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学者姓名：王岗
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Abstract ：
目的 探讨重症监护室(ICU)成年急性呼吸衰竭(acute respiratory failure,ARF)患者入ICU 24 h内静脉血糖水平及血糖变异度对患者医院病死率的影响.方法 采用回顾性队列研究,纳入ICU多参数智能监护数据库Ⅱ(multiparameter intelligent monitoring in intensive careⅡ,MIMIC-Ⅱ)中单次入ICU且患有ARF,同时入住ICU后初始24 h内有多次静脉血糖监测记录的患者.提取患者的年龄、性别、种族、首次序贯器官衰竭评分、使用注射用胰岛素及患病情况(糖尿病、心力衰竭、肾衰竭及感染).将入ICU 24 h内静脉血糖均值及血糖变异系数分别用来评估血糖水平及变异度,使用单因素及多因素Logistic回归分析评估血糖水平及血糖变异度与患者医院病死率之间的关系.并在血糖水平及血糖变异度与是否患糖尿病间分别进行交互作用分析.结果 本研究共纳入1625例患者.从24 h内平均静脉血糖指标分析,低、中、高血糖水平患者的医院病死率分别为31.6％(171例)、35.4％(192例)及43.7％(237例),高血糖水平患者的医院病死率是低血糖水平患者的1.594倍(OR=1.594,95％CI 1.206～2.105);从24 h内血糖变异系数分析,低、中、高血糖变异患者的医院病死率分别为30.7％(166例)、38.0％(206例)及42.1％(228例),高血糖变异患者的医院病死率是低血糖变异患者的1.362倍(OR=1.362,95％CI 1.035～1.792).血糖水平(Pinteraction=0.178)及血糖变异度(Pinteraction=0.119)对医院病死率的影响在糖尿病患者与非糖尿病患者两组间比较差异无统计学意义(P<0.05).结论 ARF患者入ICU 24 h内高血糖水平及高血糖变异度是其医院病死率的危险因素.
Keyword ：
急性呼吸衰竭(ARF) 血糖变异度 血糖水平 医院病死率 重症监护室(ICU)
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| GB/T 7714 | 李佳媚 , 高雅 , 张静静 et al. 血糖水平及血糖变异度对ICU成年急性呼吸衰竭患者预后的影响 [J]. | 中国急救医学 , 2021 , 41 (3) : 196-200 . |
| MLA | 李佳媚 et al. "血糖水平及血糖变异度对ICU成年急性呼吸衰竭患者预后的影响" . | 中国急救医学 41 . 3 (2021) : 196-200 . |
| APA | 李佳媚 , 高雅 , 张静静 , 李若寒 , 金旭婷 , 张小玲 et al. 血糖水平及血糖变异度对ICU成年急性呼吸衰竭患者预后的影响 . | 中国急救医学 , 2021 , 41 (3) , 196-200 . |
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Abstract ：
目的 探讨危重症患者入重症监护室(intensive care unit,ICU)时红细胞分布宽度(red cell distribution width,RDW)与病死率的相关性.方法 采用回顾性队列研究,纳入美国重症监护数据库Ⅱ 版本2.6(Multiparameter Intelligent Monitoring in Intensive CareⅡversion 2.6,MIMIC-Ⅱv2.6)中单次入院且ICU住院时长>24 h,同时有RDW检测记录的成年患者.根据RDW预测病死率的最佳cut-off值(14.55％)将研究对象分为低RDW组(RDW<14.55％)及高RDW组(RDW≥14.55％),比较两组的病死率,进一步使用单因素及多因素Logistic回归和Cox回归分析评估RDW与病死率的关系.结果 本研究最终共有13822例患者入组.高RDW组的医院病死率、ICU病死率、28 d病死率及1年病死率均高于低RDW组(分别为19.73％vs.8.42％,15.04％vs.6.65％,22.68％vs.9.12％,36.22％vs.14.45％,均P<0.001).RDW作为连续变量,多因素分析结果 显示,RDW越高,医院病死率(OR=1.227,95％CI 1.190～1.265)、ICU病死率(OR=1.180,95％CI 1.141～1.220)、28 d病死率(HR=1.161,95％CI 1.138～1.185)和1年病死率(HR=1.177,95％CI 1.159～1.195)越高.分组后回归分析结果 显示,与低水平RDW组相比,高水平RDW组患者的医院病死率增加0.912倍(OR=1.912,95％CI 1.683～2.172),ICU病死率增加0.673倍(OR=1.673,95％CI 1.452～1.928),28 d病死率增加0.850倍(HR=1.850,95％CI 1.675～2.043),1年病死率增加1.045倍(HR=2.045,95％CI 1.891～2.212),且存在统计学意义(P<0.001).结论 入ICU首次RDW增高是危重症患者死亡的危险因素.
