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学者姓名：张彦民
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Abstract ：
Background: Hepatocellular carcinoma (HCC) is a major subtype of liver cancer, with a high mortality rate, and close relation to chronic hepatitis. The components of the NLRP3 inflammasome are poorly expressed or even lost in HCC. Downregulation of the NLRP3 inflammasome expression significantly affects the clinical stages and pathological grade of HCC. According to previous research, Shuanghua decoction (SHD), a traditional folk prescription, has an inhibitory effect on nasopharyngeal cancer. Purpose: This study aimed to reveal the therapeutic potential of the traditional folk recipe, SHD and its demolition recipe for HCC, and to explore the underlying mechanism. Methods: The effect of SHD and its demolition recipe on HCC cell biological behaviors was assessed using the MTT assay, colony formation, LDH release assay, KFluor-Edu staining, annexin V-FITC/PI staining assay, Hoechst staining, wound-healing assay, transwell assay, reactive oxygen species (ROS) release assay, HPLC, nude mice model, HE staining, IHC, western blot, and immunofluorescence staining in vitro and in vivo. Results: SHD was found to inhibit HCC, and Oldenlandia and OP (Oldenlandia: Prunella spike = 2.5:1) were identified as the main ingredients that inhibited the proliferation and migration of HCC cells via the activation of the ROS-mediated NLRP3 inflammasome and inhibition of the NF-kappa B signaling pathway in vitro and in vivo. Conclusion: Overall, Chinese medicine theory and pharmacology research revealed that SHD, Oldenlandia and OP may be promising traditional Chinese medicine for the treatment of HCC.
Keyword ：
HCC cells NF-?B signaling NLRP3 inflammasome ROS Shuanghua decoction
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| GB/T 7714 | Dai, Bingling , Fan, Mengying , Huang, Xiaoyue et al. Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-?B signaling in hepatocellular carcinoma cells [J]. | PHYTOMEDICINE , 2022 , 103 . |
| MLA | Dai, Bingling et al. "Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-?B signaling in hepatocellular carcinoma cells" . | PHYTOMEDICINE 103 (2022) . |
| APA | Dai, Bingling , Fan, Mengying , Huang, Xiaoyue , Gong, Zhengyan , Cao, Hanbing , Hu, Yu et al. Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-?B signaling in hepatocellular carcinoma cells . | PHYTOMEDICINE , 2022 , 103 . |
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Abstract ：
Metallacages with suitable cavities and specific functions are promising delivery vectors in biological systems. Herein, we report a morpholine-functionalized metallacage for lysosome-targeted cell imaging. The efficient host-guest interactions between the metallacage and dyes prevent them from aggregation, so their emission in aqueous solutions is well maintained. The fluorescence quantum yield of these hostguest complexes reaches 74.40%. Therefore, the metallacage is further employed as a vector to deliver dyes with different emission colors (blue, green, and red) into lysosomes for targeted imaging. This research affords a type of vector for the delivery of various cargos toward biological applications, which will enrich the usage of metallacages in biomedical engineering.
Keyword ：
cell imaging fluorescence host-guest complexation metallacages targeted delivery
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| GB/T 7714 | Feng, Qian , Yang, Tianfeng , Ma, Lingzhi et al. Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging [J]. | ACS APPLIED MATERIALS & INTERFACES , 2022 , 14 (34) : 38594-38603 . |
| MLA | Feng, Qian et al. "Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging" . | ACS APPLIED MATERIALS & INTERFACES 14 . 34 (2022) : 38594-38603 . |
| APA | Feng, Qian , Yang, Tianfeng , Ma, Lingzhi , Li, Xiaopeng , Yuan, Hongye , Zhang, Mingming et al. Morpholine-Functionalized Multicomponent Metallacage as a Vector for Lysosome-Targeted Cell Imaging . | ACS APPLIED MATERIALS & INTERFACES , 2022 , 14 (34) , 38594-38603 . |
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Abstract ：
In recent years, the rational design and construction of drug delivery systems (DDSs) via a supramolecular approach for improving chemical therapeutics have gained significant attention. Here, we report a host-guest DDS formed from a fluorescent, chirality-responsive, and water-soluble tetraphenylethene-based octacationic cage as a fluorescent/chiral probe, solubilizer, and molecular cargo, which can recognize chiral nucleoside drugs, enhance the solubility of insoluble drugs, and protect drugs from the outside environment by forming host guest complexes in aqueous solution. Given the fluorescence properties and dynamically rotational conformation of tetraphenylethene (TPE) units, this fluorescent and chirality-responsive cage exhibits different responses including turn-on/turn-off fluorescence and negative/positive circular dichroism (CD) when binding with different chiral nucleoside drugs in water, resulting in multiple-responsive photophysical behaviors for these chiral drugs. Furthermore, this water-soluble cationic cage with a hydrophobic cavity can improve the water solubility of insoluble drugs (e.g., CPT) by forming host-guest complexes in water. More importantly, this multifunctional cage exhibits a low toxicity to both human colon and breast cancer cell lines in vitro, and drugs encapsulated by the cage are more effective in killing cancer cells than drugs alone. Finally, the on off -on fluorescence responses in the formation and dissociation processes of the cage superset of drug complexes have been successfully used to monitor drug release and track drug delivery by fluorescence microscopy in vitro. Therefore, this fluorescent, chirality-responsive, and water-soluble cage as a multifunctional molecular container can be used to construct a smart drug delivery system with several functions of fluorescence and CD detection, water solubilization, real-time monitoring, and chemotherapy.
