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Evolution of Protein Assemblies Driven by the Switching of Interplay Mode SCIE Scopus
期刊论文 | 2023 | ACS NANO
SCOPUS Cited Count: 2
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Abstract :

A protein assembly with the ability to switch interplay modes of multiple driving forces has been achieved. Although biomolecular systems driven by multiple driving forces have been exploited, work on such a protein assembly capable of switching the interplay modes at nanoscale has been rarely reported so far as a result of their great fabrication challenge. In this work, two sets of driving forces such as ligand-ligand interaction and protein-protein interaction were leveraged to antagonistically underpin the multilayered stackings and trigger the hollow evolution to afford the well-defined hollow rectangular frame of proteins. While these protein frames further collapsed into aggregates, the ligand-ligand interactions were weakened, and the interplay of two sets of driving forces thereby tended to switch into synergistic mode, converting the protein packing mode from porously loose packing to axially dense packing and thus giving rise to a morphological evolution toward a nanosized protein tube. This strategy not only provides a nanoscale understanding on the mechanism underlying the switch of interplay modes in the context of biomacromolecules but also may provide access for diverse sophisticated biomacromolecular nanostructures that are historically inaccessible for conventional self-assembly strategies.

Keyword :

evolution inducing ligand ligand-ligand interactions mode switch protein assembly

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GB/T 7714 Liu, Rongying , Li, Long , Chen, Shuyu et al. Evolution of Protein Assemblies Driven by the Switching of Interplay Mode [J]. | ACS NANO , 2023 .
MLA Liu, Rongying et al. "Evolution of Protein Assemblies Driven by the Switching of Interplay Mode" . | ACS NANO (2023) .
APA Liu, Rongying , Li, Long , Chen, Shuyu , Yang, Zhiwei , Kochovski, Zdravko , Mei, Shilin et al. Evolution of Protein Assemblies Driven by the Switching of Interplay Mode . | ACS NANO , 2023 .
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Polarization-Multiplexing Bessel Vortex Beams for Polarization Detection of Continuous Terahertz Waves SCIE Scopus
期刊论文 | 2023 | LASER & PHOTONICS REVIEWS
SCOPUS Cited Count: 12
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Abstract :

Determination of polarization states of electromagnetic waves plays a crucial role in photonic applications. However, it is very challenging to determine the polarization state of continuous terahertz (THz) waves. Here, a metasurface-like metallic waveguide array (MWA) is proposed to address this by measuring both the phase difference and amplitude ratio of its two orthogonal components based on generation and interference of polarization-multiplexing vortex beams. When a full-polarized THz wave passes through the MWA, its two orthogonal components will be converted into +1(st)- and -1(st)-order Bessel vortex beams, respectively. Their projection components in a proper polarized direction can interfere with each other, and their initial phase difference can be measured in real-time owing to its linear relationship with the azimuth of the dark fringe in interference patterns. The two Bessel beams can be further collected separately using a linear polarizer to obtain their amplitude ratio. Therefore, the polarization state of incident waves can be determined with both the phase difference and amplitude ratio. The proposed method enables a convenient polarization determination of continuous THz waves and has great potential for developing polarization-dependent investigations and applications in THz detection, communication, and sensing.

Keyword :

Bessel vortex beams metallic waveguide arrays polarization detection polarization-multiplexing terahertz waves

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GB/T 7714 Jiang, Zhao , Lu, Jinhui , Fan, Jiayu et al. Polarization-Multiplexing Bessel Vortex Beams for Polarization Detection of Continuous Terahertz Waves [J]. | LASER & PHOTONICS REVIEWS , 2023 .
MLA Jiang, Zhao et al. "Polarization-Multiplexing Bessel Vortex Beams for Polarization Detection of Continuous Terahertz Waves" . | LASER & PHOTONICS REVIEWS (2023) .
APA Jiang, Zhao , Lu, Jinhui , Fan, Jiayu , Liang, Jiaxuan , Zhang, Min , Su, Hong et al. Polarization-Multiplexing Bessel Vortex Beams for Polarization Detection of Continuous Terahertz Waves . | LASER & PHOTONICS REVIEWS , 2023 .
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Tunable Light Field Modulations with Chip- and Fiber-Compatible Monolithic Dielectric Metasurfaces SCIE Scopus
期刊论文 | 2023 , 13 (1) | NANOMATERIALS
SCOPUS Cited Count: 1
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Abstract :

