapy of deep-seated tumors. Our study will inspire further exploration of novel theranostic nanoplatforms that combine UCNPs and various AIEgen PSs for the advancement of deep-seated tumor treatments with potential clinical translations.

Keyword :

aggregation-induced emission (AIE) near infrared light active targeting photodynamic therapy tumor imaging

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GB/T 7714 Jin, Guorui , He, Rongyan , Liu, Qian et al. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles [J]. | THERANOSTICS , 2019 , 9 (1) : 246-264 .
MLA Jin, Guorui et al. "Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles" . | THERANOSTICS 9 . 1 (2019) : 246-264 .
APA Jin, Guorui , He, Rongyan , Liu, Qian , Lin, Min , Dong, Yuqing , Li, Kai et al. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles . | THERANOSTICS , 2019 , 9 (1) , 246-264 .
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Analysis of Leukocyte Behaviors on Microfluidic Chips. PubMed
期刊论文 | 2019 , e1801406 | Advanced healthcare materials
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The orchestration of massive leukocytes in the immune system protects humans from invading pathogens and abnormal cells in the body. So far, researches focusing on leukocyte behaviors are performed based on both in vivo and in vitro models. The in vivo animal models are usually less controllable due to their extreme complexity and nonignorable species issue. Therefore, many researchers turn to in vitro models. With the advances in micro/nanofabrication, the microfluidic chip has emerged as a novel platform for model construction in multiple biomedical research fields. Specifically, the microfluidic chip is used to study leukocyte behaviors, due to its incomparable advantages in high throughput, precise control, and flexible integration. Moreover, the small size of the microstructures on the microfluidic chip can better mimic the native microenvironment of leukocytes, which contributes to a more reliable recapitulation. Herein are reviewed the recent advances in microfluidic chip-based leukocyte behavior analysis to provide an overview of this field. Detailed discussions are specifically focused on host defense against pathogens, immunodiagnosis, and immunotherapy studies on microfluidic chips. Finally, the current technical challenges are discussed, as well as possible innovations in this field to improve the related applications.

Keyword :

microfluidics immunotherapy tissue-on-a-chip host defenses leukocytes immunodiagnosis

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GB/T 7714 Liu Yan , Yang Qingzhen , Cao Lei et al. Analysis of Leukocyte Behaviors on Microfluidic Chips. [J]. | Advanced healthcare materials , 2019 : e1801406 .
MLA Liu Yan et al. "Analysis of Leukocyte Behaviors on Microfluidic Chips." . | Advanced healthcare materials (2019) : e1801406 .
APA Liu Yan , Yang Qingzhen , Cao Lei , Xu Feng . Analysis of Leukocyte Behaviors on Microfluidic Chips. . | Advanced healthcare materials , 2019 , e1801406 .
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Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) SCIE
期刊论文 | 2019 , 11 | NPG ASIA MATERIALS
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GB/T 7714 Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) [J]. | NPG ASIA MATERIALS , 2019 , 11 .
MLA Zhao, Guoxu et al. "Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018)" . | NPG ASIA MATERIALS 11 (2019) .
APA Zhao, Guoxu , Qing, Huaibin , Huang, Guoyou , Genin, Guy M. , Lu, Tian Jian , Luo, Zhengtang et al. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues (vol 10, pg 982, 2018) . | NPG ASIA MATERIALS , 2019 , 11 .
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Engineering mechanical microenvironment of macrophage and its biomedical applications SCIE PubMed Scopus
期刊论文 | 2018 , 13 (5) , 555-576 | NANOMEDICINE
SCOPUS Cited Count: 1
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Abstract :

Macrophages are the most plastic cells in the hematopoietic system and can be widely found in almost all tissues. Recently studies have shown that mechanical cues (e.g., matrix stiffness and stress/strain) can significantly affect macrophage behaviors. Although existing reviews on the physical and mechanical cues that regulate the macrophage's phenotype are available, engineering mechanical microenvironment of macrophages in vitro as well as a comprehensive overview and prospects for their biomedical applications (e.g., tissue engineering and immunotherapy) has yet to be summarized. Thus, this review provides an overview on the existing methods for engineering mechanical microenvironment of macrophages in vitro and then a section on their biomedical applications and further perspectives are presented.

