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学者姓名:张彦民

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Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology SCIE CSCD
期刊论文 | 2018 , 16 (4) , 302-312 | CHINESE JOURNAL OF NATURAL MEDICINES
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Abstract :

Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present study, we used a systems pharmacology approach to identify the active ingredients of GXSTC and their corresponding targets in the calcium signaling pathway with respect to the treatment of CVDs. This method integrated chromatographic techniques, prediction of absorption, distribution, metabolism, and excretion, analysis using Kyoto Encyclopedia of Genes and Genomes, network construction, and pharmacological experiments. 12 active compounds and 33 targets were found to have a role in the treatment of CVDs, and four main active ingredients, including protocatechuic acid, cryptotanshinone, eugenol, and bomeol were selected to verify the effect of (GXSTC) on calcium signaling system in cardiomyocyte injury induced by hypoxia and reoxygenation. The results from the present study revealed the active components and targets of GXSTC in the treatment of CVDs, providing a new perspective to enhance the understanding of the role of the calcium signaling pathway in the therapeutic effect of GXSTC.

Keyword :

Mass spectrum Systems pharmacology Calcium signaling pathway Cardiovascular diseases Guanxinshutong capsule

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GB/T 7714 Liu Feng , Du Xia , Liu Pei-Rong et al. Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology [J]. | CHINESE JOURNAL OF NATURAL MEDICINES , 2018 , 16 (4) : 302-312 .
MLA Liu Feng et al. "Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology" . | CHINESE JOURNAL OF NATURAL MEDICINES 16 . 4 (2018) : 302-312 .
APA Liu Feng , Du Xia , Liu Pei-Rong , Sun Yu-Hong , Zhang Yan-Min . Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology . | CHINESE JOURNAL OF NATURAL MEDICINES , 2018 , 16 (4) , 302-312 .
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HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells SCIE PubMed Scopus
期刊论文 | 2018 , 22 (5) , 2955-2959 | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
WoS CC Cited Count: 1
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Abstract :

Looking for novel, effective and less toxic therapies for cervical cancer is of significant importance. In this study, we reported that HMQ-T-F2(F2) significantly inhibited cell proliferation and transplantable tumour growth. Mechanistically, HMQ-T-F2 inhibited HeLa cell growth through repressing the expression and nuclear translocation of beta-catenin, enhancing Axin expression, as well as downregulating the Wnt downstream targeted proteins. Knock-down of a checkpoint beta-catenin by siRNA significantly attenuated HeLa cell proliferation. Furthermore, XAV939, an inhibitor of beta-catenin, was used to treat HeLa cells and the results demonstrated that HMQ-T-F2 inhibited proliferation and migration via the inhibition of the Wnt/beta-catenin pathway.

Keyword :

cervical HeLa cells proliferation Wnt/beta-catenin signal HMQ-T-F2

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GB/T 7714 Dai, Bingling , Yang, Tianfeng , Ma, Yujiao et al. HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells [J]. | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE , 2018 , 22 (5) : 2955-2959 .
MLA Dai, Bingling et al. "HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells" . | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 22 . 5 (2018) : 2955-2959 .
APA Dai, Bingling , Yang, Tianfeng , Ma, Yujiao , Ma, Nan , Shi, Xianpeng , Zhang, Dongdong et al. HMQ-T-F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells . | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE , 2018 , 22 (5) , 2955-2959 .
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Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells SCIE PubMed Scopus
期刊论文 | 2018 , 46 , 85-92 | PHYTOMEDICINE
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Background: Colorectal cancer remains the third most common malignancies and migration is one of the main factors for its high mortality rate. Brucine, a natural plant alkaloid, has been proved to possess a variety of pharmacological functions including anti-tumor activities. Purpose: The aim of this study was to investigate the inhibitory effect of brucine on the colorectal cancer and the underlying mechanism. Methods: In this study, colony formation assay and transwell assay were used to investigate the effect of brucine on LoVo cells viability and migration. Immunofluorescence assay, western blot assay and Gelatin zymography assay were used to study the mechanism of brucine. Xenograft model in nude mice was induced to investigate the in vivo effect of brucine on LoVo cells. Results: Brucine could significantly decrease the viability, inhibit the colony formation and induce the apoptosis of LoVo cells. Brucine could also suppress the migration of LoVo cells in a dose-dependent manner. Western blot analysis elucidated that the inhibition of migration was associated with the decreasing expression of matrix metalloproteinases including MMP2, MMP3 and MMP9. Moreover, we found that treatment of brucine could downregulate the expression of Frizzled-8, Wnt5a, APC and GSNK1A1, and increase the expression of AXIN1. Meanwhile, brucine also decreased the phosphorylation level of LRP5/6 and GSK3 beta, and increased the level of p-beta-catenin. Xenografted model in nude mice study also revealed that oral administration of brucine could inhibit the growth and migration of LoVo cells by activating the expression of AXIN1 and p-beta-catenin. Conclusion: Brucine could suppress the migration of the colorectal cancer in vitro and in vivo and the effect was associated with the inhibition of the WM/beta-catenin signaling pathway.