Metasurfaces with a high engineering degree of freedom are promising building blocks for applications in metalenses, beam deflectors, metaholograms, sensing, and many others. Though the fundamental and technological challenges, proposing tunable metasurfaces is still possible. Previous efforts in this field are mainly taken on designing sophisticated structures with active materials introduced. Here, we present a generic kind of monolithic dielectric metasurfaces for tunable light field modulations. Changes in the period number and surrounding refractive index enable discrete and continuous modulations of spatial light fields, respectively. We exemplify this concept in monolithic Lithium Niobate metasurfaces for tunable metalenses and beam deflectors. The utilization of monolithic dielectric materials facilitates the ready integration of the metasurfaces with both chip and optical fiber platforms. This concept is not limited by the availability of active materials or expensive and time-consuming fabrication techniques, which can be applied to any transparent dielectric materials and various optical platforms.

Keyword :

chip platform fiber-optic platform light field modulations monolithic metasurfaces tunability

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GB/T 7714 Du, Bobo , Xu, Yunfan , Ding, Huimin et al. Tunable Light Field Modulations with Chip- and Fiber-Compatible Monolithic Dielectric Metasurfaces [J]. | NANOMATERIALS , 2023 , 13 (1) .
MLA Du, Bobo et al. "Tunable Light Field Modulations with Chip- and Fiber-Compatible Monolithic Dielectric Metasurfaces" . | NANOMATERIALS 13 . 1 (2023) .
APA Du, Bobo , Xu, Yunfan , Ding, Huimin , Jiang, Weitao , Zhang, Lei , Zhang, Yanpeng . Tunable Light Field Modulations with Chip- and Fiber-Compatible Monolithic Dielectric Metasurfaces . | NANOMATERIALS , 2023 , 13 (1) .
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Extraction of Naringin from Pomelo and Its Therapeutic Potentials against Hyperlipidemia SCIE Scopus
期刊论文 | 2022 , 27 (24) | MOLECULES
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Pomelo peel is a natural plant product with numerous pharmacological effects and is used in traditional Chinese medicine. In the present study, we extracted naringin from pomelo peel and aimed to decipher its therapeutic potential against hyperlipidemia. We used ultrasonic-assisted extraction to obtain naringin prior to identifying its structure, to evaluate its ability in binding sodium glycine cholate and sodium bovine cholate in vitro by simulating the gastrointestinal environment, so as to evaluate its blood lipid-lowering activity. The hyperlipidemia mouse model was established. Following the intragastric administration of naringin for 5 weeks, we measured the weight change, organ index, high-density lipoprotein cholesterol (HDL-C), serum total cholesterol (TC), serum triglycerides (TG), liver superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), low-density lipoprotein cholesterol (LDL-C) level, malondialdehyde (MDA), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) level of mice in the normal control and high-fat diet groups in addition to the high-, medium-, and low-dose naringin groups. The pathological changes in the liver were observed under a light microscope. The total RNA of the liver was extracted, and the mRNA expression level of lipid metabolism-related factors in mouse liver was detected via a fluorescence quantitative polymerase chain reaction (PCR). Naringin significantly (p < 0.01) reduced the body weight, organ index, serum TG, LDL-C, and TC levels of hyperlipidemic mice, but increased the serum HDL-C levels (p < 0.01). Furthermore, naringin increased GSH Px and SOD activity (p < 0.01), while decreasing MDA, ALT, and AST levels, as well as the liver index (p < 0.01). There was no statistically significant difference in the brain, heart, spleen, kidney, and other indicators (p > 0.05). A histopathological analysis of mouse liver showed that naringin could alleviate the degenerative damage of fatty liver cells in hyperlipidemic mice. Naringin could significantly (p < 0.01) reduce the expression of FAS and SREBP-1c mRNA, and simultaneously increase PPAR alpha mRNA expression. This study shows that naringin has the strong effect of lowering lipids and protecting the liver in hyperlipidemic mice. Our findings underscore the anti-hyperlipidemia potential of naringin and increase the scientific understanding of its anti-hyperlipidemia effects, that may lead to its potential application as a dietary strategy for hyperlipidemia management in the future.