Keyword ：
病死率 红细胞分布宽度(RDW) 重症监护室(ICU)
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| GB/T 7714 | 侯彦丽 , 金旭婷 , 李佳媚 et al. 红细胞分布宽度与危重症患者病死率的相关性研究 [J]. | 中国急救医学 , 2021 , 41 (2) : 111-116 . |
| MLA | 侯彦丽 et al. "红细胞分布宽度与危重症患者病死率的相关性研究" . | 中国急救医学 41 . 2 (2021) : 111-116 . |
| APA | 侯彦丽 , 金旭婷 , 李佳媚 , 张静静 , 骆艳妮 , 王小闯 et al. 红细胞分布宽度与危重症患者病死率的相关性研究 . | 中国急救医学 , 2021 , 41 (2) , 111-116 . |
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Abstract ：
目的 探讨患者△D-二聚体升高与肺栓塞(PE)的相关性.方法 采用回顾性病例对照研究,共纳入我院2017年6月～2018年7月行肺动脉血管造影检查(CTPA)的260例患者为研究对象,纳入患者均行CTPA,并且在CT-PA前1周内行两次D-二聚体监测(两次间隔时间＞1 d).根据△D-二聚体结果分为△D-二聚体＞0组与△D-二聚体≤0组.采用单因素及多因素Logistic回归模型分析△D-二聚体升高对PE发生的可能性.结果 本研究共收集△D-二聚体＞0组150例与△D-二聚体≤0组110例;△D-二聚体在肺栓塞组的中位数为2960,在非肺栓塞组为5,差异有统计学意义(P＜0.001);△D-二聚体＞0组在PE中占41.3％,△D-二聚体≤0组在PE中占20.0％,差异有统计学意义(P＜0.001).单因素Logistic回归分析显示:△D-二聚体＞0发生PE的可能性是△D-二聚体≤0的2.755倍;多因素Logistic回归分析显示:△D-二聚体＞0组发生PE的可能性是△D-二聚体≤0组的2.829倍.在非肿瘤患者中,△D-二聚体＞0发生PE的可能性是△D-二聚体≤0的3.038倍;多因素Logistic回归显示:△D-二聚体＞0组发生PE的风险是△D-二聚体≤0组的2.870倍,差异亦有统计学意义(P＜0.05).结论 △D-二聚体＞0与PE之间有较高的相关性,关注D-二聚体变化可提高PE的早期诊断率,尤其在非肿瘤患者中更显著.