Keyword :

Migration Signaling pathway Wnt/beta-catenin Brucine Colorectal cancer

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GB/T 7714 Shi Xianpeng , Zhu Man , Kang Yuan et al. Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells [J]. | PHYTOMEDICINE , 2018 , 46 : 85-92 .
MLA Shi Xianpeng et al. "Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells" . | PHYTOMEDICINE 46 (2018) : 85-92 .
APA Shi Xianpeng , Zhu Man , Kang Yuan , Yang Tianfeng , Chen Xia , Zhang Yanmin . Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells . | PHYTOMEDICINE , 2018 , 46 , 85-92 .
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Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer EI SCIE PubMed Scopus
期刊论文 | 2018 , 5 (6) | ADVANCED SCIENCE
WoS CC Cited Count: 1
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Clinical evidence indicates that drug resistance is a great obstacle in breast cancer therapy. It renders the disease uncontrollable and causes high mortality. Multiple mechanisms contribute to the development of drug resistance, but the underlying cause is usually a shift in the genetic composition of tumor cells. It is increasingly feasible to engineer the genome with the clustered regularly interspaced short palindromic repeats (CRISPR)/associated (Cas)9 technology recently developed, which might be advantageous in overcoming drug resistance. This article discusses how the CRISPR/Cas9 system might revert resistance gene mutations and identify potential resistance targets in drug-resistant breast cancer. In addition, the challenges that impede the clinical applicability of this technology and highlight the CRISPR/Cas9 systems are presented. The CRISPR/Cas9 system is poised to play an important role in preventing drug resistance in breast cancer therapy and will become an essential tool for personalized medicine.

Keyword :

drug resistance breast cancer reverting resistance drug therapy CRISPR Cas9

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GB/T 7714 Chen, Yinnan , Zhang, Yanmin . Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer [J]. | ADVANCED SCIENCE , 2018 , 5 (6) .
MLA Chen, Yinnan et al. "Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer" . | ADVANCED SCIENCE 5 . 6 (2018) .
APA Chen, Yinnan , Zhang, Yanmin . Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer . | ADVANCED SCIENCE , 2018 , 5 (6) .
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Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy Scopus CSCD PKU
期刊论文 | 2018 , 35 (5) , 667-671 | Chinese Journal of Medical Genetics
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© 2018 West China University of Medical Sciences. All rights reserved. Objective: To explore the genotype-phenotype correlation of a MYH7-D554Y mutation identified in an ethnic Han Chinese pedigree affected with hypertrophic cardiomyopathy. Methods: Ninety six cardiovascular disease-related genes were detected in the proband by exonic amplification and highthroughput sequencing. Suspected mutations were verified by Sanger sequencing among 300 healthy controls as well as family members of the proband. The pathogenicity and conservation of the detected mutations were analyzed with ClustalX, MutationTaster, PolyPhen-2, Provean and SIFT software. Results: Four of the 5 first-degree relatives of the proband were diagnosed with hypertrophic cardiomyopathy. The proband has featured extremely hypertrophic left ventricular wall with a maximal thickness of 35 mm. Genetic testing showed that four of them have carried a heterozygous c. 1660G>T (p. Asp554Tyr) mutation of the MYH7 gene, who the remaining one was phenotypically normal and did not carry the mutation. The mutation has not been recorded by the Human Gene Mutation Database (HGMD) and other databases. Bioinformatics analysis suggested that the mutation site is highly conserved and that the mutation is pathogenic. Conclusion: The p. Asp554Tyr mutation of the MYH7 gene probably underlies the hypertrophic cardiomyopathy in this pedigree.

