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学者姓名：陈斌
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Abstract ：
Flashing spray occurs when the saturated liquid is discharged into a gaseous environment at an ambient pressure lower than its saturation pressure. Internal flow is a primary determinant on the behavior of external flashing spray, so its transient effect was investigated with iso-pentane as working medium. The coupled effect of superheat level and injection pressure was comprehensively explored with initial temperature from 30 °C to 70 °C and injection pressure from 1.2 MPa to 2.4 MPa. Under different injection pressure, the stable spray patterns can still be categorized as non-shattering, partially shattering, completely shattering and flare flashing separated by the shattering index X·(Pinj/Pa)0.5 of 0.21, 0.39 and 0.76, which represents the product of homogeneous nucleation rate and the ratio of injection pressure over ambient pressure. A strong correlation between the spray cone angle and the shattering index is proposed as a piecewise function separated by X·(Pinj/Pa)0.5 = 0.39. High-void-fraction internal two-phase flow is easier to be formed in partially shattering or completely shattering pattern, which would lead to a hysteretic flashing spray with a significant increase of spray cone angle and droplets concentration. Low X·(Pinj/Pa)0.5 yields slower response of external morphological changes but larger enhancement of radial expansion. © 2022 Elsevier Ltd
Keyword ：
Flashing spray; Flow visualization; Internal flow; Iso-pentane
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| GB/T 7714 | Wang, J. , Zhou, Z. , Chen, B. et al. Flow visualization of the transient effect of the internal two-phase flow on the external iso-pentane flashing spray under different injection pressure [J]. | Fuel , 2023 , 333 . |
| MLA | Wang, J. et al. "Flow visualization of the transient effect of the internal two-phase flow on the external iso-pentane flashing spray under different injection pressure" . | Fuel 333 (2023) . |
| APA | Wang, J. , Zhou, Z. , Chen, B. , Yang, T. , Zhang, L. , Romeos, A. et al. Flow visualization of the transient effect of the internal two-phase flow on the external iso-pentane flashing spray under different injection pressure . | Fuel , 2023 , 333 . |
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Abstract ：
Prediction of blood cell flow is known as the difficult research by reason of the complexity of blood vessel. In this study, considering the complex structure of blood vessels, a mechanical model for red blood cell (RBC) based on unstructured grid has been established to study the flow characteristics of RBCs in complex blood vessels. In the model, the strain-energy function by Skalak is employed to model the shear elasticity and surface-area conservation of the membrane, and the hinge spring is used to describe the forces originating from local bending of the membrane. The immersed boundary method is utilized to couple the interphase force. Using the model, the stretching test of RBC is compared with the experiment data, and the good agreement verified the validation of the present model. The morphology of red blood cell and the blood viscosity in micro-vessel are studied. RBCs move with a symmetric shape (parachute shape) in small blood vessels, and the buckling instability is observed when the RBC flow slowly through a micro-vessel or a converging-diverging capillary. When the vessel diameter is around 10 mu m, the reverse Fahraeus-Lindqvist effect is presented. The blood apparent viscosity shows linear increase with the blood hematocrit. In addition, Malaria infection can make the RBC deformability decreased and the blood apparent viscosity increased.
Keyword ：
buckling instability immersed boundary method red blood cell stretching test tetrahedral mesh
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| GB/T 7714 | Li, Guojie , Chen, Bin , Wang, Xinkai . Numerical investigation on red blood cell flow based on unstructured grid [J]. | INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING , 2022 . |
| MLA | Li, Guojie et al. "Numerical investigation on red blood cell flow based on unstructured grid" . | INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING (2022) . |
| APA | Li, Guojie , Chen, Bin , Wang, Xinkai . Numerical investigation on red blood cell flow based on unstructured grid . | INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING , 2022 . |
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Abstract ：
Severe slugging is an unstable multiphase flow pattern occurs in a pipeline riser with low gas and liquid flowrates. It is highly undesired in practical operation because of the pressure and mass flow oscillations induced. Riser outlet choking has shown effectiveness in eliminating or reducing the severity of the slugging. This work presents an experimental and numerical study on the elimination of severe riser-induced slug by means of riser outlet choking. The test loop consists of a horizontal pipeline with 50 mm i.d. and 15 m in length, followed by a downward inclined section and a vertical riser of 2 m. It was found that by choking the flow at riser outlet, flow pattern in the riser changes from severe slugging first into slug flow and then into bubbly flow. The recognition of the flow regimes was basically according to the trends of the riser base pressure. The flow patterns were characterized in terms of pressure at riser base, as well as liquid holdup at riser top. A numerical model was developed accordingly using OLGA to investigate the dynamic behavior in the process of riser outlet choking.
