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Lung function, sleep-disordered breathing and incidence of stroke: a community-based longitudinal cohort study CPCI-S SCIE
会议论文 | 2018 , 25 , 485-485 | 4th Congress of the European-Academy-of-Neurology (EAN)
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GB/T 7714 Zhang, J. , Guo, Q. , Wang, G. . Lung function, sleep-disordered breathing and incidence of stroke: a community-based longitudinal cohort study [C] . 2018 : 485-485 .
MLA Zhang, J. 等. "Lung function, sleep-disordered breathing and incidence of stroke: a community-based longitudinal cohort study" . (2018) : 485-485 .
APA Zhang, J. , Guo, Q. , Wang, G. . Lung function, sleep-disordered breathing and incidence of stroke: a community-based longitudinal cohort study . (2018) : 485-485 .
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Reduced lung function on incident stroke in community-based population with or without sleep-disordered breathing - a prospective cohort study SCIE
期刊论文 | 2018 , 45 , 91-91 | CEREBROVASCULAR DISEASES
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GB/T 7714 Guo, Q. , Zhang, J. , Wang, G. . Reduced lung function on incident stroke in community-based population with or without sleep-disordered breathing - a prospective cohort study [J]. | CEREBROVASCULAR DISEASES , 2018 , 45 : 91-91 .
MLA Guo, Q. 等. "Reduced lung function on incident stroke in community-based population with or without sleep-disordered breathing - a prospective cohort study" . | CEREBROVASCULAR DISEASES 45 (2018) : 91-91 .
APA Guo, Q. , Zhang, J. , Wang, G. . Reduced lung function on incident stroke in community-based population with or without sleep-disordered breathing - a prospective cohort study . | CEREBROVASCULAR DISEASES , 2018 , 45 , 91-91 .
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内皮-间充质转化在肺动脉高压发病机制中的研究进展 CSCD PKU
期刊论文 | 2018 , (9) , 1724-1728 | 中国病理生理杂志
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肺动脉高压( pulmonary hypertension ,PH)是由多种已知和未知原因引起的肺循环血压异常升高的一种病理生理综合症,主要累及心血管及呼吸系统[1-2]. 根据2015年最新PH的临床分型,PH分为动脉型肺动脉高压( pulmonary arterial hypertension , PAH)、左心疾病所致PH、肺部疾病或缺氧所致PH、慢性血栓栓塞性PH ( chronic thromboembolic pulmo-nary hypertension ,CTEPH)和其它不明原因或多种机制导致的PH[3].

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内皮-间充质转化 TGF-β/BMP信号通路 肺动脉高压 α-平滑肌肌动蛋白

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GB/T 7714 张静静 , 王岗 , 李满祥 . 内皮-间充质转化在肺动脉高压发病机制中的研究进展 [J]. | 中国病理生理杂志 , 2018 , (9) : 1724-1728 .
MLA 张静静 等. "内皮-间充质转化在肺动脉高压发病机制中的研究进展" . | 中国病理生理杂志 9 (2018) : 1724-1728 .
APA 张静静 , 王岗 , 李满祥 . 内皮-间充质转化在肺动脉高压发病机制中的研究进展 . | 中国病理生理杂志 , 2018 , (9) , 1724-1728 .
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The association of neck circumference with incident congestive heart failure and coronary heart disease mortality in a community-based population with or without sleep-disordered breathing SCIE PubMed Scopus
期刊论文 | 2018 , 18 | BMC CARDIOVASCULAR DISORDERS
SCOPUS Cited Count: 1
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Background: Neck circumference (NC), representing upper body subcutaneous adipose tissue, may be correlated with increased risk of overweight/obesity, obstructive sleep apnoea, and metabolic and cardiovascular disease. However, the relationship between NC and the incidence of congestive heart failure (CHF) or mortality due to coronary heart disease (CHD) in a community-based population with and without sleep-disordered breathing (SDB) has not yet been clarified. Methods: We performed a prospective study using the Sleep Heart Health Study (SHHS) cohort. Cox proportional hazards regression models were used to estimate the association of different levels of NC with CHF incidence or CHD mortality in 2234 individuals with SDB and 2199 without SDB, respectively. Results: After adjusting for age, sex, and body mass index (BMI), NC was significantly associated with CHF when comparing the highest NC quartile group with the lowest (hazard ratio, HR, 2.265, 95% confidence interval, CI, 1.074-4.777) in the non-SDB population. This association diminished after further adjustment for other risk factors, but remained statistically significant, with an adjusted HR of 1.082 (95% CI 1.003-1.166) per unit increase in NC. Additionally, after adjustment for age, sex, and BMI, NC was also shown to be remarkably associated with CHD mortality (HR 1.141, 95% CI 1.014-1.282) per unit increase in NC in the non-SDB population but not in the SDB population. After adjustment for all the covariates, there was a significant association between NC and CHD death in those without SDB, with an adjusted HR of 1.134 (95% CI 1.001-1.284) per unit increase in NC. Conclusions: NC may correlate with CHF incidence and CHD mortality in population without SDB. NC measurement may help risk stratification for cardiovascular diseases.