Keyword ：
D-二聚体 肺动脉血管造影 肺栓塞 相关性
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| GB/T 7714 | 骆艳妮 , 王岗 , 王小闯 et al. △D-二聚体与肺栓塞发生事件的相关性 [J]. | 西部医学 , 2021 , 33 (4) : 517-520 . |
| MLA | 骆艳妮 et al. "△D-二聚体与肺栓塞发生事件的相关性" . | 西部医学 33 . 4 (2021) : 517-520 . |
| APA | 骆艳妮 , 王岗 , 王小闯 , 李佳媚 , 张静静 , 侯彦丽 . △D-二聚体与肺栓塞发生事件的相关性 . | 西部医学 , 2021 , 33 (4) , 517-520 . |
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Abstract ：
To assess the association between serum ammonia level upon admission during the initial intensive care unit (ICU) stay and mortality.This retrospective cohort study included 2703 adult patients in eICU Collaborative Research Database. The ICU mortality within ammonia deciles were assessed. Logistic regression analyses were performed to analyze the relationship between ammonia and mortality.We defined three ammonia categories: <47, 47-111, and ≥111 μg/dL, corresponding to low, intermediate, and high ICU mortality. Increased ammonia was significantly associated with increased ICU mortality (per 10 μg/dL increase: odds ratio, 1.070 [95% confidence intervals, 1.05-1.09]; intermediate vs. low: 1.90 [1.41-2.56]; high vs. low: 4.38 [2.99-6.41]) and in-hospital mortality (1.06 [1.04-1.08]; 1.45 [1.13-1.87]; 3.41 [2.43-4.79]). Adding ammonia to the Acute Physiology and Chronic Health Evaluation (APACHE) IV score improved the area under the curve from 0.826 to 0.839 (P < 0.001) and from 0.806 to 0.813 (P = 0.001) for ICU and in-hospital mortality, respectively. Interaction and subgroup analyses demonstrated consistent results in patients with different APACHE IV scores, with or without hepatic diseases.Elevated serum ammonia level in critically ill patients upon admission was an early risk factor for higher ICU and in-hospital mortality.
Keyword ：
Ammonia eICU collaborative research database Intensive care unit Mortality
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| GB/T 7714 | Li Jiamei , Li Ruohan , Gao Ya et al. Increasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study. [J]. | Journal of critical care , 2021 , 62 : 218-222 . |
| MLA | Li Jiamei et al. "Increasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study." . | Journal of critical care 62 (2021) : 218-222 . |
| APA | Li Jiamei , Li Ruohan , Gao Ya , Jin Xuting , Zhang Jingjing , Ren Jiajia et al. Increasing serum ammonia level is a risk factor for the prognosis of critically ill patients: A multicenter retrospective cohort study. . | Journal of critical care , 2021 , 62 , 218-222 . |
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Abstract ：
The coronavirus disease 2019 (COVID-19) is presently the most pressing public health concern worldwide. Cytokine storm is an important factor leading to death of patients with COVID-19. This study aims to characterize serum cytokines of patients with severe or critical COVID-19. Clinical records were obtained from 149 patients who were tested at the Sino-French New City Branch of Tongji Hospital from 30 January to 30 March 2020. Data regarding the clinical features of the patients was collected and analyzed. Among the 149, 45 (30.2%) of them had severe conditions and 104 (69.8%) of that presented critical symptoms. In the meantime, 80 (53.7%) of that 149 died during hospitalization. Of all, male patients accounted for 94 (69.1%). Compared with patients in severe COVID-19, those who in critical COVID-19 had significantly higher levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-8, and IL-10. Moreover, the passed-away patients had considerably higher levels of TNF-alpha, IL-6, IL-8, and IL-10 than those survived from it. Regression analysis revealed that serum TNF-alpha level was an independent risk factor for the death of patient with severe conditions. Among the proinflammatory cytokines (IL-1 beta, TNF-alpha, IL-8, and IL-6) analyzed herein, TNF-alpha was seen as a risk factor for the death of patients with severe or critical COVID-19. This study suggests that anti-TNF-alpha treatment allows patients with severe or critical COVID-19 pneumonia to recover.