Keyword :

anti-hyperlipidemic naringin organ index pomelo peel process condition

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GB/T 7714 Yu, Xiaolei , Meng, Xin , Yan, Yidi et al. Extraction of Naringin from Pomelo and Its Therapeutic Potentials against Hyperlipidemia [J]. | MOLECULES , 2022 , 27 (24) .
MLA Yu, Xiaolei et al. "Extraction of Naringin from Pomelo and Its Therapeutic Potentials against Hyperlipidemia" . | MOLECULES 27 . 24 (2022) .
APA Yu, Xiaolei , Meng, Xin , Yan, Yidi , Wang, Hui , Zhang, Lei . Extraction of Naringin from Pomelo and Its Therapeutic Potentials against Hyperlipidemia . | MOLECULES , 2022 , 27 (24) .
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Superior terahertz sensing metasurface based on ultrahigh-Q toroidal dipole governed by quasi-BIC SCIE Scopus
期刊论文 | 2022 , 139 (5) | EPL
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Abstract :

Sharp quasi-bound states in the continuum (quasi-BIC) in all-dielectric metasurfaces with high quality-factor (Q-factor) resonance provide an important platform for terahertz (THz) sensing technology because of its ability to enhance the strong light-matter interaction between THz waves and analytes. In this paper, we propose an ultrasensitive sensing substrate based on an all-dielectric metasurface consisting of an array of stacked high-index structures. By introducing a geometry asymmetry along the horizontal direction in the unit cell, a toroidal-dipole-dominated quasi-BIC transitioned from a distorted symmetry-protected BIC is excited with a Q-factor as high as 2.5 x 10(6), which could maintain at a high level as the structure geometry varies. After characterizing the surface sensing performance, an ultrahigh surface sensitivity is achieved to be 263 GHz per refractive index unit, while the resultant figure of merit reaches 2.5 x 10(6), which outperforms the existing designs. The proposed metasurface is promising for superior label-free sensing performance at THz regime. Copyright (C) 2022 EPLA

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GB/T 7714 Zhao, Jing , Zhang, Lei , Li, Yongdong . Superior terahertz sensing metasurface based on ultrahigh-Q toroidal dipole governed by quasi-BIC [J]. | EPL , 2022 , 139 (5) .
MLA Zhao, Jing et al. "Superior terahertz sensing metasurface based on ultrahigh-Q toroidal dipole governed by quasi-BIC" . | EPL 139 . 5 (2022) .
APA Zhao, Jing , Zhang, Lei , Li, Yongdong . Superior terahertz sensing metasurface based on ultrahigh-Q toroidal dipole governed by quasi-BIC . | EPL , 2022 , 139 (5) .
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Casted MoS2 nanostructures and their Raman properties EI SCIE Scopus
期刊论文 | 2022 , 14 (29) , 10449-10455 | NANOSCALE
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Abstract :

Two-dimensional (2D) transition metal dichalcogenides (TMDCs) have been widely investigated for optoelectronic applications. Here, by employing the nanocasting method, molybdenum disulfide (MoS2) nanostructures, including supercrystals, nanoparticles and nanowires, are synthesized with curved features by changing the precursor concentration and template types. The Raman properties of different MoS2 nanostructures are investigated by varying the laser power under both resonant and non-resonant excitations. The defect disorder induced LA(M) mode and other silent Raman modes in planar 2D materials are clearly observed under the resonant excitation. We believe that the varying optical properties of TMDC nanostructures will greatly broaden the optoelectronic applications of 2D materials.

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GB/T 7714 Hao, Rui , Li, Xiaodie , Zhang, Lingling et al. Casted MoS2 nanostructures and their Raman properties [J]. | NANOSCALE , 2022 , 14 (29) : 10449-10455 .
MLA Hao, Rui et al. "Casted MoS2 nanostructures and their Raman properties" . | NANOSCALE 14 . 29 (2022) : 10449-10455 .
APA Hao, Rui , Li, Xiaodie , Zhang, Lingling , Zhang, Lei , You, Hongjun , Fang, Jixiang . Casted MoS2 nanostructures and their Raman properties . | NANOSCALE , 2022 , 14 (29) , 10449-10455 .
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Light modulation based on the enhanced Kerr effect in molybdenum disulfide nanostructures with curved features SCIE Scopus
期刊论文 | 2022 , 24 (20) , 12208-12213 | PHYSICAL CHEMISTRY CHEMICAL PHYSICS
SCOPUS Cited Count: 1
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Abstract :

