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Investigation of the tack force of poultices using the probe tack test SCIE Scopus
期刊论文 | 2022 | JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
SCOPUS Cited Count: 1
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Abstract :

Only a few systematic tack force studies have been conducted on poultices although they are widely used in therapeutic fields. In this study, we evaluated the factors influencing the tack force of poultices using the design of experiments (DoE) approach. The effects of detachment speed, pressuring time, pressuring force, coating thickness, carbomer content, and active pharmaceutical integrant (API) content on adhesion performance were evaluated using 46 response surface designs, after which the maximum value of the stress curve (sigma(max)) was recorded. The results revealed that all factors except pressuring time significantly affected the response (at the 5% level), and two-factor interactions were identified using the DoE approach to evaluate carbomer content, pressuring force, coating thickness, and API content.

Keyword :

Indomethacin poultices multi-factor probe tack force

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GB/T 7714 Chen, Hua , Ma, Xun , Xu, Daiyue et al. Investigation of the tack force of poultices using the probe tack test [J]. | JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY , 2022 .
MLA Chen, Hua et al. "Investigation of the tack force of poultices using the probe tack test" . | JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY (2022) .
APA Chen, Hua , Ma, Xun , Xu, Daiyue , Chen, Guang , He, Langchong . Investigation of the tack force of poultices using the probe tack test . | JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY , 2022 .
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Enhanced stability designs of cell membrane chromatography for screening drug leads EI SCIE Scopus
期刊论文 | 2022 , 45 (14) , 2498-2507 | JOURNAL OF SEPARATION SCIENCE
SCOPUS Cited Count: 5
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Abstract :

Cell membrane chromatography is an effective method for screening bioactive components acting on specific receptors in complex systems, which maintains the biological activity of the membrane receptors and improves screening efficiency. However, traditional cell membrane chromatography suffers from poor stability, resulting in a limited life span and low reproducibility, greatly limiting the application of this method. To address this problem, cyanuric chloride-decorated silica gel was used for the covalent immobilization of the cell membranes. Cyanuric chloride reacts with amino groups on the cell membranes and membrane receptors to form covalent bonds. In this way, the cell membranes are not easy to fall off. The column life of the cyanuric chloride-decorated epidermal growth factor receptor/cell membrane chromatography column was extended to more than 8 days, whereas the column life of the normal cell membrane chromatography column dropped sharply in the first 3 days. A cyanuric chloride-decorated epidermal growth factor receptor/cell membrane chromatography online HPLC-IT-TOF-MSn system was applied for screening drug leads from Trifolium pratense L. One potential drug lead, formononetin, which acts on the epidermal growth factor receptor, was screened. Our strategy of covalently immobilizing cell membrane receptors also improved the stability of cell membrane chromatography.

Keyword :

cell membrane chromatography epidermal growth factor receptor traditional Chinese medicine

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GB/T 7714 Fu, Jia , Jia, Qianqian , Liang, Peida et al. Enhanced stability designs of cell membrane chromatography for screening drug leads [J]. | JOURNAL OF SEPARATION SCIENCE , 2022 , 45 (14) : 2498-2507 .
MLA Fu, Jia et al. "Enhanced stability designs of cell membrane chromatography for screening drug leads" . | JOURNAL OF SEPARATION SCIENCE 45 . 14 (2022) : 2498-2507 .
APA Fu, Jia , Jia, Qianqian , Liang, Peida , Wang, Saisai , Zhou, Huaxin , Zhang, Liyang et al. Enhanced stability designs of cell membrane chromatography for screening drug leads . | JOURNAL OF SEPARATION SCIENCE , 2022 , 45 (14) , 2498-2507 .
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Simultaneous determination of fat-soluble vitamins and carotenoids in human serum using a nanostructured ionic liquid based microextraction method EI SCIE Scopus
期刊论文 | 2022 , 1666 | JOURNAL OF CHROMATOGRAPHY A
SCOPUS Cited Count: 10
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Abstract :

