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学者姓名：李涤尘
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Abstract ：
Three-dimensional printing (3DP) technology is suitable for manufacturing personalized orthopedic implants for reconstruction surgery. Compared with traditional titanium, polyether-ether-ketone (PEEK) is the ideal material for 3DP orthopedic implants due to its various advantages, including thermoplasticity, thermal stability, high chemical stability, and radiolucency suitable elastic modulus. However, it is challenging to develop a well-designed method and manufacturing technique to meet the clinical needs because it requires elaborate details and interplays with clinical work. Furthermore, establishing surgical standards for new implants requires many clinical cases and an accumulation of surgical experience. Thus, there are few case reports on using 3DP PEEK implants in clinical practice. Herein, we formed a team with a lot of engineers, scientists, and doctors and conducted a series of studies on the 3DP PEEK implants for chest wall reconstruction. First, the thoracic surgeons sort out the specific types of chest wall defects. Then, the engineers designed the shape of the implant and performed finite element analysis for every implant. To meet the clinical needs and mechanical requirements of implants, we developed a new fused deposition modeling technology to make personalized PEEK implants. Overall, the thoracic surgeons have used 114 personalized 3DP PEEK implants to reconstruct the chest wall defect and further established the surgical standards of the implants as part of the Chinese clinical guidelines. The surface modification technique and composite process are developed to overcome the new clinical problems of implant-related complications after surgery. Finally, the major challenges and possible solutions to translating 3DP PEEK implants into a mature and prevalent clinical product are discussed in the paper.
Keyword ：
Chest wall reconstruction Fused deposition modeling Polyether-ether-ketone Three-dimensional printing
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| GB/T 7714 | Wang, Lei , Yang, Chuncheng , Sun, Changning et al. Fused Deposition Modeling PEEK Implants for Personalized Surgical Application: From Clinical Need to Biofabrication [J]. | INTERNATIONAL JOURNAL OF BIOPRINTING , 2022 , 8 (4) . |
| MLA | Wang, Lei et al. "Fused Deposition Modeling PEEK Implants for Personalized Surgical Application: From Clinical Need to Biofabrication" . | INTERNATIONAL JOURNAL OF BIOPRINTING 8 . 4 (2022) . |
| APA | Wang, Lei , Yang, Chuncheng , Sun, Changning , Yan, Xiaolong , He, Jiankang , Shi, Changquan et al. Fused Deposition Modeling PEEK Implants for Personalized Surgical Application: From Clinical Need to Biofabrication . | INTERNATIONAL JOURNAL OF BIOPRINTING , 2022 , 8 (4) . |
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Abstract ：
Gradient porous structure made by additive manufacturing (AM) technology is potential to improve the long-term stability of orthopaedic implants through bone ingrowth while maintaining mechanical safety. In this study, a parametrical optimization methodology for the customized gradient porous implants was developed based on a stress-dependent design algorithm. Clinical requirements and manufacturing capabilities of AM were considered in the design procedure. A femoral stem with a minimum bone loss proportion of 2.4% by optimizing the control parameters. This study provided a feasible and flexible design approach for the customized implant with gradient porous structure or material components.