A novel type of molybdenum disulfide (MoS2) nanoparticles (NPs) was chemically synthesized, which possessed curved features with three-dimensional (3D) freedom compared with planar two-dimensional (2D) materials. Due to the introduction of curved features, the synthesized NPs exhibited a strongly enhanced nonlinear refractive index (n(2) similar to 10(-5) cm(-2) W-1) and third-order susceptibility (chi((3)) similar to 10(-7) esu), which were experimentally verified by the spatial self-phase modulation effect in the visible wavelength range. Both the nonlinear parameters were two orders of magnitude higher than their planar MoS2 nanostructure counterparts. In addition, the relative change of the effective nonlinear refractive index Delta n(2)/n(2) was found to be distinctly dependent on the intensity of the applied electromagnetic field. Moreover, an all-optical modulation was experimentally realized based on the spatial cross-phase modulation effect. Our results demonstrate planar MoS2 materials with 3D features as potential candidates for next generation all-optical applications and open a substantial approach for the design of efficient nanomaterials with favorable optical nonlinearity.

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GB/T 7714 Li, Tianlun , Li, Xiaodie , Gao, Duorui et al. Light modulation based on the enhanced Kerr effect in molybdenum disulfide nanostructures with curved features [J]. | PHYSICAL CHEMISTRY CHEMICAL PHYSICS , 2022 , 24 (20) : 12208-12213 .
MLA Li, Tianlun et al. "Light modulation based on the enhanced Kerr effect in molybdenum disulfide nanostructures with curved features" . | PHYSICAL CHEMISTRY CHEMICAL PHYSICS 24 . 20 (2022) : 12208-12213 .
APA Li, Tianlun , Li, Xiaodie , Gao, Duorui , Mao, Jianyong , Hou, Yaping , Chen, Hui et al. Light modulation based on the enhanced Kerr effect in molybdenum disulfide nanostructures with curved features . | PHYSICAL CHEMISTRY CHEMICAL PHYSICS , 2022 , 24 (20) , 12208-12213 .
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Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4 SCIE Scopus
期刊论文 | 2022 , 604 (7907) , 771-+ | NATURE
SCOPUS Cited Count: 37
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Abstract :

Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family of receptors that often undergo autoproteolysis to produce alpha and beta subunits(1-3). A tethered agonism mediated by the 'Stachel sequence' of the beta subunit has been proposed to have central roles in aGPCR activation(4-6). Here we present three cryo-electron microscopy structures of aGPCRs coupled to the G(s) heterotrimer. Two of these aGPCRs are activated by tethered Stachel sequences-the ADGRG2-beta-G(s) complex and the ADGRG4-beta-G(s) complex (in which beta indicates the beta subunit of the aGPCR)-and the other is the full-length ADGRG2 in complex with the exogenous ADGRG2 Stachel-sequence-derived peptide agonist IP15 (ADGRG2(FL)-IP15-G(s)). The Stachel sequences of both ADGRG2-beta and ADGRG4-beta assume a U shape and insert deeply into the seven-transmembrane bundles. Constituting the FX phi phi phi X phi motif (in which cp represents a hydrophobic residue), five residues ofADGRG2-beta or ADGRG4-beta extend like fingers to mediate binding to the seven-transmembrane domain and activation of the receptor. The structure of the ADGRG2(FL)-IP15-G(s) complex reveals the structural basis for the improved binding affinity of IP15 compared with VPM-p15 and indicates that rational design of peptidic agonists could be achieved by exploiting aGPCR-beta structures. By converting the 'finger residues' to acidic residues, we develop a method to generate peptidic antagonists towards several aGPCRs. Collectively, our study provides structural and biochemical insights into the tethered activation mechanism of aGPCRs.

