To　present　a　method　of　ultrasonic　monitoring　imaging　for　the　characterization　of　lesions　in　soft　tissue　induced　by　high　intensity　focused　ultrasound　(HIFU),　differential　integrated　backscatter　(IB)　imaging　technique　was　used　to　monitor　the　HIFU-induced　lesions,　which　combined　IB　parameter　imaging　with　the　digital　differential　method.　The　experiments　of　bovine　muscle　and　liver　in　vitro　were　implemented.　The　differential　IB　images　were　acquired　as　well　as　the　corresponding　B-mode　images　and　the　differential　attenuation　images.　The　differential　IB　images　in　various　thresholds　and　calculation　window　sizes　for　spectrum　analysis　were　also　acquired.　The　differential　IB　imaging　can　characterize　the　HIFU-induced　lesions　in　soft　tissue　effectively.　It　can　identify　the　non-cavitation　lesions　which　can　not　be　detected　in　B-mode　images　and　offer　higher　contrast　and　resolution　than　the　differential　attenuation　images.