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Refined assessment of heavy metal-associated health risk due to the consumption of traditional animal medicines in humans SCIE
期刊论文 | 2019 , 191 (3) | ENVIRONMENTAL MONITORING AND ASSESSMENT
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Abstract :

Little is known about the extent of heavy metal accumulation in traditional Chinese medicines (TCMs). In this study, the levels of lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) in traditional animal medicines were monitored using inductively coupled plasma mass spectroscopy (ICP-MS). Additionally, for the first time, a heavy metal risk assessment strategy was used to evaluate the potential risks of traditional animal medicines by calculating estimated daily intake (EDI), target hazard quotient (THQ), and cancer risk (CR). To obtain a refined risk assessment, the frequency of exposure to traditional animal medicines was determined from questionnaire data, and the safe factor for TCM was applied. Based on the standard levels for leech, it was found that earthworm, hive, scorpion, and leech accumulated high levels of heavy metals. The combined THQ (cTHQ) values indicated that ingestion of most traditional animal medicines would not pose a risk to the health of either male or female human beings. However, it was indicated that attention should be paid to the potential risk associated with cicada slough, earthworm, scorpion, turtle shells, and hive. Among heavy metals, As and Hg contributed to a major extent to the risk to human health. The CR assessment for Pb and As indicated that, with the exception of earthworm, the cancer risk was less than the acceptable lifetime risk for both males and females. Owing to the higher body weight, both THQ and CR were generally lower for males than for females.

Keyword :

Risk assessment Estimated daily intake (EDI) Heavy metals Cancer risk (CR) Traditional animal medicine Target hazard quotient (THQ)

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GB/T 7714 Zuo, Tian-Tian , Li, Yao-Lei , He, Huai-Zhen et al. Refined assessment of heavy metal-associated health risk due to the consumption of traditional animal medicines in humans [J]. | ENVIRONMENTAL MONITORING AND ASSESSMENT , 2019 , 191 (3) .
MLA Zuo, Tian-Tian et al. "Refined assessment of heavy metal-associated health risk due to the consumption of traditional animal medicines in humans" . | ENVIRONMENTAL MONITORING AND ASSESSMENT 191 . 3 (2019) .
APA Zuo, Tian-Tian , Li, Yao-Lei , He, Huai-Zhen , Jin, Hong-Yu , Zhang, Lei , Sun, Lei et al. Refined assessment of heavy metal-associated health risk due to the consumption of traditional animal medicines in humans . | ENVIRONMENTAL MONITORING AND ASSESSMENT , 2019 , 191 (3) .
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Interfacial Engineering of Supported Liquid Membranes by Vapor Cross-Linking for Enhanced Separation of Carbon Dioxide EI SCIE PubMed Scopus
期刊论文 | 2018 , 11 (1) , 185-192 | CHEMSUSCHEM
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Abstract :

Supported liquid membranes (SLMs) based on ionic liquids (ILs) with not only high gas permeability and selectivity, but also high stability under high pressure, are highly desired for gas separation applications. In this work, permeable and selective polyamide network (PN) layers are deposited on the surface of SLMs by utilizing the cross-linking reaction of trimesoyl chloride, which was pre-dispersed in the SLMs, and vapor of amine linkers. The vapor cross-linking method makes it easy to control the growth and aggregation of PN layers, owing to the significantly reduced reaction rate, and thereby ensuring the good distribution of PN layers on the surface of SLMs. With rational choice of amine linkers and optimization of vapor cross-linking conditions, the prepared sandwich-like PN@SLMs with ILs embedded homogeneously within polymeric matrices displayed much-improved CO2 permeability and CO2/N-2 selectivity in relation to the pristine SLMs. Moreover, those SLMs with ILs impregnated into porous supports physically displayed improved stability under high pressure after vapor cross-linking, because the PN layers formed on the surface of SLMs help prevent the ILs from being squeezed out. This interfacial engineering strategy represents a significant advance in the surface modification of SLMs to endow them with promising applications in CO2 capture.