Keyword :

mechanical environment stress/strain biomedical application stiffness macrophages

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GB/T 7714 Li, Jing , Li, Yuhui , Gao, Bin et al. Engineering mechanical microenvironment of macrophage and its biomedical applications [J]. | NANOMEDICINE , 2018 , 13 (5) : 555-576 .
MLA Li, Jing et al. "Engineering mechanical microenvironment of macrophage and its biomedical applications" . | NANOMEDICINE 13 . 5 (2018) : 555-576 .
APA Li, Jing , Li, Yuhui , Gao, Bin , Qin, Chuanguang , He, Yining , Xu, Feng et al. Engineering mechanical microenvironment of macrophage and its biomedical applications . | NANOMEDICINE , 2018 , 13 (5) , 555-576 .
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Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture EI SCIE PubMed Scopus
期刊论文 | 2018 , 6 (4) , 885-892 | BIOMATERIALS SCIENCE
WoS CC Cited Count: 2 SCOPUS Cited Count: 2
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Hydrogel particles that can be engineered to compartmentally culture cells in a three-dimensional (3D) and high-throughput manner have attracted increasing interest in the biomedical area. However, the ability to generate hydrogel particles with specially designed structures and their potential biomedical applications need to be further explored. This work introduces a method for fabricating hydrogel particles in an ellipsoidal cap-like shape (i.e., ellipsoidal cap-like hydrogel particles) by employing an open-pore anodic aluminum oxide membrane. Hydrogel particles of different sizes are fabricated. The ability to produce ellipsoidal cap-like magnetic hydrogel particles with controlled distribution of magnetic nanoparticles is demonstrated. Encapsulated cells show high viability, indicating the potential for using these hydrogel particles as structure-and remote-controllable building blocks for tissue engineering application. Moreover, the hydrogel particles are also used as sacrificial templates for fabricating ellipsoidal cap-like concave wells, which are further applied for producing size controllable cell aggregates. The results are beneficial for the development of hydrogel particles and their applications in 3D cell culture.

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GB/T 7714 Zhang, Weiwei , Huang, Guoyou , Ng, Kelvin et al. Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture [J]. | BIOMATERIALS SCIENCE , 2018 , 6 (4) : 885-892 .
MLA Zhang, Weiwei et al. "Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture" . | BIOMATERIALS SCIENCE 6 . 4 (2018) : 885-892 .
APA Zhang, Weiwei , Huang, Guoyou , Ng, Kelvin , Ji, Yuan , Gao, Bin , Huang, Liqing et al. Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture . | BIOMATERIALS SCIENCE , 2018 , 6 (4) , 885-892 .
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Theranostics of Triple-Negative Breast Cancer Based on Conjugated Polymer Nanoparticles EI SCIE Scopus
期刊论文 | 2018 , 10 (13) , 10634-10646 | ACS APPLIED MATERIALS & INTERFACES
WoS CC Cited Count: 7 SCOPUS Cited Count: 7
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Abstract :

