A　56-year-old　man　diagnosed　with　non-Hodgkin＇s　lymphoma　underwent　autologous　bone　marrow　transplantation.　He　was　subsequently　admitted　to　the　hospital　with　fever,　and　his　symptoms　were　initially　controlled　by　multiple　antibiotics,　including　tigecycline.　He　then　developed　a　generalized　body　rash　that　improved　after　treatment　with　anti-allergy　drugs　and　steroids.　Furthermore,　tigecycline　treatment　for　a　second　time　resulted　in　a　severe　skin　reaction　with　systemic　symptoms,　suggesting　toxic　epidermal　necrolysis　syndrome　(TEN).　The　patient　was　shown　to　have　the　slow-metabolizing　cytochrome　P450　2C19　allele,　denoted　CYP2C19*2.　He　was　transferred　to　a　laminar　flow　ward　and　given　strict　mucosal　care,　together　with　corticosteroids　and　intravenous　immunoglobulin.　He　recovered　after　3　weeks　of　treatment.　Tigecycline-induced　Stevens-Johnson　syndrome　(SJS)/TEN　has　rarely　been　reported　in　the　Chinese　population.　However,　our　experience　suggests　that　Asians　are　more　likely　to　have　adverse　reactions　to　drugs　metabolized　by　the　cytochrome　P450　enzyme.　Early　identification　of　drug　reactions　and　immediate　cessation　of　the　suspected　drug　is　essential.　Additionally,　a　combined　therapy　scheme　and　a　clean　laminar　flow　environment　may　improve　the　cure　rate　of　SJS/TEN.