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学者姓名：郑焱
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Abstract ：
Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin malignancies, and its incidence rate is increasing worldwide. Proline-rich 11 (PRR11) has been reported to be involved in the occurrence and development of various tumors. However, the role of PRR11 in cSCC remains unknown. In the present study, we observed upregulated expression of PRR11 in cSCC tissues and cell lines. Knockdown of PRR11 in the cSCC cell lines A431 and SCL-1 inhibited cell proliferation by inducing cell cycle arrest during the G1/S phase transition, promoted cell apoptosis, and reduced cell migration and invasion in vitro. Conversely, overexpression of PRR11 promoted cell proliferation, decreased cell apoptosis, and enhanced cell migration and invasion. PRR11 knockdown also inhibited cSCC tumor growth in a mouse xenograft model. Mechanistic investigations by RNA sequencing revealed that 891 genes were differentially expressed genes between cells with PRR11 knockdown and control cells. Enrichment analysis of different genes showed that the epidermal growth factor receptor (EGFR) signaling pathway was the top enriched pathway. We further validated that PRR11 induced EGFR pathway activity, which contributed to cSCC progression. These data suggest that PRR11 may serve as a novel therapeutic target in cSCC.
Keyword ：
apoptosis cSCC EGFR migration proliferation PRR11
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| GB/T 7714 | Wang, Shengbang , Zhang, Xiu , Lei, Hao et al. Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway [J]. | MOLECULAR CARCINOGENESIS , 2023 . |
| MLA | Wang, Shengbang et al. "Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway" . | MOLECULAR CARCINOGENESIS (2023) . |
| APA | Wang, Shengbang , Zhang, Xiu , Lei, Hao , Song, Liumei , Huang, Yingjian , Kang, Tong et al. Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway . | MOLECULAR CARCINOGENESIS , 2023 . |
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Abstract ：
为总结单纯性汗腺棘皮瘤(hidroacanthoma simplex,HS)的临床及组织病理特点,回顾性分析我院2015年1月至2020年8月诊治的5例HS患者及CNKI中检索文献报道的16例HS患者资料.结果示21例患者平均年龄61.1岁(36～86岁),其中男8例,女13例,病程5个月至50年,皮损主要见于躯干、下肢(17/21),也可见于上肢(4/21),皮损表现为斑块,无自觉症状.组织病理表现为表皮内境界清楚的肿瘤细胞团块,肿瘤细胞呈立方形或卵圆形,部分细胞胞质内含有糖原,呈透明状,局部可见导管分化,真皮内无明显变化.免疫组化染色显示:EMA阳性,CEA在导管分化处阳性.16例患者行手术切除,随访无复发及恶变,5例患者具体治疗方式不详.
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| GB/T 7714 | 王宁 , 黄英剑 , 段琪琪 et al. 单纯性汗腺棘皮瘤的临床病理分析 [J]. | 中国麻风皮肤病杂志 , 2022 , 38 (1) : 39-42 . |
| MLA | 王宁 et al. "单纯性汗腺棘皮瘤的临床病理分析" . | 中国麻风皮肤病杂志 38 . 1 (2022) : 39-42 . |
| APA | 王宁 , 黄英剑 , 段琪琪 , 宋刘梅 , 杨鹏举 , 王声榜 et al. 单纯性汗腺棘皮瘤的临床病理分析 . | 中国麻风皮肤病杂志 , 2022 , 38 (1) , 39-42 . |
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Abstract ：
Background This study explored disparities in characteristics and mortalities among four major transmission groups on antiretroviral therapy in northwest China as well as the survival impact of each transmission route. Methods We first examined disparities in demographics and clinical characteristics of the four transmission populations. Kaplan Meier analysis was subsequently conducted to compare survival rates among all groups. At last, Cox proportional hazards regression model was employed to analyze the survival impact of a transmission route among seven main categories of survival factors associated with all-cause mortalities. Results Survival analysis showed significant differences in all-cause, AIDS- and non-AIDS-related deaths among four HIV populations (all P < 0.05). Using homosexuals as the reference, Cox proportional hazards model further revealed that the risk of all-cause death for blood and plasma donors was significantly higher than that of the reference (aHR: 5.21, 95%CI: 1.54-17.67); the risk of non-AIDS-related death for heterosexuals (aHR: 2.07, 95%CI: 1.01-4.20) and that for blood and plasma donors (aHR: 19.81, 95%CI: 5.62-69.89) were both significantly higher than that of the reference. Conclusions Significant disparities were found in characteristics and mortalities among the four transmission groups where mortality disparities were mainly due to non-AIDS-related death. Suggestions are provided for each group to improve their survivorship.