Keyword ：
choking elimination method multiphase flow pattern OLGA predictions severe slugging
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| GB/T 7714 | Li, Nailiang , Chen, Bin , Du, Xueping et al. Experimental and Numerical Study on the Elimination of Severe Slugging by Riser Outlet Choking [J]. | ENERGIES , 2022 , 15 (19) . |
| MLA | Li, Nailiang et al. "Experimental and Numerical Study on the Elimination of Severe Slugging by Riser Outlet Choking" . | ENERGIES 15 . 19 (2022) . |
| APA | Li, Nailiang , Chen, Bin , Du, Xueping , Han, Dongtai . Experimental and Numerical Study on the Elimination of Severe Slugging by Riser Outlet Choking . | ENERGIES , 2022 , 15 (19) . |
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Abstract ：
Real-time monitoring of blood flow and thrombosis formation induced by laser irradiation is critical to reveal the thermal-damage mechanism and successfully implement vascular-dermatology laser surgery. Laser speckle contrast imaging (LSCI) is a non-invasive technique to visualize perfusion in various tissues. However, the ability of the LSCI to monitor the transient thermal response of blood vessels, especially thrombus formation during laser irradiation, requires further research. In this paper, an LSCI system was constructed and a 632 nm He-Ne laser was employed to illuminate a Sprague Dawley rat dorsal skin chamber model irradiated by a 1064 nm Nd: YAG therapy laser. The anisotropic diffusion filtering (ADF) technique is implemented after temporal LSCI (tLSCI) processing to improve the SNR and temporal resolution. The speckle flow index is used to characterize the blood-flow velocity to reduce the computational cost. The combination of the tLSCI and ADF increases the temporal resolution by five times and the SNR by 17.2 times and 16.14 times, without and with laser therapy, respectively. The laser-induced thrombus formation and vascular damage during laser surgery can be visualized without any exogenous labels, which provides a powerful tool for thrombus monitoring during laser surgery. © 2022 by the authors.
Keyword ：
anisotropic diffusion filtering; blood-flow monitoring; laser speckle contrast imaging; thrombus detection; transient thermal response
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| GB/T 7714 | Sang, X. , Chen, B. , Li, D. et al. Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging [J]. | Photonics , 2022 , 9 (8) . |
| MLA | Sang, X. et al. "Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging" . | Photonics 9 . 8 (2022) . |
| APA | Sang, X. , Chen, B. , Li, D. , Pan, D. , Sang, X. . Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging . | Photonics , 2022 , 9 (8) . |
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Abstract ：
Laser lipolysis is a promising body contouring technology. However, the skin tissue could be thermally damaged owing to the laser energy absorption by water, which limits the lipolysis efficiency. To protect skin tissue and improve the lipolysis effect, cryogen spray cooling is introduced and synergized with the pulsed laser irradiation aiming to propose a new therapy protocol. By simulating heat conduction in the skin after spray cooling assisted laser lipolysis, the temperature distribution in the skin tissue was obtained to analyze the tissue damage by the Arrhenius integral. After parameter optimization according to the damage threshold of skin and adipose tissue, a new protocol with high laser intensity and short time was proposed including 150-ms R134a spray cooling with spray distance of 30 mm, and 100 ms 1064 nm laser irradiation with energy density of 20 J/cm(2), with a relaxation for 9.75 s. This cycle of 10 s can be repeated 90 to 150 times for a total of 15 to 25 min. Compared with previous treatment procedure, new protocol can increase the fat dissolution depth from 2 to 4.5 mm beneath the dermis with same order laser fluence.