Keyword :

Genotype Hypertrophic cardiomyopathy MYH7-D554Y mutation Phenotype

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GB/T 7714 Yang, Qianli , Wang, Bo , Wang, Jing et al. Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy [J]. | Chinese Journal of Medical Genetics , 2018 , 35 (5) : 667-671 .
MLA Yang, Qianli et al. "Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy" . | Chinese Journal of Medical Genetics 35 . 5 (2018) : 667-671 .
APA Yang, Qianli , Wang, Bo , Wang, Jing , Sun, Chao , Ma, Zhiling , Zuo, Lei et al. Analysis of genotype-phenotype correlation for a novel MYH7-D554Y mutation identified in an ethnic han Chinese pedigree affected with hypertrophic cardiomyopathy . | Chinese Journal of Medical Genetics , 2018 , 35 (5) , 667-671 .
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Electrodeposited reduced graphene oxide incorporating polymerization of L-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid EI SCIE PubMed Scopus
期刊论文 | 2017 , 70 , 241-249 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | IF: 5.08
WoS CC Cited Count: 24
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Abstract :

This paper demonstrates a novel strategy for the construction of a graphene hybrid composites film, which was fabricated by electrodeposited reduced graphene oxide (ERGO) incorporating polymerization of L-lysine (PLL) onto glassy carbon electrode (GCE). Here we show that graphene films can be prepared on electrodes directly from GO dispersions by one-step electrodeposition technique based on electropolymerized PLL as a positively charged polymer interface to adsorb negatively charged GO nanosheets through electrostatic attraction. The thickness of graphene film can be easily controlled by using the electrodeposition technique, a distinct advantage over previously developed methods. The electrochemically reduced process of GO and electropolymerization of L-lysine were investigated by cyclic voltammetry with a wide potential range. The surface morphology of the modified electrode was characterized by scanning electron microscopy. The ERGO/PLL/GCE shows conducive to electron transfer kinetics for Fe(CN)(6)(3-)/Fe(CN)(6)(4-) redox probes, compared with bare GCE, PLL/GCE and ERGO/GCE. The electrochemical behaviors of ascorbic acid (AA), dopamine (DA) and uric acid (UA) at ERGO/PLL/GCE were investigated by cyclic voltammetry, and the results suggest that the modified electrode exhibits enhanced electrocatalytic activity toward these important molecules. Under physiological condition and in the co-existence system of AA, DA and UA, the ERGO/PLL/GCE showed linear voltammetric responses in the concentration of 100 mu M-1200 mu M for AA, 2.0 mu M-60 mu M for DA and 20 mu M-200 mu M for UA, and with the detection limits (S/N = 3) of 2.0 mu M, 0.10 mu M and 0.15 mu M for AA, DA and UA, respectively. The developed method has been applied to simultaneous determination of AA, DA and UA in human urine with satisfactory recoveries of 104.2%, 95.4% and 99.9%, respectively. This work demonstrates that the attractive features of ERGO/PLL provide promising applications in simultaneous determination of AA, DA and UA in physiological and pathological studies. (C) 2016 Elsevier B.V. All rights reserved.

Keyword :

Ascorbic acid Graphene Uric acid Poly-L-lySine Dopamine

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GB/T 7714 Zhang, Dongdong , Li, Lingzhi , Ma, Weina et al. Electrodeposited reduced graphene oxide incorporating polymerization of L-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid [J]. | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS , 2017 , 70 : 241-249 .
MLA Zhang, Dongdong et al. "Electrodeposited reduced graphene oxide incorporating polymerization of L-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid" . | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 70 (2017) : 241-249 .
APA Zhang, Dongdong , Li, Lingzhi , Ma, Weina , Chen, Xia , Zhang, Yanmin . Electrodeposited reduced graphene oxide incorporating polymerization of L-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid . | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS , 2017 , 70 , 241-249 .
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Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2 SCIE PubMed Scopus
期刊论文 | 2017 , 25 , 45-51 | PHYTOMEDICINE | IF: 3.61
WoS CC Cited Count: 9
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Abstract :