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| GB/T 7714 | Duan, Yanjuan , Wang, Jingjing , Cheng, Lin et al. A fluorescent, chiratity-responsive, and water-soluble cage as a multifunctional molecular container for drug delivery [J]. | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (19) : 3998-4005 . |
| MLA | Duan, Yanjuan et al. "A fluorescent, chiratity-responsive, and water-soluble cage as a multifunctional molecular container for drug delivery" . | ORGANIC & BIOMOLECULAR CHEMISTRY 20 . 19 (2022) : 3998-4005 . |
| APA | Duan, Yanjuan , Wang, Jingjing , Cheng, Lin , Duan, Honghong , Tian, Ping , Zhang, Yanmin et al. A fluorescent, chiratity-responsive, and water-soluble cage as a multifunctional molecular container for drug delivery . | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (19) , 3998-4005 . |
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Abstract ：
Designing therapeutics to utilize and manipulate the aberrant high concentration of Ca2+ in tumor cells would be a promising approach for effective tumor therapy. Herein, we fabricated a nanohybrid to significantly reduce the intracellular Ca2+ of tumor cells meanwhile to perform Ca2+ triggered photothermal therapy under 660 nm irradiation for synergistic tumor treatment. This nanohybrid contains gold nanoparticle as core, ethylene glycol bis (2-aminoethyl ether)-N, N, N', N'-tetraacetic acid (EGTA, Ca2+ chelating agent) as shell and folic acid (FA, tumor targeting agent) conjugated polyethylene glycol 4000 (PEG) as corona, where the EGTA shell and PEG-FA corona was connected by esterase-cleavable ester bonds. After injection, the nanohybrid maintained a stable "off state " during blood circulation due to the anti-fouling property and EGTA-blocking performed by PEG section. The PEG-FA would be removed by over-expressed esterase in tumor cells after FA mediated tumor accumulation and endocytosis, which activated EGTA to capture Ca2+ in tumor cells, resulting in the truncation of Ca2+ signaling for tumor inhibition. Moreover, the specific chelation between Ca2+ and the nanohybrid would further cause the intracellular assembly of these nanoparticles in tumor cells, which in situ generated an excellent photothermal agent for enhanced tumor therapy under 660 nm irradiation. Both in vitro and in vivo results showed excellent tumor inhibition and high survival rate of tumor-bearing mice after treatment by our AEPF nanohybrid, indicating this synergistic therapy via on-demand Ca2+ manipulation and Ca2+ triggered photo thermal therapy could be a green approach for tumor treatment with high efficiency and minimum side effects.
Keyword ：
Accurate tumor treatment via chain activities Ca(2+)dependent photothermal therapy Esterase triggered intracellular Ca2+ regulation Intelligent Gold Nanoparticles Utilization and manipulation of tumor-specific micro-environments
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| GB/T 7714 | Guo, Xiaoyan , Su, Qi , Liu, Tao et al. Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy [J]. | CHEMICAL ENGINEERING JOURNAL , 2022 , 433 . |
| MLA | Guo, Xiaoyan et al. "Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy" . | CHEMICAL ENGINEERING JOURNAL 433 (2022) . |
| APA | Guo, Xiaoyan , Su, Qi , Liu, Tao , He, Xiaoning , Yuan, Pingyun , Tian, Ran et al. Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy . | CHEMICAL ENGINEERING JOURNAL , 2022 , 433 . |
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Induced pluripotent stem cell lines (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from the peripheral blood of a two month-old boy and the parents. Jervell and Lange-Nielsen syndrome (JLNS) was diagnosed in the boy carrying combined KCNQ1 frameshift c.431delC (p.I145Sfs*92) and nonsense c.1175G > A(p.W392X) variants inherited from his mother and father respectively. PBMCs were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and C-MYC. IPSCs were shown to express pluripotent markers, have trilineage differentiation potential, carrying identified KCNQ1 variants with corresponding PBMC, and have a normal karyotype. Thus we established three iPSC lines as useful tools for studying the pathophysiological mechanism of JLNS and drug testing.