Keyword :

vapor cross-linking polyamide network supported liquid membranes co(2) separation

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GB/T 7714 Kong, Li-Yun , Shan, Wei-Da , Han, Sheng-Li et al. Interfacial Engineering of Supported Liquid Membranes by Vapor Cross-Linking for Enhanced Separation of Carbon Dioxide [J]. | CHEMSUSCHEM , 2018 , 11 (1) : 185-192 .
MLA Kong, Li-Yun et al. "Interfacial Engineering of Supported Liquid Membranes by Vapor Cross-Linking for Enhanced Separation of Carbon Dioxide" . | CHEMSUSCHEM 11 . 1 (2018) : 185-192 .
APA Kong, Li-Yun , Shan, Wei-Da , Han, Sheng-Li , Zhang, Tao , He, Lang-Chong , Huang, Kuan et al. Interfacial Engineering of Supported Liquid Membranes by Vapor Cross-Linking for Enhanced Separation of Carbon Dioxide . | CHEMSUSCHEM , 2018 , 11 (1) , 185-192 .
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Simultaneous identification of three pseudoallergic components in Danshen injection by using high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online to HPLC-ESI-MS/MS EI SCIE PubMed Scopus
期刊论文 | 2018 , 41 (11) , 2488-2497 | JOURNAL OF SEPARATION SCIENCE
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Abstract :

Adverse drug reactions of Danshen injection mainly manifested as pseudoallergic reactions. In the present study, salvianolic acid A and a pair of geometric isomers (isosalvianolic acid C and salvianolic acid C) were identified as pseudoallergic components in Danshen injection by a high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online with high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Their pseudoallergic activities were evaluated by in vitro assay, which were consistent with the retention times on the cellmembrane chromatography column. Salvianolic acid C, the most outstanding compound, was further found to induce pseudoallergic reaction through Mas-related G protein coupled receptor X2. All the results above indicated that the system developed in this study is an effective method for simultaneously analyzing pseudoallergic components, even those with similar structures and the microcomponents in complex samples (salvianolic acid C in Danshen injection).

Keyword :

cell membrane chromatography traditional Chinese medicine isomers pseudoallergic activity microcomponents

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GB/T 7714 Lin, Yuanyuan , Wang, Cheng , Hou, Yajing et al. Simultaneous identification of three pseudoallergic components in Danshen injection by using high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online to HPLC-ESI-MS/MS [J]. | JOURNAL OF SEPARATION SCIENCE , 2018 , 41 (11) : 2488-2497 .
MLA Lin, Yuanyuan et al. "Simultaneous identification of three pseudoallergic components in Danshen injection by using high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online to HPLC-ESI-MS/MS" . | JOURNAL OF SEPARATION SCIENCE 41 . 11 (2018) : 2488-2497 .
APA Lin, Yuanyuan , Wang, Cheng , Hou, Yajing , Sun, Wei , Che, Delu , Yang, Liu et al. Simultaneous identification of three pseudoallergic components in Danshen injection by using high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online to HPLC-ESI-MS/MS . | JOURNAL OF SEPARATION SCIENCE , 2018 , 41 (11) , 2488-2497 .
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Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo SCIE PubMed Scopus
期刊论文 | 2018 , 148 , 147-154 | BIOCHEMICAL PHARMACOLOGY
WoS CC Cited Count: 1 SCOPUS Cited Count: 3
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Abstract :

Pseudo-allergic reactions-adverse, non-immunologic, anaphylaxis-like sudden onset reactions mediated through an IgE-independent pathway are activated by various basic compounds and occur at least as frequently as IgE-mediated reactions to drugs. A large family of G protein coupled receptors (Mas-related genes: Mrgprs) is closely related to pseudo-allergies. However, few therapies can directly target pseudo-allergies and related Mrgprs. Saikosaponin A (SSA) is effective in the treatment of passive cutaneous anaphylaxis (PCA), adjuvant arthritis, and delayed hypersensitiveness. In this study, we investigated the anti-pseudo-allergy effect of SSA and its underlying mechanism. We examined the effect of SSA on both IgE-independent and IgE-dependent responses using PCA and active systemic anaphylaxis models, as well as in vitro-cultured mast cells. We also evaluated whether the anti-allergy effect is related to Mrgprs by using in vitro Mrgprx2-expressing HEK293 cells. SSA dose dependently suppressed compound 48/80 (C48/80)-induced PCA and mast cell degranulation in mice. When SSA and C48/80 were administered together through the vein, C48/80-induced systemic anaphylaxis did not occur, and C48/80-induced shock ratio decreased dose-dependently upon SSA treatment. However, SSA did not affect IgE-dependent allergy. When administered topically 24 h before antigen challenge, Evans blue leakage and paw swelling were induced in the SSA-treated group and the vehicle group. Our in vitro studies revealed that SSA reduced C48/80-induced calcium flux and suppressed degranulation in LAD2 cells. SSA could also dose-dependently inhibit C48/80-induced Mrgprx2-expressing HEK293 cell activation. As a conclusion, SSA could inhibits IgE-independent allergy, but not IgE-dependent allergy, and this effect involves the Mrgprx2 pathway. This study provided a new sight on pseudo-allergy and its therapy. (C) 2017 Elsevier Inc. All rights reserved.

