Diffusion　kurtosis　imaging　(DKI),　an　extension　of　diffusion　tensor　imaging　(DTI),　provides　a　practical　method　to　describe　non-Gaussian　water　diffusion　in　neural　tissues.　The　sensitivity　of　DKI　to　detect　the　subtle　changes　in　several　chosen　brain　structures　has　been　studied.　However,　intuitive　and　holistic　methods　to　validate　the　merits　of　DKI　remain　to　be　explored.　In　this　paper,　tract-based　spatial　statistics　(TBSS)　was　used　to　demonstrate　white　matter　alterations　in　both　DKI　and　DTI　parameters　in　preschool　children　(1-6　years;　n=10).　Correlation　analysis　was　also　performed　in　multiple　regions　of　interest　(ROIs).　Fractional　anisotropy,　mean　kurtosis,　axial　kurtosis　and　radial　kurtosis　increased　with　age,　while　mean　diffusivity　and　radial　diffusivity　decreased　significantly　with　age.　Fractional　anisotropy　of　kurtosis　and　axial　diffusivity　were　found　to　be　less　sensitive　to　the　changes　with　age.　These　preliminary　findings　indicated　that　TBSS　could　be　used　to　detect　subtle　changes　of　DKI　parameters　on　the　white　matter　tract.　Kurtosis　parameters,　except　fractional　anisotropy　of　kurtosis,　demonstrated　higher　sensitivity　than　DTI　parameters.　TBSS　may　be　a　convenient　method　to　yield　higher　sensitivity　of　DKI.