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| GB/T 7714 | Zhou, Yafei , Wang, Jie , Li, Huan et al. Establishment of iPSC line from a Chinese infant (XACHi012-A) with Jervell and Lange-Nielsen syndrome carrying combined KCNQ1 frameshift c.431delC(p.I145Sfs*92) and nonsense c.1175G > A (p.W392X) variants and two iPSC lines from the parents (XACHi013-A, XACHi014-A) [J]. | STEM CELL RESEARCH , 2021 , 53 . |
| MLA | Zhou, Yafei et al. "Establishment of iPSC line from a Chinese infant (XACHi012-A) with Jervell and Lange-Nielsen syndrome carrying combined KCNQ1 frameshift c.431delC(p.I145Sfs*92) and nonsense c.1175G > A (p.W392X) variants and two iPSC lines from the parents (XACHi013-A, XACHi014-A)" . | STEM CELL RESEARCH 53 (2021) . |
| APA | Zhou, Yafei , Wang, Jie , Li, Huan , Li, Anmao , Wang, Guoxia , Tan, Xiaoqiu et al. Establishment of iPSC line from a Chinese infant (XACHi012-A) with Jervell and Lange-Nielsen syndrome carrying combined KCNQ1 frameshift c.431delC(p.I145Sfs*92) and nonsense c.1175G > A (p.W392X) variants and two iPSC lines from the parents (XACHi013-A, XACHi014-A) . | STEM CELL RESEARCH , 2021 , 53 . |
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Abstract ：
Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Overexpression of pleomorphic adenoma gene like-2 (PLAGL2) is associated with tumorigenesis. However, its function in HCC is unclear, and there are currently no anti-HCC drugs that target PLAGL2. Drug repositioning may facilitate the development of PLAGL2-targeted drug candidates. Methods The expression of PLAGL2 in HCC clinical tissue samples and HCC cell lines was analyzed by western blotting. The constructed HCC cell models were used to confirm the underlying function of PLAGL2 as a therapeutic target. Multiple in vitro and in vivo assays were conducted to determine the anti-proliferative and apoptosis-inducing effects of selenium sulfide (SeS2), which is clinically used for the treatment of seborrheic dermatitis and tinea versicolor. Results PLAGL2 expression was higher in HCC tumor tissues than in normal adjacent tissues. Its overexpression promoted the resistance of HCC cells of mitochondrial apoptosis through the regulation of the downstream C-MET/STAT3 signaling axis. SeS2 exerted significant anti-proliferative and apoptosis-inducing effects on HCC cells in a PLAGL2-dependent manner. Mechanistically, SeS2 suppressed C-MET/STAT3, AKT/mTOR, and MAPK signaling and triggered Bcl-2/Cyto C/Caspase-mediated intrinsic mitochondrial apoptosis both in vitro and in vivo. Conclusions Our data reveal an important role of PLAGL2 in apoptosis resistance in HCC and highlight the potential of using SeS2 as a PLAGL2 inhibitor in patients with HCC.