Keyword :

Pseudo-allergy Mast cells Mrgprx2 Saikosaponin A IgE-independent

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GB/T 7714 Wang, Nan , Che, Delu , Zhang, Tao et al. Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo [J]. | BIOCHEMICAL PHARMACOLOGY , 2018 , 148 : 147-154 .
MLA Wang, Nan et al. "Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo" . | BIOCHEMICAL PHARMACOLOGY 148 (2018) : 147-154 .
APA Wang, Nan , Che, Delu , Zhang, Tao , Liu, Rui , Cao, Jiao , Wang, Jue et al. Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo . | BIOCHEMICAL PHARMACOLOGY , 2018 , 148 , 147-154 .
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Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway SCIE PubMed Scopus
期刊论文 | 2018 , 315 (2) , F254-F262 | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
WoS CC Cited Count: 1 SCOPUS Cited Count: 2
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Salvianolic acid A (Sal A) has been shown to prevent and treat ischemic cardiovascular, as well as cerebral vascular diseases. However, little is known about Sal A in renal ischemia/reperfusion (I/R) injury. In this study, a renal I/R injury model in rats and a hypoxia/reoxygenation (H/R) model to damage proximal renal tubular cells (HK-2) were used to assess whether Sal A halts the development and progression of renal I/R injury. As compared with vehicle treatment, Sal A significantly attenuated kidney injury after renal I/R injury, accompanied by decreases in plasma creatinine, blood urea nitrogen levels, the number of apoptosis-positive tubular cells, and kidney oxidative stress. Sal A also activated phosphorylated protein kinase B (p-Akt) and phosphorylated-mammalian target of rapamycin (p-mTOR) compared with vehicle-treated I/R injury rats. In H/R-injured HK-2 cells. Sal A can reduce the levels of reactive oxygen species in a dose-related manner. Similar to the results from in vivo experiments, in vitro Sal A also increased the protein expression of phosphorylated-eukaryotic initiation factor 4E binding protein 1 (p-4EBP1) compared with vehicle. Furthermore. the cytoprotective activity of Sal A was inhibited by LY294002 and rapamycin. These findings indicate that Sal A can ameliorate renal I/R injury and promote tubular cell survival partly via the Akt/mTOR/4EBP1pathway. Sal A could be a candidate compound to prevent ischemic tissue damage.

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GB/T 7714 Song, Ying , Liu, Weihai , Ding, Yi et al. Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway [J]. | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY , 2018 , 315 (2) : F254-F262 .
MLA Song, Ying et al. "Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway" . | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 315 . 2 (2018) : F254-F262 .
APA Song, Ying , Liu, Weihai , Ding, Yi , Jia, Yanyan , Zhao, Jinyi , Wang, Fan et al. Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway . | AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY , 2018 , 315 (2) , F254-F262 .
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A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer SCIE PubMed Scopus
期刊论文 | 2018 , 40 (2) , 1064-1072 | ONCOLOGY REPORTS
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We recently reported that TPD7 suppressed tumor cell proliferation, and inhibited invasion, through the suppression of C-X-C chemokine receptor type 4 (CXCR4). In the present study, we investigated the anticancer effect of TPD7 on apoptosis and invasion of cervical cancer HeLa cells. Cell cycle analysis revealed that TPD7 decreased cyclin-dependent kinase (CDK)1 and cyclin D1 expression, and increased cyclin A expression, following S phase blockade. TPD7 induced chromatin condensation and significantly elevated the number of apoptotic cells, suggesting that its inhibitory effect on HeLa cells was due to the induction of cell cycle blockade and apoptosis. Mechanistically, TPD7 altered the extrinsic apoptosis pathway by upregulating Fas expression, and the intrinsic pathway by modulating Bcl-2 family proteins, p53, and NF-B p65, leading to enhanced apoptosis. TPD7 inhibited HeLa cell invasion by downregulating the expression of matrix metalloproteinase (MMP)-9 and CXCR4 proteins. In vivo experiments revealed that TPD7 inhibited tumor growth in HeLa cell xenografted mice. These findings indicated that TPD7 may be a potential chemoprevention agent for the management of cervical carcinoma.