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GB/T 7714 Xiao, Peng , Guo, Shengchao , Wen, Xin et al. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4 [J]. | NATURE , 2022 , 604 (7907) : 771-+ .
MLA Xiao, Peng et al. "Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4" . | NATURE 604 . 7907 (2022) : 771-+ .
APA Xiao, Peng , Guo, Shengchao , Wen, Xin , He, Qing-Tao , Lin, Hui , Huang, Shen-Ming et al. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4 . | NATURE , 2022 , 604 (7907) , 771-+ .
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Quasi-BIC Based Low-Voltage Phase Modulation on Lithium Niobite Metasurface EI SCIE Scopus
期刊论文 | 2022 , 34 (20) , 1077-1080 | IEEE PHOTONICS TECHNOLOGY LETTERS
SCOPUS Cited Count: 1
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Efficient phase modulation plays a key role in optical and electro-optic (EO) devices. The rising metasurfaces provide a versatile platform for flexible phase control within subwavelength scale. Lithium niobate (LN) with excellent optical properties is one of the most outstanding EO materials. Here, we numerically design a LN-based metasurface which consists of two identical nanobars in each unit cell. By slightly breaking the structure symmetry, a quasi-bound state in the continuum (quasi-BIC) is excited with a high quality-factor (Q-factor), which also holds a strong local field enhancement. Significantly, by taking advantage of the EO effect of LN, the reflection phase delay can be modulated in the range of 0-pi using an external voltage as low as 14 V. Simultaneously, the reflectivity remains higher than 30% as voltage varies. Our design suggests a promising scheme for metasurface-based spatial light modulators.

Keyword :

Bound state in the continuum electro-optic effect lithium niobite phase modulator

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GB/T 7714 Xu, Yunfan , Zhang, Lei , Du, Bobo et al. Quasi-BIC Based Low-Voltage Phase Modulation on Lithium Niobite Metasurface [J]. | IEEE PHOTONICS TECHNOLOGY LETTERS , 2022 , 34 (20) : 1077-1080 .
MLA Xu, Yunfan et al. "Quasi-BIC Based Low-Voltage Phase Modulation on Lithium Niobite Metasurface" . | IEEE PHOTONICS TECHNOLOGY LETTERS 34 . 20 (2022) : 1077-1080 .
APA Xu, Yunfan , Zhang, Lei , Du, Bobo , Chen, Hui , Hou, Yaping , Li, Tianlun et al. Quasi-BIC Based Low-Voltage Phase Modulation on Lithium Niobite Metasurface . | IEEE PHOTONICS TECHNOLOGY LETTERS , 2022 , 34 (20) , 1077-1080 .
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Third-Order Nonlinear Effect and Polarization-Dependent Modulation Using Spherical-Like MoS2 Nanoparticles EI SCIE Scopus
期刊论文 | 2022 , 535 (1) | ANNALEN DER PHYSIK
SCOPUS Cited Count: 1
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Abstract :

A type of MoS2 nanoparticle with a spherical-like shape is chemically synthesized with favorable third-order and suppressed second-order nonlinear optical response, which results from the isotropy induced by the geometrical uniformity of nanoparticles and an artificial symmetry center. It is found that the linewidth of third harmonic signal is broadened due to the self-phase modulation effect, another third-order nonlinearity. Moreover, the intensity of harmonic signal can be conveniently adjusted by controlling the polarization state of applied optical field. The artificially designed material morphology may provide a reference for designing all-optical modulation devices.

Keyword :

isotropy medium nonlinear optics polarization dependence third harmonic generation transition metal dichalcogenide materials

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GB/T 7714 Li, Tianlun , Hao, Rui , Hou, Yaping et al. Third-Order Nonlinear Effect and Polarization-Dependent Modulation Using Spherical-Like MoS2 Nanoparticles [J]. | ANNALEN DER PHYSIK , 2022 , 535 (1) .
MLA Li, Tianlun et al. "Third-Order Nonlinear Effect and Polarization-Dependent Modulation Using Spherical-Like MoS2 Nanoparticles" . | ANNALEN DER PHYSIK 535 . 1 (2022) .
APA Li, Tianlun , Hao, Rui , Hou, Yaping , Gao, Duorui , Xu, Yunfan , Zhang, Yanpeng et al. Third-Order Nonlinear Effect and Polarization-Dependent Modulation Using Spherical-Like MoS2 Nanoparticles . | ANNALEN DER PHYSIK , 2022 , 535 (1) .
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