C5F10O-insulated　environmental-friendly　power　equipment　has　great　potential　to　be　used　in　the　near　future　to　reduce　greenhouse　effect.　During　maintenance,　C5F10O　should　be　supplemented　or　replaced,　and　the　released　gas　is　promisingly　to　be　removed　by　advanced　oxidation　processes,　but　chemical　kinetics　of　C5F10O　with　the　most　reactive　and　dominant　species　center　dot　OH　radical　in　air　plasma　is　still　not　clear.　Therefore,　this　paper　studied　the　degradation　pathways　and　rate　constants　of　C5F10O　+　center　dot　OH　in　both　gaseous　and　aqueous　phases　with　M06-2X/6-31G*　method　and　transition　state　theory.　A　continuum　solvation　model　was　also　employed　to　study　the　influence　of　solvent　on　chemical　kinetics　of　C5F10O　+　center　dot　OH.　The　results　show　that　most　reactions　(except　for　R7　and　R8)　in　both　phases　have　a　similar　transition　state　vibration　mode　leading　to　same　products　but　rate　constants　are　different.　The　rate　constants　of　reactions　R5　and　S5　are　highest　in　corresponding　states,　respectively,　playing　a　dominant　role　in　the　degradation　of　C5F10O　+　center　dot　OH,　but　the　rate　constant　of　reaction　S5　is　much　lower　indicating　that　AOP　treatment　for　C5F10O　in　gas　phase　is　more　effective.　This　work　lays　a　theoretical　basis　for　plasma　modeling　and　experimental　investigation　for　C5F10O　degradation　by　advanced　oxidation　process.