Keyword ：
AIDS Antiretroviral therapy Cohort study HIV Homosexuals Transmission category
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| GB/T 7714 | Feng, Shuo , Zhu, Zirong , Yang, Pengju et al. A comparative analysis on characteristics and mortalities of four key transmission populations on antiretroviral therapy: a retrospective cohort study in Northwest China [J]. | BMC INFECTIOUS DISEASES , 2022 , 22 (1) . |
| MLA | Feng, Shuo et al. "A comparative analysis on characteristics and mortalities of four key transmission populations on antiretroviral therapy: a retrospective cohort study in Northwest China" . | BMC INFECTIOUS DISEASES 22 . 1 (2022) . |
| APA | Feng, Shuo , Zhu, Zirong , Yang, Pengju , Jin, Juan , Tuo, Huihui , Wang, Ning et al. A comparative analysis on characteristics and mortalities of four key transmission populations on antiretroviral therapy: a retrospective cohort study in Northwest China . | BMC INFECTIOUS DISEASES , 2022 , 22 (1) . |
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Abstract ：
Purpose: Cutaneous squamous cell carcinoma (cSCC) is a skin malignant tumor account for approximately one-third of all nonmelanoma skin cancers. Studies have shown that TEA domain transcription factor 1 (TEAD1) is discovered to be involved in the pathogenesis of some human cancers, but to our knowledge its role in cSCC has not been reported.Patients and Methods: Samples from 16 cSCC patients and 27 healthy individuals were obtained for immunohistochemical staining of TEAD1. The expressions of TEAD1 in SCL-1, HSC-1 cells compared with the primary neonatal human epithelial keratinocytes were detected by Western blot and RT-qPCR. Proliferation and cell cycle of TEAD1 knockdown in cSCC cell lines were examined by MTT and flow cytometry analysis. Annexin V/PI and JC-1 staining were used to determine the cell apoptosis.Results: The expression of TEAD1 decreased significantly in cSCC compared to its expression in normal skin tissues and cell lines. Down-regulation of TEAD1 in cSCC cell lines promoted cell growth via regulation of the G2/M progression. Additionally, silence of TEAD1 also protected cells against 5-Fluorouracil-induced apoptosis and decreased the expression of apoptosis-related protein (p53). Conclusion: Our results suggested that TEAD1 expression is down-regulated and functioned as a tumor suppressor in cSCC and that it may serve as a biomarker or therapeutic target of cSCC.