Keyword ：
additive manufacturing customized implant elastic modulus finite element analysis Gradient porous implant
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| GB/T 7714 | Sun, Changning , Kang, Jianfeng , Wang, Ling et al. Stress-dependent design and optimization methodology of gradient porous implant and application in femoral stem [J]. | COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING , 2022 . |
| MLA | Sun, Changning et al. "Stress-dependent design and optimization methodology of gradient porous implant and application in femoral stem" . | COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2022) . |
| APA | Sun, Changning , Kang, Jianfeng , Wang, Ling , Jin, Zhongmin , Liu, Chaozong , Li, Dichen . Stress-dependent design and optimization methodology of gradient porous implant and application in femoral stem . | COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING , 2022 . |
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Abstract ：
Additive Manufactured (AM) Polyether-ether-ketone (PEEK) orthopaedic implants offer new opportunities for bone substitutes. However, owing to its chemical inertness, the integration between PEEK implants and soft tissue represents a major challenge threatening the early success of the PEEK implants. Here we investigated the influence of hydroxyapatite (HA) fillers and porous structure of AM HA/PEEK scaffolds on the integration with soft tissue through in-vitro cellular experiments and in-vivo rabbit experiments. Among the animal experiments, HA/PEEK composite scaffolds with HA contents of 0, 20 wt%, 40 wt% and pore sizes of 0.8 mm, 1.6 mm were manufactured by fused filament fabrication. The results indicated that HA promoted the proliferation and adhesion of myofibroblasts on PEEK-based composites by releasing Ca2+ to active FAK and its downstream proteins, while the surface morphology of the scaffolds was also roughened by the HA particles, both of which led to the tighter adhesion between HA/PEEK scaffolds and soft tissue in-vivo. The macroscopic bonding force be-tween soft tissue and scaffolds was dominated by the pore size of the scaffolds but was hardly affected by neither the HA content and nor the surface morphology. Scaffolds with larger pore size bonded more strongly to the soft tissue, and the maximum bonding force reached to 5.61 +/- 2.55 N for 40 wt% HA/PEEK scaffolds with pore size of 1.6 mm, which was higher than that between natural bone and soft tissue of rabbits. Although the larger pore size and higher HA content of the PEEK-based scaffolds facilitated the bonding with the soft tissue, the conse-quent outcome of reduced mechanical properties has to be compromised in the design of the porous PEEK-based composite implants. The present study provides engineering-accessible synergistic strategies on material com-ponents and porous architecture of AM PEEK orthopaedic implants for improving the integration with soft tissue.
Keyword ：
Additive manufacturing Polyether-ether-ketone composites Porous scaffolds Soft tissue
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| GB/T 7714 | Sun, Changning , Zhao, Huiyu , Wang, Lei et al. Additive manufactured polyether-ether-ketone composite scaffolds with hydroxyapatite filler and porous structure promoted the integration with soft tissue [J]. | BIOMATERIALS ADVANCES , 2022 , 141 . |
| MLA | Sun, Changning et al. "Additive manufactured polyether-ether-ketone composite scaffolds with hydroxyapatite filler and porous structure promoted the integration with soft tissue" . | BIOMATERIALS ADVANCES 141 (2022) . |
| APA | Sun, Changning , Zhao, Huiyu , Wang, Lei , Zhang, Jinghua , Zheng, Jibao , Yang, Zijian et al. Additive manufactured polyether-ether-ketone composite scaffolds with hydroxyapatite filler and porous structure promoted the integration with soft tissue . | BIOMATERIALS ADVANCES , 2022 , 141 . |
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Abstract ：
Although the initial mechanical properties of additive-manufactured (AM) metal scaffolds have been thoroughly studied and have become a cornerstone in the design of porous orthopaedic implants, the potential promotion of the mechanical properties of the scaffolds by bone ingrowth has barely been studied. In this study, the promotion of bone ingrowth on the mechanical properties of AM titanium alloy scaffolds was investigated through in vivo experiments and numerical simulation. On one hand, the osseointegration characteristics of scaffolds with architectures of body-centred cubic (BCC) and diamond were compared through animal experiments in which the mechanical properties of both scaffolds were not enhanced by the four-week implantation. On the other hand, the influences of the type and morphology of bone tissue in the BCC scaffolds on its mechanical properties were investigated by the finite element model of osseointegrated scaffolds, which was calibrated by the results of biomechanical testing. Significant promotion of the mechanical properties of AM metal scaffolds was only found when cortical bone filled the pores in the scaffolds. This paper provides a numerical prediction method to investigate the effect of bone ingrowth on the mechanical properties of AM porous implants, which might be valuable for the design of porous implants.