Keyword ：
COVID-19 cytokine storm illness severity mortality TNF-alpha
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| GB/T 7714 | Jia, Fang , Wang, Gang , Xu, Jing et al. Role of tumor necrosis factor-a in the mortality of hospitalized patients with severe and critical COVID-19 pneumonia [J]. | AGING-US , 2021 , 13 (21) : 23895-23912 . |
| MLA | Jia, Fang et al. "Role of tumor necrosis factor-a in the mortality of hospitalized patients with severe and critical COVID-19 pneumonia" . | AGING-US 13 . 21 (2021) : 23895-23912 . |
| APA | Jia, Fang , Wang, Gang , Xu, Jing , Long, Junhong , Deng, Fuxue , Jiang, Wei . Role of tumor necrosis factor-a in the mortality of hospitalized patients with severe and critical COVID-19 pneumonia . | AGING-US , 2021 , 13 (21) , 23895-23912 . |
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Abstract ：
Background: The inflammatory reaction is the main cause of acute respiratory distress syndrome and multiple organ failure in patients with Coronavirus disease 2019, especially those with severe and critical illness. Several studies suggested that high-dose vitamin C reduced inflammatory reaction associated with sepsis and acute respiratory distress syndrome. This study aimed to determine the efficacy and safety of high-dose vitamin C in Coronavirus disease 2019. Methods: We included 76 patients with Coronavirus disease 2019, classified into the high-dose vitamin C group (loading dose of 6g intravenous infusion per 12 hr on the first day, and 6g once for the following 4 days, n=46) and the standard therapy group (standard therapy alone, n=30). Results: The risk of 28-day mortality was reduced for the high-dose vitamin C versus the standard therapy group (HR=0.14, 95% CI, 0.03-0.72). Oxygen support status was improved more with high-dose vitamin C than standard therapy (63.9% vs 36.1%). No safety events were associated with high-dose vitamin C therapy. Conclusion: High-dose vitamin C may reduce the mortality and improve oxygen support status in patients with Coronavirus disease 2019 without adverse events.
Keyword ：
ascorbic acid coronavirus disease 2019 COVID-19 mortality safety
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| GB/T 7714 | Gao, Dengfeng , Xu, Min , Wang, Gang et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study [J]. | AGING-US , 2021 , 13 (5) : 7020-7034 . |
| MLA | Gao, Dengfeng et al. "The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study" . | AGING-US 13 . 5 (2021) : 7020-7034 . |
| APA | Gao, Dengfeng , Xu, Min , Wang, Gang , Lv, Jianrui , Ma, Xiaorong , Guo, Yonghong et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study . | AGING-US , 2021 , 13 (5) , 7020-7034 . |
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Evidence indicates that glucose variation (GV) plays an important role in mortality of critically ill patients. We aimed to investigate the relationship between the coefficient of variation of 24-h venous blood glucose (24-hVBGCV) and mortality among patients with acute respiratory failure. The records of 1625 patients in the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II) database were extracted. The 24-hVBGCV was calculated as the ratio of the standard deviation (SD) to the mean venous blood glucose level, expressed as a percentage. The outcomes included ICU mortality and in-hospital mortality. Participants were divided into three subgroups based on tertiles of 24-hVBGCV. Multivariable logistic regression models were used to evaluate the relationship between 24-hVBGCV and mortality. Sensitivity analyses were also performed in groups of patients with and without diabetes mellitus. Taking the lowest tertile as a reference, after adjustment for all the covariates, the highest tertile was significantly associated with ICU mortality [odds ratio (OR), 1.353; 95% confidence interval (CI), 1.018-1.797] and in-hospital mortality (OR, 1.319; 95% CI, 1.003-1.735), especially in the population without diabetes. The 24-hVBGCV may be associated with ICU and in-hospital mortality in patients with acute respiratory failure in the ICU, especially in those without diabetes.
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| GB/T 7714 | Zhang, Xiaoling , Zhang, Jingjing , Li, Jiamei et al. Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure [J]. | SCIENTIFIC REPORTS , 2021 , 11 (1) . |
| MLA | Zhang, Xiaoling et al. "Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure" . | SCIENTIFIC REPORTS 11 . 1 (2021) . |
| APA | Zhang, Xiaoling , Zhang, Jingjing , Li, Jiamei , Gao, Ya , Li, Ruohan , Jin, Xuting et al. Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure . | SCIENTIFIC REPORTS , 2021 , 11 (1) . |
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Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhage. Previous studies on TIC have mainly focused on hemorrhagic coagulopathy caused by the hypocoagulable phenotype of TIC, while recent studies have found that trauma-induced hypercoagulopathy can occur in as many as 22.2-85.1% of trauma patients, in whom it can increase the risk of thrombotic events and mortality by 2- to 4-fold. Therefore, the Chinese People's Liberation Army Professional Committee of Critical Care Medicine and the Chinese Society of Thrombosis, Hemostasis and Critical Care, Chinese Medicine Education Association jointly formulated this Chinese Expert Consensus comprising 15 recommendations for the definition, pathophysiological mechanism, assessment, prevention, and treatment of trauma-induced hypercoagulopathy.