The determination of fat-soluble vitamins and carotenoids in human serum provides reliable information for diagnosing malnutrition and for establishing appropriate intervention programs. Due to the complex composition of the biological samples, the efficient sample preparation is the key to the analysis. We report here a surface active ionic liquid (SAIL)-based dispersive liquid-liquid microextraction (DLLME) method coupled with a high performance liquid chromatography (HPLC) to determine four fat-soluble vitamins and six carotenoids in human serum simultaneously. Liquid crystal structures were formed in the extract phase. And the enrichment factor of the analytes treated by DLLME was 4 to 26 times of the traditional LLE method except lycopene. The limit of determination for these compounds was determined to be between 0.002 and 0.076 mu g/mL. The accuracy was validated by the standard addition method with recoveries ranging from 82.4 to 114.1%. The intra-day and inter-day relative standard deviations were 2.76-12.63% and 4.01-13.54%, respectively. The proposed DLLME coupled with the HPLC method was successfully applied in the determination of fat-soluble micronutrients in human serum. (c) 2022 Elsevier B.V. All rights reserved.

Keyword :

Carotenoids DLLME Fat-soluble vitamins Human serum Surface-active ionic liquid

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GB/T 7714 Kong, Liyun , Wang, Jiaqi , Gao, Qingpeng et al. Simultaneous determination of fat-soluble vitamins and carotenoids in human serum using a nanostructured ionic liquid based microextraction method [J]. | JOURNAL OF CHROMATOGRAPHY A , 2022 , 1666 .
MLA Kong, Liyun et al. "Simultaneous determination of fat-soluble vitamins and carotenoids in human serum using a nanostructured ionic liquid based microextraction method" . | JOURNAL OF CHROMATOGRAPHY A 1666 (2022) .
APA Kong, Liyun , Wang, Jiaqi , Gao, Qingpeng , Li, Xiaoqian , Zhang, Wenbin , Wang, Ping et al. Simultaneous determination of fat-soluble vitamins and carotenoids in human serum using a nanostructured ionic liquid based microextraction method . | JOURNAL OF CHROMATOGRAPHY A , 2022 , 1666 .
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Clarithromycin-treated chronic spontaneous urticaria with the negative regulation of FceRI and MRGPRX2 activation via CD300f SCIE Scopus
期刊论文 | 2022 , 110 | INTERNATIONAL IMMUNOPHARMACOLOGY
SCOPUS Cited Count: 2
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Abstract :

Mast cells (MCs) are main effector cells in chronic spontaneous urticaria (CSU). Both Fc epsilon RI (FceRI)-and MAS-related G coupled receptor-X2 (MRGPRX2)-mediated MC activations affect CSU course. Leukocyte mono-immunoglobulin-like receptor 3 (CD300f) has been shown to regulate FceRI activation. However, no study has verified CD300f is a target to cure CSU. Therefore this study aimed to verify whether clarithromycin (CLA) regulates FceRI-and MRGPRX2-mediated MC activations via CD300f and shows therapeutic effect on CSU. The target of CLA was verification. CLA inhibited FceRI-and MRGPRX2-mediated MC activations were shown in vivo and in vitro. A single-center, self-comparison study was performed, and CLA-treated CSU was investigated in 28 patients who were not sensitive to the third-generation antihistamines. Serum inflammatory mediators in pa-tients before and after CLA administration were analyzed. CLA effectively inhibited type I anaphylactic reactions and pseudo-allergic reactions in mice. Moreover, CLA inhibited FceRI-and MRGPRX2-mediated MC signaling pathway activation. Regulatory effects of CLA were decreased significantly after CD300f knockdown. CLA effectively alleviated the symptoms of wheal and itch and reduced serum cytokine levels in patients. CLA negatively regulated FceRI-and MRGPRX2-mediated MC activation via CD300f and showed significant thera-peutic effect on CSU.