Keyword ：
apoptosis cutaneous squamous cell carcinomas p53 proliferation TEAD1
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| GB/T 7714 | Wang, Ziyang , Liu, Meng , Lei, Hao et al. TEAD1 Silencing Regulates Cell Proliferation and Resistance to 5-Fluorouracil in Cutaneous Squamous Cell Carcinoma [J]. | CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY , 2022 , 15 . |
| MLA | Wang, Ziyang et al. "TEAD1 Silencing Regulates Cell Proliferation and Resistance to 5-Fluorouracil in Cutaneous Squamous Cell Carcinoma" . | CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY 15 (2022) . |
| APA | Wang, Ziyang , Liu, Meng , Lei, Hao , Xiao, Shengxiang , Zheng, Yan . TEAD1 Silencing Regulates Cell Proliferation and Resistance to 5-Fluorouracil in Cutaneous Squamous Cell Carcinoma . | CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY , 2022 , 15 . |
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Abstract ：
Background: The aim of this study was to analyze and compare melanoma gene expression profiles in TCGA database through the application of different genes to explore the pathogenesis of melanoma. Furthermore, we confirmed the extent of the role of KYNU in melanoma and whether it can be a potential target for the diagnosis and treatment of melanoma. Methods: The gene expression profiles of melanoma samples were downloaded from TCGA database, and matrix files were synthesized to screen differential genes. The Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis and GCDA broad institute were used to analyze common gene locus mutations and expression changes in melanoma, as well as methylation. In addition, the expression patterns of KYNU in melanoma were quantified by immunohistochemistry, Western blotting, qRT-PCR, software such as GEO DataSets and the Human Protein Atlas, and meta-analysis of skin diseases. KYNU was overexpressed in keratinocytes (HaCaT and HEKα) and melanoma cells (A375 and H1205-lu). CFDA-SE, Annexin V–PI double staining, and PI single staining were used to investigate the mechanism of KYNU in melanoma and its effects on melanoma proliferation, apoptosis, invasion, and migration. Results: The main signaling pathways involved in melanoma were EGF/EGFR–RAS–BRAF–MEK–ERK–CyclinD1/CDK4, Ras–PI3K–PTEN–PKB/AKT, and p14/p16 (CDKN2A)–MDM2–p53–p21–cyclinD1/CDK4/6–Rb/E2F. Moreover, MITF, KIT, CDH1. NRAS, AKT1, EGFR, TP53, KIT, and CDK4 were elevated in melanoma, whereas PTEN, cAMP, and BCL2 were reduced in melanoma. The copy number of tumor-promoting genes increased, while the copy number of tumor suppressor genes decreased. Changes in the copy number of the above tumor genes enriched in chromosomes were found through SNP gene mutations. The genes whose expression was negatively regulated by DNA methylation in melanoma included KRT18, CDK2, JAK3, BCL2, MITF, MET, CXCL10, EGF, SOX10, SOCS3, and KIT. The mutation rate of KYNU was high according to TCGA database. The KYNU level was decreased in melanoma. Overexpression of KYNU can promote changes in apoptotic BCL-2, metabolic KYN, 3-HAA, invasion and migration MMP9, E-cadherin, and other related proteins in melanoma. Fluorescence staining and flow analysis showed that a slower proliferation rate led to a stronger fluorescence intensity. In melanoma tumor cells with a low expression of KYNU, overexpression of KYNU could promote tumor cell apoptosis. IL-10 induced immunoregulatory changes in melanoma. The expression of MMP9 and AMPK decreased in A375, but the change in BCL-2 was not obvious. The expression of BCL-2 decreased significantly in H1205-lu. A375 showed cell-cycle arrest, indicating that IL-10 could slow down the cell cycle of melanoma. Conclusions: These results provide insights into the pathologic mechanisms of melanoma target genes and KYNU as a biomarker and potential therapeutic factor for melanoma. © 2022 by the authors.