Triple-negative breast cancer (TNBC) does not respond to many targeted drugs due to the lack of three receptors (i.e., estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2), which makes it difficult for TNBC detection and treatment. As compared to traditional breast cancer treatments such as surgery and chemotherapy, photodynamic therapy (PDT) has emerged as a promising approach for treating TNBC due to its precise controllability, high spatiotemporal accuracy, and minimal invasive nature. However, traditional photosensitizers used in PDT are associated with limitations of aggregation-caused quenching (ACQ), and the ACQ induced a significant decrease in reactive oxygen species (ROS) generation. To address these, we synthesized a cyclic arginine-glycine-aspartic acid (cRGD) peptide-decorated conjugated polymer (CP) nanoparticles with poly[2-methoxy-5-(2-ethyl-hexyloxy)-1,4-phenylenevinylene] (MEH-PPV) as the photosensitizer for the theranostics of TNBC. The synthesized CP nanoparticles show bright fluorescence with high stability and could effectively produce ROS under light irradiation. Cell viability studies showed that the CP nanoparticles have negligible dark cytotoxicity and could efficiently kill the alpha(v)beta(3) integrin-overexpressed MDA-MB-231 cells (one subtype of TNBC cells) in a selective way. With the use of cRGD-modified MEH-PPV nanoparticles as the theranostic agent, it permits targeted imaging and PDT of TNBC both in the in vitro 3D tumor model and in living mice. The application of CP nanoparticles in the successful theranostics of TNBC could pave the way for future development of CP-based photosensitizers for clinical applications.

Keyword :

conjugated polymer photodynamic therapy theranostics triple-negative breast cancer therapy tumor imaging

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GB/T 7714 Jin, Guorui , He, Rongyan , Liu, Qian et al. Theranostics of Triple-Negative Breast Cancer Based on Conjugated Polymer Nanoparticles [J]. | ACS APPLIED MATERIALS & INTERFACES , 2018 , 10 (13) : 10634-10646 .
MLA Jin, Guorui et al. "Theranostics of Triple-Negative Breast Cancer Based on Conjugated Polymer Nanoparticles" . | ACS APPLIED MATERIALS & INTERFACES 10 . 13 (2018) : 10634-10646 .
APA Jin, Guorui , He, Rongyan , Liu, Qian , Dong, Yuqing , Lin, Min , Li, Wenfang et al. Theranostics of Triple-Negative Breast Cancer Based on Conjugated Polymer Nanoparticles . | ACS APPLIED MATERIALS & INTERFACES , 2018 , 10 (13) , 10634-10646 .
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Droplet based vitrification for cell aggregates: Numerical analysis EI SCIE PubMed Scopus
期刊论文 | 2018 , 82 , 383-393 | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
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Abstract :

Cell aggregates represent the main format of cells existing in vivo and have been widely used as tissue and disease models in vitro. Nevertheless, the preservation of cell aggregates while maintaining their functionalities for off the -shelf applications is still challenging. Among various preservation methods, droplet-based vitrification exhibits superior advantages for the cryopreservation of cell aggregates; however, the physical mechanisms underlying droplet-based vitrification of cell aggregate using this method remain elusive. To address this issue, we proposed a voronoi model to construct two-dimensional geometric morphologies of cell aggregates and established a coupled physical model to describe the diffusion, heat transfer and crystallization processes during vitrification. Based on these models, we performed a numerical study on the variation and distribution of cryoprotectant (CPA) concentration, temperature and crystallization in cell aggregates during droplet-based vitrification. The results show that although cell membrane is not an obvious barrier in heat transfer, it affects the diffusion of CPA remarkably as a biologic film and thus the following crystallization in cell aggregates. The effective protection of CPA during vitrification occurs during the initial stage of CPA diffusion, thus a longer CPA loading time does not necessarily lead to significant decrease in crystallization, but rather may induce more toxicity to cells.

Keyword :

Cell aggregates Cell membrane Simulation Vitrification

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GB/T 7714 Shi, Meng , Feng, Shangsheng , Zhang, Xiaohui et al. Droplet based vitrification for cell aggregates: Numerical analysis [J]. | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS , 2018 , 82 : 383-393 .
MLA Shi, Meng et al. "Droplet based vitrification for cell aggregates: Numerical analysis" . | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 82 (2018) : 383-393 .
APA Shi, Meng , Feng, Shangsheng , Zhang, Xiaohui , Ji, Changchun , Xu, Feng , Lu, Tian Jian . Droplet based vitrification for cell aggregates: Numerical analysis . | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS , 2018 , 82 , 383-393 .
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Non-contact tensile viscoelastic characterization of microscale biological materials EI SCIE CSCD Scopus
期刊论文 | 2018 , 34 (3) , 589-599 | ACTA MECHANICA SINICA
WoS CC Cited Count: 2 SCOPUS Cited Count: 2
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Abstract :