Keyword :

Chronic spontaneous urticarial Clarithromycin Leukocyte mono-immunoglobulin-like receptor 3 Mast cell Negatively regulation

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GB/T 7714 Che, Delu , Zhang, Tao , Zhang, Tianxiao et al. Clarithromycin-treated chronic spontaneous urticaria with the negative regulation of FceRI and MRGPRX2 activation via CD300f [J]. | INTERNATIONAL IMMUNOPHARMACOLOGY , 2022 , 110 .
MLA Che, Delu et al. "Clarithromycin-treated chronic spontaneous urticaria with the negative regulation of FceRI and MRGPRX2 activation via CD300f" . | INTERNATIONAL IMMUNOPHARMACOLOGY 110 (2022) .
APA Che, Delu , Zhang, Tao , Zhang, Tianxiao , Zheng, Yi , Hou, Yajing , Geng, Songmei et al. Clarithromycin-treated chronic spontaneous urticaria with the negative regulation of FceRI and MRGPRX2 activation via CD300f . | INTERNATIONAL IMMUNOPHARMACOLOGY , 2022 , 110 .
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MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix SCIE Scopus
期刊论文 | 2022 , 414 (19) , 5741-5753 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
SCOPUS Cited Count: 8
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Abstract :

Pseudo-allergic reactions (PARs) are IgE-independent hypersensitivity reactions. Mas-related G protein-coupled receptor-X2 (MrgX2) was proved the key receptor of PAR. The anti-pseudo-allergic compound discovery based on MrgX2 was of great value. Cell membrane chromatography (CMC) based on MrgX2 provides a convenient and effective tool in anti-pseudoallergic compound screening and discovery, and further improvements of this method are still needed. In this work, SNAP-tag was introduced at C-terminal of Mas-related G protein-coupled receptor (MrgX2-SNAP-tag), and an MrgX2-SNAP-tag/ CMC model was then conducted using CMC technique. Comparative experiments showed that the new model not only satisfied the good selectivity and specificity of screening but also exhibited more stable and longer life span than traditional MrgX2/CMC model. By coupling with HPLC-MS, two compounds were screened out from Arnebiae Radix and identified as shikonin and acetylshikonin. Nonlinear chromatography was performed to study the interactions between two screened compounds and MrgX2, and binding constant (K-A) of shikonin and acetylshikonin with MrgX2 were 2075.67 +/- 0.34 M-1 and 32201.36 +/- 0.35 M-1, respectively. Furthermore, beta-hexosaminidase and histamine release assay in vitro demonstrated that shikonin (1-5 mu M) and acetylshikonin (2.5-10 mu M) could both antagonize C48/80-induced allergic reaction. In conclusion, the MrgX2-SNAP-tag/CMC could be a reliable model for screening pseudo-allergy-related components from complex systems.

Keyword :

Anti-pseudo-allergic Arnebiae Radix Cell membrane chromatography MrgX2 SNAP-tag

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GB/T 7714 Jia, Qianqian , Fu, Jia , Gao, Chunlei et al. MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix [J]. | ANALYTICAL AND BIOANALYTICAL CHEMISTRY , 2022 , 414 (19) : 5741-5753 .
MLA Jia, Qianqian et al. "MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix" . | ANALYTICAL AND BIOANALYTICAL CHEMISTRY 414 . 19 (2022) : 5741-5753 .
APA Jia, Qianqian , Fu, Jia , Gao, Chunlei , Wang, Hong , Wang, Saisai , Liang, Peida et al. MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix . | ANALYTICAL AND BIOANALYTICAL CHEMISTRY , 2022 , 414 (19) , 5741-5753 .
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Purification and determination of antibody drugs in bio-samples by EGFR/ cell membrane chromatography method SCIE Scopus
期刊论文 | 2022 , 217 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
SCOPUS Cited Count: 1
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Abstract :

