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学者姓名:张彦民

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Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-?B signaling in hepatocellular carcinoma cells SCIE Scopus
期刊论文 | 2022 , 103 | PHYTOMEDICINE
SCOPUS Cited Count: 5
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Abstract :

Background: Hepatocellular carcinoma (HCC) is a major subtype of liver cancer, with a high mortality rate, and close relation to chronic hepatitis. The components of the NLRP3 inflammasome are poorly expressed or even lost in HCC. Downregulation of the NLRP3 inflammasome expression significantly affects the clinical stages and pathological grade of HCC. According to previous research, Shuanghua decoction (SHD), a traditional folk prescription, has an inhibitory effect on nasopharyngeal cancer. Purpose: This study aimed to reveal the therapeutic potential of the traditional folk recipe, SHD and its demolition recipe for HCC, and to explore the underlying mechanism. Methods: The effect of SHD and its demolition recipe on HCC cell biological behaviors was assessed using the MTT assay, colony formation, LDH release assay, KFluor-Edu staining, annexin V-FITC/PI staining assay, Hoechst staining, wound-healing assay, transwell assay, reactive oxygen species (ROS) release assay, HPLC, nude mice model, HE staining, IHC, western blot, and immunofluorescence staining in vitro and in vivo. Results: SHD was found to inhibit HCC, and Oldenlandia and OP (Oldenlandia: Prunella spike = 2.5:1) were identified as the main ingredients that inhibited the proliferation and migration of HCC cells via the activation of the ROS-mediated NLRP3 inflammasome and inhibition of the NF-kappa B signaling pathway in vitro and in vivo. Conclusion: Overall, Chinese medicine theory and pharmacology research revealed that SHD, Oldenlandia and OP may be promising traditional Chinese medicine for the treatment of HCC.

Keyword :

HCC cells NF-?B signaling NLRP3 inflammasome ROS Shuanghua decoction

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GB/T 7714 Dai, Bingling , Fan, Mengying , Huang, Xiaoyue et al. Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-?B signaling in hepatocellular carcinoma cells [J]. | PHYTOMEDICINE , 2022 , 103 .
MLA Dai, Bingling et al. "Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-?B signaling in hepatocellular carcinoma cells" . | PHYTOMEDICINE 103 (2022) .
APA Dai, Bingling , Fan, Mengying , Huang, Xiaoyue , Gong, Zhengyan , Cao, Hanbing , Hu, Yu et al. Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-?B signaling in hepatocellular carcinoma cells . | PHYTOMEDICINE , 2022 , 103 .
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Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy EI SCIE Scopus
期刊论文 | 2022 , 433 | CHEMICAL ENGINEERING JOURNAL
WoS CC Cited Count: 1 SCOPUS Cited Count: 10
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Abstract :

Designing therapeutics to utilize and manipulate the aberrant high concentration of Ca2+ in tumor cells would be a promising approach for effective tumor therapy. Herein, we fabricated a nanohybrid to significantly reduce the intracellular Ca2+ of tumor cells meanwhile to perform Ca2+ triggered photothermal therapy under 660 nm irradiation for synergistic tumor treatment. This nanohybrid contains gold nanoparticle as core, ethylene glycol bis (2-aminoethyl ether)-N, N, N', N'-tetraacetic acid (EGTA, Ca2+ chelating agent) as shell and folic acid (FA, tumor targeting agent) conjugated polyethylene glycol 4000 (PEG) as corona, where the EGTA shell and PEG-FA corona was connected by esterase-cleavable ester bonds. After injection, the nanohybrid maintained a stable "off state " during blood circulation due to the anti-fouling property and EGTA-blocking performed by PEG section. The PEG-FA would be removed by over-expressed esterase in tumor cells after FA mediated tumor accumulation and endocytosis, which activated EGTA to capture Ca2+ in tumor cells, resulting in the truncation of Ca2+ signaling for tumor inhibition. Moreover, the specific chelation between Ca2+ and the nanohybrid would further cause the intracellular assembly of these nanoparticles in tumor cells, which in situ generated an excellent photothermal agent for enhanced tumor therapy under 660 nm irradiation. Both in vitro and in vivo results showed excellent tumor inhibition and high survival rate of tumor-bearing mice after treatment by our AEPF nanohybrid, indicating this synergistic therapy via on-demand Ca2+ manipulation and Ca2+ triggered photo thermal therapy could be a green approach for tumor treatment with high efficiency and minimum side effects.