Background: Berberine, a plant-derived compound isolated from Coptis chinensis used in traditional Chinese medicine, has been shown to possess anti-cancer properties. However, no study has shown that berberine could target ephrin-B2, which plays a critical role in cell proliferation and migration. Purpose: The aim of this study is to investigate the effect of berberine on cancer cell growth and migration, through the regulation of ephrin-B2 and downstream signaling molecules. Methods: In this study, a high ephrin-B2-expressing cell membrane chromatography method was developed to investigate 48 crude extracts from traditional Chinese medicine that could act on ephrin-B2. Cell proliferative and wound-healing assays were used to study the effect of berberine on cancer cell growth and migration. The mechanism of berberine was investigated using western blot. Results: Berberine was isolated from C. chinensis extracts and showed activity on the HEK293/ephrin-B2 cell membrane chromatography column. Berberine showed a greater inhibitory effect in high-expressing ephrin-B2 cells (HEK293/ephrin-B2 cells) than in normal HEK293 cells, and decreased the expression of ephrin-B2 and its PDZ binding proteins, which indicates that ephrin-B2 is a target of berberine. Furthermore, berberine downregulates the phosphorylation of VEGFR2 and downstream signaling members (AKT and Erk1/2), which in turn downregulates the expression of MMP2 and MMP9. Conclusion: The above data confirm the inhibitory effects of berberine on ZR-75-30 cell proliferation and cell migration. Overall, our studies demonstrate that berberine inhibits cell growth and migration by targeting ephrin-B2. (C) 2016 Elsevier GmbH. All rights reserved.

Keyword :

Ephrin-B2 Berberine Cell growth Breast cancer Cell migration

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GB/T 7714 Ma, Weina , Zhu, Man , Zhang, Dongdong et al. Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2 [J]. | PHYTOMEDICINE , 2017 , 25 : 45-51 .
MLA Ma, Weina et al. "Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2" . | PHYTOMEDICINE 25 (2017) : 45-51 .
APA Ma, Weina , Zhu, Man , Zhang, Dongdong , Yang, Liu , Yang, Tianfeng , Li, Xin et al. Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2 . | PHYTOMEDICINE , 2017 , 25 , 45-51 .
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Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling SCIE PubMed Scopus
期刊论文 | 2017 , 31 (9) , 1392-1399 | PHYTOTHERAPY RESEARCH | IF: 3.349
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TPD7, a novel biphenyl urea taspine derivative, and berberine have presented inhibition on VEGFR2 that can be regulated by ephrin-B2 reverse signaling through interactions with the PDZ domain. The purpose of this study is to investigate the inhibitory effect of the combination of TPD7 and berberine (TAB) on T-cell acute lymphoblastic leukemia cell growth. TPD7 and berberine together synergistically inhibited the proliferation of Jurkat cells. Also, the combination of TAB induced G(1)-phase cell-cycle arrest by downregulating the level of cyclin D1, cyclin E, and CDC2. Furthermore, the combination of TAB significantly enhanced apoptosis in Jurkat cells, and the apoptosis most likely resulted from the modulation of the level of Bcl-2 family members. Most importantly, the concomitant treatment simultaneously regulated the ephrin-B2 and VEGFR2 signaling, as well as modulated the MEK/ERK and PTEN/PI3K/AKT/mTOR signaling. Therefore, the combination treatment of TAB may be a promising therapeutic method in treating T-cell acute lymphoblastic leukemia. Copyright (c) 2017 John Wiley & Sons, Ltd.

Keyword :