Keyword ：
IL-10; KYNU; melanoma; TCGA; tumor target factors
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| GB/T 7714 | Wang, M. , Liu, M. , Huang, Y. et al. Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma [J]. | Journal of Personalized Medicine , 2022 , 12 (8) . |
| MLA | Wang, M. et al. "Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma" . | Journal of Personalized Medicine 12 . 8 (2022) . |
| APA | Wang, M. , Liu, M. , Huang, Y. , Wang, Z. , Wang, Y. , He, K. et al. Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma . | Journal of Personalized Medicine , 2022 , 12 (8) . |
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Abstract ：
Psoriasis is a chronic inflammatory skin disease, and elevation of proinflammatory cytokine levels is a critical driver of the pathogenesis of psoriasis. Extracellular cold-inducible RNA-binding protein (eCIRP) has been shown to play a role in various acute and chronic inflammatory diseases. C23, a short peptide derived from CIRP, competitively binds CIRP receptors and reduces damage in inflammatory diseases. However, the effect of eCIRP in psoriasis has not been studied. In the present study, we investigated the role of eCIRP in the expression of proinflammatory cytokines in keratinocytes. Our data show that eCIRP expression was increased in the sera of psoriasis patients and imiquimod- (IMQ-) induced psoriatic mice and cells stimulated with proinflammatory cytokines (IL-1 alpha, IL-17A, IL-22, oncostatin M, and TNF-alpha; mix M5). Recombinant human CIRP (rhCIRP) promoted the expression of the proinflammatory cytokines TNF-alpha, IL-6, and IL-8 and the activation of NF-kappaB (NF-kappa B) and ERK1/2 in cultured keratinocytes. We then found that the above effects of eCIRP could be blocked by C23 in both normal keratinocytes and M5-stimulated psoriatic keratinocytes. In addition, in vivo experiments revealed that C23 could effectively ameliorate IMQ-induced psoriatic dermatitis. TNF-alpha and IL-6 mRNA expressions were reduced in the skin lesions of mice with C23-treated IMQ-induced psoriasis, and this effect was accompanied by inhibition of the NF-kappa B and ERK1/2 signaling pathways. In summary, eCIRP plays an important role in the pathogenesis of psoriasis and may become a new target for psoriasis treatment.
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| GB/T 7714 | Zhang, Xiu , Wang, Shengbang , Wang, Wei et al. Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes [J]. | MEDIATORS OF INFLAMMATION , 2022 , 2022 . |
| MLA | Zhang, Xiu et al. "Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes" . | MEDIATORS OF INFLAMMATION 2022 (2022) . |
| APA | Zhang, Xiu , Wang, Shengbang , Wang, Wei , Song, Liumei , Feng, Shuo , Wang, Jingping et al. Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes . | MEDIATORS OF INFLAMMATION , 2022 , 2022 . |
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Abstract ：
Background Eruptive syringomas is a rare variant of syringoma, which is a benign adenoma differentiated from the terminal ducts of the eccrine glands. Nowadays, it's widely valued because of obvious skin lesions, large scope of influence, and high misdiagnosis rate. Objectives We aim to explore the clinical features of eruptive syringomas and the current research progress. Materials and Methods We firstly summarized the clinical features of 90 cases of eruptive syringomas. Then, the chi-square test was used to analyze the relationship between the onset site of eruptive syringomas and age, as well as gender. Finally, we briefly reviewed the previous literature. Results During 12 years, 90 cases of eruptive syringomas were diagnosed in our hospital, including 28 males (31.1%) and 62 females (68.9%). The average diagnosed age was 28.8. Patients from 20 to 40 years old is 63 (70%), which is the most. 60 (66.7%) patients had the course for more than 1 year. Among onset sites, the neck, chest, and abdomen were in the top three. The chi-square test showed that there were no significant differences in the onset sites of patients aged <= 20 and >20 years old (p-value = 0.181), as well as male and female (p-value = 0.363). Conclusion We found that more female than male was affected, and the most common onset sites were the neck, chest, and abdomen. Neither age nor gender was significantly associated with onset site distribution. Our study provides some data support for the research of eruptive syringomas.
Keyword ：
eruptive syringomas etiology onset site review treatment
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| GB/T 7714 | Lei, Hao , Wang, Ziyang , Ma, Xinyu et al. Eruptive syringomas: Summary of ninety cases and a brief literature review [J]. | JOURNAL OF COSMETIC DERMATOLOGY , 2022 . |
| MLA | Lei, Hao et al. "Eruptive syringomas: Summary of ninety cases and a brief literature review" . | JOURNAL OF COSMETIC DERMATOLOGY (2022) . |
| APA | Lei, Hao , Wang, Ziyang , Ma, Xinyu , Zhang, Zhaohan , Feng, Yiguo , Zheng, Yan . Eruptive syringomas: Summary of ninety cases and a brief literature review . | JOURNAL OF COSMETIC DERMATOLOGY , 2022 . |
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Abstract ：
目的 分析GBD 2017数据库中国银屑病数据,探讨中国银屑病疾病流行病学负担,为银屑病的防控提供理论依据.方法 检索GBD 2017数据库中国银屑病的患病数/率、发病数/率、DALYs/DALY率及中国和全球的社会人口学指数(SDI值),统计中国1990-2017年银屑病的流行趋势及年龄、时期、出生队列趋势,并研究银屑病发病率与SDI之间的关系.结果 2017年,中国银屑病患病率及发病率均位于全球偏低水平,患病人数为1990年的1.95倍,患病率、发病率及DALY率均持续上升.中国银屑病发病率年龄趋势呈中间高两头低形态,且男性高于女性.随着SDI值的增加,银屑病的发病率呈线性上升趋势.结论 1990-2017年间,中国银屑病疾病负担显著上升,且与社会发展程度呈正相关.积极研究银屑病准确的流行病学资料及与社会发展水平的关系,对于银屑病诊治、卫生政策制定具有重要意义.