Keyword :

Accurate tumor treatment via chain activities Ca(2+)dependent photothermal therapy Esterase triggered intracellular Ca2+ regulation Intelligent Gold Nanoparticles Utilization and manipulation of tumor-specific micro-environments

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GB/T 7714 Guo, Xiaoyan , Su, Qi , Liu, Tao et al. Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy [J]. | CHEMICAL ENGINEERING JOURNAL , 2022 , 433 .
MLA Guo, Xiaoyan et al. "Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy" . | CHEMICAL ENGINEERING JOURNAL 433 (2022) .
APA Guo, Xiaoyan , Su, Qi , Liu, Tao , He, Xiaoning , Yuan, Pingyun , Tian, Ran et al. Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy . | CHEMICAL ENGINEERING JOURNAL , 2022 , 433 .
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Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging EI SCIE Scopus
期刊论文 | 2022 , 14 (34) , 38594-38603 | ACS APPLIED MATERIALS & INTERFACES
SCOPUS Cited Count: 17
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Abstract :

Metallacages with suitable cavities and specific functions are promising delivery vectors in biological systems. Herein, we report a morpholine-functionalized metallacage for lysosome-targeted cell imaging. The efficient host-guest interactions between the metallacage and dyes prevent them from aggregation, so their emission in aqueous solutions is well maintained. The fluorescence quantum yield of these hostguest complexes reaches 74.40%. Therefore, the metallacage is further employed as a vector to deliver dyes with different emission colors (blue, green, and red) into lysosomes for targeted imaging. This research affords a type of vector for the delivery of various cargos toward biological applications, which will enrich the usage of metallacages in biomedical engineering.

Keyword :

cell imaging fluorescence host-guest complexation metallacages targeted delivery

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GB/T 7714 Feng, Qian , Yang, Tianfeng , Ma, Lingzhi et al. Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging [J]. | ACS APPLIED MATERIALS & INTERFACES , 2022 , 14 (34) : 38594-38603 .
MLA Feng, Qian et al. "Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging" . | ACS APPLIED MATERIALS & INTERFACES 14 . 34 (2022) : 38594-38603 .
APA Feng, Qian , Yang, Tianfeng , Ma, Lingzhi , Li, Xiaopeng , Yuan, Hongye , Zhang, Mingming et al. Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging . | ACS APPLIED MATERIALS & INTERFACES , 2022 , 14 (34) , 38594-38603 .
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A fluorescent, chiratity-responsive, and water-soluble cage as a multifunctional molecular container for drug delivery EI SCIE Scopus
期刊论文 | 2022 , 20 (19) , 3998-4005 | ORGANIC & BIOMOLECULAR CHEMISTRY
SCOPUS Cited Count: 7
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In recent years, the rational design and construction of drug delivery systems (DDSs) via a supramolecular approach for improving chemical therapeutics have gained significant attention. Here, we report a host-guest DDS formed from a fluorescent, chirality-responsive, and water-soluble tetraphenylethene-based octacationic cage as a fluorescent/chiral probe, solubilizer, and molecular cargo, which can recognize chiral nucleoside drugs, enhance the solubility of insoluble drugs, and protect drugs from the outside environment by forming host guest complexes in aqueous solution. Given the fluorescence properties and dynamically rotational conformation of tetraphenylethene (TPE) units, this fluorescent and chirality-responsive cage exhibits different responses including turn-on/turn-off fluorescence and negative/positive circular dichroism (CD) when binding with different chiral nucleoside drugs in water, resulting in multiple-responsive photophysical behaviors for these chiral drugs. Furthermore, this water-soluble cationic cage with a hydrophobic cavity can improve the water solubility of insoluble drugs (e.g., CPT) by forming host-guest complexes in water. More importantly, this multifunctional cage exhibits a low toxicity to both human colon and breast cancer cell lines in vitro, and drugs encapsulated by the cage are more effective in killing cancer cells than drugs alone. Finally, the on off -on fluorescence responses in the formation and dissociation processes of the cage superset of drug complexes have been successfully used to monitor drug release and track drug delivery by fluorescence microscopy in vitro. Therefore, this fluorescent, chirality-responsive, and water-soluble cage as a multifunctional molecular container can be used to construct a smart drug delivery system with several functions of fluorescence and CD detection, water solubilization, real-time monitoring, and chemotherapy.

