In　view　of　the　lack　of　appropriate　evaluation　indexes　and　calculation　formulas　of　adsorption　performance　for　vertical　radial　flow　adsorber,　the　effects　of　operation　and　structural　parameters　on　the　flow　uniformity　and　adsorption　time　of　adsorption　layers　were　investigated　and　the　quantitative　relationships　between　various　adsorption　performance　indexes　were　compared　by　using　computational　fluid　dynamics　(CFD)　technology　and　Kriging　response　surface.　The　results　show　that　in　the　adsorption　process,　the　main　adsorption　area　of　H2O　is　on　the　lower　side　of　the　adsorption　layer,　and　the　main　adsorption　area　and　penetration　area　of　CO2　are　gradually　transferred　from　the　lower　side　to　the　upper　side　of　the　adsorption　layer.　The　main　parameters　affecting　the　flow　uniformity　are　the　central　channel　diameter　and　the　adsorption　layer　length,　while　the　main　parameters　affecting　the　adsorption　time　are　the　molecular　sieve　layer　thickness　and　the　operating　flow　rate,　so　the　flow　uniformity　insufficiently　reflect　the　adsorption　performance　of　the　adsorber.　According　to　the　data　of　Kriging　response　surface,　the　correlation　of　adsorption　time　is　obtained,　and　the　fitting　degree　of　the　correlation　is　99.1%,　which　provides　a　theoretical　reference　for　the　design　and　manufacture　of　vertical　radial　flow　adsorber.　©　2022,　Editorial　Board　of　Journal　of　Huazhong　University　of　Science　and　Technology.　All　right　reserved.