Biofabrication　is　an　emerging　multidiscipline　by　integrating　the　manufacturing　technology　and　the　life　science.　It　offeres　new　technical　supports　for　the　manufacturing　of　large　scale　human　tissue/organs,　as　well　as　important　opportunities　for　the　innovative　development　in　manufacturing　technology.　For　the　future　development　of　manufacturing,　a　5D　Printing　was　proposed.　The　connotation　of　5D　printing　was　discussed,　and　the　key　technical　issues　were　put　forward.　Combined　with　the　development　of　biofabriction　technology,　the　fabrication　of　myocardium　scaffolds,　the　brain-like　neuron　tissue　manufacturing,　and　the　manufacturing　of　the　life　machine　hybrid　crawling　robots　were　introduced,　providing　new　solutions　for　the　biofabrication　technology　and　its　innovative　progresses.　©　2020,　China　Mechanical　Engineering　Magazine　Office.　All　right　reserved.