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GB/T 7714 Duan, Yanjuan , Wang, Jingjing , Cheng, Lin et al. A fluorescent, chiratity-responsive, and water-soluble cage as a multifunctional molecular container for drug delivery [J]. | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (19) : 3998-4005 .
MLA Duan, Yanjuan et al. "A fluorescent, chiratity-responsive, and water-soluble cage as a multifunctional molecular container for drug delivery" . | ORGANIC & BIOMOLECULAR CHEMISTRY 20 . 19 (2022) : 3998-4005 .
APA Duan, Yanjuan , Wang, Jingjing , Cheng, Lin , Duan, Honghong , Tian, Ping , Zhang, Yanmin et al. A fluorescent, chiratity-responsive, and water-soluble cage as a multifunctional molecular container for drug delivery . | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (19) , 3998-4005 .
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Establishment of iPSC line from a Chinese infant (XACHi012-A) with Jervell and Lange-Nielsen syndrome carrying combined KCNQ1 frameshift c.431delC(p.I145Sfs*92) and nonsense c.1175G > A (p.W392X) variants and two iPSC lines from the parents (XACHi013-A, XACHi014-A) SCIE PubMed
期刊论文 | 2021 , 53 | STEM CELL RESEARCH
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Induced pluripotent stem cell lines (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from the peripheral blood of a two month-old boy and the parents. Jervell and Lange-Nielsen syndrome (JLNS) was diagnosed in the boy carrying combined KCNQ1 frameshift c.431delC (p.I145Sfs*92) and nonsense c.1175G > A(p.W392X) variants inherited from his mother and father respectively. PBMCs were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and C-MYC. IPSCs were shown to express pluripotent markers, have trilineage differentiation potential, carrying identified KCNQ1 variants with corresponding PBMC, and have a normal karyotype. Thus we established three iPSC lines as useful tools for studying the pathophysiological mechanism of JLNS and drug testing.

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GB/T 7714 Zhou, Yafei , Wang, Jie , Li, Huan et al. Establishment of iPSC line from a Chinese infant (XACHi012-A) with Jervell and Lange-Nielsen syndrome carrying combined KCNQ1 frameshift c.431delC(p.I145Sfs*92) and nonsense c.1175G > A (p.W392X) variants and two iPSC lines from the parents (XACHi013-A, XACHi014-A) [J]. | STEM CELL RESEARCH , 2021 , 53 .
MLA Zhou, Yafei et al. "Establishment of iPSC line from a Chinese infant (XACHi012-A) with Jervell and Lange-Nielsen syndrome carrying combined KCNQ1 frameshift c.431delC(p.I145Sfs*92) and nonsense c.1175G > A (p.W392X) variants and two iPSC lines from the parents (XACHi013-A, XACHi014-A)" . | STEM CELL RESEARCH 53 (2021) .
APA Zhou, Yafei , Wang, Jie , Li, Huan , Li, Anmao , Wang, Guoxia , Tan, Xiaoqiu et al. Establishment of iPSC line from a Chinese infant (XACHi012-A) with Jervell and Lange-Nielsen syndrome carrying combined KCNQ1 frameshift c.431delC(p.I145Sfs*92) and nonsense c.1175G > A (p.W392X) variants and two iPSC lines from the parents (XACHi013-A, XACHi014-A) . | STEM CELL RESEARCH , 2021 , 53 .
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Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma SCIE PubMed
期刊论文 | 2021 , 11 (9) | CLINICAL AND TRANSLATIONAL MEDICINE
WoS CC Cited Count: 4
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Abstract :

Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Overexpression of pleomorphic adenoma gene like-2 (PLAGL2) is associated with tumorigenesis. However, its function in HCC is unclear, and there are currently no anti-HCC drugs that target PLAGL2. Drug repositioning may facilitate the development of PLAGL2-targeted drug candidates. Methods The expression of PLAGL2 in HCC clinical tissue samples and HCC cell lines was analyzed by western blotting. The constructed HCC cell models were used to confirm the underlying function of PLAGL2 as a therapeutic target. Multiple in vitro and in vivo assays were conducted to determine the anti-proliferative and apoptosis-inducing effects of selenium sulfide (SeS2), which is clinically used for the treatment of seborrheic dermatitis and tinea versicolor. Results PLAGL2 expression was higher in HCC tumor tissues than in normal adjacent tissues. Its overexpression promoted the resistance of HCC cells of mitochondrial apoptosis through the regulation of the downstream C-MET/STAT3 signaling axis. SeS2 exerted significant anti-proliferative and apoptosis-inducing effects on HCC cells in a PLAGL2-dependent manner. Mechanistically, SeS2 suppressed C-MET/STAT3, AKT/mTOR, and MAPK signaling and triggered Bcl-2/Cyto C/Caspase-mediated intrinsic mitochondrial apoptosis both in vitro and in vivo. Conclusions Our data reveal an important role of PLAGL2 in apoptosis resistance in HCC and highlight the potential of using SeS2 as a PLAGL2 inhibitor in patients with HCC.

Keyword :

C-MET HCC PLAGL2 selenium sulfide STAT3

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GB/T 7714 Yang, Tianfeng , Huo, Jian , Xu, Rui et al. Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma [J]. | CLINICAL AND TRANSLATIONAL MEDICINE , 2021 , 11 (9) .
MLA Yang, Tianfeng et al. "Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma" . | CLINICAL AND TRANSLATIONAL MEDICINE 11 . 9 (2021) .
APA Yang, Tianfeng , Huo, Jian , Xu, Rui , Su, Qi , Tang, Wenjuan , Zhang, Dongdong et al. Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma . | CLINICAL AND TRANSLATIONAL MEDICINE , 2021 , 11 (9) .
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Near-infrared and tumor environment Co-activated nanoplatform for precise tumor therapy in multiple models EI SCIE
期刊论文 | 2021 , 24 | APPLIED MATERIALS TODAY
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Chemotherapy based on anti-tumor drugs is one of the most commonly utilized approaches for tumor treatment. However, the uncontrollable toxicity of these drugs to healthy tissue, insufficient therapeutic efficiency and chemotherapeutic resistance induced by hypoxic environment in most types of solid tumors still limited the clinical application of chemotherapy. Herein, a smart nanoplatform responsive to near-infrared (NIR) light and tumor-specific microenvironment is developed for precise and effective tumor therapy via chain procedures of rapid hypoxia inhibition, promoted catalytic medicine and low-resistance chemotherapy. The concept is demonstrated by co-encapsulating ferroferric oxide nanoparticles (Fe3O4 NPs, photothermal agent and catalyst), calcium peroxide (CaO2, H2O2/O-2 generator) and pa-clitaxel (PTX, anticancer drug) into an enzyme and thermal breakable capsule, which contained a bi-layer shell of hyaluronic acid (HA) and lauric acid (LA). The HA layer serves as tumor target agent to guide the nanoplatform to accumulate in tumor tissue, which would be subsequently degraded by the over-expressed hyaluronidase to expose LA layer for further activation by NIR irradiation. Due to the well-defined melting point of LA at 44 degrees C and excellent photothermal property of Fe3O4, the LA layer un-dertakes a NIR-triggered phase-change to release the encapsulated therapeutic agents (CaO2, Fe3O4 and PTX) for controllable tumor therapy. The exposed CaO2 would react with water or acid in tumor cells to produce O-2 and H2O2, where the O-2 not only press PTX out of the capsule to accelerate its release, but reverse the hypoxic environment to inhibit the hypoxia-induced drug resistance for enhanced chemother-apy. The H2O2 would be further converted to cytotoxic hydroxyl radical by Fe3O4 via catalytic medicine (Fenton reaction), resulting in an enhanced anticancer activity. Near-infrared and tumor environment co-activated nanoplatform, Effective hypoxia inhibition, Promoted catalytic medicine, Low-resistance chemotherapy, Precise tumor therapy via chain activities (C) 2021 Elsevier Ltd. All rights reserved.