Keyword ：
Coagulation dysfunction Diagnosis Thrombosis Trauma Treatment
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| GB/T 7714 | Song, Jing-Chun , Yang, Li-Kun , Zhao, Wei et al. Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy [J]. | MILITARY MEDICAL RESEARCH , 2021 , 8 (1) . |
| MLA | Song, Jing-Chun et al. "Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy" . | MILITARY MEDICAL RESEARCH 8 . 1 (2021) . |
| APA | Song, Jing-Chun , Yang, Li-Kun , Zhao, Wei , Zhu, Feng , Wang, Gang , Chen, Yao-Peng et al. Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy . | MILITARY MEDICAL RESEARCH , 2021 , 8 (1) . |
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Diabetic nephropathy (DN) is the major cause of chronic kidney disease and end-stage renal disease. Previous studies have demonstrated that long-chain omega-3 polyunsaturated fatty acids (PUFAs) might have therapeutic potential in reducing proteinuria in DN. However, the local level of eicosanoids derived from PUFAs in the plasma of DN patients remains unclear. This work aims to study the eicosanoid profile difference in plasma of DN patients and type 2 diabetes (T2D) without DN. A total of 27 T2D patients with similar diabetic duration were recruited and divided into T2D+DN group and T2D+NDN (non-DN) group based on urinary albumin excretion (UAE) detection. Using LC-MS/MS-based metabolomics, DN patients showed increased level of lipoxygenase (LOX) metabolites (5-HETE and LTB4) and decreased levels of eicosanoids derived according to the cytochrome P450s (CYP450) metabolic pathway (5,6-DHET; 14,15-DHET and 9,10-diHOME). Receiver operating characteristics and logistic regression analysis revealed increased level LOX metabolites and decreased level of CYP450 metabolites were significantly correlated with the incidence of DN in T2D patients. LOX and CYP450 metabolites correlated with DN incidence in T2D patients, which might be treatment targets for DN in T2D patients.
Keyword ：
cytochrome P450s diabetic nephropathy eicosanoids lipoxygenase metabolomics
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| GB/T 7714 | Peng, Liyuan , Sun, Bei , Liu, Yajin et al. Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients [J]. | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY , 2021 , 48 (5) : 679-685 . |
| MLA | Peng, Liyuan et al. "Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients" . | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 48 . 5 (2021) : 679-685 . |
| APA | Peng, Liyuan , Sun, Bei , Liu, Yajin , Huang, Jing , Chen, Guangzhi , Zhang, Xu et al. Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients . | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY , 2021 , 48 (5) , 679-685 . |
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| GB/T 7714 | Yu, Yue-Tian , Liu, Jiao , Hu, Bo et al. Expert consensus on the use of human serum albumin in critically ill patients [J]. | CHINESE MEDICAL JOURNAL , 2021 , 134 (14) : 1639-1654 . |
| MLA | Yu, Yue-Tian et al. "Expert consensus on the use of human serum albumin in critically ill patients" . | CHINESE MEDICAL JOURNAL 134 . 14 (2021) : 1639-1654 . |
| APA | Yu, Yue-Tian , Liu, Jiao , Hu, Bo , Wang, Rui-Lan , Yang, Xiang-Hong , Shang, Xiu-Ling et al. Expert consensus on the use of human serum albumin in critically ill patients . | CHINESE MEDICAL JOURNAL , 2021 , 134 (14) , 1639-1654 . |
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