Keyword ：
additive manufacturing finite element analysis osseointegration porous scaffolds
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| GB/T 7714 | Sun, Changning , Dong, Enchun , Chen, Jiayu et al. The Promotion of Mechanical Properties by Bone Ingrowth in Additive-Manufactured Titanium Scaffolds [J]. | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2022 , 13 (3) . |
| MLA | Sun, Changning et al. "The Promotion of Mechanical Properties by Bone Ingrowth in Additive-Manufactured Titanium Scaffolds" . | JOURNAL OF FUNCTIONAL BIOMATERIALS 13 . 3 (2022) . |
| APA | Sun, Changning , Dong, Enchun , Chen, Jiayu , Zheng, Jibao , Kang, Jianfeng , Jin, Zhongmin et al. The Promotion of Mechanical Properties by Bone Ingrowth in Additive-Manufactured Titanium Scaffolds . | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2022 , 13 (3) . |
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Abstract ：
Laser powder bed fusion (LPBF) technology is of great significance to the rapid manufacturing of high-performance metal parts. To improve the mechanical behavior of an LPBFed AlSi10Mg alloy, the influence of nano-Si3N4 reinforcement on densification behavior, microstructure, and tensile property of AlSi10Mg was studied. The experimental results show that 97% relative density of the 3 vol.% nano-Si3N4/AlSi10Mg composite was achieved via optimization of the LPBF process. With the increase in the nano-Si3N4 content, the tensile strength and the yield strength of the composite steadily increase as per the Orowan strengthening mechanism while the elongation decreases. In addition, nano-Si3N4 reinforcement reduces the width of the coarse cell structure region and the thermal influence region of the AlSi10Mg matrix. After annealing, the tensile strength of the nano-Si3N4/AlSi10Mg composite decreases and the elongation increases significantly.
Keyword ：
AlSi10Mg heat treatment laser powder bed fusion (LPBF) mechanical properties nano-Si3N4
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| GB/T 7714 | Lu, Zhongliang , Han, Yu , Gao, Yunpeng et al. Effect of Nano-Si3N4 Reinforcement on the Microstructure and Mechanical Properties of Laser-Powder-Bed-Fusioned AlSi10Mg Composites [J]. | CRYSTALS , 2022 , 12 (3) . |
| MLA | Lu, Zhongliang et al. "Effect of Nano-Si3N4 Reinforcement on the Microstructure and Mechanical Properties of Laser-Powder-Bed-Fusioned AlSi10Mg Composites" . | CRYSTALS 12 . 3 (2022) . |
| APA | Lu, Zhongliang , Han, Yu , Gao, Yunpeng , Cao, Fusheng , Zhang, Haitian , Miao, Kai et al. Effect of Nano-Si3N4 Reinforcement on the Microstructure and Mechanical Properties of Laser-Powder-Bed-Fusioned AlSi10Mg Composites . | CRYSTALS , 2022 , 12 (3) . |
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Abstract ：
Implantable nerve electrodes, as a bridge between the brain and external devices, have been widely used in areas such as brain function exploration, neurological disease treatment and human-computer interaction. However, the mechanical properties mismatch between the electrode material and the brain tissue seriously affects the stability of electrode signal acquisition and the effectiveness of long-term service in vivo. In this study, a modified neuroelectrode was developed with conductive biomaterials. The electrode has good biocompatibility and a gradient microstructure suitable for cell growth. Compared with metal electrodes, bioelectrodes not only greatly reduced the elastic modulus (<10 kpa) but also increased the conductivity of the electrode by 200 times. Through acute electrophysiological analysis and a 12-week chronic in vivo experiment, the bioelectrode clearly recorded the rat's brain electrical signals, effectively avoided the generation of glial scars and induced neurons to move closer to the electrode. The new conductive biomaterial electrodes developed in this research make long-term implantation of cortical nerve electrodes possible.
