In　order　to　reveal　the　laws　of　heat　and　mass　transfer　of　competitive　adsorption　of　CO2　and　H2O　in　the　adsorption　layers　of　vertical　radial　flow　adsorber,　based　on　the　existing　experimental　data　of　CO2　and　H2O　adsorption　of　alumina　and　molecular　sieve,　CFD　(Computational　Fluid　Dynamics)　technology　is　used　to　study　the　binary　adsorption　process　of　CO2　and　H2O　in　the　adsorption　layers.　A　mathematical　model　of　heat　and　mass　transfer　of　competitive　adsorption　of　CO2　and　H2O　in　the　adsorption　layer　is　established,　the　relationship　between　flow　uniformity　and　adsorption　performance　is　analyzed,　and　the　adsorption　performance　of　four　types　of　adsorbers　is　compared.　The　results　show　that　the　flow　uniformity　in　the　adsorption　process　is　a　parameter　reflecting　the　flow　field　distribution　in　the　adsorbers,　which　has　a　similar　change　law　with　the　adsorption　performance　and　can　be　used　to　reflect　the　adsorbent　utilization　rate　and　adsorption　performance　of　vertical　radial　flow　adsorbers.　The　CO2　and　H2O　penetration　regions　of　centripetal　Z-type　are　different,　while　those　of　the　other　three　structures　are　the　same.　The　CO2　penetration　region　and　main　adsorption　region　of　centripetal　π-type　are　the　adsorption　layer　near　the　inlet　side,　and　those　of　the　other　three　structures　are　the　adsorption　layer　opposite　to　the　inlet　side.　In　terms　of　the　adsorber　performance,　the　centrifugal　π-type　has　the　best　performance,　the　pressure　drop　is　12.0%　lower　than　that　of　centripetal　Z-type,　and　the　adsorption　time　is　2.34　times　that　of　centripetal　Z-type.　The　research　results　provide　a　theoretical　reference　for　the　selection　and　design　of　vertical　radial　flow　adsorber.　©　2022,　Editorial　Office　of　Journal　of　Xi＇an　Jiaotong　University.　All　right　reserved.