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GB/T 7714 Chen, Li , Yang, Tianfeng , Tian, Ran et al. Near-infrared and tumor environment Co-activated nanoplatform for precise tumor therapy in multiple models [J]. | APPLIED MATERIALS TODAY , 2021 , 24 .
MLA Chen, Li et al. "Near-infrared and tumor environment Co-activated nanoplatform for precise tumor therapy in multiple models" . | APPLIED MATERIALS TODAY 24 (2021) .
APA Chen, Li , Yang, Tianfeng , Tian, Ran , Yin, Tian , Weng, Lin , Bai, Yongkang et al. Near-infrared and tumor environment Co-activated nanoplatform for precise tumor therapy in multiple models . | APPLIED MATERIALS TODAY , 2021 , 24 .
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MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer. PubMed SCIE
期刊论文 | 2021 , 189 | Biochemical pharmacology
WoS CC Cited Count: 7
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Pancreatic Cancer (PC) is a severe form of malignancy all over the world. Delayed diagnosis and chemoresistance are the major factors contributing to its poor prognosis and high mortality rate. The genetic and epigenetic regulations of biological pathways further complicate the progression and chemotherapy response to this cancer. MicroRNAs (MiRNAs) involvement has been observed in all types of cancers including PC. The understanding and categorization of miRNAs according to their specific targets are very important to develop early diagnostic and therapeutic interventions. The current review, emphasizing recent research findings, has categorized miRNAs that directly target the potential onco-factors that act as central converging signal-nodes in five major cancer-related pathways i.e., MAPK/ERK, JAK/STAT, Wnt/β-catenin, AKT/mTOR, and TGFβ in PC. The therapeutic perspectives of miRNAs in PC have also been discussed. This will help to understand the interplay of various miRNAs within foremost signaling pathways and develop a multifactorial approach to treat difficult-to-treat PC.

Keyword :

Clinical applications MicroRNAs Natural compounds Onco-targets

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GB/T 7714 Sarwar Ammar , Wang Bo , Su Qi et al. MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer. [J]. | Biochemical pharmacology , 2021 , 189 .
MLA Sarwar Ammar et al. "MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer." . | Biochemical pharmacology 189 (2021) .
APA Sarwar Ammar , Wang Bo , Su Qi , Zhang Yanmin . MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer. . | Biochemical pharmacology , 2021 , 189 .
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Carnosic acid-induced co-self-assembly of metal-peptide complexes into a nanocluster-based framework with tumor-specific accumulation for augmented immunotherapy EI SCIE
期刊论文 | 2021 , 416 | Chemical Engineering Journal
WoS CC Cited Count: 8
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Tumor immunotherapy by PD-1/PD-L1 blockade (PPB) has emerged as a standard of care treatment and can bring long-lasting clinical benefits, yet less than one-third of patients respond to it. While combination PPB therapies have shown improved outcomes, more optimal multimodality therapies, particularly those combinations with molecularly targeted therapies, are still required to improve the therapeutic benefit of PPB. Herein, we describe a design of PPB sensitizer with supramolecular nanostructure constructed through a dynamic combinatorial chemistry (DCC)-based co-self-assembled strategy. Upon the stimulation of a β-catenin inhibitor termed carnosic acid (CA), two competing molecular blocks three-dimensionally and orderly co-self-assembled into a nanocluster-based framework (CA-NBF) under thermo-dynamic control. With properties of tumor-specific accumulation and glutathione-triggered release, CA-NBF potently suppressed the Wnt/β-catenin signaling cascade in vitro and in vivo, while keeping a favorable safety feature. Moreover, CA-NBF potently restored the intratumoral infiltration of cytotoxic T lymphocyte cells and consequently promoted tumor response to Anti-PD-L1 antibody in B16F10 melanoma model and Anti-PD1 antibody in MC38 model of colon cancer. Given these encouraging results, this work may provide a new option for promoting the response of PPB therapy, and the DCC-based co-self-assembled strategy may be a promising tool to develop a class of supramolecular nanomedicines for the molecular targeted therapy of diseases including cancer. © 2021 Elsevier B.V.