Keyword ：
conductive biomaterial glial response neural electrode polyaniline
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| GB/T 7714 | Hao, Zhiyan , Wang, Sen , Zhang, Kun et al. Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into [J]. | MATERIALS , 2021 , 14 (16) . |
| MLA | Hao, Zhiyan et al. "Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into" . | MATERIALS 14 . 16 (2021) . |
| APA | Hao, Zhiyan , Wang, Sen , Zhang, Kun , Zhou, Jiajia , Li, Dichen , He, Jiankang et al. Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into . | MATERIALS , 2021 , 14 (16) . |
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Abstract ：
Y YThe pathological research and drug development of brain diseases require appropriate brain models. Given the complex, layered structure of the cerebral cortex, as well as the constraints on the medical ethics and the inaccuracy of animal models, it is necessary to construct a brain-like model in vitro. In this study, we designed and built integrated three-dimensional (3D) printing equipment for cell printing/culture, which can guarantee cell viability in the printing process and provide the equipment foundation for manufacturing the layered structures with gradient distribution of pore size. Based on this printing equipment, to achieve the purpose of printing the layered structures with multiple materials, we conducted research on the performance of bio-inks with different compositions and optimized the printing process. By extruding and stacking materials, we can print the layered structure with the uniform distribution of cells and the gradient distribution of pore sizes. Finally, we can accurately print a structure with 30 layers. The line width (resolution) of the printed monolayer structure was about 478 mu m, the forming accuracy can reach 97.24%, and the viability of cells in the printed structure is as high as 94.5%.
Keyword ：
3D bio-printing Brain-like model Integrated cell printing/culture equipment Layered gradient structure
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| GB/T 7714 | Pei, Na , Hao, Zhiyan , Wang, Sen et al. 3D Printing of Layered Gradient Pore Structure of Brain-like Tissue [J]. | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) : 71-85 . |
| MLA | Pei, Na et al. "3D Printing of Layered Gradient Pore Structure of Brain-like Tissue" . | INTERNATIONAL JOURNAL OF BIOPRINTING 7 . 3 (2021) : 71-85 . |
| APA | Pei, Na , Hao, Zhiyan , Wang, Sen , Pan, Binglei , Fang, Ao , Kang, Jianfeng et al. 3D Printing of Layered Gradient Pore Structure of Brain-like Tissue . | INTERNATIONAL JOURNAL OF BIOPRINTING , 2021 , 7 (3) , 71-85 . |
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Abstract ：
The conventional method of preparing metal-ceramic composite structures causes delamination and cracking defects due to differences in the composite structures' properties, such as the coefficient of thermal expansion between metal and ceramic materials. Laser-directed energy deposition (LDED) technology has a unique advantage in that the composition of the materials can be changed during the forming process. This technique can overcome existing problems by forming composite structures. In this study, a multilayer composite structure was prepared using LDED technology, and different materials were deposited with their own appropriate process parameters. A layer of Al2O3 ceramic was deposited first, and then three layers of a NbMoTa multi-principal element alloy (MPEA) were deposited as a single composite structural unit. A specimen of the NbMoTa-Al2O3 multilayer composite structure, composed of multiple composite structural units, was formed on the upper surface of a phi 20 mm x 60 mm cylinder. The wear resistance was improved by 55% compared to the NbMoTa. The resistivity was 1.55 x 10(-5) ohm x m in the parallel forming direction and 1.29 x 10(-7) ohm x m in the vertical forming direction. A new, electrically anisotropic material was successfully obtained, and this study provides experimental methods and data for the preparation of smart materials and new sensors.