Keyword :

apoptosis Bcl-2 TPD7 cervical cancer Fas

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GB/T 7714 Zhan, Yingzhuan , Zhang, Han , Dai, Bingling et al. A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer [J]. | ONCOLOGY REPORTS , 2018 , 40 (2) : 1064-1072 .
MLA Zhan, Yingzhuan et al. "A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer" . | ONCOLOGY REPORTS 40 . 2 (2018) : 1064-1072 .
APA Zhan, Yingzhuan , Zhang, Han , Dai, Bingling , Zhang, Yanmin , Zhang, Jie , He, Langchong . A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer . | ONCOLOGY REPORTS , 2018 , 40 (2) , 1064-1072 .
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Accurate quantification of β-hexosaminidase released from laboratory of allergic diseases 2 cells via liquid chromatography tandem mass spectrometry method. EI PubMed Scopus SCIE
期刊论文 | 2018 , 1578 , 106-111 | Journal of chromatography. A
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β-Hexosaminidase is one of the enzymes that is secreted from mast cells via antigen-induced degranulation and has frequently been used as an indicator of anaphylactic reactions. The main method for determining β-hexosaminidase is indirect, "substrate-based" and shows limitations. Hence, development of an accurate detecting method is particularly important and urgently needed. In this study we developed a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for measuring β-hexosaminidase. Laboratory of allergic diseases 2 (LAD2) cells were stimulated with compound 48/80 (C48/80), the supernatant was collected and subjected to in-solution protein digestion; the obtained peptides were desalted, concentrated, separated and analyzed with an LC-tandem MS instrument. A peptide with the sequence "LAPGTIVEVWK" was selected for quantitative analysis, and four other peptides for qualitative research. The time-effect relationship curve was studied, and the results of the LC-MS/MS method were found to be almost consistent with those obtained via the conventional method. The method was then employed to measure β-hexosaminidase released from LAD2 cells stimulated with potential allergens, and the results showed that it can be applied to determine the potential allergenicity of drugs. This new method showed good specificity, high sensitivity and a wide application range. It could be used to evaluate allergic reactions, providing a guide for medication safety during clinical testing.

Keyword :

LAD2 cell Anaphylactoid reaction β-Hexosaminidase Mass spectrometry LC–MS/MS

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GB/T 7714 Lv Yanni , Fu Jia , Jia Qianqian et al. Accurate quantification of β-hexosaminidase released from laboratory of allergic diseases 2 cells via liquid chromatography tandem mass spectrometry method. [J]. | Journal of chromatography. A , 2018 , 1578 : 106-111 .
MLA Lv Yanni et al. "Accurate quantification of β-hexosaminidase released from laboratory of allergic diseases 2 cells via liquid chromatography tandem mass spectrometry method." . | Journal of chromatography. A 1578 (2018) : 106-111 .
APA Lv Yanni , Fu Jia , Jia Qianqian , Che Delu , Lin Yuanyuan , Han Shengli et al. Accurate quantification of β-hexosaminidase released from laboratory of allergic diseases 2 cells via liquid chromatography tandem mass spectrometry method. . | Journal of chromatography. A , 2018 , 1578 , 106-111 .
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Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction. PubMed Scopus CSCD SCIE
期刊论文 | 2018 , 8 (3) , 147-152 | Journal of pharmaceutical analysis
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Drug-receptor interaction plays an important role in a series of biological effects, such as cell proliferation, immune response, tumor metastasis, and drug delivery. Therefore, the research on drug-receptor interaction is growing rapidly. The equilibrium dissociation constant (<i>K</i>D) is the basic parameter to evaluate the binding property of the drug-receptor. Thus, a variety of analytical methods have been established to determine the <i>K</i>D values, including radioligand binding assay, surface plasmon resonance method, fluorescence energy resonance transfer method, affinity chromatography, and isothermal titration calorimetry. With the invention and innovation of new technology and analysis method, there is a deep exploration and comprehension about drug-receptor interaction. This review discusses the different methods of determining the <i>K</i>D values, and analyzes the applicability and the characteristic of each analytical method. Conclusively, the aim is to provide the guidance for researchers to utilize the most appropriate analytical tool to determine the <i>K</i>D values.

Keyword :

Affinity chromatography Equilibrium dissociation constant SPR Drug-receptor interaction RBA FRET