Keyword ：
C-MET HCC PLAGL2 selenium sulfide STAT3
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| GB/T 7714 | Yang, Tianfeng , Huo, Jian , Xu, Rui et al. Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma [J]. | CLINICAL AND TRANSLATIONAL MEDICINE , 2021 , 11 (9) . |
| MLA | Yang, Tianfeng et al. "Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma" . | CLINICAL AND TRANSLATIONAL MEDICINE 11 . 9 (2021) . |
| APA | Yang, Tianfeng , Huo, Jian , Xu, Rui , Su, Qi , Tang, Wenjuan , Zhang, Dongdong et al. Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma . | CLINICAL AND TRANSLATIONAL MEDICINE , 2021 , 11 (9) . |
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Abstract ：
Lung cancer (LC) is one of the leading causes of cancer-related death. As one of the key features of tumor microenvironment, hypoxia conditions are associated with poor prognosis in LC patients. Upregulation of hypoxic-induced factor-1 alpha (HIF-1 alpha) leads to the activation of various factors that contribute to the increased drug resistance, proliferation, and migration of tumor cells. Apurinic/apyrimidinic endonuclease-1 (APEX1) is a multi-functional protein that regulates several transcription factors, including HIF-1 alpha, that contribute to tumor growth, oxidative stress responses, and DNA damage. In this study, we explored the mechanisms underlying cell responses to hypoxia and modulation of APEX1, which regulate HIF-1 alpha and downstream pathways. We found that hypoxia-induced APEX1/HIF-1 alpha pathways regulate several key cellular functions, including reactive oxygen species (ROS) production, carbonic anhydrase 9 (CA9)-mediated intracellular pH, migration, and angiogenesis. Cephalomannine (CPM), a natural compound, exerted inhibitory effects in hypoxic LC cells via the inhibition of APEX1/HIF-1 alpha interaction in vitro and in vivo. CPM can significantly inhibit cell viability, ROS production, intracellular pH, and migration in hypoxic LC cells as well as angiogenesis of HUVECs under hypoxia through the inhibition of APEX1/HIF-1 alpha interaction. Taken together, CPM could be considered as a promising compound for LC treatment.
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| GB/T 7714 | Ullah, Asmat , Leong, Sze Wei , Wang, Jingjing et al. Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1 alpha interaction in lung cancer [J]. | CELL DEATH & DISEASE , 2021 , 12 (5) . |
| MLA | Ullah, Asmat et al. "Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1 alpha interaction in lung cancer" . | CELL DEATH & DISEASE 12 . 5 (2021) . |
| APA | Ullah, Asmat , Leong, Sze Wei , Wang, Jingjing , Wu, Qing , Ghauri, Mohsin Ahmad , Sarwar, Ammar et al. Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1 alpha interaction in lung cancer . | CELL DEATH & DISEASE , 2021 , 12 (5) . |
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Abstract ：
Chemotherapy based on anti-tumor drugs is one of the most commonly utilized approaches for tumor treatment. However, the uncontrollable toxicity of these drugs to healthy tissue, insufficient therapeutic efficiency and chemotherapeutic resistance induced by hypoxic environment in most types of solid tumors still limited the clinical application of chemotherapy. Herein, a smart nanoplatform responsive to near-infrared (NIR) light and tumor-specific microenvironment is developed for precise and effective tumor therapy via chain procedures of rapid hypoxia inhibition, promoted catalytic medicine and low-resistance chemotherapy. The concept is demonstrated by co-encapsulating ferroferric oxide nanoparticles (Fe3O4 NPs, photothermal agent and catalyst), calcium peroxide (CaO2, H2O2/O-2 generator) and pa-clitaxel (PTX, anticancer drug) into an enzyme and thermal breakable capsule, which contained a bi-layer shell of hyaluronic acid (HA) and lauric acid (LA). The HA layer serves as tumor target agent to guide the nanoplatform to accumulate in tumor tissue, which would be subsequently degraded by the over-expressed hyaluronidase to expose LA layer for further activation by NIR irradiation. Due to the well-defined melting point of LA at 44 degrees C and excellent photothermal property of Fe3O4, the LA layer un-dertakes a NIR-triggered phase-change to release the encapsulated therapeutic agents (CaO2, Fe3O4 and PTX) for controllable tumor therapy. The exposed CaO2 would react with water or acid in tumor cells to produce O-2 and H2O2, where the O-2 not only press PTX out of the capsule to accelerate its release, but reverse the hypoxic environment to inhibit the hypoxia-induced drug resistance for enhanced chemother-apy. The H2O2 would be further converted to cytotoxic hydroxyl radical by Fe3O4 via catalytic medicine (Fenton reaction), resulting in an enhanced anticancer activity. Near-infrared and tumor environment co-activated nanoplatform, Effective hypoxia inhibition, Promoted catalytic medicine, Low-resistance chemotherapy, Precise tumor therapy via chain activities (C) 2021 Elsevier Ltd. All rights reserved.