synergistic effect cell growth berberine TPD7 Jurkat ephrin-B2

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GB/T 7714 Ma, Weina , Zhu, Man , Yang, Liu et al. Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling [J]. | PHYTOTHERAPY RESEARCH , 2017 , 31 (9) : 1392-1399 .
MLA Ma, Weina et al. "Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling" . | PHYTOTHERAPY RESEARCH 31 . 9 (2017) : 1392-1399 .
APA Ma, Weina , Zhu, Man , Yang, Liu , Yang, Tianfeng , Zhang, Yanmin . Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling . | PHYTOTHERAPY RESEARCH , 2017 , 31 (9) , 1392-1399 .
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Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways SCIE PubMed Scopus
期刊论文 | 2016 , 41 , 39-44 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | IF: 2.313
WoS CC Cited Count: 3
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Both PI3K/AKT/mTOR and mitogen activated protein kinase (MAPK) signaling cascades played an important role in tumorigenesis, a more complete understanding of these signaling pathways allowed the development of new therapeutic strategies. Total saponins isolated from Radix et Rhizoma Leonticis (RLTS) was recognized with anticancer properties. In a murine hepatocellular carcinoma H22 cell-bearing mouse model, RLTS exhibited significant inhibitory effect on tumor growth. Here, we investigated the role of RLTS on the PI3K/AKT/mTOR signaling pathway and MAPK pathways in liver and lung cancer cells. Results obtained showed RLTS inhibited cell proliferation and induced cell apoptosis in vitro, which attributed to the inhibition on the activation of PI3K/AKT/mTOR cascade and its related signaling molecules, such as activated VEGFR and NF-kappa B, and activation of p38 MAPK in tumor cells. Additional, RLTS inhibited cell migration and downregulated proteins that mediated metastasis including CXCR4, MMP2 and MMP9. Overall, these findings suggested that RLTS interfered with multiple signaling cascades involved in tumorigenesis and had potential in cancer therapy. (C) 2015 Elsevier B.V. All rights reserved.

Keyword :

PI3K/Akt/mTOR Total saponins Lung cancer Hepatocellular carcinoma p38 MAPK

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GB/T 7714 Zhan, Yingzhuan , Liu, Rui , Wang, Wenjie et al. Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways [J]. | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY , 2016 , 41 : 39-44 .
MLA Zhan, Yingzhuan et al. "Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways" . | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 41 (2016) : 39-44 .
APA Zhan, Yingzhuan , Liu, Rui , Wang, Wenjie , Li, Jing , Yang, Xiaoyan Ou , Zhang, Yanmin . Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways . | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY , 2016 , 41 , 39-44 .
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Electrochemical Behavior and Voltammetric Determination of Curcumin at Electrochemically Reduced Graphene Oxide Modified Glassy Carbon Electrode SCIE Scopus
期刊论文 | 2016 , 28 (4) , 749-756 | ELECTROANALYSIS | IF: 2.851
WoS CC Cited Count: 12
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This work presents a sensitive voltammetric method for determination of curcumin by using a electrochemically reduced graphene oxide (ERGO) modified glass carbon electrode (GCE) in 100 mM KCl-10 mM sodium phosphate buffer solution (pH 7.40), The electrochemical behaviors of curcumin at ERGO/GCE were investigated by cyclic voltammetry, suggesting that the ERGO/GCE. exhibits excellent electrocatalytic activity towards curcumin, compared with bare GCE and GO/GCE electrodes. The electrochemical reaction mechanisms of curcumin, demethoxycurcumin and bisdemethoxycurcumin at the ERGO/GCE were also investigated and discussed systematically. Under physiological condition, the modified electrode showed linear voltammetric response from 0.2 mu M to 60.0 mu M for curcumin, with the detection limit of 0.1 mu m. This work demonstrates that the graphene-modified electrode is a promising strategy for electrochemical determination of biological important phenolic compounds.

Keyword :

Graphene Voltammetry Modified electrode Curcumin Electrochemistry

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GB/T 7714 Zhang, Dongdong , Ouyang, Xiaoyan , Ma, Jing et al. Electrochemical Behavior and Voltammetric Determination of Curcumin at Electrochemically Reduced Graphene Oxide Modified Glassy Carbon Electrode [J]. | ELECTROANALYSIS , 2016 , 28 (4) : 749-756 .
MLA Zhang, Dongdong et al. "Electrochemical Behavior and Voltammetric Determination of Curcumin at Electrochemically Reduced Graphene Oxide Modified Glassy Carbon Electrode" . | ELECTROANALYSIS 28 . 4 (2016) : 749-756 .
APA Zhang, Dongdong , Ouyang, Xiaoyan , Ma, Jing , Li, Lingzhi , Zhang, Yanmin . Electrochemical Behavior and Voltammetric Determination of Curcumin at Electrochemically Reduced Graphene Oxide Modified Glassy Carbon Electrode . | ELECTROANALYSIS , 2016 , 28 (4) , 749-756 .
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