Keyword ：
GBD 2017 负担 银屑病 中国
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| GB/T 7714 | 李慧贤 , 胡丽 , 郑焱 et al. 基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析 [J]. | 中国皮肤性病学杂志 , 2021 , 35 (4) : 386-392 . |
| MLA | 李慧贤 et al. "基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析" . | 中国皮肤性病学杂志 35 . 4 (2021) : 386-392 . |
| APA | 李慧贤 , 胡丽 , 郑焱 , 张键 , 刘文丽 , 高田原 et al. 基于全球疾病负担(GBD)大数据的中国银屑病流行病学负担分析 . | 中国皮肤性病学杂志 , 2021 , 35 (4) , 386-392 . |
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Abstract ：
八年制医学教育模式是皮肤病学教学体系的新生事物.教育部门及高校对其投入大量精力物力,力求为培养皮肤科新一代有潜力的高层次人才奠定基础.挖掘其优势与不足,对于培养新型皮肤科医生,具有应用价值和指导意义.充分利用综合高校优势或前期理工科学院合作培养模式、同时开展器官-系统整合模块教学、PBL、数字化新媒体教学、双语教学等新型教育模式有利于加强对人体各系统的疾病的综合理解并培养具有国际视野的医工交叉复合型皮肤病学人才.综合分析其招生模式、课程体系结构、培养目标定位、质量控制标准与职业发展,为改进皮肤病学八年制教育模式提供参考.
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| GB/T 7714 | 王子阳 , 张梦迪 , 汪炜 et al. 八年制教育模式下皮肤病学医学生的优劣势分析 [J]. | 中国继续医学教育 , 2021 , 13 (24) : 111-114 . |
| MLA | 王子阳 et al. "八年制教育模式下皮肤病学医学生的优劣势分析" . | 中国继续医学教育 13 . 24 (2021) : 111-114 . |
| APA | 王子阳 , 张梦迪 , 汪炜 , 郑焱 . 八年制教育模式下皮肤病学医学生的优劣势分析 . | 中国继续医学教育 , 2021 , 13 (24) , 111-114 . |
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Abstract ：
科研型研究生的培养是加强皮肤性病学人才队伍建设的重要环节.笔者从皮肤性病学科研型研究生的培养现状与问题入手,并从编制个性化培养方案、双轨提升科研和临床能力、关注研究生心理健康发展等角度对解决问题的策略和方案进行了深入的分析与探讨.
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| GB/T 7714 | 丰硕 , 张梦迪 , 吴佳纹 et al. 皮肤性病学科研型研究生培养方式的思考与探讨 [J]. | 皮肤病与性病 , 2021 , 43 (3) : 409-410 . |
| MLA | 丰硕 et al. "皮肤性病学科研型研究生培养方式的思考与探讨" . | 皮肤病与性病 43 . 3 (2021) : 409-410 . |
| APA | 丰硕 , 张梦迪 , 吴佳纹 , 汪炜 , 郑焱 . 皮肤性病学科研型研究生培养方式的思考与探讨 . | 皮肤病与性病 , 2021 , 43 (3) , 409-410 . |
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