Keyword ：
1064-nm laser Arrhenius integral Cryogen spray cooling Laser lipolysis Pennes heat transfer model
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| GB/T 7714 | Yu, Fangbo , Xin, Hui , Chen, Bin et al. New protocol for the R134a cryogen spray cooling assisted 1064-nm laser lipolysis [J]. | LASERS IN MEDICAL SCIENCE , 2022 , 37 (6) : 2605-2614 . |
| MLA | Yu, Fangbo et al. "New protocol for the R134a cryogen spray cooling assisted 1064-nm laser lipolysis" . | LASERS IN MEDICAL SCIENCE 37 . 6 (2022) : 2605-2614 . |
| APA | Yu, Fangbo , Xin, Hui , Chen, Bin , Zhou, Zhifu , Zhou, Linjie , Gan, Hongwan et al. New protocol for the R134a cryogen spray cooling assisted 1064-nm laser lipolysis . | LASERS IN MEDICAL SCIENCE , 2022 , 37 (6) , 2605-2614 . |
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Abstract ：
The 1064 nm Nd:YAG laser shows a good prospect for the treatment of port-wine stain (PWS), but it is necessary to enhance the blood absorption to laser energy by exogenous chromophore. Owing to the conjunction effect of local surface plasmon resonance (LSPR) by gold nanoparticle and drug delivery as well as lumen blockage abilities by liposome, liposome@Au core-shell nanoparticles are used as exogenous chromophore, and the efficiency of photothermal therapy is studied systematically. In this work, theoretical simulations were conducted to investigate the electric field and solid heat conduction of liposome@Au core-shell nanoparticles with various size and particles distance, aiming to achieve maximum photothermal conversion efficiency during the laser irradiation. Thereafter, liposome@Au core-shell nanoparticles with optimal size and structure were prepared, and in vivo experiments were conducted to evaluate the thermal damage of blood vessels enhanced by liposome@Au core-shell nanoparticles. Theoretical results imply that maximum temperature rise (167 K) is obtained when radius is 45 nm and shell thickness is 5 nm with distance of 4 nm. Liposome@Au core-shell nanoparticles were prepared with diameter of 101 nm and shell thickness of 5 nm according to the finite element simulation of electric field and solid heat conduction. When the molar ratio of chloroauric acid to phospholipid is 2.25, the LSPR absorption peak is about 981 nm, which is close to the wavelength of Nd:YAG laser. In vivo experiments show that injecting liposome@Au core-shell nanoparticles into the blood vessels can effectively reduce the number of laser pulses and the corresponding energy density required for obvious vasoconstriction.
Keyword ：
Liposome@Au core-shell nanoparticles Localized surface plasmon resonance Photothermal conversion Port-wine stains
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| GB/T 7714 | Li, Dong , Zhang, Qianqian , Xing, Linzhuang et al. Theoretical and in vivo experimental investigation of laser hyperthermia for vascular dermatology mediated by liposome@Au core-shell nanoparticles [J]. | LASERS IN MEDICAL SCIENCE , 2022 , 37 (8) : 3269-3277 . |
| MLA | Li, Dong et al. "Theoretical and in vivo experimental investigation of laser hyperthermia for vascular dermatology mediated by liposome@Au core-shell nanoparticles" . | LASERS IN MEDICAL SCIENCE 37 . 8 (2022) : 3269-3277 . |
| APA | Li, Dong , Zhang, Qianqian , Xing, Linzhuang , Chen, Bin . Theoretical and in vivo experimental investigation of laser hyperthermia for vascular dermatology mediated by liposome@Au core-shell nanoparticles . | LASERS IN MEDICAL SCIENCE , 2022 , 37 (8) , 3269-3277 . |
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Abstract ：
Nanoparticle mediated laser induced breakdown can be used for Nanoparticle synthesis, cell nanosurgery and laser induced breakdown spectroscopy. To investi-gate the photo-thermal conversion of gold nanoparticles during pulsed laser irra-diation, the electron-phonon two temperature model was established in this study. The impact of laser energy density and pulse width on the thermal conversion and morphology change of gold nanorods were investigated and compared with exper-imental observations. The results show that the melting threshold of gold nanorods under nanosecond laser irradiation is about twenty times that of femtosecond laser irradiation. The mechanisms of nanorod fragmentation are different between femto and nanosecond laser irradiation: particle melting is more likely to occur in nano-second laser irradiation, while the Coulomb explosion is highly likely to occur in femtosecond laser irradiation.