Keyword :

Sleep-disordered breathing Coronary heart disease Neck circumference Mortality Congestive heart failure

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GB/T 7714 Zhang, Jingjing , Guo, Qi , Peng, Liyuan et al. The association of neck circumference with incident congestive heart failure and coronary heart disease mortality in a community-based population with or without sleep-disordered breathing [J]. | BMC CARDIOVASCULAR DISORDERS , 2018 , 18 .
MLA Zhang, Jingjing et al. "The association of neck circumference with incident congestive heart failure and coronary heart disease mortality in a community-based population with or without sleep-disordered breathing" . | BMC CARDIOVASCULAR DISORDERS 18 (2018) .
APA Zhang, Jingjing , Guo, Qi , Peng, Liyuan , Li, Jiamei , Gao, Ya , Yan, Bin et al. The association of neck circumference with incident congestive heart failure and coronary heart disease mortality in a community-based population with or without sleep-disordered breathing . | BMC CARDIOVASCULAR DISORDERS , 2018 , 18 .
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Influence of lung function and sleep-disordered breathing on stroke: a community-based study SCIE PubMed Scopus
期刊论文 | 2018 , 25 (11) , 1307-E112 | EUROPEAN JOURNAL OF NEUROLOGY
WoS CC Cited Count: 4 SCOPUS Cited Count: 4
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Background and purposeImpaired lung function is regarded as a risk factor for stroke in patients with chronic obstructive pulmonary disease. However, the association between reduced lung function and incident stroke in a community-based population with sleep-disordered breathing (SDB) remains unknown. MethodsA prospective study was performed within the Sleep Heart Health Study cohort. Full montage home sleep testing and spirometry data on 2082 and 2072 individuals with and without SDB, respectively, were analysed. Cox proportional hazards regression models were used to estimate the association between lung function and incident stroke. ResultsOver 11.7 years, 183 cases of stroke were identified in participants without pre-existing cardiovascular diseases, including 71 and 112 with an apnoea-hypopnoea index <5 events/h and 5 events/h, respectively. In the entire population, lung function was inversely associated with incident stroke [hazard ratio (HR) 0.913 (95% confidence interval 0.839-0.994) for every 10% increase in percentage of predicted forced vital capacity]. When the population was divided according to the presence/absence of SDB, the association of lung function with incident stroke became stronger in individuals with SDB [HR 0.899 (0.822-0.984) for every 10% increase in percentage of predicted forced expiratory volume in 1 s; HR 0.881 (0.787-0.987) for every 10% increase in percentage of predicted forced vital capacity] but not in individuals without SDB. ConclusionsLung function may serve as a risk factor for incident stroke in a community-based population, especially in those with SDB. Spirometry may help improve the risk management for primary care in community-based populations.

Keyword :

sleep-disordered breathing stroke cohort study lung function community

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GB/T 7714 Zhang, J. , Gong, Z. , Li, R. et al. Influence of lung function and sleep-disordered breathing on stroke: a community-based study [J]. | EUROPEAN JOURNAL OF NEUROLOGY , 2018 , 25 (11) : 1307-E112 .
MLA Zhang, J. et al. "Influence of lung function and sleep-disordered breathing on stroke: a community-based study" . | EUROPEAN JOURNAL OF NEUROLOGY 25 . 11 (2018) : 1307-E112 .
APA Zhang, J. , Gong, Z. , Li, R. , Gao, Y. , Li, Y. , Li, J. et al. Influence of lung function and sleep-disordered breathing on stroke: a community-based study . | EUROPEAN JOURNAL OF NEUROLOGY , 2018 , 25 (11) , 1307-E112 .
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颅骨钻孔软管负压引流术治疗慢性硬膜下血肿52例
期刊论文 | 2017 , (2) , 97-98 | 中国临床神经外科杂志
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颅骨钻孔引流术 软管负压引流术 慢性硬膜下血肿 疗效

