Engineering of gold nanorods as multifunctional theranostic agent for photothermal-enhanced radiotherapy of cancer - Details

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Abstract：

Radiotherapy　(RT)　is　an　important　method　in　cancer　treatment.　Devising　conveniently　synthesizable　and　smart　multifunctional　radiosensitizers　is　of　tremendous　significance　to　improve　the　cure　rate　of　RT.　Gold　nanorods　(GNRs),　which　exhibit　high　X-ray　absorption　capacity　and　near-infrared　(NIR)　photothermal　conversion　effectiveness,　could　be　utilized　as　radiosensitizers.　In　the　present　study,　an　all-in-one　theranostic　nanoagent　for　photothermal-enhanced　RT　of　cancer　was　devised　based　on　engineered　GNRs　with　aggregation-induced　emission　(AIE)　attributes.　This　nanoagent-mediated　photothermal　therapy　(PTT)　in　combination　with　RT　(PTT-RT)　demonstrated　excellent　photothermal-enhanced　RT　effect　by　significantly　inhibiting　migration　and　invasion,　increasing　reactive　oxygen　species　(ROS)　production　and　causing　more　DNA　damage　in　two　different　pathological　types　of　cell　lines　of　cervical　cancer,　compared　with　mere　RT.　The　PTT-RT　based　on　this　nanoagent　further　showed　enhanced　RT　effect　in　vivo,　and　increased　the　production　of　some　metabolites　remarkablely　enriched　in　the　phenylalanine　metabolism　pathway　revealed　by　the　metabolomics　analysis,　compared　with　RT　alone.　Meanwhile,　this　nanoagent　exhibited　excellent　computed　tomography　imaging　(CTI)/photoacoustic　imaging　(PAI)/fluorescence　imaging　(FLI)/photothermal　imaging　(PTI)　multi-modal　imaging　capability.　The　present　research　provides　a　multifunctional　platform　for　optimizing　the　efficacy　of　RT　and　enriches　the　mechanism　study　for　GNRs-mediated　photothermal-enhanced　RT.　©　2022　The　Authors

Keyword：

Amino acids Cell culture Computerized tomography Diseases Gold Infrared devices Metabolites Nanoribbons Nanorods Plasmons Radiotherapy X ray absorption

Author Community：

[ 1 ] [Xie, Lina]Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 2 ] [Ying, Xia]Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou; 310006, China
[ 3 ] [Li, Xinyue]Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 4 ] [Tan, Xinyue]Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 5 ] [Zhang, Tianzi]Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 6 ] [Zhang, Xujia]Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 7 ] [Cai, Wen]Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 8 ] [An, Feifei]School of Public Health, Health Science Center, Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 9 ] [Liu, Xiaoli]Institute of Regenerative and Reconstructive Medicine, Med-X Institute, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an 710049, China
[ 10 ] [Liu, Xiaoli]National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China
[ 11 ] [Han, Suxia]Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an 710061, China

Reprint Author's Address：

W. Cai;;Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China;;email: caiwen2016@xjtu.edu.cn;;

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