Mechanotransduction　is　the　process　by　which　cells　convert　external　forces　and　physical　constraints　into　biochemical　signals　that　control　several　aspects　of　cellular　behavior.　A　number　of　approaches　have　been　proposed　to　investigate　the　mechanisms　of　mechanotransduction;　however,　it　remains　a　great　challenge　to　develop　a　platform　for　dynamic　multivariate　mechanical　stimulation　of　single　cells　and　small　colonies　of　cells.　In　this　study,　we　combined　polydimethylsiloxane　(PDMS)　and　PDMS/Mxene　nanoplatelets　(MNPs)　to　construct　a　soft　bilayer　nanocomposite　for　extracellular　mechanical　stimulation.　Fast　backlash　actuation　of　the　bilayer　as　a　result　of　near-infrared　irradiation　caused　mechanical　force　stimulation　of　cells　in　a　controllable　manner.　The　excellent　controllability　of　the　light　intensity　and　frequency　allowed　backlash　bending　acceleration　and　frequency　to　be　manipulated.　As　gastric　gland　carcinoma　cell　line　MKN-45　was　the　research　subject,　mechanical　force　loading　conditions　could　trigger　apoptosis　of　the　cells　in　a　stimulation　duration　time-dependent　manner.　Cell　apoptotic　rates　were　positively　related　to　the　duration　time.　In　the　case　of　6　min　mechanical　force　loading,　apoptotic　cell　percentage　rose　to　34.46%　from　5.5%　of　the　control.　This　approach　helps　apply　extracellular　mechanical　forces,　even　with　predesigned　loading　cycles,　and　provides　a　solution　to　study　cell　mechanotransduction　in　complex　force　conditions.　It　is　also　a　promising　therapeutic　technique　for　combining　physical　therapy　and　biomechanics.