With the rapid development of therapeutic monoclonal antibody drugs, it is increasingly difficult to meet clinical needs using traditional antibody purification techniques. In this study, epidermal growth factor receptor (EGFR)SNAP-tag was expressed in HEK293 cells. Then we captured the EGFR-SNAP-tag from the cell membrane suspension onto a O-6-benzylguanine-modified silica gel to prepare a new EGFR stationary phase as a bioactive material, which could specifically recognize its antibody in bio-samples. The EGFR stationary phase was systematically characterized via scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and fourier transform infrared spectroscopy. Then we used EGFR stationary phase to establish a new EGFR cell membrane chromatography (CMC) model. The EGFR/CMC-online-ion exchange chromatography (IEC)/high performance liquid chromatography (HPLC) was established for the efficient purification and specific identification of cetuximab, nituzumab, and panizumab from cell culture medium and human serum. The results show that the EGFR stationary phase prepared by one-step immobilized technique can maintain biological activity and stability like EGFR in cell membrane. The EGFR/CMC-online-IEC/HPLC method has a high specificity, accuracy and sensitivity. Therefore, it will present a valuable method for the purification, identification, and analysis of monoclonal antibody drugs.

Keyword :

Antibody purification cell Epidermal growth factor receptor membrane chromatography SNAP-tag

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GB/T 7714 Fu, Jia , Lv, Yanni , Jia, Qianqian et al. Purification and determination of antibody drugs in bio-samples by EGFR/ cell membrane chromatography method [J]. | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS , 2022 , 217 .
MLA Fu, Jia et al. "Purification and determination of antibody drugs in bio-samples by EGFR/ cell membrane chromatography method" . | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 217 (2022) .
APA Fu, Jia , Lv, Yanni , Jia, Qianqian , Wang, Cheng , Wang, Saisai , Liang, Peida et al. Purification and determination of antibody drugs in bio-samples by EGFR/ cell membrane chromatography method . | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS , 2022 , 217 .
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Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2 SCIE PubMed
期刊论文 | 2021 , 93 (5) , 3143-3151 | JOURNAL OF MEDICAL VIROLOGY
WoS CC Cited Count: 10
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Abstract :

Since December 2019, the new coronavirus (also known as severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2, 2019-nCoV])-induced disease, COVID-19, has spread rapidly worldwide. Studies have reported that the traditional Chinese medicine Salvia miltiorrhiza possesses remarkable antiviral properties; however, the anti-coronaviral activity of its main components, salvianolic acid A (SAA), salvianolic acid B (SAB), and salvianolic acid C (SAC) is still debated. In this study, we used Cell Counting Kit-8 staining and flow cytometry to evaluate the toxicity of SAA, SAB, and SAC on ACE2 (angiotensin-converting enzyme 2) high-expressing HEK293T cells (ACE2(h) cells). We found that SAA, SAB, and SAC had a minor effect on the viability of ACE2(h) cells at concentrations below 100 mu M. We further evaluated the binding capacity of SAA, SAB, and SAC to ACE2 and the spike protein of 2019-nCoV using molecular docking and surface plasmon resonance. They could bind to the receptor-binding domain (RBD) of the 2019-nCoV with a binding constant (K-D) of (3.82 +/- 0.43) e-6 M, (5.15 +/- 0.64)e-7 M, and (2.19 +/- 0.14)e-6 M; and bind to ACE2 with K-D (4.08 +/- 0.61)e-7 M, (2.95 +/- 0.78)e-7 M, and (7.32 +/- 0.42)e-7 M, respectively. As a result, SAA, SAB, and SAC were determined to inhibit the entry of 2019-nCoV Spike pseudovirus with an EC50 of 11.31, 6.22, and 10.14 mu M on ACE2(h) cells, respectively. In conclusion, our study revealed that three Salvianolic acids can inhibit the entry of 2019-nCoV spike pseudovirus into ACE2(h) cells by binding to the RBD of the 2019-nCoV spike protein and ACE2 protein.

