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Author:

Li, Jialiang (Li, Jialiang.) | Li, Jiaxi (Li, Jiaxi.) | Yang, Yubing (Yang, Yubing.) | He, Xijing (He, Xijing.) | Wei, Xinyu (Wei, Xinyu.) | Tan, Qinghua (Tan, Qinghua.) | Wang, Yiqun (Wang, Yiqun.) | Xu, Siyue (Xu, Siyue.) | Chang, Sue (Chang, Sue.) | Liu, Weiwei (Liu, Weiwei.)

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Abstract:

Beta-tricalcium phosphate (beta-TCP) bioceramics have an inorganic composition similar to the human bone. While conventional methods can only produce ceramic scaffolds with poor controllability, the advancement of 3D-printing, especially stereolithography, made it possible to manufacture controllable, highly precise, micropore ceramic scaffolds. In this study, the stereolithography was applied to produce beta-TCP bioceramics, while ZrO2, Al2O3, Ti6Al4V, and polyetheretherketone (PEEK) were used as controls. Phase analysis, water contact angle tests, and Micro-CT were applied to evaluate the surface properties and scaffold. Hemolytic toxicity, cell proliferation, and morphological assessment were performed to evaluate the biocompatibility. Alkaline phosphatase (ALP) level, mineralization, and qRT-PCR were measured to evaluate the osteointegration. During the manufacturing of beta-TCP, no evident impurity substance and hemolytic toxicity was found. Cells on beta-TCP had good morphologies, and their proliferation capability was similar to Ti6Al4V, which was higher than the other materials. Cells on beta-TCP had higher ALP levels than PEEK. The degree of mineralization was significantly higher on beta-TCP. The expression of osteogenesis-related genes on beta-TCP was similar to Ti6Al4V and higher than the other materials. In this study, the beta-TCP produced by stereolithography had no toxicity, high accuracy, and excellent osteointegration capability, thus resulting as a good choice for bone implants.

Keyword:

beta-TCP bioceramics biocompatibility osteogenesis stereolithography

Author Community:

  • [ 1 ] [Li, Jialiang]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 2 ] [Li, Jiaxi]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 3 ] [Yang, Yubing]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 4 ] [He, Xijing]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 5 ] [Tan, Qinghua]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 6 ] [Wang, Yiqun]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 7 ] [Xu, Siyue]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 8 ] [Chang, Sue]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian, Shaanxi, Peoples R China
  • [ 9 ] [Wei, Xinyu]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Hlth Management, Xian, Shaanxi, Peoples R China
  • [ 10 ] [Liu, Weiwei]Natl Innovat Inst Addit Mfg, Equipment Res Inst, Dept Precis Med Grp, Xian, Shaanxi, Peoples R China

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Source :

OPEN LIFE SCIENCES

ISSN: 2391-5412

Year: 2023

Issue: 1

Volume: 18

0 . 9 3 8

JCR@2020

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 4

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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