Many structures and materials in nature and physiology have important "meso-scale" structures at the micron length-scale whose tensile responses have proven difficult to characterize mechanically. Although techniques such as atomic force microscopy and micro- and nano-identation are mature for compression and indentation testing at the nano-scale, and standard uniaxial and shear rheometry techniques exist for the macroscale, few techniques are applicable for tensile-testing at the micrometre-scale, leaving a gap in our understanding of hierarchical biomaterials. Here, we present a novel magnetic mechanical testing (MMT) system that enables viscoelastic tensile testing at this critical length scale. The MMT system applies non-contact loading, avoiding gripping and surface interaction effects. We demonstrate application of the MMT system to the first analyses of the pure tensile responses of several native and engineered tissue systems at the mesoscale, showing the broad potential of the system for exploring micro- and meso-scale analysis of structured and hierarchical biological systems.

Keyword :

Hierarchical biomaterials Mechanical testing Microscale analysis Non-contact actuation

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GB/T 7714 Li, Yuhui , Hong, Yuan , Xu, Guang-Kui et al. Non-contact tensile viscoelastic characterization of microscale biological materials [J]. | ACTA MECHANICA SINICA , 2018 , 34 (3) : 589-599 .
MLA Li, Yuhui et al. "Non-contact tensile viscoelastic characterization of microscale biological materials" . | ACTA MECHANICA SINICA 34 . 3 (2018) : 589-599 .
APA Li, Yuhui , Hong, Yuan , Xu, Guang-Kui , Liu, Shaobao , Shi, Qiang , Tang, Deding et al. Non-contact tensile viscoelastic characterization of microscale biological materials . | ACTA MECHANICA SINICA , 2018 , 34 (3) , 589-599 .
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An improved detection limit and working range of lateral flow assays based on a mathematical model SCIE PubMed Scopus
期刊论文 | 2018 , 143 (12) , 2775-2783 | ANALYST
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Lateral flow assays (LFAs) have attracted considerable attention in biomedical diagnostics. However, it's still challenging to achieve a high detection sensitivity and extensive working range, mainly because the underlying mechanism of complex reaction processes in LFAs remains unclear. Many mathematical models have been developed to analyze the complex reaction processes, which are only qualitative with limited guidance for LFA design. Now, a semi-quantitative convection-diffusion-reaction model is developed by considering the kinetics of renaturation of nucleic acids and the model is validated by our experiments. We established a method to convert the LFA design parameters between the simulation and experiment (i.e., inlet reporter particle concentration, initial capture probe concentration, and association rate constant), with which we achieved a semi-quantitative comparison of the detection limit and working range between simulations and experiments. Based on our model, we have improved the detection sensitivity and working range by using high concentrations of the inlet reporter particles and initial capture probe. Besides, we also found that target nucleic acid sequences with a high association rate constant are beneficial to improve the LFA performance. The developed model can predict the detection limit and working range and would be helpful to optimize the design of LFAs.

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GB/T 7714 Liu, Zhi , Qu, Zhiguo , Tang, Ruihua et al. An improved detection limit and working range of lateral flow assays based on a mathematical model [J]. | ANALYST , 2018 , 143 (12) : 2775-2783 .
MLA Liu, Zhi et al. "An improved detection limit and working range of lateral flow assays based on a mathematical model" . | ANALYST 143 . 12 (2018) : 2775-2783 .
APA Liu, Zhi , Qu, Zhiguo , Tang, Ruihua , He, Xiaocong , Yang, Hui , Bai, Dan et al. An improved detection limit and working range of lateral flow assays based on a mathematical model . | ANALYST , 2018 , 143 (12) , 2775-2783 .
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