Keyword ：
electron-phonon-two-temperature model gold nanorods laser induced optical breakdown photo-thermal effect
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| GB/T 7714 | LI, Dong , Zhao, Penghui , Feng, Jing et al. THEORETICAL AND EXPERIMENTAL INVESTIGATIONS ON THE PHOTO-THERMAL EFFECT OF GOLD NANORODS IRRADIATED BY FEMTOSECOND AND NANOSECOND LASER [J]. | THERMAL SCIENCE , 2022 , 26 (4) : 3133-3142 . |
| MLA | LI, Dong et al. "THEORETICAL AND EXPERIMENTAL INVESTIGATIONS ON THE PHOTO-THERMAL EFFECT OF GOLD NANORODS IRRADIATED BY FEMTOSECOND AND NANOSECOND LASER" . | THERMAL SCIENCE 26 . 4 (2022) : 3133-3142 . |
| APA | LI, Dong , Zhao, Penghui , Feng, Jing , Xing, Linzhuang , Chen, Bin , Liao, Dingying . THEORETICAL AND EXPERIMENTAL INVESTIGATIONS ON THE PHOTO-THERMAL EFFECT OF GOLD NANORODS IRRADIATED BY FEMTOSECOND AND NANOSECOND LASER . | THERMAL SCIENCE , 2022 , 26 (4) , 3133-3142 . |
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Abstract ：
Laser therapy has become the golden standard of port wine stain (PWS), but complete clearance of resistant PWSs is still difficult. The application of photodynamic therapy (PDT) in the treatment of PWS shows potential in clinical practice, especially for large-area and deep lesions. In this work, in vivo animal experimental investigation on the coupling effect of PDT with multi-pulse laser (MPL) irradiation on the treatment of PWS was conducted by using a dorsal skin window chamber model. Through visualization of the thermal response of blood vessels and damage evaluation, it is found that the combination of PDT with MPL results in 96.2% more vascular injury than PDT alone and 90% more than MPL alone, thus reducing side effects such as purpura after treatment. The combined therapy also has the benefit of large treatment area, uniform fading effect, shortened light duration, and reduced photosensitizer admit.
Keyword ：
Dorsal skin window chamber In vivo experiment Nd:YAG laser Photodynamic therapy Port wine stain
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| GB/T 7714 | Chen, Bin , Cheng, Lu , Li, Dong et al. Experimental study of combined photodynamic and photothermal therapy in the treatment of port wine stain [J]. | LASERS IN MEDICAL SCIENCE , 2022 , 38 (1) . |
| MLA | Chen, Bin et al. "Experimental study of combined photodynamic and photothermal therapy in the treatment of port wine stain" . | LASERS IN MEDICAL SCIENCE 38 . 1 (2022) . |
| APA | Chen, Bin , Cheng, Lu , Li, Dong , Wu, Tingting , Zeng, Weihui . Experimental study of combined photodynamic and photothermal therapy in the treatment of port wine stain . | LASERS IN MEDICAL SCIENCE , 2022 , 38 (1) . |
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Abstract ：
As one of the most promising thermal management solutions, spray cooling has the advantages of high heat-transfer coefficient and maintaining a low temperature of the cooling surface. By summarizing the influential factors and practical applications of spray cooling, the current challenges and bottlenecks were indicated so as to prompt its potential applications in the future. Firstly, this paper reviewed the heat-transfer mechanism of spray cooling and found that spray cooling is more advantageous for heat dissipation in high-power electronic devices by comparing it with other cooling techniques. Secondly, the latest experimental studies on spray cooling were reviewed in detail, especially the effects of spray parameters, types of working fluid, surface modification, and environmental parameters on the performance of cooling system. Afterwards, the configuration and design of the spray cooling system, as well as its applications in the actual industry (data centers, hybrid electric vehicles, and so on) were enumerated and summarized. Finally, the scientific challenges and technical bottlenecks encountered in the theoretical research and industrial application of spray cooling technology were discussed, and the direction of future efforts were reasonably speculated.