Keyword :

Antibodies Biochips Disease control Diseases Nanoclusters Patient treatment Peptides Self assembly Supramolecular chemistry Tumors

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GB/T 7714 Yan, Jin , He, Wangxiao , Li, Xiao et al. Carnosic acid-induced co-self-assembly of metal-peptide complexes into a nanocluster-based framework with tumor-specific accumulation for augmented immunotherapy [J]. | Chemical Engineering Journal , 2021 , 416 .
MLA Yan, Jin et al. "Carnosic acid-induced co-self-assembly of metal-peptide complexes into a nanocluster-based framework with tumor-specific accumulation for augmented immunotherapy" . | Chemical Engineering Journal 416 (2021) .
APA Yan, Jin , He, Wangxiao , Li, Xiao , You, Weiming , Liu, Xiaojing , Lin, Shumei et al. Carnosic acid-induced co-self-assembly of metal-peptide complexes into a nanocluster-based framework with tumor-specific accumulation for augmented immunotherapy . | Chemical Engineering Journal , 2021 , 416 .
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The facile formation of hierarchical mesoporous silica nanocarriers for tumor-selective multimodal theranostics EI SCIE PubMed
期刊论文 | 2021 , 9 (15) , 5237-5246 | BIOMATERIALS SCIENCE
WoS CC Cited Count: 1
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The combination of therapeutic and diagnostic functions in a single platform has aroused great interest due to the more optimal synergistic effects that can be obtained as compared to any single theranostic approach alone. However, current nanotheranostics are normally formed via complicated construction steps involving the pre-synthesis of each component and further conjugation via chemical bonds, which may cause low integration efficiency and limit production and applications. Herein, a tumor-targeting and tumor-responsive all-in-one nanoplatform based on mesoporous silica nanocarriers (MSNs) was fabricated via a facile approach utilizing efficient and nondestructive physical interactions for long-wavelength fluorescence imaging-guided synergistic chemo-catalytic-photothermal tumor therapy. The MSNs were endowed with these multimodal theranostics via a simple hydrothermal method after coordinating with Fe2+ and glutathione (GSH) to introduce ferroferric oxide and carbon dots in situ. The former acts as a photothermal agent and catalytic agent to generate local heat under 808 nm irradiation and also when toxic hydroxyl radicals (OH) are in contact with abundant hydrogen peroxide in cancer cells, while the latter participates in fluorescence imaging. After loading with paclitaxel (PTX), polyester and folic-acid-conjugated cyclodextrin were employed to serve as an esterase-sensitive gatekeeper controlling PTX release from the MSN pores and as a tumor-targeting agent for accurate therapy, respectively. As expected, the nanoplatform was efficiently taken up by tumor cells over healthy cells, and then, synergetic chemo-catalytic-photothermal therapy was performed, resulting in 5-fold greater apoptosis of tumor cells as compared to healthy cells under 808 nm irradiation. Moreover, in vivo data from tumor-bearing mouse models showed that tumors were significantly inhibited, and the survival rates of these mice increased to greater than 80% after 5 weeks of treatment with our nanoplatform. These therapeutic processes could be directly tracked via fluorescence imaging enabled by carbon dots and, therefore, our nanoplatform provides a promising theranostics approach for tumor treatment.

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GB/T 7714 Guo, Xiaoyan , Zhu, Man , Yuan, Pingyun et al. The facile formation of hierarchical mesoporous silica nanocarriers for tumor-selective multimodal theranostics [J]. | BIOMATERIALS SCIENCE , 2021 , 9 (15) : 5237-5246 .
MLA Guo, Xiaoyan et al. "The facile formation of hierarchical mesoporous silica nanocarriers for tumor-selective multimodal theranostics" . | BIOMATERIALS SCIENCE 9 . 15 (2021) : 5237-5246 .
APA Guo, Xiaoyan , Zhu, Man , Yuan, Pingyun , Liu, Tao , Tian, Ran , Bai, Yongkang et al. The facile formation of hierarchical mesoporous silica nanocarriers for tumor-selective multimodal theranostics . | BIOMATERIALS SCIENCE , 2021 , 9 (15) , 5237-5246 .
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