The　microstructure,　mechanical　properties　and　anisotropy　of　Ti-6Al-3Nb-2Zr-1Mo　alloy　made　by　CMT-Wire　Arc　additive　manufacturing(CMT-WAAM)　were　studied.　The　as-built　microstructures　exhibit　irregular　polygons　prior　β　and　grain　boundary　α.　This　technology　can　refine　the　grains,　and　no　columnar　prior　β　grain　morphology　is　observed.　No　martensite　phase　was　discovered.　The　tensile　strength　in　both　directions　have　reached　the　standard　requirements　of　the　same　level　forging.　No　obvious　texture　is　observed,　and　the　anisotropy　in　tensile　behavior　is　not　obvious.　There　is　no　obvious　texture　and　anisotropy　in　the　manufactured　structure.　The　ductility　in　transverse　specimens　was　limited　by　the　presence　of　lack-of-fusion　porosity.　The　impact　toughness　of　x　and　z　direction　is　not　less　than　65　J.　The　impact　fracture　is　typical　ductile　fracture,which　consists　of　a　large　number　of　dimples.　Copyright　©　2021　Transactions　of　the　China　Welding　Institution.　All　rights　reserved.