Keyword ：
cooling performance industrial applications spray cooling thermal management
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| GB/T 7714 | Yin, Jing , Wang, Shangming , Sang, Xuehao et al. Spray Cooling as a High-Efficient Thermal Management Solution: A Review [J]. | ENERGIES , 2022 , 15 (22) . |
| MLA | Yin, Jing et al. "Spray Cooling as a High-Efficient Thermal Management Solution: A Review" . | ENERGIES 15 . 22 (2022) . |
| APA | Yin, Jing , Wang, Shangming , Sang, Xuehao , Zhou, Zhifu , Chen, Bin , Thrassos, Panidis et al. Spray Cooling as a High-Efficient Thermal Management Solution: A Review . | ENERGIES , 2022 , 15 (22) . |
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Abstract ：
Background and Objective Owing to the greater absorption affinity for lipo-rich tissue than water, the 1210 nm laser is a promising candidate for transcutaneous lipolysis in the near-infrared band. However, fat reduction is limited because laser therapy may yield thermal injury of normal tissue. A new protocol to incorporate multipulsed cryogen spray cooling is beneficial to improve the lipolysis effect, and the parameters of laser and cooling can be optimized via skin histopathological analysis. Materials and Methods A murine in vivo model of inguinal tissue of SD rats was established to test the effectivity of transcutaneous lipolysis protocol by R134a multipulsed spray cooling assisted 1210 nm laser irradiation. Tissue response of lipolysis with/without cooling 10 days post the treatment was evaluated by histopathological analysis of skin samples stained with hematoxylin-eosin (HE), through which safe and effective parameters for lipolysis were determined. Results From histopathological analysis of the inguinal tissue of SD rats irradiated by the 1210 nm laser alone, the optimal durations are respectively 7 and 3 s (seconds) for low-dosage (6 W) and high-dosage (9 W) therapy, with pronounced lipolysis effect and minimum injury of skin tissue. The multipulsed spray cooling by R134a with a pulse duration of 10 ms (milliseconds), a pulse delay of 2000 ms, and a pulse number of 5 can be introduced to assist the 1210 nm laser therapy with a power of 9 W and a duration of 7 s to achieve desirable fat liquefaction while keeping the complete structure of skin tissue as well as esthetic-related beneficial effects of hair removal and skin rejuvenation. Conclusion Excellent lipolysis effect can be achieved via R134a multipulsed spray cooling assisted high-dosage 1210 nm laser irradiation with reasonably matched laser and cooling parameters. The protocol is as follows: Start MP-CSC for one cycle, and then fire the laser with specific power and duration, while keeping MP-CSC accordingly. This new protocol may promote the safe and effective clinical implement of transcutaneous laser lipolysis in body contouring.
Keyword ：
1210 nm laser histopathological analysis in vivo experiment laser lipolysis multipulsed cryogen spray cooling
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| GB/T 7714 | Xin, Hui , Deng, Chenggang , Zhou, Hongmei et al. Histopathological evaluation of the R134a multipulsed spray cooling assisted 1210 nm laser lipolysis by the murine model in vivo [J]. | LASERS IN SURGERY AND MEDICINE , 2022 , 54 (10) : 1298-1308 . |
| MLA | Xin, Hui et al. "Histopathological evaluation of the R134a multipulsed spray cooling assisted 1210 nm laser lipolysis by the murine model in vivo" . | LASERS IN SURGERY AND MEDICINE 54 . 10 (2022) : 1298-1308 . |
| APA | Xin, Hui , Deng, Chenggang , Zhou, Hongmei , Sang, Xuehao , Chen, Bin . Histopathological evaluation of the R134a multipulsed spray cooling assisted 1210 nm laser lipolysis by the murine model in vivo . | LASERS IN SURGERY AND MEDICINE , 2022 , 54 (10) , 1298-1308 . |
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