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GB/T 7714 Ma Weina , Yang Liu , He Langchong . Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction. [J]. | Journal of pharmaceutical analysis , 2018 , 8 (3) : 147-152 .
MLA Ma Weina et al. "Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction." . | Journal of pharmaceutical analysis 8 . 3 (2018) : 147-152 .
APA Ma Weina , Yang Liu , He Langchong . Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction. . | Journal of pharmaceutical analysis , 2018 , 8 (3) , 147-152 .
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HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway Scopus SCIE PubMed
期刊论文 | 2018 , 22 (11) , 5231-5243 | Journal of Cellular and Molecular Medicine
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© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. Hepatocellular carcinoma (HCC) is a highly prevalent cancer worldwide and it is necessary to discover and develop novel preventive strategies and therapeutic approaches for HCC. Herein, we report that EphrinB2 expression is correlated with liver cancer progression. Moreover, by using phosphorylated proteomics array, we reveal a pro-apoptosis protein whose phosphorylation and activation levels are up-regulated upon EphrinB2 knockdown. These results suggest that EphrinB2 may act as an anti-apoptotic protein in liver cancer cells. We also explored the therapeutic potential of HMQ-T-B10 (B10), which was designed and synthesized in our laboratory, for HCC and its underlying mechanisms in vitro and in vivo. Our data demonstrate that B10 could bind EphrinB2 and show inhibitory activity on human liver cancer cells. Moreover, induction of human liver cancer cell apoptosis by B10 could be augmented upon EphrinB2 knockdown. B10 inhibited HCC cell growth and induced HCC cell apoptosis by repressing the EphrinB2 and VEGFR2 signalling pathway. Growth of xenograft tumours derived from Hep3B in nude mice was also significantly inhibited by B10. Collectively, these findings highlight the potential molecular mechanisms of B10 and its potential as an effective antitumour agent for HCC.

Keyword :

apoptosis EphrinB2 HMQ-T-B10 liver cancer cell

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GB/T 7714 Dai, Bingling , Shi, Xianpeng , Ma, Nan et al. HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway [J]. | Journal of Cellular and Molecular Medicine , 2018 , 22 (11) : 5231-5243 .
MLA Dai, Bingling et al. "HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway" . | Journal of Cellular and Molecular Medicine 22 . 11 (2018) : 5231-5243 .
APA Dai, Bingling , Shi, Xianpeng , Ma, Nan , Ma, Weina , Zhang, Yanmin , Yang, Tianfeng et al. HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway . | Journal of Cellular and Molecular Medicine , 2018 , 22 (11) , 5231-5243 .
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Simultaneous identification of the anaphylactoid components from traditional Chinese medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dual-mixed/cell membrane chromatography model SCIE PubMed Scopus
期刊论文 | 2018 , 39 (9-10) , 1181-1189 | ELECTROPHORESIS
WoS CC Cited Count: 1 SCOPUS Cited Count: 1
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Traditional Chinese medicine (TCM) has been used for prevention and treatment of various diseases for many decades. TCM injection is a new dosage form, with incidence of anaphylactoid reactions increasing every year. In this study, the rat basophilic leukemia 2H3 (RBL-2H3) and laboratory of allergic disease 2 (LAD2) dual-mixed/CMC was established and was coupled with an HPLC-ESI-IT-TOF-MS system to identify the potential allergenic components in Haqing injection. Cinobufagin, piperine, osthole, praeruptorin A, and schizandrin A were screened from Haqing injection via this coupled system. Competitive binding assay showed piperine, praeruptorin A, and schizandrin A acting on MrgprX2 and cinobufagin and osthole act on the IgE receptor. The release of mediators of anaphylaxis results showed cinobufagin and osthole can cause anaphylactoid reactions by triggering the release of -hexosaminidase and histamine via IgE-R. Praeruptorin A and schizandrin A could promote the release of -hexosaminidase and histamine via MrgprX2 receptor. In summary, the dual-mixed/CMC model can significantly improve the efficiency of target component identification from a complex sample. When combined with competitive binding assay and validation of biological activities, this model enables accurate determination of the dual-target components, offering improved methods for quality control of TCM injections.

Keyword :

HPLC-ESI-IT-TOF-MS Haqing injection Allergenic components Dual-mixed cell membrane chromatography Competitive binding assay

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GB/T 7714 Han, Shengli , Lv, Yanni , Kong, Liyun et al. Simultaneous identification of the anaphylactoid components from traditional Chinese medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dual-mixed/cell membrane chromatography model [J]. | ELECTROPHORESIS , 2018 , 39 (9-10) : 1181-1189 .
MLA Han, Shengli et al. "Simultaneous identification of the anaphylactoid components from traditional Chinese medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dual-mixed/cell membrane chromatography model" . | ELECTROPHORESIS 39 . 9-10 (2018) : 1181-1189 .
APA Han, Shengli , Lv, Yanni , Kong, Liyun , Sun, Yueming , Fu, Jia , Li, Lingjun et al. Simultaneous identification of the anaphylactoid components from traditional Chinese medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dual-mixed/cell membrane chromatography model . | ELECTROPHORESIS , 2018 , 39 (9-10) , 1181-1189 .
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