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| GB/T 7714 | Chen, Li , Yang, Tianfeng , Tian, Ran et al. Near-infrared and tumor environment Co-activated nanoplatform for precise tumor therapy in multiple models [J]. | APPLIED MATERIALS TODAY , 2021 , 24 . |
| MLA | Chen, Li et al. "Near-infrared and tumor environment Co-activated nanoplatform for precise tumor therapy in multiple models" . | APPLIED MATERIALS TODAY 24 (2021) . |
| APA | Chen, Li , Yang, Tianfeng , Tian, Ran , Yin, Tian , Weng, Lin , Bai, Yongkang et al. Near-infrared and tumor environment Co-activated nanoplatform for precise tumor therapy in multiple models . | APPLIED MATERIALS TODAY , 2021 , 24 . |
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Pancreatic Cancer (PC) is a severe form of malignancy all over the world. Delayed diagnosis and chemoresistance are the major factors contributing to its poor prognosis and high mortality rate. The genetic and epigenetic regulations of biological pathways further complicate the progression and chemotherapy response to this cancer. MicroRNAs (MiRNAs) involvement has been observed in all types of cancers including PC. The understanding and categorization of miRNAs according to their specific targets are very important to develop early diagnostic and therapeutic interventions. The current review, emphasizing recent research findings, has categorized miRNAs that directly target the potential onco-factors that act as central converging signal-nodes in five major cancer-related pathways i.e., MAPK/ERK, JAK/STAT, Wnt/β-catenin, AKT/mTOR, and TGFβ in PC. The therapeutic perspectives of miRNAs in PC have also been discussed. This will help to understand the interplay of various miRNAs within foremost signaling pathways and develop a multifactorial approach to treat difficult-to-treat PC.
Keyword ：
Clinical applications MicroRNAs Natural compounds Onco-targets
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| GB/T 7714 | Sarwar Ammar , Wang Bo , Su Qi et al. MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer. [J]. | Biochemical pharmacology , 2021 , 189 . |
| MLA | Sarwar Ammar et al. "MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer." . | Biochemical pharmacology 189 (2021) . |
| APA | Sarwar Ammar , Wang Bo , Su Qi , Zhang Yanmin . MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer. . | Biochemical pharmacology , 2021 , 189 . |
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Sufficient energy generation based on effective transport of nutrient via abundant blood vessels in tumor tissue and subsequent oxidative metabolism in mitochondria is critical for growth, proliferation and migration of tumor. Thus the strategy to cut off this transport pathway (blood vessels) and simultaneously close the power house (mitochondria) is highly desired for tumor treatment. Herein, we fabricated a bionic nanocarrier with core-shell-corona structure to give selective and effective tumor therapy via stepwise destruction of existed tumor vessel, inhibition of tumor angiogenesis and dysfunction of tumor mitochondria. The core of this bionic nanocarrier consists of combretastatin A4 phosphate (CA4P) and vitamin K2 (VK2) co-loaded mesoporous silica nanoparticle (MSNs), which is in charge of the vasculature destruction and mitochondrial dysfunction after cargos release. The N-tert-butylacrylamide (TBAM) and tri-sulfated N-acetylglucosamine (TSAG) shell served as artificial affinity reagent against vascular endothelial growth factor (VEGF) for angiogenesis inhibition. As to guarantee that these actions only happened in tumor, the hyaluronic acid (HA) corona was introduced to endow the nanocarrier with tumor targeting property and stimuli-responsiveness for accurate therapy. Both in vitro and in vivo results indicated that the CA4P/VK2-MSNs-TBAM/TSAG-HA (CVMMGH for short) nanocarrier combined well-controllable manipulation of tumor vasculature and tumor mitochondria to effectivly cut off the tumorigenic energy supply, which performed significant inhibition of tumor growth, demonstrating the great candidate of our strategy for effective tumor therapy. © 2021 Elsevier Ltd
Keyword ：
Blood Blood vessels Energy resources Hyaluronic acid Mitochondria Silica nanoparticles Tumors
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| GB/T 7714 | Yu, Xiaoqian , Su, Qi , Chang, Xiaowei et al. Multimodal obstruction of tumorigenic energy supply via bionic nanocarriers for effective tumor therapy [J]. | Biomaterials , 2021 , 278 . |
| MLA | Yu, Xiaoqian et al. "Multimodal obstruction of tumorigenic energy supply via bionic nanocarriers for effective tumor therapy" . | Biomaterials 278 (2021) . |
| APA | Yu, Xiaoqian , Su, Qi , Chang, Xiaowei , Chen, Kun , Yuan, Pingyun , Liu, Tao et al. Multimodal obstruction of tumorigenic energy supply via bionic nanocarriers for effective tumor therapy . | Biomaterials , 2021 , 278 . |
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