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Author:

Yuan Na (Yuan Na.) | Meng Min (Meng Min.) | Liu Caigang (Liu Caigang.) | Feng Lu (Feng Lu.) | Hou Lei (Hou Lei.) | Ning Qian (Ning Qian.) | Xin Guohong (Xin Guohong.) | Pei Li (Pei Li.) | Gu Shanzhi (Gu Shanzhi.) | Li Xiao (Li Xiao.) | Zhao Xinhan (Zhao Xinhan.)

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Abstract:

It is well-established that triple-negative breast cancer (TNBC) is a subtype of breast cancer, characterized by a poor prognosis and aggressive biological behavior. However, the available relevant data on TNBC in non-Western populations are limited. In order to analyze the clinicopathological and molecular biological characteristics and observe survival and prognostic factors, 972 breast cancer patients (156 of whom had TNBC) who received treatment at the First Affiliated Hospital of Medical School of Xi'an Jiaotong University and the First Hospital of China Medical University, between January, 2004 and January, 2007 were retrospectively evaluated. In the univariate analysis, tumor size, TNM stage, axillary lymph node status and recurrence or metastasis were identified as prognostic factors for 7-year disease-free survival (DFS) and overall survival (OS). Our multivariate Cox's regression analysis demonstrated that tumor size and axillary lymph node status were significant prognostic factors for 7-year DFS and OS. Notably, tumor subgroup (TNBC vs. non-TNBC) was a significant prognostic factor associated with 7-year DFS and OS in breast cancer. It was suggested that TNBC exhibited a worse 7-year survival compared with that in non-TNBC patients, most likely due to its more aggressive behavior and insensitivity to specific therapy.

Keyword:

clinicopathological characteristics prognostic analysis survival analysis triple-negative breast cancer

Author Community:

  • [ 1 ] [Yuan Na;Meng Min;Feng Lu;Hou Lei;Ning Qian;Xin Guohong;Pei Li;Zhao Xinhan]Department of Oncology, First Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
  • [ 2 ] [Gu Shanzhi]Department of Forensic Medicine, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
  • [ 3 ] [Li Xiao]Department of Statistics, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.
  • [ 4 ] [Liu Caigang]Department of Breast Surgery, Research Unit of General Surgery, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

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Source :

Molecular and clinical oncology

ISSN: 2049-9450

Year: 2014

Issue: 2

Volume: 2

Page: 245-251

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

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