©,　2015,　Editorial　Board　of　Journal　of　Xi＇an　Jiaotong　University(Medical　Sciences).　All　right　reserved.Objective:　To　evaluate　the　effects　of　transforming　growth　factor　β1(TGF-β1)　on　migration,　adhesion　and　proliferation　of　periodontal　ligament　stem　cells　(PDLSCs)　and　explore　the　mechanisms　of　PDLSCs-induced　periodontal　remodeling.　Methods:　PDLSCs　were　isolated　and　identified　from　human　teeth.　The　effect　of　TGF-β1　on　migration　of　PDLSCs　was　evaluated　using　transwell　migration　assay.　Cells　attachment　assay　was　used　to　test　the　effect　of　TGF-β1　on　the　adhesion　of　PDLSCs.　In　addition,　the　effect　of　TGF-β1　on　the　proliferation　of　PDLSCs　was　evaluated　by　MTT　and　cell　growth　rate　assay.　Results:　The　results　showed　that　TGF-β1　induced　the　migration　of　PDLSCs　in　a　dose-dependent　manner,　improved　the　adhesion　and　proliferation　of　PDLSCs.　So　we　propose　that　TGF-β1　may　promote　periodium　remodeling　by　inducing　PDLSCs　migration,　following　adhesion　and　proliferation　in　these　areas.　Conclusion:　This　study　demonstrated　for　the　first　time　that　TGF-β1　increases　the　adhesion　and　migration　of　PDLSCs　in　vitro.　The　signal　pathway　is　involved　in　the　TGF-β1-induced　migration　of　PDLSCs　and　the　mechanical-chemical　interaction　during　the　orthodontic　periodontal　remodeling　will　be　researched　in　our　further　studies.