Keyword ：
anisotropy ceramic composite structures laser additive manufacturing metal– MPEA
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| GB/T 7714 | Zhang, Hang , Chen, Zihao , He, Yaoyao et al. High Performance NbMoTa-Al2O3 Multilayer Composite Structure Manufacturing by Laser Directed Energy Deposition [J]. | MATERIALS , 2021 , 14 (7) . |
| MLA | Zhang, Hang et al. "High Performance NbMoTa-Al2O3 Multilayer Composite Structure Manufacturing by Laser Directed Energy Deposition" . | MATERIALS 14 . 7 (2021) . |
| APA | Zhang, Hang , Chen, Zihao , He, Yaoyao , Guo, Xin , Li, Qingyu , Ji, Shaokun et al. High Performance NbMoTa-Al2O3 Multilayer Composite Structure Manufacturing by Laser Directed Energy Deposition . | MATERIALS , 2021 , 14 (7) . |
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Abstract ：
Customized spinal implants fabricated by additive manufacturing have been increasingly used clinically to restore the physiological functions. However, the mechanisms and methods about the design for the spinal implants are not clear, especially for the reconstruction of multi-segment vertebral. This study aims to develop a novel multi-objective optimization methodology based on various normal spinal activities, to design the artificial vertebral implant (AVI) with lightweight, high-strength and high-stability. The biomechanical performance for two types of AVI was analyzed and compared under different loading conditions by finite element method. These implants were manufactured via selective laser melting technology and evaluated via compressive testing. Results showed the maximum Mises stress of the optimized implant under various load cases were about 41.5% of that of the trussed implant, and below fatigue strength of 3D printed titanium materials. The optimized implant was about 2 times to trussed implant in term of the maximum compression load and compression stiffness to per unit mass, which indicated the optimized implant can meet the safety requirement. Finally, the optimized implant has been used in clinical practice and good short-term clinical outcomes were achieved. Therefore, the novel developed method provides a favorable guarantee for the design of 3D printed multi-segment artificial vertebral implants.
Keyword ：
Additive manufacturing Artificial vertebral implant Biomechanical evaluation Finite element analysis Topology optimization design
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| GB/T 7714 | Kang, Jianfeng , Dong, Enchun , Li, Xiangdong et al. Topological design and biomechanical evaluation for 3D printed multi-segment artificial vertebral implants [J]. | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS , 2021 , 127 . |
| MLA | Kang, Jianfeng et al. "Topological design and biomechanical evaluation for 3D printed multi-segment artificial vertebral implants" . | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 127 (2021) . |
| APA | Kang, Jianfeng , Dong, Enchun , Li, Xiangdong , Guo, Zheng , Shi, Lei , Li, Dichen et al. Topological design and biomechanical evaluation for 3D printed multi-segment artificial vertebral implants . | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS , 2021 , 127 . |
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Abstract ：
Gradient composite metastructures have been demonstrated in effectively improving the microwave absorbing performance. However, the preparation of the complex structures still remains challenging. Herein, a complex gradient composite microwave absorbing metastructure is designed and fabricated by the low cost, high-efficiency fused deposition modeling of 3D printing technologies. The metastructure is composed of flaky carbonyl iron particles and Polyether-ether-ketone composite which demands only 50% loss material mass addition. Structural parameters are investigated and optimized for absorbing bandwidth and reflectivity intensity. Simulations and experiments demonstrate that the designed complex gradient metastructure with the thickness of 10 mm can achieve the-10 dB absorbing bandwidth in the frequency range from 5.1 to 40 GHz, and the absorbing bandwidth corresponding to-15 dB in 7.7- 14.7 GHz and 22.6-36.3 GHz. Meanwhile, this metastructure also can maintain the broadband and strong microwave absorption with incident angle from 0 degrees to 55 degrees for transverse electric polarization and 0 degrees to 70 degrees for transverse magnetic polarization. Moreover, the proposed metastructure is also demonstrated with good compression strength which shows preferable mechanical stability. This work provides a simple and promising route of broadband and wide-angle microwave strong absorption for practical application. (c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
3D printing Broadband absorption Complex gradient metastructure Strong absorption Wide-angle absorption
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| GB/T 7714 | Duan, Yubing , Liang, Qingxuan , Yang, Zhen et al. A wide-angle broadband electromagnetic absorbing metastructure using 3D printing technology [J]. | MATERIALS & DESIGN , 2021 , 208 . |
| MLA | Duan, Yubing et al. "A wide-angle broadband electromagnetic absorbing metastructure using 3D printing technology" . | MATERIALS & DESIGN 208 (2021) . |
| APA | Duan, Yubing , Liang, Qingxuan , Yang, Zhen , Li, Zhaohui , Yin, Haoyu , Cao, Yi et al. A wide-angle broadband electromagnetic absorbing metastructure using 3D printing technology . | MATERIALS & DESIGN , 2021 , 208 . |
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