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GB/T 7714 王飞 , 冉红军 , 李峰 et al. 颅骨钻孔软管负压引流术治疗慢性硬膜下血肿52例 [J]. | 中国临床神经外科杂志 , 2017 , (2) : 97-98 .
MLA 王飞 et al. "颅骨钻孔软管负压引流术治疗慢性硬膜下血肿52例" . | 中国临床神经外科杂志 2 (2017) : 97-98 .
APA 王飞 , 冉红军 , 李峰 , 王岗 . 颅骨钻孔软管负压引流术治疗慢性硬膜下血肿52例 . | 中国临床神经外科杂志 , 2017 , (2) , 97-98 .
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NT-proBNP联合CVP监测在机械通气患者撤机过程中的指导作用
期刊论文 | 2017 , (8) | 临床急诊杂志
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N端脑钠素前体 机械通气 液体平衡 撤机 中心静脉压

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GB/T 7714 刘杰 , 王岗 , 孙师元 . NT-proBNP联合CVP监测在机械通气患者撤机过程中的指导作用 [J]. | 临床急诊杂志 , 2017 , (8) .
MLA 刘杰 et al. "NT-proBNP联合CVP监测在机械通气患者撤机过程中的指导作用" . | 临床急诊杂志 8 (2017) .
APA 刘杰 , 王岗 , 孙师元 . NT-proBNP联合CVP监测在机械通气患者撤机过程中的指导作用 . | 临床急诊杂志 , 2017 , (8) .
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The underlying risks of circadian blood pressure variation for carotid plaque in treated hypertensive patients with normal blood pressure SCIE PubMed Scopus
期刊论文 | 2017 , 22 (4) , 191-195 | BLOOD PRESSURE MONITORING | IF: 1.194
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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ObjectivesThe aim of this study was to investigate the relationship between 24h variation of blood pressure (BP) and carotid plaque in essential hypertensive patients with normal BP under anti-hypertensive treatment.Participants and methodsA total of 322 hypertensive patients with systolic BP (SBP) and diastolic BP (DBP) within the normal range after routine treatment were continuously recruited and evaluated by ambulatory BP monitoring from 1 January 2014 to 31 July 2015. The exclusion criteria included participants younger than 18 or older than 90 years of age, pregnancy, night-work employment, and suffering from secondary hypertension. The prevalence of carotid plaque between different circadian BP pattern groups was analyzed using a (2)-test. Logistic regression was applied to analyze the relationship between carotid plaque and ambulatory BP monitoring variables.ResultsAll the individuals were divided into a carotid plaque' group (n=197) and a non-plaque' group (n=125) on the basis of whether the thickness of each plaque was at least 0.5mm under the carotid ultrasound. In addition, patients were grouped into a dipper (10-20% nocturnal fall of BP in SBP) group and a nondipper (<10% nocturnal fall of BP in SBP) group on the basis of individual SBP variation. In the nondipper group, the number of patients with carotid plaque was higher than the patients without plaque (P=0.017). Logistic analysis showed that the nondipper pattern of BP was significantly associated with the formation of carotid plaque (odds ratio=1.731, P=0.041).ConclusionA nondipper pattern of BP may serve as a risk factor for carotid plaque in treated hypertensive individuals with normal BP.

Keyword :

dipping status essential hypertension carotid plaque blood pressure variation cross-sectional study