Keyword :

2019&#8208 ACE2 nCoV salvianolic acid A salvianolic acid B salvianolic acid C

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GB/T 7714 Hu, Shiling , Wang, Jue , Zhang, Yongjing et al. Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2 [J]. | JOURNAL OF MEDICAL VIROLOGY , 2021 , 93 (5) : 3143-3151 .
MLA Hu, Shiling et al. "Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2" . | JOURNAL OF MEDICAL VIROLOGY 93 . 5 (2021) : 3143-3151 .
APA Hu, Shiling , Wang, Jue , Zhang, Yongjing , Bai, Haoyun , Wang, Cheng , Wang, Nan et al. Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2 . | JOURNAL OF MEDICAL VIROLOGY , 2021 , 93 (5) , 3143-3151 .
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Substance P-induced lung inflammation in mice is mast cell dependent SCIE PubMed Scopus
期刊论文 | 2021 , 52 (1) , 46-58 | CLINICAL AND EXPERIMENTAL ALLERGY
WoS CC Cited Count: 2 SCOPUS Cited Count: 6
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Abstract :

Background Allergic asthma is a common inflammatory lung disease and a major health problem worldwide. Mast cells (MCs) play a key role in the early-stage pathophysiology of allergic asthma. Substance P (SP) functions in neurogenic inflammation by activating MCs, and therefore, it may to participate in the occurrence and development of asthma. Objective We examined the relationship between SP and lung inflammation, and also whether SP can directly trigger asthma. Methods We measured the number of peripheral blood eosinophils, neutrophils and basophils and evaluated the levels of IgE and SP in blood samples of 86 individuals with allergic asthma. Serum IgE and SP levels were also determined in 29 healthy individuals. C57BL/6 mice were subjected to different doses of SP, and bronchoalveolar lavage fluid (BALF) was collected to count the inflammatory cells. Lung tissues were analysed using histopathological methods to evaluate lung peribronchial inflammation, fibrosis and glycogen deposition. Levels of IgE, interleukin (IL)-1, IL-2, IL-4, IL-5, IL-13, IL-17 and IFN-gamma were determined in mouse serum. Results Substance P levels were increased in the serum samples of patients with asthma. SP induced mouse lung peribronchial inflammation, fibrosis and glycogen deposition, with high levels of Th2-related cytokines such as IL-4, IL-5 and IL-13 observed in the BALF. Furthermore, low level of total IgE was noted in the serum, and SP had little effect on MC-deficient kit(W-sh/W-sh) mice. Conclusions & clinical relevance Substance P levels increased significantly in serum of asthmatic patients and independently associated with the risk of asthma. Furthermore, SP induced Th2 lung inflammation in mice, which was dependent on MCs.

Keyword :

asthma mast cell SP Th2

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GB/T 7714 Wang, Nan , Wang, Jue , Zhang, Yongjing et al. Substance P-induced lung inflammation in mice is mast cell dependent [J]. | CLINICAL AND EXPERIMENTAL ALLERGY , 2021 , 52 (1) : 46-58 .
MLA Wang, Nan et al. "Substance P-induced lung inflammation in mice is mast cell dependent" . | CLINICAL AND EXPERIMENTAL ALLERGY 52 . 1 (2021) : 46-58 .
APA Wang, Nan , Wang, Jue , Zhang, Yongjing , Hu, Shiling , Zhang, Tianxiao , Wu, Yuanyuan et al. Substance P-induced lung inflammation in mice is mast cell dependent . | CLINICAL AND EXPERIMENTAL ALLERGY , 2021 , 52 (1) , 46-58 .
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A paper-based ELISA for rapid sensitive determination of anaphylaxis-related MRGPRX2 in human peripheral blood EI SCIE PubMed
期刊论文 | 2021 , 633 | Analytical Biochemistry
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Mas-related G-protein-coupled receptor X2 (MRGPRX2) has recently been reported to be associated with anaphylaxis. Detection of MRGPRX2 levels in human peripheral blood might serve as a powerful tool for predicting the predisposition of patients to anaphylactic reactions. For rapid measurement of MRGPRX2, we established a paper-based double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) using mouse monoclonal antibody and horseradish peroxidase (HRP)-labelled rabbit polyclonal antibody as capture antibody and detection antibody, respectively. We avoided chemical functionalization of the cellulose paper by introducing bovine serum albumin (BSA) to provide COOH and NH2 groups for covalent immobilization of the capture antibody. Through amide condensation, a two-layer immobilization strategy was applied with BSA-BSA and BSA-capture antibody networks as the first and second layers, respectively. This strategy improved the quantity, activity and stability of the immobilized antibody. We then established a paper-based ELISA to detect MRGPRX2 in human peripheral blood. Our method is less laborious, easier to implement, and more cost-effective than conventional ELISA, while offering similar sensitivity, specificity, and accuracy. Therefore, it could serve as an innovative clinical point-of-care diagnostic tool, especially in areas that lack advanced clinical equipment. © 2021 Elsevier Inc.