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GB/T 7714 Gao, Ya , Guo, Qi , Zhang, Jingjing et al. The underlying risks of circadian blood pressure variation for carotid plaque in treated hypertensive patients with normal blood pressure [J]. | BLOOD PRESSURE MONITORING , 2017 , 22 (4) : 191-195 .
MLA Gao, Ya et al. "The underlying risks of circadian blood pressure variation for carotid plaque in treated hypertensive patients with normal blood pressure" . | BLOOD PRESSURE MONITORING 22 . 4 (2017) : 191-195 .
APA Gao, Ya , Guo, Qi , Zhang, Jingjing , Feng, Yanjing , Yan, Bin , Su, Dan et al. The underlying risks of circadian blood pressure variation for carotid plaque in treated hypertensive patients with normal blood pressure . | BLOOD PRESSURE MONITORING , 2017 , 22 (4) , 191-195 .
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Serum sPD-L1, Upregulated in Sepsis, May Reflect Disease Severity and Clinical Outcomes in Septic Patients SCIE PubMed Scopus
期刊论文 | 2017 , 85 (1) , 66-72 | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | IF: 2.314
WoS CC Cited Count: 7 SCOPUS Cited Count: 2
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We aimed to find the correlation between serum sPD-L1 (soluble programmed cell death L-1 ligand) and sepsis. Totally 91 consecutive patients with sepsis were performed in a 15-bed medical intensive care unit (ICU) of the second affiliated hospital, Xi'an Jiaotong University in Xi'an, China, between February 2015 and May 2016. Healthy controls (HC) consisted of 29 healthy volunteer. Baseline demographic data were recorded. Blood samples were collected through an indwelling central venous or by peripheral venipuncture. Serum sPD-L1 and sPD-1 levels were determined with enzyme-linked immunosorbent assay kits (Elabscience Biotechnology Co. Ltd, Wuhan, China). SPSS19.0 software (SPSS Inc., Chicago, Illinois, USA) was used for statistical analysis. Kaplan-Meier survival analysis and Cox regression analysis were also performed. Serum sPD-L1 levels and sPD-1 levels were significantly increased in septic patients compared with HC (P = 0.000). Serum sPD-L1 levels were significantly increased in non-survivors compared with survivors (P < 0.05), but there was no statistically difference on serum sPD-1 levels between non-survivors and survivors (P > 0.05). Serum sPD-L1 levels were correlated with absolute lymphocyte (ALC), platelets and SOFA scores. Serum sPD-L1/sPD-1 levels were negatively correlated with ALC and platelets, and SOFA scores. The prognostic accuracy of the sPD-L1 level to predict 28-day mortality was similar to that of the APACHE-II scores and SOFA scores. Cox regression analysis showed that sPD-L1 was an independent prognostic factor. Serum sPD-L1 is upregulated in sepsis and may reflect disease severity and clinical outcomes in patients. Serum sPD-L1 may be an independent prognostic factor for sepsis.

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GB/T 7714 Liu, M. , Zhang, X. , Chen, H. et al. Serum sPD-L1, Upregulated in Sepsis, May Reflect Disease Severity and Clinical Outcomes in Septic Patients [J]. | SCANDINAVIAN JOURNAL OF IMMUNOLOGY , 2017 , 85 (1) : 66-72 .
MLA Liu, M. et al. "Serum sPD-L1, Upregulated in Sepsis, May Reflect Disease Severity and Clinical Outcomes in Septic Patients" . | SCANDINAVIAN JOURNAL OF IMMUNOLOGY 85 . 1 (2017) : 66-72 .
APA Liu, M. , Zhang, X. , Chen, H. , Wang, G. , Zhang, J. , Dong, P. et al. Serum sPD-L1, Upregulated in Sepsis, May Reflect Disease Severity and Clinical Outcomes in Septic Patients . | SCANDINAVIAN JOURNAL OF IMMUNOLOGY , 2017 , 85 (1) , 66-72 .
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Cluster analysis: a new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients SCIE PubMed Scopus
期刊论文 | 2017 , 7 | SCIENTIFIC REPORTS | IF: 4.122
WoS CC Cited Count: 7 SCOPUS Cited Count: 7
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Grading of essential hypertension according to blood pressure (BP) level may not adequately reflect clinical heterogeneity of hypertensive patients. This study was carried out to explore clinical phenotypes in essential hypertensive patients using cluster analysis. This study recruited 513 hypertensive patients and evaluated BP variations with ambulatory blood pressure monitoring. Four distinct hypertension groups were identified using cluster analysis: (1) younger male smokers with relatively high BP had the most severe carotid plaque thickness but no coronary artery disease (CAD); (2) older women with relatively low diastolic BP had more diabetes; (3) non-smokers with a low systolic BP level had neither diabetes nor CAD; (4) hypertensive patients with BP reverse dipping were most likely to have CAD but had least severe carotid plaque thickness. In binary logistic analysis, reverse dipping was significantly associated with prevalence of CAD. Cluster analysis was shown to be a feasible approach for investigating the heterogeneity of essential hypertension in clinical studies. BP reverse dipping might be valuable for prediction of CAD in hypertensive patients when compared with carotid plaque thickness. However, large-scale prospective trials with more information of plaque morphology are necessary to further compare the predicative power between BP dipping pattern and carotid plaque.

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GB/T 7714 Guo, Qi , Lu, Xiaoni , Gao, Ya et al. Cluster analysis: a new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients [J]. | SCIENTIFIC REPORTS , 2017 , 7 .
MLA Guo, Qi et al. "Cluster analysis: a new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients" . | SCIENTIFIC REPORTS 7 (2017) .
APA Guo, Qi , Lu, Xiaoni , Gao, Ya , Zhang, Jingjing , Yan, Bin , Su, Dan et al. Cluster analysis: a new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients . | SCIENTIFIC REPORTS , 2017 , 7 .
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