Keyword :

Amides Blood Chemical detection Cost effectiveness Diagnosis Mammals Monoclonal antibodies Paper

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GB/T 7714 Ding, Yuanyuan , Li, Xiaoqian , Gao, Qingpeng et al. A paper-based ELISA for rapid sensitive determination of anaphylaxis-related MRGPRX2 in human peripheral blood [J]. | Analytical Biochemistry , 2021 , 633 .
MLA Ding, Yuanyuan et al. "A paper-based ELISA for rapid sensitive determination of anaphylaxis-related MRGPRX2 in human peripheral blood" . | Analytical Biochemistry 633 (2021) .
APA Ding, Yuanyuan , Li, Xiaoqian , Gao, Qingpeng , Dong, Xinyan , Kong, Liyun , Han, Shengli et al. A paper-based ELISA for rapid sensitive determination of anaphylaxis-related MRGPRX2 in human peripheral blood . | Analytical Biochemistry , 2021 , 633 .
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Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis SCIE PubMed
期刊论文 | 2021 , 338 | CHEMICO-BIOLOGICAL INTERACTIONS
WoS CC Cited Count: 8
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Abstract :

Currently, there is an urgent need to find a treatment for the highly infectious coronavirus disease (COVID-19). However, the development of a new, effective, and safe vaccine or drug often requires years and poses great risks. At this critical stage, there is an advantage in using existing clinically approved drugs to treat COVID-19. In this study, in vitro severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike pseudotyped viral infection experiments indicated that histamine H-1 antagonists loratadine (LOR) and desloratadine (DES) could prevent entry of the pseudotyped virus into ACE2-overexpressing HEK293T cells and showed that DES was more effective. Further binding experiments using cell membrane chromatography and surface plasmon resonance demonstrated that both antagonists could bind to ACE2 and that the binding affinity of DES was much stronger than that of LOR. Molecular docking results elucidated that LOR and DES could bind to ACE2 on the interface of the SARS-CoV-2-binding area. Additionally, DES could form one hydrogen bond with LYS31 but LOR binding relied on non-hydrogen bonds. To our knowledge, this study is the first to demonstrate the inhibitory effect of LOR and DES on SARS-CoV-2 spike pseudotyped virus viropexis by blocking spike protein-ACE2 interaction. This study may provide a new strategy for finding an effective therapeutic option for COVID-19.

Keyword :

ACE2 COVID-19 Desloratadine Loratadine SARS-CoV-2

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GB/T 7714 Hou, Yajing , Ge, Shuai , Li, Xiaowei et al. Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis [J]. | CHEMICO-BIOLOGICAL INTERACTIONS , 2021 , 338 .
MLA Hou, Yajing et al. "Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis" . | CHEMICO-BIOLOGICAL INTERACTIONS 338 (2021) .
APA Hou, Yajing , Ge, Shuai , Li, Xiaowei , Wang, Cheng , He, Huaizhen , He, Langchong . Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis . | CHEMICO-BIOLOGICAL INTERACTIONS , 2021 , 338 .
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